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nNOS-Expressing Neurons in the Ventral Tegmental Area and Substantia Nigra Pars Compacta.

Paul EJ, Kalk E, Tossell K, Irvine EE, Franks NP, Wisden W, Withers DJ, Leiper J, Ungless MA.

eNeuro. 2018 Nov 16;5(5). pii: ENEURO.0381-18.2018. doi: 10.1523/ENEURO.0381-18.2018. eCollection 2018 Sep-Oct.


Rapid onset of severe septic shock in the pregnant mouse†.

Zöllner J, Lambden S, Nasri NM, Leiper J, Johnson MR.

Biol Reprod. 2019 Feb 1;100(2):505-513. doi: 10.1093/biolre/ioy193.


Regulation of fluid reabsorption in rat or mouse proximal renal tubules by asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase 1.

Bell T, Araujo M, Luo Z, Tomlinson J, Leiper J, Welch WJ, Wilcox CS.

Am J Physiol Renal Physiol. 2018 Jul 1;315(1):F74-F78. doi: 10.1152/ajprenal.00560.2017. Epub 2018 Mar 7.


NRF2 prevents hypertension, increased ADMA, microvascular oxidative stress, and dysfunction in mice with two weeks of ANG II infusion.

Wang C, Luo Z, Carter G, Wellstein A, Jose PA, Tomlinson J, Leiper J, Welch WJ, Wilcox CS, Wang D.

Am J Physiol Regul Integr Comp Physiol. 2018 Mar 1;314(3):R399-R406. doi: 10.1152/ajpregu.00122.2017. Epub 2017 Nov 22.


The response of the innate immune and cardiovascular systems to LPS in pregnant and nonpregnant mice.

Zöllner J, Howe LG, Edey LF, O'Dea KP, Takata M, Gordon F, Leiper J, Johnson MR.

Biol Reprod. 2017 Aug 1;97(2):258-272. doi: 10.1093/biolre/iox076.


Metabolomic profiling of amines in sepsis predicts changes in NOS canonical pathways.

Tesfai A, MacCallum N, Kirkby NS, Gashaw H, Gray N, Want E, Quinlan GJ, Mumby S, Leiper JM, Paul-Clark M, Ahmetaj-Shala B, Mitchell JA.

PLoS One. 2017 Aug 15;12(8):e0183025. doi: 10.1371/journal.pone.0183025. eCollection 2017.


A Novel Pathway for Metabolism of the Cardiovascular Risk Factor Homoarginine by alanine:glyoxylate aminotransferase 2.

Rodionov RN, Oppici E, Martens-Lobenhoffer J, Jarzebska N, Brilloff S, Burdin D, Demyanov A, Kolouschek A, Leiper J, Maas R, Cellini B, Weiss N, Bode-Böger SM.

Sci Rep. 2016 Oct 18;6:35277. doi: 10.1038/srep35277.


Hypoxia causes increased monocyte nitric oxide synthesis which is mediated by changes in dimethylarginine dimethylaminohydrolase 2 expression in animal and human models of normobaric hypoxia.

Lambden S, Martin D, Vanezis K, Lee B, Tomlinson J, Piper S, Boruc O, Mythen M, Leiper J.

Nitric Oxide. 2016 Aug 31;58:59-66. doi: 10.1016/j.niox.2016.06.003. Epub 2016 Jun 16.


Dimethylarginine dimethylaminohydrolase-2 deficiency promotes vascular regeneration and attenuates pathological angiogenesis.

Lange C, Mowat F, Sayed H, Mehad M, Duluc L, Piper S, Luhmann U, Nandi M, Kelly P, Smith A, Ali R, Leiper J, Bainbridge J.

Exp Eye Res. 2016 Jun;147:148-155. doi: 10.1016/j.exer.2016.05.007. Epub 2016 May 12.


Reply to letter regarding article, "evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs".

Ahmetaj-Shala B, Kirkby NS, Knowles R, Al'Yamani M, Mazi S, Wang Z, Tucker AT, Mackenzie LS, Armstrong PC, Nüsing RM, Tomlinson JA, Warner TD, Leiper J, Mitchell JA.

Circulation. 2015 Oct 27;132(17):e213-4. doi: 10.1161/CIRCULATIONAHA.115.017260. No abstract available.


Executive summary and conclusions from the European Hydration Institute Expert Conference on human hydration, health, and performance.

Benton D, Braun H, Cobo JC, Edmonds C, Elmadfa I, El-Sharkawy A, Feehally J, Gellert R, Holdsworth J, Kapsokefalou M, Kenney WL, Leiper JB, Macdonald IA, Maffeis C, Maughan RJ, Shirreffs SM, Toth-Heyn P, Watson P.

Nutr Rev. 2015 Sep;73 Suppl 2:148-50. doi: 10.1093/nutrit/nuv056.


