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A drug safety review of treating eosinophilic asthma with monoclonal antibodies.

Mitchell P, Leigh R.

Expert Opin Drug Saf. 2019 Oct 21:1-10. doi: 10.1080/14740338.2019.1675634. [Epub ahead of print]


Bringing Open Data to Whole Slide Imaging.

Besson S, Leigh R, Linkert M, Allan C, Burel JM, Carroll M, Gault D, Gozim R, Li S, Lindner D, Moore J, Moore W, Walczysko P, Wong F, Swedlow JR.

Digit Pathol (2019). 2019 Apr;2019:3-10. doi: 10.1007/978-3-030-23937-4_1. Epub 2019 Jul 3.


MRI-based thrombolytic therapy in patients with acute ischemic stroke presenting with a low NIHSS.

Majidi S, Luby M, Lynch JK, Hsia AW, Benson RT, Kalaria CP, Nadareishvili Z, Latour LL, Leigh R.

Neurology. 2019 Oct 15;93(16):e1507-e1513. doi: 10.1212/WNL.0000000000008312. Epub 2019 Sep 13.


Studying human exposure to vehicular emissions using computational fluid dynamics and an urban mobility simulator: The effect of sidewalk residence time, vehicular technologies and a traffic-calming device.

Zavala-Reyes JC, Jeanjean APR, Leigh RJ, Hernández-Paniagua IY, Rosas-Pérez I, Jazcilevich A.

Sci Total Environ. 2019 Oct 15;687:720-731. doi: 10.1016/j.scitotenv.2019.05.422. Epub 2019 Jun 6.


Effects of indoor particulate matter exposure on daily asthma control.

Hussain S, Parker S, Edwards K, Finch J, Jeanjean A, Leigh R, Gonem S.

Ann Allergy Asthma Immunol. 2019 Oct;123(4):375-380.e3. doi: 10.1016/j.anai.2019.07.020. Epub 2019 Jul 26.


Neuroimaging of Cerebral Small Vessel Disease and Age-Related Cognitive Changes.

Caunca MR, De Leon-Benedetti A, Latour L, Leigh R, Wright CB.

Front Aging Neurosci. 2019 Jun 27;11:145. doi: 10.3389/fnagi.2019.00145. eCollection 2019. Review.


Mathematical models: An extension of the clinician's mind.

Leigh RJ, Zee DS.

Prog Brain Res. 2019;248:19-26. doi: 10.1016/bs.pbr.2018.11.001. Epub 2019 Jan 11.


Clinical applications of control systems models: The neural integrators for eye movements.

Sadeghpour S, Zee DS, Leigh RJ.

Prog Brain Res. 2019;248:103-114. doi: 10.1016/bs.pbr.2018.12.001. Epub 2019 Feb 8.


Rapid Apparent Diffusion Coefficient Evolution After Early Revascularization.

Hsia AW, Luby M, Cullison K, Burton S, Armonda R, Liu AH, Leigh R, Nadareishvili Z, Benson RT, Lynch JK, Latour LL.

Stroke. 2019 Aug;50(8):2086-2092. doi: 10.1161/STROKEAHA.119.025784. Epub 2019 Jun 26. Erratum in: Stroke. 2019 Sep;50(9):e282.


Molecular signature of penumbra in acute ischemic stroke: a pilot transcriptomics study.

Nadareishvili Z, Kelley D, Luby M, Simpkins AN, Leigh R, Lynch JK, Hsia AW, Benson RT, Johnson KR, Hallenbeck JM, Latour LL.

Ann Clin Transl Neurol. 2019 Mar 13;6(4):817-820. doi: 10.1002/acn3.757. eCollection 2019 Apr.


Omalizumab in patients with severe asthma and persistent sputum eosinophilia.

Mukherjee M, Kjarsgaard M, Radford K, Huang C, Leigh R, Dorscheid DR, Lemiere C, Boulet LP, Waserman S, Martin J, Nair P.

