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Transcatheter aortic valve replacements alter circulating serum factors to mediate myofibroblast deactivation.

Aguado BA, Schuetze KB, Grim JC, Walker CJ, Cox AC, Ceccato TL, Tan AC, Sucharov CC, Leinwand LA, Taylor MRG, McKinsey TA, Anseth KS.

Sci Transl Med. 2019 Sep 11;11(509). pii: eaav3233. doi: 10.1126/scitranslmed.aav3233.


The ATPase cycle of human muscle myosin II Isoforms: adaptation of a single mechanochemical cycle for different physiological roles.

Johnson CA, Walklate J, Svicevic M, Mijailovich SM, Vera CD, Karabina A, Leinwand LA, Geeves MA.

J Biol Chem. 2019 Aug 6. pii: jbc.RA119.009825. doi: 10.1074/jbc.RA119.009825. [Epub ahead of print]


Expression of Normally Repressed Myosin Heavy Chain 7b in the Mammalian Heart Induces Dilated Cardiomyopathy.

Peter AK, Rossi AC, Buvoli M, Ozeroff CD, Crocini C, Perry AR, Buvoli AE, Lee LA, Leinwand LA.

J Am Heart Assoc. 2019 Aug 6;8(15):e013318. doi: 10.1161/JAHA.119.013318. Epub 2019 Jul 31.


Three-dimensional encapsulation of adult mouse cardiomyocytes in hydrogels with tunable stiffness.

Crocini C, Walker CJ, Anseth KS, Leinwand LA.

Prog Biophys Mol Biol. 2019 May 20. pii: S0079-6107(19)30051-3. doi: 10.1016/j.pbiomolbio.2019.04.008. [Epub ahead of print]


PEG-Anthracene Hydrogels as an On-Demand Stiffening Matrix To Study Mechanobiology.

Günay KA, Ceccato TL, Silver JS, Bannister KL, Bednarski OJ, Leinwand LA, Anseth KS.

Angew Chem Int Ed Engl. 2019 Jul 15;58(29):9912-9916. doi: 10.1002/anie.201901989. Epub 2019 Jun 11.


The ancient sarcomeric myosins found in specialized muscles.

Lee LA, Karabina A, Broadwell LJ, Leinwand LA.

Skelet Muscle. 2019 Mar 5;9(1):7. doi: 10.1186/s13395-019-0192-3. Review.


Entrepreneurialism in the Translational Biologic Sciences: Why, How, and However.

Bristow MR, Leinwand LA, Olson EN.

JACC Basic Transl Sci. 2018 Mar 1;3(1):1-8. doi: 10.1016/j.jacbts.2017.10.004. eCollection 2018 Feb.


Pregnancy late in rodent life has detrimental effects on the heart.

Chung E, Haizlip KM, Leinwand LA.

Am J Physiol Heart Circ Physiol. 2018 Sep 1;315(3):H482-H491. doi: 10.1152/ajpheart.00020.2018. Epub 2018 May 11.


Dilated cardiomyopathy myosin mutants have reduced force-generating capacity.

Ujfalusi Z, Vera CD, Mijailovich SM, Svicevic M, Yu EC, Kawana M, Ruppel KM, Spudich JA, Geeves MA, Leinwand LA.

J Biol Chem. 2018 Jun 8;293(23):9017-9029. doi: 10.1074/jbc.RA118.001938. Epub 2018 Apr 17.


Allele-specific differences in transcriptome, miRNome, and mitochondrial function in two hypertrophic cardiomyopathy mouse models.

Vakrou S, Fukunaga R, Foster DB, Sorensen L, Liu Y, Guan Y, Woldemichael K, Pineda-Reyes R, Liu T, Tardiff JC, Leinwand LA, Tocchetti CG, Abraham TP, O'Rourke B, Aon MA, Abraham MR.

JCI Insight. 2018 Mar 22;3(6). pii: 94493. doi: 10.1172/jci.insight.94493.


Transcriptome and Functional Profile of Cardiac Myocytes Is Influenced by Biological Sex.

Trexler CL, Odell AT, Jeong MY, Dowell RD, Leinwand LA.

Circ Cardiovasc Genet. 2017 Oct;10(5). pii: e001770. doi: 10.1161/CIRCGENETICS.117.001770.


