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Commentary: Fc Gamma Receptors are Expressed in the Developing Rat Brain and Activate Downstream Signaling Molecules upon Cross-Linking with Immune Complex.

Stamou M, Lein PJ.

J Neurol Neuromedicine. 2019;4(1):26-29. doi: 10.29245/2572.942X/2019/1.1243. Epub 2019 Feb 18. No abstract available.


Changes in thyroid hormone activity disrupt photomotor behavior of larval zebrafish.

Walter KM, Miller GW, Chen X, Harvey DJ, Puschner B, Lein PJ.

Neurotoxicology. 2019 May 20;74:47-57. doi: 10.1016/j.neuro.2019.05.008. [Epub ahead of print]


MicroRNAs are Necessary for BMP-7-induced Dendritic Growth in Cultured Rat Sympathetic Neurons.

Pravoverov K, Whiting K, Thapa S, Bushong T, Trang K, Lein PJ, Chandrasekaran V.

Cell Mol Neurobiol. 2019 May 18. doi: 10.1007/s10571-019-00688-2. [Epub ahead of print]


TSPO PET Using [18F]PBR111 Reveals Persistent Neuroinflammation Following Acute Diisopropylfluorophosphate Intoxication in the Rat.

Hobson BA, Rowland DJ, Sisó S, Guignet MA, Harmany ZT, Bandara S, Saito N, Harvey DJ, Bruun DA, Garbow JR, Chaudhari AJ, Lein PJ.

Toxicol Sci. 2019 Apr 17. pii: kfz096. doi: 10.1093/toxsci/kfz096. [Epub ahead of print]


Organophosphorus Pesticides Induce Cytokine Release from Differentiated Human THP1 Cells.

Proskocil BJ, Grodzki ACG, Jacoby DB, Lein PJ, Fryer AD.

Am J Respir Cell Mol Biol. 2019 Apr 12. doi: 10.1165/rcmb.2018-0257OC. [Epub ahead of print]


Neurotoxicity of polychlorinated biphenyls and related organohalogens.

Pessah IN, Lein PJ, Seegal RF, Sagiv SK.

Acta Neuropathol. 2019 Apr 11. doi: 10.1007/s00401-019-01978-1. [Epub ahead of print] Review.


Persistent behavior deficits, neuroinflammation, and oxidative stress in a rat model of acute organophosphate intoxication.

Guignet M, Dhakal K, Flannery BM, Hobson BA, Zolkowska D, Dhir A, Bruun DA, Li S, Wahab A, Harvey DJ, Silverman JL, Rogawski MA, Lein PJ.

Neurobiol Dis. 2019 Mar 21. pii: S0969-9961(19)30073-7. doi: 10.1016/j.nbd.2019.03.019. [Epub ahead of print] Review.


Pretreatment with pyridostigmine bromide has no effect on seizure behavior or 24 hour survival in the rat model of acute diisopropylfluorophosphate intoxication.

Bruun DA, Guignet M, Harvey DJ, Lein PJ.

Neurotoxicology. 2019 Mar 7;73:81-84. doi: 10.1016/j.neuro.2019.03.001. [Epub ahead of print]


Comparative Analyses of the 12 Most Abundant PCB Congeners Detected in Human Maternal Serum for Activity at the Thyroid Hormone Receptor and Ryanodine Receptor.

Sethi S, Morgan RK, Feng W, Lin Y, Li X, Luna C, Koch M, Bansal R, Duffel MW, Puschner B, Zoeller RT, Lehmler HJ, Pessah IN, Lein PJ.

Environ Sci Technol. 2019 Apr 2;53(7):3948-3958. doi: 10.1021/acs.est.9b00535. Epub 2019 Mar 19.


Effects of thyroid hormone disruption on the ontogenetic expression of thyroid hormone signaling genes in developing zebrafish (Danio rerio).

Walter KM, Miller GW, Chen X, Yaghoobi B, Puschner B, Lein PJ.

Gen Comp Endocrinol. 2019 Feb 1;272:20-32. doi: 10.1016/j.ygcen.2018.11.007. Epub 2018 Nov 15.


Sex-Dependent Effects of 2,2',3,5',6-Pentachlorobiphenyl on Dendritic Arborization of Primary Mouse Neurons.

Keil KP, Sethi S, Lein PJ.

Toxicol Sci. 2019 Mar 1;168(1):95-109. doi: 10.1093/toxsci/kfy277.


Increased severity of fragile X spectrum disorders in the agricultural community of Ricaurte, Colombia.

