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Molecular signature of penumbra in acute ischemic stroke: a pilot transcriptomics study.

Nadareishvili Z, Kelley D, Luby M, Simpkins AN, Leigh R, Lynch JK, Hsia AW, Benson RT, Johnson KR, Hallenbeck JM, Latour LL.

Ann Clin Transl Neurol. 2019 Mar 13;6(4):817-820. doi: 10.1002/acn3.757. eCollection 2019 Apr.


Omalizumab in patients with severe asthma and persistent sputum eosinophilia.

Mukherjee M, Kjarsgaard M, Radford K, Huang C, Leigh R, Dorscheid DR, Lemiere C, Boulet LP, Waserman S, Martin J, Nair P.

Allergy Asthma Clin Immunol. 2019 Apr 3;15:21. doi: 10.1186/s13223-019-0337-2. eCollection 2019.


Post-Stroke Blood-Brain Barrier Disruption and Poor Functional Outcome in Patients Receiving Thrombolytic Therapy.

Nadareishvili Z, Simpkins AN, Hitomi E, Reyes D, Leigh R.

Cerebrovasc Dis. 2019 Apr 10:1-8. doi: 10.1159/000499666. [Epub ahead of print]


Glucocorticoid-driven transcriptomes in human airway epithelial cells: commonalities, differences and functional insight from cell lines and primary cells.

Mostafa MM, Rider CF, Shah S, Traves SL, Gordon PMK, Miller-Larsson A, Leigh R, Newton R.

BMC Med Genomics. 2019 Jan 31;12(1):29. doi: 10.1186/s12920-018-0467-2.


Sustained Opening of the Blood-Brain Barrier with Progressive Accumulation of White Matter Hyperintensities Following Ischemic Stroke.

Naqvi I, Hitomi E, Leigh R.

Brain Sci. 2019 Jan 21;9(1). pii: E16. doi: 10.3390/brainsci9010016.


The Efficacy of IV Tissue Plasminogen Activator for Restoring Cerebral Blood Flow in the Hours Immediately after Administration in Patients with Acute Stroke.

Majidi S, Simpkins AN, Leigh R; NIH Natural History of Stroke Investigators.

J Neuroimaging. 2019 Mar;29(2):206-210. doi: 10.1111/jon.12587. Epub 2018 Dec 3.


Rhinovirus and Bacteria Synergistically Induce IL-17C Release from Human Airway Epithelial Cells To Promote Neutrophil Recruitment.

Jamieson KC, Traves SL, Kooi C, Wiehler S, Dumonceaux CJ, Maciejewski BA, Arnason JW, Michi AN, Leigh R, Proud D.

J Immunol. 2019 Jan 1;202(1):160-170. doi: 10.4049/jimmunol.1800547. Epub 2018 Nov 30.


Recurrent thrombolysis of a stuttering lacunar infarction captured on serial MRIs.

Naqvi I, Simpkins AN, Cullison K, Elliott E, Reyes D, Leigh R, Lynch JK.

eNeurologicalSci. 2018 Oct 30;13:14-17. doi: 10.1016/j.ensci.2018.10.001. eCollection 2018 Dec.


Assessment of the long-term safety of mepolizumab and durability of clinical response in patients with severe eosinophilic asthma.

Khatri S, Moore W, Gibson PG, Leigh R, Bourdin A, Maspero J, Barros M, Buhl R, Howarth P, Albers FC, Bradford ES, Gilson M, Price RG, Yancey SW, Ortega H.

J Allergy Clin Immunol. 2019 May;143(5):1742-1751.e7. doi: 10.1016/j.jaci.2018.09.033. Epub 2018 Oct 23.


Co-occurrence of Asthma and the Inflammatory Bowel Diseases: A Systematic Review and Meta-analysis.

Kuenzig ME, Bishay K, Leigh R, Kaplan GG, Benchimol EI; Crowdscreen SR Review Team.