Cyclin D2 is a critical mediator of exercise-induced cardiac hypertrophy.

Luckey SW, Haines CD, Konhilas JP, Luczak ED, Messmer-Kratzsch A, Leinwand LA.

Exp Biol Med (Maywood). 2017 Dec;242(18):1820-1830. doi: 10.1177/1535370217731503. Epub 2017 Sep 13.


Expanding our scientific horizons: utilization of unique model organisms in biological research.

Peter AK, Crocini C, Leinwand LA.

EMBO J. 2017 Aug 15;36(16):2311-2314. doi: 10.15252/embj.201797640. Epub 2017 Jul 10. No abstract available.


Molecular Mechanisms Underlying Cardiac Adaptation to Exercise.

Vega RB, Konhilas JP, Kelly DP, Leinwand LA.

Cell Metab. 2017 May 2;25(5):1012-1026. doi: 10.1016/j.cmet.2017.04.025. Review.


Computational Approach to Measuring Myocyte Disarray in Animal Models of Heart Disease.

Wan W, Leinwand L.

Curr Protoc Hum Genet. 2017 Apr 6;93:15.11.1-15.11.9. doi: 10.1002/cphg.35.


Myoblast replication is reduced in the IUGR fetus despite maintained proliferative capacity in vitro.

Soto SM, Blake AC, Wesolowski SR, Rozance PJ, Barthel KB, Gao B, Hetrick B, McCurdy CE, Garza NG, Hay WW Jr, Leinwand LA, Friedman JE, Brown LD.

J Endocrinol. 2017 Mar;232(3):475-491. doi: 10.1530/JOE-16-0123. Epub 2017 Jan 4.


Letter to the editor: Comments on Stuart et al. (2016): "Myosin content of individual human muscle fibers isolated by laser capture microdissection".

Schiaffino S, Murgia M, Leinwand LA, Reggiani C.

Am J Physiol Cell Physiol. 2016 Dec 1;311(6):C1048-C1049. doi: 10.1152/ajpcell.00294.2016. No abstract available.


Two novel MYH7 proline substitutions cause Laing Distal Myopathy-like phenotypes with variable expressivity and neck extensor contracture.

Feinstein-Linial M, Buvoli M, Buvoli A, Sadeh M, Dabby R, Straussberg R, Shelef I, Dayan D, Leinwand LA, Birk OS.

BMC Med Genet. 2016 Aug 12;17(1):57. doi: 10.1186/s12881-016-0315-1.


Biology of the cardiac myocyte in heart disease.

Peter AK, Bjerke MA, Leinwand LA.

Mol Biol Cell. 2016 Jul 15;27(14):2149-60. doi: 10.1091/mbc.E16-01-0038. Review.


Estrogen receptor profiling and activity in cardiac myocytes.

Pugach EK, Blenck CL, Dragavon JM, Langer SJ, Leinwand LA.

Mol Cell Endocrinol. 2016 Aug 15;431:62-70. doi: 10.1016/j.mce.2016.05.004. Epub 2016 May 7.


The Importance of Biological Sex and Estrogen in Rodent Models of Cardiovascular Health and Disease.

Blenck CL, Harvey PA, Reckelhoff JF, Leinwand LA.

Circ Res. 2016 Apr 15;118(8):1294-312. doi: 10.1161/CIRCRESAHA.116.307509. Review.


The Most Prevalent Freeman-Sheldon Syndrome Mutations in the Embryonic Myosin Motor Share Functional Defects.

Walklate J, Vera C, Bloemink MJ, Geeves MA, Leinwand L.

J Biol Chem. 2016 May 6;291(19):10318-31. doi: 10.1074/jbc.M115.707489. Epub 2016 Mar 4.


A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice.

Green EM, Wakimoto H, Anderson RL, Evanchik MJ, Gorham JM, Harrison BC, Henze M, Kawas R, Oslob JD, Rodriguez HM, Song Y, Wan W, Leinwand LA, Spudich JA, McDowell RS, Seidman JG, Seidman CE.

Science. 2016 Feb 5;351(6273):617-21. doi: 10.1126/science.aad3456.


Contractility parameters of human β-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function.

Nag S, Sommese RF, Ujfalusi Z, Combs A, Langer S, Sutton S, Leinwand LA, Geeves MA, Ruppel KM, Spudich JA.

