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Modeling the Architecture of Depolymerase-Containing Receptor Binding Proteins in Klebsiella Phages.

Latka A, Leiman PG, Drulis-Kawa Z, Briers Y.

Front Microbiol. 2019 Nov 15;10:2649. doi: 10.3389/fmicb.2019.02649. eCollection 2019.


Target highlights in CASP13: Experimental target structures through the eyes of their authors.

Lepore R, Kryshtafovych A, Alahuhta M, Veraszto HA, Bomble YJ, Bufton JC, Bullock AN, Caba C, Cao H, Davies OR, Desfosses A, Dunne M, Fidelis K, Goulding CW, Gurusaran M, Gutsche I, Harding CJ, Hartmann MD, Hayes CS, Joachimiak A, Leiman PG, Loppnau P, Lovering AL, Lunin VV, Michalska K, Mir-Sanchis I, Mitra AK, Moult J, Phillips GN Jr, Pinkas DM, Rice PA, Tong Y, Topf M, Walton JD, Schwede T.

Proteins. 2019 Dec;87(12):1037-1057. doi: 10.1002/prot.25805. Epub 2019 Sep 9.


Structure and Function of the Branched Receptor-Binding Complex of Bacteriophage CBA120.

Plattner M, Shneider MM, Arbatsky NP, Shashkov AS, Chizhov AO, Nazarov S, Prokhorov NS, Taylor NMI, Buth SA, Gambino M, Gencay YE, Brøndsted L, Kutter EM, Knirel YA, Leiman PG.

J Mol Biol. 2019 Sep 6;431(19):3718-3739. doi: 10.1016/j.jmb.2019.07.022. Epub 2019 Jul 17.


Structure and transformation of bacteriophage A511 baseplate and tail upon infection of Listeria cells.

Guerrero-Ferreira RC, Hupfeld M, Nazarov S, Taylor NM, Shneider MM, Obbineni JM, Loessner MJ, Ishikawa T, Klumpp J, Leiman PG.

EMBO J. 2019 Feb 1;38(3). pii: e99455. doi: 10.15252/embj.201899455. Epub 2019 Jan 2.


Salmonella Phage S16 Tail Fiber Adhesin Features a Rare Polyglycine Rich Domain for Host Recognition.

Dunne M, Denyes JM, Arndt H, Loessner MJ, Leiman PG, Klumpp J.

Structure. 2018 Dec 4;26(12):1573-1582.e4. doi: 10.1016/j.str.2018.07.017. Epub 2018 Sep 20.


Structure and Analysis of R1 and R2 Pyocin Receptor-Binding Fibers.

Buth SA, Shneider MM, Scholl D, Leiman PG.

Viruses. 2018 Aug 14;10(8). pii: E427. doi: 10.3390/v10080427.


Contractile injection systems of bacteriophages and related systems.

Taylor NMI, van Raaij MJ, Leiman PG.

Mol Microbiol. 2018 Apr;108(1):6-15. doi: 10.1111/mmi.13921. Epub 2018 Feb 26. Review.


Stretching the arms of the type VI secretion sheath protein.

Leiman PG.

EMBO Rep. 2018 Feb;19(2):191-193. doi: 10.15252/embr.201745627. Epub 2018 Jan 22. No abstract available.


The O-specific polysaccharide lyase from the phage LKA1 tailspike reduces Pseudomonas virulence.

Olszak T, Shneider MM, Latka A, Maciejewska B, Browning C, Sycheva LV, Cornelissen A, Danis-Wlodarczyk K, Senchenkova SN, Shashkov AS, Gula G, Arabski M, Wasik S, Miroshnikov KA, Lavigne R, Leiman PG, Knirel YA, Drulis-Kawa Z.

Sci Rep. 2017 Nov 24;7(1):16302. doi: 10.1038/s41598-017-16411-4.


Refined Cryo-EM Structure of the T4 Tail Tube: Exploring the Lowest Dose Limit.

Zheng W, Wang F, Taylor NMI, Guerrero-Ferreira RC, Leiman PG, Egelman EH.

Structure. 2017 Sep 5;25(9):1436-1441.e2. doi: 10.1016/j.str.2017.06.017. Epub 2017 Jul 27.


Function of bacteriophage G7C esterase tailspike in host cell adsorption.