Fate of ingested fluids: factors affecting gastric emptying and intestinal absorption of beverages in humans.

Leiper JB.

Nutr Rev. 2015 Sep;73 Suppl 2:57-72. doi: 10.1093/nutrit/nuv032. Review.


Dimethylarginine dimethylaminohydrolase 1 is involved in spinal nociceptive plasticity.

DʼMello R, Sand CA, Pezet S, Leiper JM, Gaurilcikaite E, McMahon SB, Dickenson AH, Nandi M.

Pain. 2015 Oct;156(10):2052-60. doi: 10.1097/j.pain.0000000000000269.


Endothelial Dimethylarginine Dimethylaminohydrolase 1 Is an Important Regulator of Angiogenesis but Does Not Regulate Vascular Reactivity or Hemodynamic Homeostasis.

Dowsett L, Piper S, Slaviero A, Dufton N, Wang Z, Boruc O, Delahaye M, Colman L, Kalk E, Tomlinson J, Birdsey G, Randi AM, Leiper J.

Circulation. 2015 Jun 23;131(25):2217-25. doi: 10.1161/CIRCULATIONAHA.114.015064. Epub 2015 Apr 24.


Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in polymicrobial sepsis.

Lambden S, Kelly P, Ahmetaj-Shala B, Wang Z, Lee B, Nandi M, Torondel B, Delahaye M, Dowsett L, Piper S, Tomlinson J, Caplin B, Colman L, Boruc O, Slaviero A, Zhao L, Oliver E, Khadayate S, Singer M, Arrigoni F, Leiper J.

Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1382-92. doi: 10.1161/ATVBAHA.115.305278. Epub 2015 Apr 9.


Reduced Renal Methylarginine Metabolism Protects against Progressive Kidney Damage.

Tomlinson JA, Caplin B, Boruc O, Bruce-Cobbold C, Cutillas P, Dormann D, Faull P, Grossman RC, Khadayate S, Mas VR, Nitsch DD, Wang Z, Norman JT, Wilcox CS, Wheeler DC, Leiper J.

J Am Soc Nephrol. 2015 Dec;26(12):3045-59. doi: 10.1681/ASN.2014030280. Epub 2015 Apr 8.


Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs.

Ahmetaj-Shala B, Kirkby NS, Knowles R, Al'Yamani M, Mazi S, Wang Z, Tucker AT, Mackenzie L, Armstrong PC, Nüsing RM, Tomlinson JA, Warner TD, Leiper J, Mitchell JA.

Circulation. 2015 Feb 17;131(7):633-42. doi: 10.1161/CIRCULATIONAHA.114.011591. Epub 2014 Dec 9.


Overexpression of GTP cyclohydrolase 1 feedback regulatory protein is protective in a murine model of septic shock.

Starr A, Sand CA, Heikal L, Kelly PD, Spina D, Crabtree M, Channon KM, Leiper JM, Nandi M.

Shock. 2014 Nov;42(5):432-9. doi: 10.1097/SHK.0000000000000235.


miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia.

Iannone L, Zhao L, Dubois O, Duluc L, Rhodes CJ, Wharton J, Wilkins MR, Leiper J, Wojciak-Stothard B.

Biochem J. 2014 Aug 15;462(1):103-12. doi: 10.1042/BJ20140486.


Epigenetic and neurological effects and safety of high-dose nicotinamide in patients with Friedreich's ataxia: an exploratory, open-label, dose-escalation study.

Libri V, Yandim C, Athanasopoulos S, Loyse N, Natisvili T, Law PP, Chan PK, Mohammad T, Mauri M, Tam KT, Leiper J, Piper S, Ramesh A, Parkinson MH, Huson L, Giunti P, Festenstein R.

Lancet. 2014 Aug 9;384(9942):504-13. doi: 10.1016/S0140-6736(14)60382-2. Epub 2014 Apr 30.


Response to letters regarding article, "unexpected effect of proton pump inhibitors: elevation of the cardiovascular risk factor asymmetric dimethylarginine".

Ghebremariam YT, Lee JC, LePendu P, Erlanson DA, Slaviero A, Shah NH, Leiper JM, Cooke JP.

Circulation. 2014 Apr 1;129(13):e428. doi: 10.1161/CIRCULATIONAHA.114.009343. No abstract available.


Role of asymmetric methylarginine and connexin 43 in the regulation of pulmonary endothelial function.

Tsang H, Leiper J, Hou Lao K, Dowsett L, Delahaye MW, Barnes G, Wharton J, Howard L, Iannone L, Lang NN, Wilkins MR, Wojciak-Stothard B.

Pulm Circ. 2013 Sep;3(3):675-91. doi: 10.1086/674440. Epub 2013 Dec 4.


