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Items: 1 to 50 of 143

1.

Granulysin species segregate to different lysosome-related effector vesicles (LREV) and get mobilized by either classical or non-classical degranulation.

Lettau M, Dietz M, Dohmen K, Leippe M, Kabelitz D, Janssen O.

Mol Immunol. 2019 Mar;107:44-53. doi: 10.1016/j.molimm.2018.12.031. Epub 2019 Jan 16.

PMID:
30658247
2.

The Saposin-Like Protein AplD Displays Pore-Forming Activity and Participates in Defense Against Bacterial Infection During a Multicellular Stage of Dictyostelium discoideum.

Dhakshinamoorthy R, Bitzhenner M, Cosson P, Soldati T, Leippe M.

Front Cell Infect Microbiol. 2018 Mar 15;8:73. doi: 10.3389/fcimb.2018.00073. eCollection 2018.

3.

The Caenorhabditis elegans Proteome Response to Naturally Associated Microbiome Members of the Genus Ochrobactrum.

Cassidy L, Petersen C, Treitz C, Dierking K, Schulenburg H, Leippe M, Tholey A.

Proteomics. 2018 Apr;18(8):e1700426. doi: 10.1002/pmic.201700426. Epub 2018 Mar 30.

PMID:
29513928
4.

Miniaturized dispersive liquid-liquid microextraction and MALDI MS using ionic liquid matrices for the detection of bacterial communication molecules and virulence factors.

Leipert J, Bobis I, Schubert S, Fickenscher H, Leippe M, Tholey A.

Anal Bioanal Chem. 2018 Jul;410(19):4737-4748. doi: 10.1007/s00216-018-0937-6. Epub 2018 Feb 22.

PMID:
29470663
5.

Identification and Quantification of N-Acyl Homoserine Lactones Involved in Bacterial Communication by Small-Scale Synthesis of Internal Standards and Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry.

Leipert J, Treitz C, Leippe M, Tholey A.

J Am Soc Mass Spectrom. 2017 Dec;28(12):2538-2547. doi: 10.1007/s13361-017-1777-x. Epub 2017 Aug 30.

PMID:
28856620
6.

Adhesion forces and mechanics in mannose-mediated acanthamoeba interactions.

Huth S, Reverey JF, Leippe M, Selhuber-Unkel C.

PLoS One. 2017 May 4;12(5):e0176207. doi: 10.1371/journal.pone.0176207. eCollection 2017.

7.

Prejudice and terror management at trial: Effects of defendant race/ethnicity and mortality salience on mock-jurors' verdict judgments.

Leippe MR, Bergold AN, Eisenstadt D.

J Soc Psychol. 2017;157(3):279-294. doi: 10.1080/00224545.2016.1184128. Epub 2016 May 2.

PMID:
27136391
8.

Killing of Trypanozoon Parasites by the Equine Cathelicidin eCATH1.

Cauchard S, Van Reet N, Büscher P, Goux D, Grötzinger J, Leippe M, Cattoir V, Laugier C, Cauchard J.

Antimicrob Agents Chemother. 2016 Apr 22;60(5):2610-9. doi: 10.1128/AAC.01127-15. Print 2016 May.

9.

Superdiffusion dominates intracellular particle motion in the supercrowded cytoplasm of pathogenic Acanthamoeba castellanii.

Reverey JF, Jeon JH, Bao H, Leippe M, Metzler R, Selhuber-Unkel C.

Sci Rep. 2015 Jun 30;5:11690. doi: 10.1038/srep11690.

10.

Overlapping and unique signatures in the proteomic and transcriptomic responses of the nematode Caenorhabditis elegans toward pathogenic Bacillus thuringiensis.

Yang W, Dierking K, Esser D, Tholey A, Leippe M, Rosenstiel P, Schulenburg H.

Dev Comp Immunol. 2015 Jul;51(1):1-9. doi: 10.1016/j.dci.2015.02.010. Epub 2015 Feb 23.

11.