Prokhorov NS, Riccio C, Zdorovenko EL, Shneider MM, Browning C, Knirel YA, Leiman PG, Letarov AV.

Mol Microbiol. 2017 Aug;105(3):385-398. doi: 10.1111/mmi.13710. Epub 2017 Jun 19.


Genetic, Structural, and Phenotypic Properties of MS2 Coliphage with Resistance to ClO2 Disinfection.

Zhong Q, Carratalà A, Nazarov S, Guerrero-Ferreira RC, Piccinini L, Bachmann V, Leiman PG, Kohn T.

Environ Sci Technol. 2016 Dec 20;50(24):13520-13528. Epub 2016 Oct 25.


Structure of the T4 baseplate and its function in triggering sheath contraction.

Taylor NM, Prokhorov NS, Guerrero-Ferreira RC, Shneider MM, Browning C, Goldie KN, Stahlberg H, Leiman PG.

Nature. 2016 May 19;533(7603):346-52. doi: 10.1038/nature17971.


Structure and Biophysical Properties of a Triple-Stranded Beta-Helix Comprising the Central Spike of Bacteriophage T4.

Buth SA, Menin L, Shneider MM, Engel J, Boudko SP, Leiman PG.

Viruses. 2015 Aug 18;7(8):4676-706. doi: 10.3390/v7082839.


Atomic structures of a bactericidal contractile nanotube in its pre- and postcontraction states.

Ge P, Scholl D, Leiman PG, Yu X, Miller JF, Zhou ZH.

Nat Struct Mol Biol. 2015 May;22(5):377-82. doi: 10.1038/nsmb.2995. Epub 2015 Mar 30.


Introduction to “Viruses of Microbes III” special section of Virology.

Leiman PG, Molineux IJ.

Virology. 2015 Mar;477:99. doi: 10.1016/j.virol.2015.01.001. Epub 2015 Feb 7. No abstract available.


Structure and biochemical characterization of bacteriophage phi92 endosialidase.

Schwarzer D, Browning C, Stummeyer K, Oberbeck A, Mühlenhoff M, Gerardy-Schahn R, Leiman PG.

Virology. 2015 Mar;477:133-143. doi: 10.1016/j.virol.2014.11.002. Epub 2014 Dec 1.


Listeria phage A511, a model for the contractile tail machineries of SPO1-related bacteriophages.

Habann M, Leiman PG, Vandersteegen K, Van den Bossche A, Lavigne R, Shneider MM, Bielmann R, Eugster MR, Loessner MJ, Klumpp J.

Mol Microbiol. 2014 Apr;92(1):84-99. doi: 10.1111/mmi.12539. Epub 2014 Feb 28.


Structure and properties of the C-terminal β-helical domain of VgrG protein from Escherichia coli O157.

Uchida K, Leiman PG, Arisaka F, Kanamaru S.

J Biochem. 2014 Mar;155(3):173-82. doi: 10.1093/jb/mvt109. Epub 2013 Dec 3.


PAAR-repeat proteins sharpen and diversify the type VI secretion system spike.

Shneider MM, Buth SA, Ho BT, Basler M, Mekalanos JJ, Leiman PG.

Nature. 2013 Aug 15;500(7462):350-353. doi: 10.1038/nature12453. Epub 2013 Aug 7.


Improving binding affinity and stability of peptide ligands by substituting glycines with D-amino acids.

Chen S, Gfeller D, Buth SA, Michielin O, Leiman PG, Heinis C.

Chembiochem. 2013 Jul 22;14(11):1316-22. doi: 10.1002/cbic.201300228. Epub 2013 Jul 4.


Bicyclic peptide ligands pulled out of cysteine-rich peptide libraries.

Chen S, Rentero Rebollo I, Buth SA, Morales-Sanfrutos J, Touati J, Leiman PG, Heinis C.

J Am Chem Soc. 2013 May 1;135(17):6562-9. doi: 10.1021/ja400461h. Epub 2013 Apr 17.


Crystal structure and location of gp131 in the bacteriophage phiKZ virion.

Sycheva LV, Shneider MM, Sykilinda NN, Ivanova MA, Miroshnikov KA, Leiman PG.

Virology. 2012 Dec 20;434(2):257-64. doi: 10.1016/j.virol.2012.09.001. Epub 2012 Sep 29.