Saldarriaga W, Salcedo-Arellano MJ, Rodriguez-Guerrero T, Ríos M, Fandiño-Losada A, Ramirez-Cheyne J, Lein PJ, Tassone F, Hagerman RJ.

Int J Dev Neurosci. 2019 Feb;72:1-5. doi: 10.1016/j.ijdevneu.2018.10.002. Epub 2018 Oct 29.


Teratological and Behavioral Screening of the National Toxicology Program 91-Compound Library in Zebrafish (Danio rerio).

Dach K, Yaghoobi B, Schmuck MR, Carty DR, Morales KM, Lein PJ.

Toxicol Sci. 2019 Jan 1;167(1):77-91. doi: 10.1093/toxsci/kfy266.


Genetic mutations in Ca2+ signaling alter dendrite morphology and social approach in juvenile mice.

Keil KP, Sethi S, Wilson MD, Silverman JL, Pessah IN, Lein PJ.

Genes Brain Behav. 2019 Jan;18(1):e12526. doi: 10.1111/gbb.12526. Epub 2018 Nov 6.


Developmental exposure to silver nanoparticles at environmentally relevant concentrations alters swimming behavior in zebrafish (Danio rerio).

González EA, Carty DR, Tran FD, Cole AM, Lein PJ.

Environ Toxicol Chem. 2018 Dec;37(12):3018-3024. doi: 10.1002/etc.4275. Epub 2018 Nov 8.


3,3'-Dichlorobiphenyl (PCB 11) promotes dendritic arborization in primary rat cortical neurons via a CREB-dependent mechanism.

Sethi S, Keil KP, Lein PJ.

Arch Toxicol. 2018 Nov;92(11):3337-3345. doi: 10.1007/s00204-018-2307-8. Epub 2018 Sep 17.


PCB 95 promotes dendritic growth in primary rat hippocampal neurons via mTOR-dependent mechanisms.

Keil KP, Miller GW, Chen H, Sethi S, Schmuck MR, Dhakal K, Kim JW, Lein PJ.

Arch Toxicol. 2018 Oct;92(10):3163-3173. doi: 10.1007/s00204-018-2285-x. Epub 2018 Aug 21.


Mechanisms of organophosphorus pesticide toxicity in the context of airway hyperreactivity and asthma.

Shaffo FC, Grodzki AC, Fryer AD, Lein PJ.

Am J Physiol Lung Cell Mol Physiol. 2018 Oct 1;315(4):L485-L501. doi: 10.1152/ajplung.00211.2018. Epub 2018 Jun 28.


The Organophosphorus Pesticide Chlorpyrifos Induces Sex-Specific Airway Hyperreactivity in Adult Rats.

Shaffo FC, Grodzki AC, Schelegle ES, Lein PJ.

Toxicol Sci. 2018 Sep 1;165(1):244-253. doi: 10.1093/toxsci/kfy158.


A Microfluidic Platform to Study Astrocyte Adhesion on Nanoporous Gold Thin Films.

Hampe AE, Li Z, Sethi S, Lein PJ, Seker E.

Nanomaterials (Basel). 2018 Jun 21;8(7). pii: E452. doi: 10.3390/nano8070452.


Bifenthrin causes transcriptomic alterations in mTOR and ryanodine receptor-dependent signaling and delayed hyperactivity in developing zebrafish (Danio rerio).

Frank DF, Miller GW, Harvey DJ, Brander SM, Geist J, Connon RE, Lein PJ.

Aquat Toxicol. 2018 Jul;200:50-61. doi: 10.1016/j.aquatox.2018.04.003. Epub 2018 Apr 18.


Opportunities and challenges for using the zebrafish to study neuronal connectivity as an endpoint of developmental neurotoxicity.

Miller GW, Chandrasekaran V, Yaghoobi B, Lein PJ.

Neurotoxicology. 2018 Jul;67:102-111. doi: 10.1016/j.neuro.2018.04.016. Epub 2018 Apr 25. Review.


Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes.

Fritsche E, Grandjean P, Crofton KM, Aschner M, Goldberg A, Heinonen T, Hessel EVS, Hogberg HT, Bennekou SH, Lein PJ, Leist M, Mundy WR, Paparella M, Piersma AH, Sachana M, Schmuck G, Solecki R, Terron A, Monnet-Tschudi F, Wilks MF, Witters H, Zurich MG, Bal-Price A.

Toxicol Appl Pharmacol. 2018 Sep 1;354:3-6. doi: 10.1016/j.taap.2018.02.004. Epub 2018 Feb 12.


Developmental social communication deficits in the Shank3 rat model of phelan-mcdermid syndrome and autism spectrum disorder.