Clin Transl Gastroenterol. 2018 Sep 24;9(9):188. doi: 10.1038/s41424-018-0054-z.


Stem cells are the most sensitive screening tool to identify toxicity of GATA4-targeted novel small-molecule compounds.

Karhu ST, Välimäki MJ, Jumppanen M, Kinnunen SM, Pohjolainen L, Leigh RS, Auno S, Földes G, Boije Af Gennäs G, Yli-Kauhaluoma J, Ruskoaho H, Talman V.

Arch Toxicol. 2018 Sep;92(9):2897-2911. doi: 10.1007/s00204-018-2257-1. Epub 2018 Jul 9.


A phase IIa proof-of-concept, placebo-controlled, randomized, double-blind, crossover, single-dose clinical trial of a new class of bronchodilator for acute asthma.

Swystun V, Green FHY, Dennis JH, Rampakakis E, Lalli G, Fadayomi M, Chiu A, Shrestha G, El Shahat SG, Nelson DE, El Mays TY, Pieron CA, Leigh R.

Trials. 2018 Jun 18;19(1):321. doi: 10.1186/s13063-018-2720-6.


Effectiveness of a standardized electronic admission order set for acute exacerbation of chronic obstructive pulmonary disease.

Pendharkar SR, Ospina MB, Southern DA, Hirani N, Graham J, Faris P, Bhutani M, Leigh R, Mody CH, Stickland MK.

BMC Pulm Med. 2018 May 30;18(1):93. doi: 10.1186/s12890-018-0657-x.


Safety of intravenous alteplase within 4.5 hours for patients awakening with stroke symptoms.

Urrutia VC, Faigle R, Zeiler SR, Marsh EB, Bahouth M, Cerdan Trevino M, Dearborn J, Leigh R, Rice S, Lane K, Saheed M, Hill P, Llinas RH.

PLoS One. 2018 May 22;13(5):e0197714. doi: 10.1371/journal.pone.0197714. eCollection 2018.


Severe, eosinophilic asthma in primary care in Canada: a longitudinal study of the clinical burden and economic impact based on linked electronic medical record data.

Husereau D, Goodfield J, Leigh R, Borrelli R, Cloutier M, Gendron A.

Allergy Asthma Clin Immunol. 2018 Apr 24;14:15. doi: 10.1186/s13223-018-0241-1. eCollection 2018.


Effects of personal air pollution exposure on asthma symptoms, lung function and airway inflammation.

Chambers L, Finch J, Edwards K, Jeanjean A, Leigh R, Gonem S.

Clin Exp Allergy. 2018 Jul;48(7):798-805. doi: 10.1111/cea.13130. Epub 2018 Apr 10.


Development of a patient-centred, evidence-based and consensus-based discharge care bundle for patients with acute exacerbation of chronic obstructive pulmonary disease.

Ospina MB, Michas M, Deuchar L, Leigh R, Bhutani M, Rowe BH, Marciniuk D, Goodridge D, Dechman G, Bourbeau J, Balter M, Camp P, Hernandez P, Goldstein RS, Stickland MK.

BMJ Open Respir Res. 2018 Jan 30;5(1):e000265. doi: 10.1136/bmjresp-2017-000265. eCollection 2018.


Blood-ocular barrier disruption in patients with acute stroke.

Hitomi E, Simpkins AN, Luby M, Latour LL, Leigh RJ, Leigh R.

Neurology. 2018 Mar 13;90(11):e915-e923. doi: 10.1212/WNL.0000000000005123. Epub 2018 Feb 7.


White Matter Hyperintensity-Associated Blood-Brain Barrier Disruption and Vascular Risk Factors.

Gupta N, Simpkins AN, Hitomi E, Dias C, Leigh R; NIH Natural History of Stroke Investigators.

J Stroke Cerebrovasc Dis. 2018 Feb;27(2):466-471. doi: 10.1016/j.jstrokecerebrovasdis.2017.09.026. Epub 2017 Oct 31.