A multivalent adsorption apparatus explains the broad host range of phage phi92: a comprehensive genomic and structural analysis.

Schwarzer D, Buettner FF, Browning C, Nazarov S, Rabsch W, Bethe A, Oberbeck A, Bowman VD, Stummeyer K, Mühlenhoff M, Leiman PG, Gerardy-Schahn R.

J Virol. 2012 Oct;86(19):10384-98. doi: 10.1128/JVI.00801-12. Epub 2012 Jul 11.


Phage pierces the host cell membrane with the iron-loaded spike.

Browning C, Shneider MM, Bowman VD, Schwarzer D, Leiman PG.

Structure. 2012 Feb 8;20(2):326-39. doi: 10.1016/j.str.2011.12.009.


Contractile tail machines of bacteriophages.

Leiman PG, Shneider MM.

Adv Exp Med Biol. 2012;726:93-114. doi: 10.1007/978-1-4614-0980-9_5. Review.


Morphogenesis of the T4 tail and tail fibers.

Leiman PG, Arisaka F, van Raaij MJ, Kostyuchenko VA, Aksyuk AA, Kanamaru S, Rossmann MG.

Virol J. 2010 Dec 3;7:355. doi: 10.1186/1743-422X-7-355. Review.


The baseplate wedges of bacteriophage T4 spontaneously assemble into hubless baseplate-like structure in vitro.

Yap ML, Mio K, Leiman PG, Kanamaru S, Arisaka F.

J Mol Biol. 2010 Jan 15;395(2):349-60. doi: 10.1016/j.jmb.2009.10.071. Epub 2009 Nov 5.


The structure of gene product 6 of bacteriophage T4, the hinge-pin of the baseplate.

Aksyuk AA, Leiman PG, Shneider MM, Mesyanzhinov VV, Rossmann MG.

Structure. 2009 Jun 10;17(6):800-8. doi: 10.1016/j.str.2009.04.005.


Crystallographic insights into the autocatalytic assembly mechanism of a bacteriophage tail spike.

Xiang Y, Leiman PG, Li L, Grimes S, Anderson DL, Rossmann MG.

Mol Cell. 2009 May 15;34(3):375-86. doi: 10.1016/j.molcel.2009.04.009.


Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.

Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ.

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4154-9. doi: 10.1073/pnas.0813360106. Epub 2009 Feb 27.


The tail sheath structure of bacteriophage T4: a molecular machine for infecting bacteria.

Aksyuk AA, Leiman PG, Kurochkina LP, Shneider MM, Kostyuchenko VA, Mesyanzhinov VV, Rossmann MG.

EMBO J. 2009 Apr 8;28(7):821-9. doi: 10.1038/emboj.2009.36. Epub 2009 Feb 19. Erratum in: EMBO J. 2012 Aug 15;31(16):3507.


Evolution of a new enzyme activity from the same motif fold.

Leiman PG, Molineux IJ.

Mol Microbiol. 2008 Jul;69(2):287-90. doi: 10.1111/j.1365-2958.2008.06241.x.


The structures of bacteriophages K1E and K1-5 explain processive degradation of polysaccharide capsules and evolution of new host specificities.

Leiman PG, Battisti AJ, Bowman VD, Stummeyer K, Mühlenhoff M, Gerardy-Schahn R, Scholl D, Molineux IJ.

J Mol Biol. 2007 Aug 17;371(3):836-49. Epub 2007 Jun 2.


From structure of the complex to understanding of the biology.

Rossmann MG, Arisaka F, Battisti AJ, Bowman VD, Chipman PR, Fokine A, Hafenstein S, Kanamaru S, Kostyuchenko VA, Mesyanzhinov VV, Shneider MM, Morais MC, Leiman PG, Palermo LM, Parrish CR, Xiao C.

Acta Crystallogr D Biol Crystallogr. 2007 Jan;63(Pt 1):9-16. Epub 2006 Dec 13.


Evolution of bacteriophage tails: Structure of T4 gene product 10.

Leiman PG, Shneider MM, Mesyanzhinov VV, Rossmann MG.

J Mol Biol. 2006 May 5;358(3):912-21. Epub 2006 Mar 9.