Allergy Asthma Clin Immunol. 2019 Apr 3;15:21. doi: 10.1186/s13223-019-0337-2. eCollection 2019.


Post-Stroke Blood-Brain Barrier Disruption and Poor Functional Outcome in Patients Receiving Thrombolytic Therapy.

Nadareishvili Z, Simpkins AN, Hitomi E, Reyes D, Leigh R.

Cerebrovasc Dis. 2019;47(3-4):135-142. doi: 10.1159/000499666. Epub 2019 Apr 10.


Glucocorticoid-driven transcriptomes in human airway epithelial cells: commonalities, differences and functional insight from cell lines and primary cells.

Mostafa MM, Rider CF, Shah S, Traves SL, Gordon PMK, Miller-Larsson A, Leigh R, Newton R.

BMC Med Genomics. 2019 Jan 31;12(1):29. doi: 10.1186/s12920-018-0467-2.


Sustained Opening of the Blood-Brain Barrier with Progressive Accumulation of White Matter Hyperintensities Following Ischemic Stroke.

Naqvi I, Hitomi E, Leigh R.

Brain Sci. 2019 Jan 21;9(1). pii: E16. doi: 10.3390/brainsci9010016.


The Efficacy of IV Tissue Plasminogen Activator for Restoring Cerebral Blood Flow in the Hours Immediately after Administration in Patients with Acute Stroke.

Majidi S, Simpkins AN, Leigh R; NIH Natural History of Stroke Investigators.

J Neuroimaging. 2019 Mar;29(2):206-210. doi: 10.1111/jon.12587. Epub 2018 Dec 3.


Rhinovirus and Bacteria Synergistically Induce IL-17C Release from Human Airway Epithelial Cells To Promote Neutrophil Recruitment.

Jamieson KC, Traves SL, Kooi C, Wiehler S, Dumonceaux CJ, Maciejewski BA, Arnason JW, Michi AN, Leigh R, Proud D.

J Immunol. 2019 Jan 1;202(1):160-170. doi: 10.4049/jimmunol.1800547. Epub 2018 Nov 30.


Recurrent thrombolysis of a stuttering lacunar infarction captured on serial MRIs.

Naqvi I, Simpkins AN, Cullison K, Elliott E, Reyes D, Leigh R, Lynch JK.

eNeurologicalSci. 2018 Oct 30;13:14-17. doi: 10.1016/j.ensci.2018.10.001. eCollection 2018 Dec.


Assessment of the long-term safety of mepolizumab and durability of clinical response in patients with severe eosinophilic asthma.

Khatri S, Moore W, Gibson PG, Leigh R, Bourdin A, Maspero J, Barros M, Buhl R, Howarth P, Albers FC, Bradford ES, Gilson M, Price RG, Yancey SW, Ortega H.

J Allergy Clin Immunol. 2019 May;143(5):1742-1751.e7. doi: 10.1016/j.jaci.2018.09.033. Epub 2018 Oct 23.


Co-occurrence of Asthma and the Inflammatory Bowel Diseases: A Systematic Review and Meta-analysis.

Kuenzig ME, Bishay K, Leigh R, Kaplan GG, Benchimol EI; Crowdscreen SR Review Team.

Clin Transl Gastroenterol. 2018 Sep 24;9(9):188. doi: 10.1038/s41424-018-0054-z.


Stem cells are the most sensitive screening tool to identify toxicity of GATA4-targeted novel small-molecule compounds.

Karhu ST, Välimäki MJ, Jumppanen M, Kinnunen SM, Pohjolainen L, Leigh RS, Auno S, Földes G, Boije Af Gennäs G, Yli-Kauhaluoma J, Ruskoaho H, Talman V.

Arch Toxicol. 2018 Sep;92(9):2897-2911. doi: 10.1007/s00204-018-2257-1. Epub 2018 Jul 9.


