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Items: 13


Proenkephalin Compared to Conventional Methods to Assess Kidney Function in Critically Ill Sepsis Patients.

Beunders R, van Groenendael R, Leijte G, Kox M, Pickkers P.

Shock. 2020 Jan 21. doi: 10.1097/SHK.0000000000001510. [Epub ahead of print]


Differentiation and activation of eosinophils in the human bone marrow during experimental human endotoxemia.

Hassani M, Leijte G, Bruse N, Kox M, Pickkers P, Vrisekoop N, Koenderman L.

J Leukoc Biol. 2020 Jan 10. doi: 10.1002/JLB.1AB1219-493R. [Epub ahead of print]


Frontline Science: Endotoxin-induced immunotolerance is associated with loss of monocyte metabolic plasticity and reduction of oxidative burst.

Grondman I, Arts RJW, Koch RM, Leijte GP, Gerretsen J, Bruse N, Kempkes RWM, Ter Horst R, Kox M, Pickkers P, Netea MG, Gresnigt MS.

J Leukoc Biol. 2019 Jul;106(1):11-25. doi: 10.1002/JLB.5HI0119-018R. Epub 2019 Jun 6.


Characterization of the phenotype of human eosinophils and their progenitors in the bone marrow of healthy individuals.

Hassani M, van Staveren S, van Grinsven E, Bartels M, Tesselaar K, Leijte G, Kox M, Pickkers P, Vrisekoop N, Koenderman L.

Haematologica. 2020 Jan 31;105(2):e52-e56. doi: 10.3324/haematol.2019.219048. Print 2020. No abstract available.


A randomized double-blind, placebo-controlled clinical phase IIa trial on safety, immunomodulatory effects and pharmacokinetics of EA-230 during experimental human endotoxaemia.

van Groenendael R, Kox M, Leijte G, Koeneman B, Gerretsen J, van Eijk L, Pickkers P.

Br J Clin Pharmacol. 2019 Jul;85(7):1559-1571. doi: 10.1111/bcp.13941. Epub 2019 May 23.


Fever in Sepsis: Still a Hot Topic.

Leijte GP, Kox M, Pickkers P.

Am J Respir Crit Care Med. 2019 Jul 15;200(2):263-264. doi: 10.1164/rccm.201903-0484LE. No abstract available.


Comparison of different lots of endotoxin and evaluation of in vivo potency over time in the experimental human endotoxemia model.

Kiers D, Leijte GP, Gerretsen J, Zwaag J, Kox M, Pickkers P.

Innate Immun. 2019 Jan;25(1):34-45. doi: 10.1177/1753425918819754.


Mitochondrial DNA: Innocent in Plasma, but Guilty in Urine?

Leijte GP, Pickkers P, Kox M.

Shock. 2019 Feb;51(2):266. doi: 10.1097/SHK.0000000000001142. No abstract available.


Treatment With Acetylsalicylic Acid Reverses Endotoxin Tolerance in Humans In Vivo: A Randomized Placebo-Controlled Study.

Leijte GP, Kiers D, van der Heijden W, Jansen A, Gerretsen J, Boerrigter V, Netea MG, Kox M, Pickkers P.

Crit Care Med. 2019 Apr;47(4):508-516. doi: 10.1097/CCM.0000000000003630.


New frontiers in precision medicine for sepsis-induced immunoparalysis.

Bruse N, Leijte GP, Pickkers P, Kox M.

Expert Rev Clin Immunol. 2019 Mar;15(3):251-263. doi: 10.1080/1744666X.2019.1562336. Epub 2019 Jan 7.


Experimental human endotoxemia as a model of systemic inflammation.

van Lier D, Geven C, Leijte GP, Pickkers P.

Biochimie. 2019 Apr;159:99-106. doi: 10.1016/j.biochi.2018.06.014. Epub 2018 Jun 22. Review.


Increased Plasma Levels of Danger-Associated Molecular Patterns Are Associated With Immune Suppression and Postoperative Infections in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy.

Leijte GP, Custers H, Gerretsen J, Heijne A, Roth J, Vogl T, Scheffer GJ, Pickkers P, Kox M.

Front Immunol. 2018 Apr 5;9:663. doi: 10.3389/fimmu.2018.00663. eCollection 2018.


Release of Danger-Associated Molecular Patterns following Chemotherapy Does Not Induce Immunoparalysis in Leukemia Patients.

Timmermans K, Leijte GP, Kox M, Scheffer GJ, Blijlevens NMA, Pickkers PP.

Acta Haematol. 2017;138(1):39-43. doi: 10.1159/000477530. Epub 2017 Jul 20.


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