Mechanistic insights into the lipid interaction of an ancient saposin-like protein.

Michalek M, Leippe M.

Biochemistry. 2015 Mar 10;54(9):1778-86. doi: 10.1021/acs.biochem.5b00094. Epub 2015 Feb 26.

PMID:
25715682
12.

Potent antimicrobial peptides against Legionella pneumophila and its environmental host, Acanthamoeba castellanii.

Schlusselhuber M, Humblot V, Casale S, Méthivier C, Verdon J, Leippe M, Berjeaud JM.

Appl Microbiol Biotechnol. 2015 Jun;99(11):4879-91. doi: 10.1007/s00253-015-6381-z. Epub 2015 Jan 16.

PMID:
25592737
13.

Quantitative proteome analysis of Caenorhabditis elegans upon exposure to nematicidal Bacillus thuringiensis.

Treitz C, Cassidy L, Höckendorf A, Leippe M, Tholey A.

J Proteomics. 2015 Jan 15;113:337-50. doi: 10.1016/j.jprot.2014.09.027. Epub 2014 Oct 30.

PMID:
25452134
14.

Characterization and function of the first antibiotic isolated from a vent organism: the extremophile metazoan Alvinella pompejana.

Tasiemski A, Jung S, Boidin-Wichlacz C, Jollivet D, Cuvillier-Hot V, Pradillon F, Vetriani C, Hecht O, Sönnichsen FD, Gelhaus C, Hung CW, Tholey A, Leippe M, Grötzinger J, Gaill F.

PLoS One. 2014 Apr 28;9(4):e95737. doi: 10.1371/journal.pone.0095737. eCollection 2014.

15.

Determination of disulfide linkages in antimicrobial peptides of the macin family by combination of top-down and bottom-up proteomics.

Hung CW, Jung S, Grötzinger J, Gelhaus C, Leippe M, Tholey A.

J Proteomics. 2014 May 30;103:216-26. doi: 10.1016/j.jprot.2014.04.001. Epub 2014 Apr 18.

PMID:
24747305
16.

Pore-forming toxins from pathogenic amoebae.

Leippe M.

Appl Microbiol Biotechnol. 2014 May;98(10):4347-53. doi: 10.1007/s00253-014-5673-z. Epub 2014 Mar 28. Review.

PMID:
24676751
17.

In vitro adhesion of Acanthamoeba castellanii to soft contact lenses depends on water content and disinfection procedure.

Reverey JF, Fromme R, Leippe M, Selhuber-Unkel C.

Cont Lens Anterior Eye. 2014 Aug;37(4):262-6. doi: 10.1016/j.clae.2013.11.010. Epub 2013 Dec 19.

PMID:
24361096
18.

In vitro effectiveness of the antimicrobial peptide eCATH1 against antibiotic-resistant bacterial pathogens of horses.

Schlusselhuber M, Guldbech K, Sevin C, Leippe M, Petry S, Grötzinger J, Giguère S, Cauchard J.

FEMS Microbiol Lett. 2014 Jan;350(2):216-22. doi: 10.1111/1574-6968.12337. Epub 2013 Dec 18.

19.

The equine antimicrobial peptide eCATH1 is effective against the facultative intracellular pathogen Rhodococcus equi in mice.

Schlusselhuber M, Torelli R, Martini C, Leippe M, Cattoir V, Leclercq R, Laugier C, Grötzinger J, Sanguinetti M, Cauchard J.

Antimicrob Agents Chemother. 2013 Oct;57(10):4615-21. doi: 10.1128/AAC.02044-12. Epub 2013 Jul 1.

20.

EGFR signaling in the brain is necessary for olfactory learning in Drosophila larvae.

Rahn T, Leippe M, Roeder T, Fedders H.

Learn Mem. 2013 Mar 19;20(4):194-200. doi: 10.1101/lm.029934.112.

PMID:
23512935
21.

Structure and function of a unique pore-forming protein from a pathogenic acanthamoeba.