A phase IIa proof-of-concept, placebo-controlled, randomized, double-blind, crossover, single-dose clinical trial of a new class of bronchodilator for acute asthma.

Swystun V, Green FHY, Dennis JH, Rampakakis E, Lalli G, Fadayomi M, Chiu A, Shrestha G, El Shahat SG, Nelson DE, El Mays TY, Pieron CA, Leigh R.

Trials. 2018 Jun 18;19(1):321. doi: 10.1186/s13063-018-2720-6.


Effectiveness of a standardized electronic admission order set for acute exacerbation of chronic obstructive pulmonary disease.

Pendharkar SR, Ospina MB, Southern DA, Hirani N, Graham J, Faris P, Bhutani M, Leigh R, Mody CH, Stickland MK.

BMC Pulm Med. 2018 May 30;18(1):93. doi: 10.1186/s12890-018-0657-x.


Safety of intravenous alteplase within 4.5 hours for patients awakening with stroke symptoms.

Urrutia VC, Faigle R, Zeiler SR, Marsh EB, Bahouth M, Cerdan Trevino M, Dearborn J, Leigh R, Rice S, Lane K, Saheed M, Hill P, Llinas RH.

PLoS One. 2018 May 22;13(5):e0197714. doi: 10.1371/journal.pone.0197714. eCollection 2018.


Severe, eosinophilic asthma in primary care in Canada: a longitudinal study of the clinical burden and economic impact based on linked electronic medical record data.

Husereau D, Goodfield J, Leigh R, Borrelli R, Cloutier M, Gendron A.

Allergy Asthma Clin Immunol. 2018 Apr 24;14:15. doi: 10.1186/s13223-018-0241-1. eCollection 2018.


Effects of personal air pollution exposure on asthma symptoms, lung function and airway inflammation.

Chambers L, Finch J, Edwards K, Jeanjean A, Leigh R, Gonem S.

Clin Exp Allergy. 2018 Jul;48(7):798-805. doi: 10.1111/cea.13130. Epub 2018 Apr 10.


Development of a patient-centred, evidence-based and consensus-based discharge care bundle for patients with acute exacerbation of chronic obstructive pulmonary disease.

Ospina MB, Michas M, Deuchar L, Leigh R, Bhutani M, Rowe BH, Marciniuk D, Goodridge D, Dechman G, Bourbeau J, Balter M, Camp P, Hernandez P, Goldstein RS, Stickland MK.

BMJ Open Respir Res. 2018 Jan 30;5(1):e000265. doi: 10.1136/bmjresp-2017-000265. eCollection 2018.


Blood-ocular barrier disruption in patients with acute stroke.

Hitomi E, Simpkins AN, Luby M, Latour LL, Leigh RJ, Leigh R.

Neurology. 2018 Mar 13;90(11):e915-e923. doi: 10.1212/WNL.0000000000005123. Epub 2018 Feb 7.


White Matter Hyperintensity-Associated Blood-Brain Barrier Disruption and Vascular Risk Factors.

Gupta N, Simpkins AN, Hitomi E, Dias C, Leigh R; NIH Natural History of Stroke Investigators.

J Stroke Cerebrovasc Dis. 2018 Feb;27(2):466-471. doi: 10.1016/j.jstrokecerebrovasdis.2017.09.026. Epub 2017 Oct 31.


Blood-brain barrier leakage increases with small vessel disease in acute ischemic stroke.

Arba F, Leigh R, Inzitari D, Warach SJ, Luby M, Lees KR; STIR/VISTA Imaging Collaboration.

Neurology. 2017 Nov 21;89(21):2143-2150. doi: 10.1212/WNL.0000000000004677. Epub 2017 Oct 25.


Sex differences in outcomes after discharge from Alberta emergency departments for asthma: A large population-based study.

Rosychuk RJ, Ospina M, Zhang J, Leigh R, Cave A, Rowe BH.

J Asthma. 2018 Aug;55(8):817-825. doi: 10.1080/02770903.2017.1373805. Epub 2017 Oct 16.