Functional role of the N-terminal domain of bacteriophage T4 gene product 11.

Vishnevskiy AY, Kurochkina LP, Sykilinda NN, Solov'eva NV, Shneider MM, Leiman PG, Mesyanzhinov VV.

Biochemistry (Mosc). 2005 Oct;70(10):1111-8.


The tail structure of bacteriophage T4 and its mechanism of contraction.

Kostyuchenko VA, Chipman PR, Leiman PG, Arisaka F, Mesyanzhinov VV, Rossmann MG.

Nat Struct Mol Biol. 2005 Sep;12(9):810-3. Epub 2005 Aug 14.


Structural and functional similarities between the capsid proteins of bacteriophages T4 and HK97 point to a common ancestry.

Fokine A, Leiman PG, Shneider MM, Ahvazi B, Boeshans KM, Steven AC, Black LW, Mesyanzhinov VV, Rossmann MG.

Proc Natl Acad Sci U S A. 2005 May 17;102(20):7163-8. Epub 2005 May 6.


Combining X-ray crystallography and electron microscopy.

Rossmann MG, Morais MC, Leiman PG, Zhang W.

Structure. 2005 Mar;13(3):355-62. Review.


Molecular architecture of bacteriophage T4.

Mesyanzhinov VV, Leiman PG, Kostyuchenko VA, Kurochkina LP, Miroshnikov KA, Sykilinda NN, Shneider MM.

Biochemistry (Mosc). 2004 Nov;69(11):1190-202. Review.


Three-dimensional rearrangement of proteins in the tail of bacteriophage T4 on infection of its host.

Leiman PG, Chipman PR, Kostyuchenko VA, Mesyanzhinov VV, Rossmann MG.

Cell. 2004 Aug 20;118(4):419-29.


The bacteriophage T4 DNA injection machine.

Rossmann MG, Mesyanzhinov VV, Arisaka F, Leiman PG.

Curr Opin Struct Biol. 2004 Apr;14(2):171-80. Review.


Molecular architecture of the prolate head of bacteriophage T4.

Fokine A, Chipman PR, Leiman PG, Mesyanzhinov VV, Rao VB, Rossmann MG.

Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6003-8. Epub 2004 Apr 7.


Structure and morphogenesis of bacteriophage T4.

Leiman PG, Kanamaru S, Mesyanzhinov VV, Arisaka F, Rossmann MG.

Cell Mol Life Sci. 2003 Nov;60(11):2356-70. Review.


Three-dimensional structure of bacteriophage T4 baseplate.

Kostyuchenko VA, Leiman PG, Chipman PR, Kanamaru S, van Raaij MJ, Arisaka F, Mesyanzhinov VV, Rossmann MG.

Nat Struct Biol. 2003 Sep;10(9):688-93. Epub 2003 Aug 17.


Structure and location of gene product 8 in the bacteriophage T4 baseplate.

Leiman PG, Shneider MM, Kostyuchenko VA, Chipman PR, Mesyanzhinov VV, Rossmann MG.

J Mol Biol. 2003 May 9;328(4):821-33.


Note to the Paper by Guasch et al. (2002) Detailed Architecture of a DNA Translocating Machine: The High-resolution Structure of the Bacteriophage ϕ29 Connector Particle.

Guasch A, Pous J, Ibarra B, Gomis-Rüth FX, Valpuesta JM, Sousa N, Carrascosa JL, Coll M, Simpson AA, Tao Y, Leiman PG, Badasso MO, He Y, Jardine PJ, Olson NH, Morais MC, Grimes S, Anderson DL, Baker TS, Rossmann MG.

J Mol Biol. 2002 Aug 9;321(2):379-380. No abstract available.


Structure of the cell-puncturing device of bacteriophage T4.

Kanamaru S, Leiman PG, Kostyuchenko VA, Chipman PR, Mesyanzhinov VV, Arisaka F, Rossmann MG.

Nature. 2002 Jan 31;415(6871):553-7.


Structure determination of the head-tail connector of bacteriophage phi29.

Simpson AA, Leiman PG, Tao Y, He Y, Badasso MO, Jardine PJ, Anderson DL, Rossmann MG.

Acta Crystallogr D Biol Crystallogr. 2001 Sep;57(Pt 9):1260-9. Epub 2001 Aug 23.


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