Michalek M, Sönnichsen FD, Wechselberger R, Dingley AJ, Hung CW, Kopp A, Wienk H, Simanski M, Herbst R, Lorenzen I, Marciano-Cabral F, Gelhaus C, Gutsmann T, Tholey A, Grötzinger J, Leippe M.

Nat Chem Biol. 2013 Jan;9(1):37-42. doi: 10.1038/nchembio.1116. Epub 2012 Nov 11.

PMID:
23143413
22.

Isolation of erythrocytes infected with viable early stages of Plasmodium falciparum by flow cytometry.

Philipp S, Oberg HH, Janssen O, Leippe M, Gelhaus C.

Cytometry A. 2012 Dec;81(12):1048-54. doi: 10.1002/cyto.a.22226. Epub 2012 Nov 7.

23.

The natural anticancer compounds rocaglamides inhibit the Raf-MEK-ERK pathway by targeting prohibitin 1 and 2.

Polier G, Neumann J, Thuaud F, Ribeiro N, Gelhaus C, Schmidt H, Giaisi M, Köhler R, Müller WW, Proksch P, Leippe M, Janssen O, Désaubry L, Krammer PH, Li-Weber M.

Chem Biol. 2012 Sep 21;19(9):1093-104. doi: 10.1016/j.chembiol.2012.07.012.

24.

Structures of lysenin reveal a shared evolutionary origin for pore-forming proteins and its mode of sphingomyelin recognition.

De Colibus L, Sonnen AF, Morris KJ, Siebert CA, Abrusci P, Plitzko J, Hodnik V, Leippe M, Volpi E, Anderluh G, Gilbert RJ.

Structure. 2012 Sep 5;20(9):1498-507. doi: 10.1016/j.str.2012.06.011. Epub 2012 Jul 19.

25.

SPP-3, a saposin-like protein of Caenorhabditis elegans, displays antimicrobial and pore-forming activity and is located in the intestine and in one head neuron.

Hoeckendorf A, Leippe M.

Dev Comp Immunol. 2012 Sep;38(1):181-6. doi: 10.1016/j.dci.2012.05.007. Epub 2012 Jun 5.

PMID:
22677064
26.

Cationic detergents enable the separation of membrane proteins of Plasmodium falciparum-infected erythrocytes by 2D gel electrophoresis.

Philipp S, Jakoby T, Tholey A, Janssen O, Leippe M, Gelhaus C.

Electrophoresis. 2012 Apr;33(7):1120-8. doi: 10.1002/elps.201100520.

PMID:
22539315
27.
28.

Macin family of antimicrobial proteins combines antimicrobial and nerve repair activities.

Jung S, Sönnichsen FD, Hung CW, Tholey A, Boidin-Wichlacz C, Haeusgen W, Gelhaus C, Desel C, Podschun R, Waetzig V, Tasiemski A, Leippe M, Grötzinger J.

J Biol Chem. 2012 Apr 20;287(17):14246-58. doi: 10.1074/jbc.M111.336495. Epub 2012 Mar 6.

29.

In vitro potential of equine DEFA1 and eCATH1 as alternative antimicrobial drugs in rhodococcosis treatment.

Schlusselhuber M, Jung S, Bruhn O, Goux D, Leippe M, Leclercq R, Laugier C, Grötzinger J, Cauchard J.

Antimicrob Agents Chemother. 2012 Apr;56(4):1749-55. doi: 10.1128/AAC.05797-11. Epub 2012 Jan 9.

30.

Membrane-active antimicrobial peptides and human placental lysosomal extracts are highly active against mycobacteria.

Jena P, Mishra B, Leippe M, Hasilik A, Griffiths G, Sonawane A.

Peptides. 2011 May;32(5):881-7. doi: 10.1016/j.peptides.2011.03.002. Epub 2011 Mar 17.

PMID:
21396418
31.

Effector granules in human T lymphocytes: the luminal proteome of secretory lysosomes from human T cells.

Schmidt H, Gelhaus C, Nebendahl M, Lettau M, Lucius R, Leippe M, Kabelitz D, Janssen O.

