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Items: 9


Amyloid-β precursor protein mutant zebrafish exhibit seizure susceptibility that depends on prion protein.

Kanyo R, Leighton PLA, Neil GJ, Locskai LF, Allison WT.

Exp Neurol. 2020 Jun;328:113283. doi: 10.1016/j.expneurol.2020.113283. Epub 2020 Mar 9.


Prion gene paralogs are dispensable for early zebrafish development and have nonadditive roles in seizure susceptibility.

Leighton PLA, Kanyo R, Neil GJ, Pollock NM, Allison WT.

J Biol Chem. 2018 Aug 10;293(32):12576-12592. doi: 10.1074/jbc.RA117.001171. Epub 2018 Jun 14.


An ancient conserved role for prion protein in learning and memory.

Leighton PLA, Nadolski NJ, Morrill A, Hamilton TJ, Allison WT.

Biol Open. 2018 Jan 22;7(1). pii: bio025734. doi: 10.1242/bio.025734.


Reduced Abundance and Subverted Functions of Proteins in Prion-Like Diseases: Gained Functions Fascinate but Lost Functions Affect Aetiology.

Allison WT, DuVal MG, Nguyen-Phuoc K, Leighton PLA.

Int J Mol Sci. 2017 Oct 24;18(10). pii: E2223. doi: 10.3390/ijms18102223. Review.


Protein Misfolding in Prion and Prion-Like Diseases: Reconsidering a Required Role for Protein Loss-of-Function.

Leighton PL, Allison WT.

J Alzheimers Dis. 2016 Jul 6;54(1):3-29. doi: 10.3233/JAD-160361. Review.


Zebrafish prion protein PrP2 controls collective migration process during lateral line sensory system development.

Huc-Brandt S, Hieu N, Imberdis T, Cubedo N, Silhol M, Leighton PL, Domaschke T, Allison WT, Perrier V, Rossel M.

PLoS One. 2014 Dec 1;9(12):e113331. doi: 10.1371/journal.pone.0113331. eCollection 2014.


Evaluating the mutagenic activity of targeted endonucleases containing a Sharkey FokI cleavage domain variant in zebrafish.

Pillay LM, Selland LG, Fleisch VC, Leighton PL, Cheng CS, Famulski JK, Ritzel RG, March LD, Wang H, Allison WT, Waskiewicz AJ.

Zebrafish. 2013 Sep;10(3):353-64. doi: 10.1089/zeb.2012.0832. Epub 2013 Jun 19.


Targeted mutation of the gene encoding prion protein in zebrafish reveals a conserved role in neuron excitability.

Fleisch VC, Leighton PL, Wang H, Pillay LM, Ritzel RG, Bhinder G, Roy B, Tierney KB, Ali DW, Waskiewicz AJ, Allison WT.

Neurobiol Dis. 2013 Jul;55:11-25. doi: 10.1016/j.nbd.2013.03.007. Epub 2013 Mar 21.


Amyloid beta precursor protein and prion protein have a conserved interaction affecting cell adhesion and CNS development.

Kaiser DM, Acharya M, Leighton PL, Wang H, Daude N, Wohlgemuth S, Shi B, Allison WT.

PLoS One. 2012;7(12):e51305. doi: 10.1371/journal.pone.0051305. Epub 2012 Dec 7.

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