Berg EL, Copping NA, Rivera JK, Pride MC, Careaga M, Bauman MD, Berman RF, Lein PJ, Harony-Nicolas H, Buxbaum JD, Ellegood J, Lerch JP, Wöhr M, Silverman JL.

Autism Res. 2018 Apr;11(4):587-601. doi: 10.1002/aur.1925. Epub 2018 Jan 29.


Simultaneous quantification of T4, T3, rT3, 3,5-T2 and 3,3'-T2 in larval zebrafish (Danio rerio) as a model to study exposure to polychlorinated biphenyls.

Chen X, Walter KM, Miller GW, Lein PJ, Puschner B.

Biomed Chromatogr. 2018 Jun;32(6):e4185. doi: 10.1002/bmc.4185. Epub 2018 Jan 29.


Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex.

Stamou M, Grodzki AC, van Oostrum M, Wollscheid B, Lein PJ.

J Neuroinflammation. 2018 Jan 6;15(1):7. doi: 10.1186/s12974-017-1050-z.


Species and Sex Differences in the Morphogenic Response of Primary Rodent Neurons to 3,3'-Dichlorobiphenyl (PCB 11).

Sethi S, Keil KP, Lein PJ.

Toxics. 2017 Dec 23;6(1). pii: E4. doi: 10.3390/toxics6010004.


Transcriptomic profiling of mTOR and ryanodine receptor signaling molecules in developing zebrafish in the absence and presence of PCB 95.

Frank DF, Miller GW, Connon RE, Geist J, Lein PJ.

PeerJ. 2017 Nov 29;5:e4106. doi: 10.7717/peerj.4106. eCollection 2017.


A magnetic resonance imaging study of early brain injury in a rat model of acute DFP intoxication.

Hobson BA, Rowland DJ, Supasai S, Harvey DJ, Lein PJ, Garbow JR.

Neurotoxicology. 2018 May;66:170-178. doi: 10.1016/j.neuro.2017.11.009. Epub 2017 Nov 26.


In vivo and in vitro sex differences in the dendritic morphology of developing murine hippocampal and cortical neurons.

Keil KP, Sethi S, Wilson MD, Chen H, Lein PJ.

Sci Rep. 2017 Aug 16;7(1):8486. doi: 10.1038/s41598-017-08459-z.


A multi-tiered, in vivo, quantitative assay suite for environmental disruptors of thyroid hormone signaling.

Mengeling BJ, Wei Y, Dobrawa LN, Streekstra M, Louisse J, Singh V, Singh L, Lein PJ, Wulff H, Murk AJ, Furlow JD.

Aquat Toxicol. 2017 Sep;190:1-10. doi: 10.1016/j.aquatox.2017.06.019. Epub 2017 Jun 21.


Nanoporous Gold Biointerfaces: Modifying Nanostructure to Control Neural Cell Coverage and Enhance Electrophysiological Recording Performance.

Chapman CAR, Wang L, Chen H, Garrison J, Lein PJ, Seker E.

Adv Funct Mater. 2017 Jan 19;27(3). pii: 1604631. doi: 10.1002/adfm.201604631. Epub 2016 Dec 12.


Detection of 3,3'-Dichlorobiphenyl in Human Maternal Plasma and Its Effects on Axonal and Dendritic Growth in Primary Rat Neurons.

Sethi S, Keil KP, Chen H, Hayakawa K, Li X, Lin Y, Lehmler HJ, Puschner B, Lein PJ.

Toxicol Sci. 2017 Aug 1;158(2):401-411. doi: 10.1093/toxsci/kfx100.


Editor's Highlight: Congener-Specific Disposition of Chiral Polychlorinated Biphenyls in Lactating Mice and Their Offspring: Implications for PCB Developmental Neurotoxicity.

Kania-Korwel I, Lukasiewicz T, Barnhart CD, Stamou M, Chung H, Kelly KM, Bandiera S, Lein PJ, Lehmler HJ.

Toxicol Sci. 2017 Jul 1;158(1):101-115. doi: 10.1093/toxsci/kfx071.


Nanostructure Introduces Artifacts in Quantitative Immunofluorescence by Influencing Fluorophore Intensity.

Chapman CA, Zhu X, Chen H, Yanik AA, Lein PJ, Seker E.

Sci Rep. 2017 Mar 27;7(1):427. doi: 10.1038/s41598-017-00447-7.


Editor's Highlight: Spatiotemporal Progression and Remission of Lesions in the Rat Brain Following Acute Intoxication With Diisopropylfluorophosphate.

Sisó S, Hobson BA, Harvey DJ, Bruun DA, Rowland DJ, Garbow JR, Lein PJ.