Pharmacological inhibition of DDAH1 improves survival, haemodynamics and organ function in experimental septic shock.

Wang Z, Lambden S, Taylor V, Sujkovic E, Nandi M, Tomlinson J, Dyson A, McDonald N, Caddick S, Singer M, Leiper J.

Biochem J. 2014 Jun 1;460(2):309-16. doi: 10.1042/BJ20131666.


Unexpected effect of proton pump inhibitors: elevation of the cardiovascular risk factor asymmetric dimethylarginine.

Ghebremariam YT, LePendu P, Lee JC, Erlanson DA, Slaviero A, Shah NH, Leiper J, Cooke JP.

Circulation. 2013 Aug 20;128(8):845-53. doi: 10.1161/CIRCULATIONAHA.113.003602. Epub 2013 Jul 3.


Alanine-glyoxylate aminotransferase-2 metabolizes endogenous methylarginines, regulates NO, and controls blood pressure.

Caplin B, Wang Z, Slaviero A, Tomlinson J, Dowsett L, Delahaye M, Salama A; International Consortium for Blood Pressure Genome-Wide Association Studies, Wheeler DC, Leiper J.

Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):2892-900. doi: 10.1161/ATVBAHA.112.254078. Epub 2012 Sep 27.


Genetic and pharmacological inhibition of dimethylarginine dimethylaminohydrolase 1 is protective in endotoxic shock.

Nandi M, Kelly P, Torondel B, Wang Z, Starr A, Ma Y, Cunningham P, Stidwill R, Leiper J.

Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):2589-97. doi: 10.1161/ATVBAHA.112.300232. Epub 2012 Sep 20.


The effects of Ramadan intermittent fasting on athletic performance: recommendations for the maintenance of physical fitness.

Chaouachi A, Leiper JB, Chtourou H, Aziz AR, Chamari K.

J Sports Sci. 2012;30 Suppl 1:S53-73. doi: 10.1080/02640414.2012.698297. Epub 2012 Jun 27. Review.


Endogenous nitric oxide synthase inhibitors in the biology of disease: markers, mediators, and regulators?

Caplin B, Leiper J.

Arterioscler Thromb Vasc Biol. 2012 Jun;32(6):1343-53. doi: 10.1161/ATVBAHA.112.247726. Epub 2012 Mar 29. Review.


The role of ATM in response to metformin treatment and activation of AMPK.

Woods A, Leiper JM, Carling D.

Nat Genet. 2012 Mar 28;44(4):360-1. doi: 10.1038/ng.2235. No abstract available.


The role of dimethylarginine dimethylaminohydrolase in idiopathic pulmonary fibrosis.

Pullamsetti SS, Savai R, Dumitrascu R, Dahal BK, Wilhelm J, Konigshoff M, Zakrzewicz D, Ghofrani HA, Weissmann N, Eickelberg O, Guenther A, Leiper J, Seeger W, Grimminger F, Schermuly RT.

Sci Transl Med. 2011 Jun 15;3(87):87ra53. doi: 10.1126/scitranslmed.3001725.


Symmetric dimethylarginine (SDMA) is raised in women with polycystic ovary syndrome: a pilot study.

Lakhani K, Kay AR, Leiper J, Barry JA, Hardiman PJ.

J Obstet Gynaecol. 2011 Jul;31(5):417-9. doi: 10.3109/01443615.2011.569779.


Active site mutant dimethylarginine dimethylaminohydrolase 1 expression confers an intermediate tumour phenotype in C6 gliomas.

Boult JK, Walker-Samuel S, Jamin Y, Leiper JM, Whitley GS, Robinson SP.

J Pathol. 2011 Nov;225(3):344-52. doi: 10.1002/path.2904. Epub 2011 May 18.


The therapeutic potential of targeting endogenous inhibitors of nitric oxide synthesis.

Leiper J, Nandi M.

Nat Rev Drug Discov. 2011 Apr;10(4):277-91. doi: 10.1038/nrd3358. Review.


cAMP phosphodiesterase inhibitors increases nitric oxide production by modulating dimethylarginine dimethylaminohydrolases.

Pullamsetti SS, Savai R, Schaefer MB, Wilhelm J, Ghofrani HA, Weissmann N, Schudt C, Fleming I, Mayer K, Leiper J, Seeger W, Grimminger F, Schermuly RT.

Circulation. 2011 Mar 22;123(11):1194-204. doi: 10.1161/CIRCULATIONAHA.110.941484. Epub 2011 Mar 7.


The biology and therapeutic potential of the DDAH/ADMA pathway.

Arrigoni F, Ahmetaj B, Leiper J.

Curr Pharm Des. 2010;16(37):4089-102. Review.


Adenoviral-mediated overexpression of DDAH improves vascular tone regulation.