An expert system feedback tool improves the reliability of clinical gait kinematics for older adults with lower limb osteoarthritis.

Osis ST, Kobsar D, Leigh RJ, Macaulay CAJ, Ferber R.

Gait Posture. 2017 Oct;58:261-267. doi: 10.1016/j.gaitpost.2017.08.011. Epub 2017 Aug 10.


Consensus statement on current and emerging methods for the diagnosis and evaluation of cerebrovascular disease.

Donahue MJ, Achten E, Cogswell PM, De Leeuw FE, Derdeyn CP, Dijkhuizen RM, Fan AP, Ghaznawi R, Heit JJ, Ikram MA, Jezzard P, Jordan LC, Jouvent E, Knutsson L, Leigh R, Liebeskind DS, Lin W, Okell TW, Qureshi AI, Stagg CJ, van Osch MJ, van Zijl PC, Watchmaker JM, Wintermark M, Wu O, Zaharchuk G, Zhou J, Hendrikse J.

J Cereb Blood Flow Metab. 2018 Sep;38(9):1391-1417. doi: 10.1177/0271678X17721830. Epub 2017 Aug 17. Review.


Clinical News.

Moore M, Fricker J, Leigh R, Brahmania M, van Hazel G.

Br J Hosp Med (Lond). 2017 Aug 2;78(8):428-431. doi: 10.12968/hmed.2017.78.8.428. No abstract available.


Practical Use of Metal Oxide Semiconductor Gas Sensors for Measuring Nitrogen Dioxide and Ozone in Urban Environments.

Peterson PJD, Aujla A, Grant KH, Brundle AG, Thompson MR, Vande Hey J, Leigh RJ.

Sensors (Basel). 2017 Jul 19;17(7). pii: E1653. doi: 10.3390/s17071653.


An MRI Hyperintense Acute Reperfusion Marker Is Related to Elevated Peripheral Monocyte Count in Acute Ischemic Stroke.

Nadareishvili Z, Luby M, Leigh R, Shah J, Lynch JK, Hsia AW, Benson RT, Latour LL.

J Neuroimaging. 2018 Jan;28(1):57-60. doi: 10.1111/jon.12462. Epub 2017 Jul 19.


Early Change in Stroke Size Performs Best in Predicting Response to Therapy.

Simpkins AN, Dias C, Norato G, Kim E, Leigh R; NIH Natural History of Stroke Investigators.

Cerebrovasc Dis. 2017;44(3-4):141-149. doi: 10.1159/000477945. Epub 2017 Jul 7.


Improving the detection sensitivity of pH-weighted amide proton transfer MRI in acute stroke patients using extrapolated semisolid magnetization transfer reference signals.

Heo HY, Zhang Y, Burton TM, Jiang S, Zhao Y, van Zijl PCM, Leigh R, Zhou J.

Magn Reson Med. 2017 Sep;78(3):871-880. doi: 10.1002/mrm.26799. Epub 2017 Jun 21.


Electrophysiological signatures of phonological and semantic maintenance in sentence repetition.

Meltzer JA, Kielar A, Panamsky L, Links KA, Deschamps T, Leigh RC.

Neuroimage. 2017 Aug 1;156:302-314. doi: 10.1016/j.neuroimage.2017.05.030. Epub 2017 May 17.


Human β-defensin-2 production upon viral and bacterial co-infection is attenuated in COPD.

Arnason JW, Murphy JC, Kooi C, Wiehler S, Traves SL, Shelfoon C, Maciejewski B, Dumonceaux CJ, Lewenza WS, Proud D, Leigh R.

PLoS One. 2017 May 10;12(5):e0175963. doi: 10.1371/journal.pone.0175963. eCollection 2017.


Recovery of orthographic processing after stroke: A longitudinal fMRI study.

Purcell J, Sebastian R, Leigh R, Jarso S, Davis C, Posner J, Wright A, Hillis AE.