Sci Adv. 2015 Oct 9;1(9):e1500511. doi: 10.1126/sciadv.1500511. eCollection 2015 Oct.


Developmental myosins: expression patterns and functional significance.

Schiaffino S, Rossi AC, Smerdu V, Leinwand LA, Reggiani C.

Skelet Muscle. 2015 Jul 15;5:22. doi: 10.1186/s13395-015-0046-6. eCollection 2015.


Skip residues modulate the structural properties of the myosin rod and guide thick filament assembly.

Taylor KC, Buvoli M, Korkmaz EN, Buvoli A, Zheng Y, Heinze NT, Cui Q, Leinwand LA, Rayment I.

Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3806-15. doi: 10.1073/pnas.1505813112. Epub 2015 Jul 6.


Prolonged Cre expression driven by the α-myosin heavy chain promoter can be cardiotoxic.

Pugach EK, Richmond PA, Azofeifa JG, Dowell RD, Leinwand LA.

J Mol Cell Cardiol. 2015 Sep;86:54-61. doi: 10.1016/j.yjmcc.2015.06.019. Epub 2015 Jul 2.


Oestrogen enhances cardiotoxicity induced by Sunitinib by regulation of drug transport and metabolism.

Harvey PA, Leinwand LA.

Cardiovasc Res. 2015 Jul 1;107(1):66-77. doi: 10.1093/cvr/cvv152. Epub 2015 May 25.


Spontaneous Aortic Regurgitation and Valvular Cardiomyopathy in Mice.

Hajj GP, Chu Y, Lund DD, Magida JA, Funk ND, Brooks RM, Baumbach GL, Zimmerman KA, Davis MK, El Accaoui RN, Hameed T, Doshi H, Chen B, Leinwand LA, Song LS, Heistad DD, Weiss RM.

Arterioscler Thromb Vasc Biol. 2015 Jul;35(7):1653-62. doi: 10.1161/ATVBAHA.115.305729. Epub 2015 May 21.


miR-30 family microRNAs regulate myogenic differentiation and provide negative feedback on the microRNA pathway.

Guess MG, Barthel KK, Harrison BC, Leinwand LA.

PLoS One. 2015 Feb 17;10(2):e0118229. doi: 10.1371/journal.pone.0118229. eCollection 2015.


Sex-based differences in skeletal muscle kinetics and fiber-type composition.

Haizlip KM, Harrison BC, Leinwand LA.

Physiology (Bethesda). 2015 Jan;30(1):30-9. doi: 10.1152/physiol.00024.2014. Review.


Dietary phytoestrogens present in soy dramatically increase cardiotoxicity in male mice receiving a chemotherapeutic tyrosine kinase inhibitor.

Harvey PA, Leinwand LA.

Mol Cell Endocrinol. 2015 Jan 5;399:330-5. doi: 10.1016/j.mce.2014.10.011. Epub 2014 Oct 30.


The python project: a unique model for extending research opportunities to undergraduate students.

Harvey PA, Wall C, Luckey SW, Langer S, Leinwand LA.

CBE Life Sci Educ. 2014 Winter;13(4):698-710. doi: 10.1187/cbe.14-05-0089.


Diet and sex modify exercise and cardiac adaptation in the mouse.

Konhilas JP, Chen H, Luczak E, McKee LA, Regan J, Watson PA, Stauffer BL, Khalpey ZI, Mckinsey TA, Horn T, LaFleur B, Leinwand LA.

Am J Physiol Heart Circ Physiol. 2015 Jan 15;308(2):H135-45. doi: 10.1152/ajpheart.00532.2014. Epub 2014 Nov 14.


Cardiac valve cells and their microenvironment--insights from in vitro studies.

Wang H, Leinwand LA, Anseth KS.

Nat Rev Cardiol. 2014 Dec;11(12):715-27. doi: 10.1038/nrcardio.2014.162. Epub 2014 Oct 14. Review.


Roles of transforming growth factor-β1 and OB-cadherin in porcine cardiac valve myofibroblast differentiation.

Wang H, Leinwand LA, Anseth KS.

FASEB J. 2014 Oct;28(10):4551-62. doi: 10.1096/fj.14-254623. Epub 2014 Jul 9.


New mechanistic and therapeutic targets for pediatric heart failure: report from a National Heart, Lung, and Blood Institute working group.