Cell Commun Signal. 2011 Jan 21;9(1):4. doi: 10.1186/1478-811X-9-4.

32.

Effector granules in human T lymphocytes: proteomic evidence for two distinct species of cytotoxic effector vesicles.

Schmidt H, Gelhaus C, Nebendahl M, Lettau M, Lucius R, Leippe M, Kabelitz D, Janssen O.

J Proteome Res. 2011 Apr 1;10(4):1603-20. doi: 10.1021/pr100967v. Epub 2011 Feb 22.

PMID:
21247065
33.

Localization of antimicrobial peptides in the tunic of Ciona intestinalis (Ascidiacea, Tunicata) and their involvement in local inflammatory-like reactions.

Di Bella MA, Fedders H, De Leo G, Leippe M.

Results Immunol. 2011 Sep 22;1(1):70-5. doi: 10.1016/j.rinim.2011.09.001. eCollection 2011.

34.

Human beta-defensin 2 and beta-defensin 3 chimeric peptides reveal the structural basis of the pathogen specificity of their parent molecules.

Jung S, Mysliwy J, Spudy B, Lorenzen I, Reiss K, Gelhaus C, Podschun R, Leippe M, Grötzinger J.

Antimicrob Agents Chemother. 2011 Mar;55(3):954-60. doi: 10.1128/AAC.00872-10. Epub 2010 Dec 28.

35.

Allicin and derivates are cysteine protease inhibitors with antiparasitic activity.

Waag T, Gelhaus C, Rath J, Stich A, Leippe M, Schirmeister T.

Bioorg Med Chem Lett. 2010 Sep 15;20(18):5541-3. doi: 10.1016/j.bmcl.2010.07.062. Epub 2010 Aug 6.

PMID:
20692829
36.

The antimicrobial peptide Ci-MAM-A24 is highly active against multidrug-resistant and anaerobic bacteria pathogenic for humans.

Fedders H, Podschun R, Leippe M.

Int J Antimicrob Agents. 2010 Sep;36(3):264-6. doi: 10.1016/j.ijantimicag.2010.04.008.

PMID:
20627462
37.

Constrained peptidomimetics as antiplasmodial falcipain-2 inhibitors.

Bova F, Ettari R, Micale N, Carnovale C, Schirmeister T, Gelhaus C, Leippe M, Grasso S, Zappalà M.

Bioorg Med Chem. 2010 Jul 15;18(14):4928-38. doi: 10.1016/j.bmc.2010.06.010. Epub 2010 Jun 10.

PMID:
20598553
38.

Synthesis of novel peptidomimetics as inhibitors of protozoan cysteine proteases falcipain-2 and rhodesain.

Ettari R, Zappalà M, Micale N, Schirmeister T, Gelhaus C, Leippe M, Evers A, Grasso S.

Eur J Med Chem. 2010 Jul;45(7):3228-33. doi: 10.1016/j.ejmech.2010.04.003. Epub 2010 Apr 14.

PMID:
20434817
39.

Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids.

Breuning A, Degel B, Schulz F, Büchold C, Stempka M, Machon U, Heppner S, Gelhaus C, Leippe M, Leyh M, Kisker C, Rath J, Stich A, Gut J, Rosenthal PJ, Schmuck C, Schirmeister T.

J Med Chem. 2010 Mar 11;53(5):1951-63. doi: 10.1021/jm900946n.

PMID:
20131843
40.

The adapter protein Nck: role of individual SH3 and SH2 binding modules for protein interactions in T lymphocytes.

Lettau M, Pieper J, Gerneth A, Lengl-Janssen B, Voss M, Linkermann A, Schmidt H, Gelhaus C, Leippe M, Kabelitz D, Janssen O.

Protein Sci. 2010 Apr;19(4):658-69. doi: 10.1002/pro.334.

41.

Caenopore-5: the three-dimensional structure of an antimicrobial protein from Caenorhabditis elegans.