Toxicol Sci. 2017 Jun 1;157(2):330-341. doi: 10.1093/toxsci/kfx048.


From the Cover: MagneticResonance Imaging Reveals Progressive Brain Injury in Rats Acutely Intoxicated With Diisopropylfluorophosphate.

Hobson BA, Sisó S, Rowland DJ, Harvey DJ, Bruun DA, Garbow JR, Lein PJ.

Toxicol Sci. 2017 Jun 1;157(2):342-353. doi: 10.1093/toxsci/kfx049.


BDE-99 impairs differentiation of human and mouse NPCs into the oligodendroglial lineage by species-specific modes of action.

Dach K, Bendt F, Huebenthal U, Giersiefer S, Lein PJ, Heuer H, Fritsche E.

Sci Rep. 2017 Mar 20;7:44861. doi: 10.1038/srep44861.


Neurotoxicity in Preclinical Models of Occupational Exposure to Organophosphorus Compounds.

Voorhees JR, Rohlman DS, Lein PJ, Pieper AA.

Front Neurosci. 2017 Jan 18;10:590. doi: 10.3389/fnins.2016.00590. eCollection 2016. Review.


Valid statistical approaches for analyzing sholl data: Mixed effects versus simple linear models.

Wilson MD, Sethi S, Lein PJ, Keil KP.

J Neurosci Methods. 2017 Mar 1;279:33-43. doi: 10.1016/j.jneumeth.2017.01.003. Epub 2017 Jan 16. Review.


Dental Pulp Stem Cells Model Early Life and Imprinted DNA Methylation Patterns.

Dunaway K, Goorha S, Matelski L, Urraca N, Lein PJ, Korf I, Reiter LT, LaSalle JM.

Stem Cells. 2017 Apr;35(4):981-988. doi: 10.1002/stem.2563. Epub 2017 Jan 19.


From the Cover: BDE-47 and BDE-49 Inhibit Axonal Growth in Primary Rat Hippocampal Neuron-Glia Co-Cultures via Ryanodine Receptor-Dependent Mechanisms.

Chen H, Streifel KM, Singh V, Yang D, Mangini L, Wulff H, Lein PJ.

Toxicol Sci. 2017 Apr 1;156(2):375-386. doi: 10.1093/toxsci/kfw259.


Mechanisms of Reduced Astrocyte Surface Coverage in Cortical Neuron-Glia Co-cultures on Nanoporous Gold Surfaces.

Chapman CA, Chen H, Stamou M, Lein PJ, Seker E.

Cell Mol Bioeng. 2016 Sep;9(3):433-442. Epub 2016 May 31.


Persistent neuroinflammation and cognitive impairment in a rat model of acute diisopropylfluorophosphate intoxication.

Flannery BM, Bruun DA, Rowland DJ, Banks CN, Austin AT, Kukis DL, Li Y, Ford BD, Tancredi DJ, Silverman JL, Cherry SR, Lein PJ.

J Neuroinflammation. 2016 Oct 12;13(1):267.


Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents.

Pessah IN, Rogawski MA, Tancredi DJ, Wulff H, Zolkowska D, Bruun DA, Hammock BD, Lein PJ.

Ann N Y Acad Sci. 2016 Aug;1378(1):124-136. doi: 10.1111/nyas.13137. Epub 2016 Jul 28. Review.


Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use.

Aschner M, Ceccatelli S, Daneshian M, Fritsche E, Hasiwa N, Hartung T, Hogberg HT, Leist M, Li A, Mundi WR, Padilla S, Piersma AH, Bal-Price A, Seiler A, Westerink RH, Zimmer B, Lein PJ.

ALTEX. 2017;34(1):49-74. doi: 10.14573/altex.1604201. Epub 2016 Jul 25.


Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity.

Bal-Price A, Lein PJ, Keil KP, Sethi S, Shafer T, Barenys M, Fritsche E, Sachana M, Meek MEB.

Neurotoxicology. 2017 Mar;59:240-255. doi: 10.1016/j.neuro.2016.05.010. Epub 2016 May 17. Review.


DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders?

Keil KP, Lein PJ.

Environ Epigenet. 2016 Mar;2(1). pii: dvv012. Epub 2016 Jan 30.


Chasing the Elusive Benzofuran Impurity of the THR Antagonist NH-3: Synthesis, Isotope Labeling, and Biological Activity.

Singh L, Pressly B, Mengeling BJ, Fettinger JC, Furlow JD, Lein PJ, Wulff H, Singh V.

J Org Chem. 2016 Mar 4;81(5):1870-6. doi: 10.1021/acs.joc.5b02665. Epub 2016 Feb 18.

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