Burns KM, Byrne BJ, Gelb BD, Kühn B, Leinwand LA, Mital S, Pearson GD, Rodefeld M, Rossano JW, Stauffer BL, Taylor MD, Towbin JA, Redington AN.

Circulation. 2014 Jul 1;130(1):79-86. doi: 10.1161/CIRCULATIONAHA.113.007980. No abstract available.


Metabolic crosstalk between the heart and liver impacts familial hypertrophic cardiomyopathy.

Magida JA, Leinwand LA.

EMBO Mol Med. 2014 Apr;6(4):482-95. doi: 10.1002/emmm.201302852. Epub 2014 Feb 24.


Pregnancy as a cardiac stress model.

Chung E, Leinwand LA.

Cardiovasc Res. 2014 Mar 15;101(4):561-70. doi: 10.1093/cvr/cvu013. Epub 2014 Jan 20. Review.


The hypertrophic cardiomyopathy myosin mutation R453C alters ATP binding and hydrolysis of human cardiac β-myosin.

Bloemink M, Deacon J, Langer S, Vera C, Combs A, Leinwand L, Geeves MA.

J Biol Chem. 2014 Feb 21;289(8):5158-67. doi: 10.1074/jbc.M113.511204. Epub 2013 Dec 16.


Frank Ruddle (1929-2013).

Kucherlapati R, Leinwand LA.

Am J Hum Genet. 2013 Jun 6;92(6):839-40. doi: 10.1016/j.ajhg.2013.05.012. No abstract available.


Hydrogels preserve native phenotypes of valvular fibroblasts through an elasticity-regulated PI3K/AKT pathway.

Wang H, Tibbitt MW, Langer SJ, Leinwand LA, Anseth KS.

Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19336-41. doi: 10.1073/pnas.1306369110. Epub 2013 Nov 11.


Calcineurin activity is required for cardiac remodelling in pregnancy.

Chung E, Yeung F, Leinwand LA.

Cardiovasc Res. 2013 Dec 1;100(3):402-10. doi: 10.1093/cvr/cvt208. Epub 2013 Aug 28.


Characterization of cell subpopulations expressing progenitor cell markers in porcine cardiac valves.

Wang H, Sridhar B, Leinwand LA, Anseth KS.

PLoS One. 2013 Jul 23;8(7):e69667. doi: 10.1371/journal.pone.0069667. Print 2013.


Measuring microRNA reporter activity in skeletal muscle using hydrodynamic limb vein injection of plasmid DNA combined with in vivo imaging.

Guess MG, Barthel KK, Pugach EK, Leinwand LA.

Skelet Muscle. 2013 Aug 1;3(1):19. doi: 10.1186/2044-5040-3-19.


The superfast human extraocular myosin is kinetically distinct from the fast skeletal IIa, IIb, and IId isoforms.

Bloemink MJ, Deacon JC, Resnicow DI, Leinwand LA, Geeves MA.

J Biol Chem. 2013 Sep 20;288(38):27469-79. doi: 10.1074/jbc.M113.488130. Epub 2013 Aug 1.


Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human β-cardiac myosin motor function.

Sommese RF, Sung J, Nag S, Sutton S, Deacon JC, Choe E, Leinwand LA, Ruppel K, Spudich JA.

Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12607-12. doi: 10.1073/pnas.1309493110. Epub 2013 Jun 24.


Young at heart.

Leinwand LA, Harrison BC.

Cell. 2013 May 9;153(4):743-5. doi: 10.1016/j.cell.2013.04.038.


Hibernating squirrel muscle activates the endurance exercise pathway despite prolonged immobilization.

Xu R, Andres-Mateos E, Mejias R, MacDonald EM, Leinwand LA, Merriman DK, Fink RH, Cohn RD.

Exp Neurol. 2013 Sep;247:392-401. doi: 10.1016/j.expneurol.2013.01.005. Epub 2013 Jan 16.


A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy.

Ruas JL, White JP, Rao RR, Kleiner S, Brannan KT, Harrison BC, Greene NP, Wu J, Estall JL, Irving BA, Lanza IR, Rasbach KA, Okutsu M, Nair KS, Yan Z, Leinwand LA, Spiegelman BM.

Cell. 2012 Dec 7;151(6):1319-31. doi: 10.1016/j.cell.2012.10.050.

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