Torondel B, Nandi M, Kelly P, Wojciak-Stothard B, Fleming I, Leiper J.

Vasc Med. 2010 Jun;15(3):205-13. doi: 10.1177/1358863X09360264. Epub 2010 Mar 10.


Effects of Ramadan intermittent fasting on sports performance and training: a review.

Chaouachi A, Leiper JB, Souissi N, Coutts AJ, Chamari K.

Int J Sports Physiol Perform. 2009 Dec;4(4):419-34. Review.


Circulating methylarginine levels and the decline in renal function in patients with chronic kidney disease are modulated by DDAH1 polymorphisms.

Caplin B, Nitsch D, Gill H, Hoefield R, Blackwell S, MacKenzie D, Cooper JA, Middleton RJ, Talmud PJ, Veitch P, Norman J, Wheeler DC, Leiper JM.

Kidney Int. 2010 Mar;77(5):459-67. doi: 10.1038/ki.2009.463. Epub 2009 Dec 9.


Regulation of the ADMA-DDAH system in endothelial cells: a novel mechanism for the sterol response element binding proteins, SREBP1c and -2.

Ivashchenko CY, Bradley BT, Ao Z, Leiper J, Vallance P, Johns DG.

Am J Physiol Heart Circ Physiol. 2010 Jan;298(1):H251-8. doi: 10.1152/ajpheart.00195.2009. Epub 2009 Nov 13.


The ADMA/DDAH pathway regulates VEGF-mediated angiogenesis.

Fiedler LR, Bachetti T, Leiper J, Zachary I, Chen L, Renné T, Wojciak-Stothard B.

Arterioscler Thromb Vasc Biol. 2009 Dec;29(12):2117-24. doi: 10.1161/ATVBAHA.109.194035. Epub 2009 Sep 24.


A role for Dimethylarginine Dimethylaminohydrolase 1 (DDAH1) in mammalian development.

Breckenridge RA, Kelly P, Nandi M, Vallance PJ, Ohun TJ, Leiper J.

Int J Dev Biol. 2010;54(1):215-20. doi: 10.1387/ijdb.072356rb.


Immunolocalisation and activity of DDAH I and II in the heart and modification post-myocardial infarction.

Gray GA, Patrizio M, Sherry L, Miller AA, Malaki M, Wallace AF, Leiper JM, Vallance P.

Acta Histochem. 2010 Sep;112(5):413-23. doi: 10.1016/j.acthis.2009.02.009. Epub 2009 May 29.


Intensity of a training session during Ramadan in fasting and non-fasting Tunisian youth football players.

Leiper JB, Watson P, Evans G, Dvorak J.

J Sports Sci. 2008 Dec;26 Suppl 3:S71-9. doi: 10.1080/02640410802526924.


Alteration of subjective feelings in football players undertaking their usual training and match schedule during the Ramadan fast.

Leiper JB, Junge A, Maughan RJ, Zerguini Y, Dvorak J.

J Sports Sci. 2008 Dec;26 Suppl 3:S55-69. doi: 10.1080/02640410802538176.


Effect of Ramadan fasting on some biochemical and haematological parameters in Tunisian youth soccer players undertaking their usual training and competition schedule.

Maughan RJ, Leiper JB, Bartagi Z, Zrifi R, Zerguini Y, Dvorak J.

J Sports Sci. 2008 Dec;26 Suppl 3:S39-46. doi: 10.1080/02640410802491368.


The influence of Ramadan on physical performance measures in young Muslim footballers.

Kirkendall DT, Leiper JB, Bartagi Z, Dvorak J, Zerguini Y.

J Sports Sci. 2008 Dec;26 Suppl 3:S15-27. doi: 10.1080/02640410802422199.


The F-MARC study on Ramadan and football: research design, population, and environmental conditions.

Leiper JB, Maughan RJ, Kirkendall DT, Bartagi Z, Zerguini Y, Junge A, Dvorak J.

J Sports Sci. 2008 Dec;26 Suppl 3:S7-13. doi: 10.1080/02640410802392723.


Influence of Ramadan fasting on physiological and performance variables in football players: summary of the F-MARC 2006 Ramadan fasting study.

Zerguini Y, Dvorak J, Maughan RJ, Leiper JB, Bartagi Z, Kirkendall DT, Al-Riyami M, Junge A.

J Sports Sci. 2008 Dec;26 Suppl 3:S3-6. doi: 10.1080/02640410802614944.


Modulation of Rac1 activity by ADMA/DDAH regulates pulmonary endothelial barrier function.

Wojciak-Stothard B, Torondel B, Zhao L, Renné T, Leiper JM.

Mol Biol Cell. 2009 Jan;20(1):33-42. doi: 10.1091/mbc.E08-04-0395. Epub 2008 Oct 15.

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