Cortex. 2017 Jul;92:103-118. doi: 10.1016/j.cortex.2017.03.022. Epub 2017 Apr 8.


Perfusion Deficits and Association with Clinical Outcome in Patients with Anterior Choroidal Artery Stroke.

Alqahtani SA, Luby M, Nadareishvili Z, Benson RT, Hsia AW, Leigh R, Lynch JK.

J Stroke Cerebrovasc Dis. 2017 Aug;26(8):1755-1759. doi: 10.1016/j.jstrokecerebrovasdis.2017.04.001. Epub 2017 Apr 27.


The association between air pollution and type 2 diabetes in a large cross-sectional study in Leicester: The CHAMPIONS Study.

O'Donovan G, Chudasama Y, Grocock S, Leigh R, Dalton AM, Gray LJ, Yates T, Edwardson C, Hill S, Henson J, Webb D, Khunti K, Davies MJ, Jones AP, Bodicoat DH, Wells A.

Environ Int. 2017 Jul;104:41-47. doi: 10.1016/j.envint.2017.03.027. Epub 2017 Apr 13.


Imaging the physiological evolution of the ischemic penumbra in acute ischemic stroke.

Leigh R, Knutsson L, Zhou J, van Zijl PC.

J Cereb Blood Flow Metab. 2018 Sep;38(9):1500-1516. doi: 10.1177/0271678X17700913. Epub 2017 Mar 27. Review.


Ranking current and prospective NO2 pollution mitigation strategies: An environmental and economic modelling investigation in Oxford Street, London.

Jeanjean APR, Gallagher J, Monks PS, Leigh RJ.

Environ Pollut. 2017 Jun;225:587-597. doi: 10.1016/j.envpol.2017.03.027. Epub 2017 Mar 21.


Rhinovirus-bacteria coexposure synergistically induces CCL20 production from human bronchial epithelial cells.

Maciejewski BA, Jamieson KC, Arnason JW, Kooi C, Wiehler S, Traves SL, Leigh R, Proud D.

Am J Physiol Lung Cell Mol Physiol. 2017 May 1;312(5):L731-L740. doi: 10.1152/ajplung.00362.2016. Epub 2017 Mar 10.


Human Rhinovirus Infection of Epithelial Cells Modulates Airway Smooth Muscle Migration.

Shariff S, Shelfoon C, Holden NS, Traves SL, Wiehler S, Kooi C, Proud D, Leigh R.

Am J Respir Cell Mol Biol. 2017 Jun;56(6):796-803. doi: 10.1165/rcmb.2016-0252OC.


Ocular stability and set-point adaptation.

Zee DS, Jareonsettasin P, Leigh RJ.

Philos Trans R Soc Lond B Biol Sci. 2017 Apr 19;372(1718). pii: 20160199. doi: 10.1098/rstb.2016.0199. Review.


An inhaled dose of budesonide induces genes involved in transcription and signaling in the human airways: enhancement of anti- and proinflammatory effector genes.

Leigh R, Mostafa MM, King EM, Rider CF, Shah S, Dumonceaux C, Traves SL, McWhae A, Kolisnik T, Kooi C, Slater DM, Kelly MM, Bieda M, Miller-Larsson A, Newton R.

Pharmacol Res Perspect. 2016 Jul 12;4(4):e00243. doi: 10.1002/prp2.243. eCollection 2016 Aug.


Stuttering lacunar infarction captured on serial MRIs.

Tahsili-Fahadan P, Simpkins AN, Leigh R, Merino JG.

Neurol Clin Pract. 2016 Oct;6(5):e37-e39. No abstract available.


Increased ventilatory response to carbon dioxide in COPD patients following vitamin C administration.

Hartmann SE, Kissel CK, Szabo L, Walker BL, Leigh R, Anderson TJ, Poulin MJ.

ERJ Open Res. 2015 Sep 15;1(1). pii: 00017-2015. eCollection 2015 May.

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