Mysliwy J, Dingley AJ, Stanisak M, Jung S, Lorenzen I, Roeder T, Leippe M, Grötzinger J.

Dev Comp Immunol. 2010 Mar;34(3):323-30. doi: 10.1016/j.dci.2009.11.003. Epub 2009 Nov 26.

PMID:
19917307
42.

Caenopores are antimicrobial peptides in the nematode Caenorhabditis elegans instrumental in nutrition and immunity.

Roeder T, Stanisak M, Gelhaus C, Bruchhaus I, Grötzinger J, Leippe M.

Dev Comp Immunol. 2010 Feb;34(2):203-9. doi: 10.1016/j.dci.2009.09.010. Epub 2009 Oct 21.

PMID:
19818806
43.

On-bead screening of a combinatorial fumaric acid derived peptide library yields antiplasmodial cysteine protease inhibitors with unusual peptide sequences.

Machon U, Büchold C, Stempka M, Schirmeister T, Gelhaus C, Leippe M, Gut J, Rosenthal PJ, Kisker C, Leyh M, Schmuck C.

J Med Chem. 2009 Sep 24;52(18):5662-72. doi: 10.1021/jm900629w.

PMID:
19715342
44.

Novel 2H-isoquinolin-3-ones as antiplasmodial falcipain-2 inhibitors.

Micale N, Ettari R, Schirmeister T, Evers A, Gelhaus C, Leippe M, Zappalà M, Grasso S.

Bioorg Med Chem. 2009 Sep 15;17(18):6505-11. doi: 10.1016/j.bmc.2009.08.013. Epub 2009 Aug 12.

PMID:
19709887
45.

Enrichment and analysis of secretory lysosomes from lymphocyte populations.

Schmidt H, Gelhaus C, Lucius R, Nebendahl M, Leippe M, Janssen O.

BMC Immunol. 2009 Jul 29;10:41. doi: 10.1186/1471-2172-10-41.

46.

2-D DIGE analysis of the proteome of extracts from peanut variants reveals striking differences in major allergen contents.

Schmidt H, Gelhaus C, Latendorf T, Nebendahl M, Petersen A, Krause S, Leippe M, Becker WM, Janssen O.

Proteomics. 2009 Jul;9(13):3507-21. doi: 10.1002/pmic.200800938.

PMID:
19609960
47.

Cell-free synthesis and combinatorial selective 15N-labeling of the cytotoxic protein amoebapore A from Entamoeba histolytica.

Xun Y, Tremouilhac P, Carraher C, Gelhaus C, Ozawa K, Otting G, Dixon NE, Leippe M, Grötzinger J, Dingley AJ, Kralicek AV.

Protein Expr Purif. 2009 Nov;68(1):22-7. doi: 10.1016/j.pep.2009.06.017. Epub 2009 Jun 30.

PMID:
19573603
48.

Major cysteine peptidases of Entamoeba histolytica are required for aggregation and digestion of erythrocytes but are dispensable for phagocytosis and cytopathogenicity.

Irmer H, Tillack M, Biller L, Handal G, Leippe M, Roeder T, Tannich E, Bruchhaus I.

Mol Microbiol. 2009 May;72(3):658-67. doi: 10.1111/j.1365-2958.2009.06672.x.

49.

Novel peptidomimetics containing a vinyl ester moiety as highly potent and selective falcipain-2 inhibitors.

Ettari R, Micale N, Schirmeister T, Gelhaus C, Leippe M, Nizi E, Di Francesco ME, Grasso S, Zappalà M.

J Med Chem. 2009 Apr 9;52(7):2157-60. doi: 10.1021/jm900047j.

PMID:
19296600
50.

Membrane activity of a C-reactive protein.

Harrington JM, Chou HT, Gutsmann T, Gelhaus C, Stahlberg H, Leippe M, Armstrong PB.

FEBS Lett. 2009 Mar 18;583(6):1001-5. doi: 10.1016/j.febslet.2009.02.019. Epub 2009 Feb 21.

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