Blood-brain barrier leakage increases with small vessel disease in acute ischemic stroke.

Arba F, Leigh R, Inzitari D, Warach SJ, Luby M, Lees KR; STIR/VISTA Imaging Collaboration.

Neurology. 2017 Nov 21;89(21):2143-2150. doi: 10.1212/WNL.0000000000004677. Epub 2017 Oct 25.


Sex differences in outcomes after discharge from Alberta emergency departments for asthma: A large population-based study.

Rosychuk RJ, Ospina M, Zhang J, Leigh R, Cave A, Rowe BH.

J Asthma. 2018 Aug;55(8):817-825. doi: 10.1080/02770903.2017.1373805. Epub 2017 Oct 16.


An expert system feedback tool improves the reliability of clinical gait kinematics for older adults with lower limb osteoarthritis.

Osis ST, Kobsar D, Leigh RJ, Macaulay CAJ, Ferber R.

Gait Posture. 2017 Oct;58:261-267. doi: 10.1016/j.gaitpost.2017.08.011. Epub 2017 Aug 10.


Consensus statement on current and emerging methods for the diagnosis and evaluation of cerebrovascular disease.

Donahue MJ, Achten E, Cogswell PM, De Leeuw FE, Derdeyn CP, Dijkhuizen RM, Fan AP, Ghaznawi R, Heit JJ, Ikram MA, Jezzard P, Jordan LC, Jouvent E, Knutsson L, Leigh R, Liebeskind DS, Lin W, Okell TW, Qureshi AI, Stagg CJ, van Osch MJ, van Zijl PC, Watchmaker JM, Wintermark M, Wu O, Zaharchuk G, Zhou J, Hendrikse J.

J Cereb Blood Flow Metab. 2018 Sep;38(9):1391-1417. doi: 10.1177/0271678X17721830. Epub 2017 Aug 17.


Clinical News.

Moore M, Fricker J, Leigh R, Brahmania M, van Hazel G.

Br J Hosp Med (Lond). 2017 Aug 2;78(8):428-431. doi: 10.12968/hmed.2017.78.8.428. No abstract available.


Practical Use of Metal Oxide Semiconductor Gas Sensors for Measuring Nitrogen Dioxide and Ozone in Urban Environments.

Peterson PJD, Aujla A, Grant KH, Brundle AG, Thompson MR, Vande Hey J, Leigh RJ.

Sensors (Basel). 2017 Jul 19;17(7). pii: E1653. doi: 10.3390/s17071653.


An MRI Hyperintense Acute Reperfusion Marker Is Related to Elevated Peripheral Monocyte Count in Acute Ischemic Stroke.

Nadareishvili Z, Luby M, Leigh R, Shah J, Lynch JK, Hsia AW, Benson RT, Latour LL.

J Neuroimaging. 2018 Jan;28(1):57-60. doi: 10.1111/jon.12462. Epub 2017 Jul 19.


Early Change in Stroke Size Performs Best in Predicting Response to Therapy.

Simpkins AN, Dias C, Norato G, Kim E, Leigh R; NIH Natural History of Stroke Investigators.

Cerebrovasc Dis. 2017;44(3-4):141-149. doi: 10.1159/000477945. Epub 2017 Jul 7.


Improving the detection sensitivity of pH-weighted amide proton transfer MRI in acute stroke patients using extrapolated semisolid magnetization transfer reference signals.

Heo HY, Zhang Y, Burton TM, Jiang S, Zhao Y, van Zijl PCM, Leigh R, Zhou J.

Magn Reson Med. 2017 Sep;78(3):871-880. doi: 10.1002/mrm.26799. Epub 2017 Jun 21.


Electrophysiological signatures of phonological and semantic maintenance in sentence repetition.

Meltzer JA, Kielar A, Panamsky L, Links KA, Deschamps T, Leigh RC.

Neuroimage. 2017 Aug 1;156:302-314. doi: 10.1016/j.neuroimage.2017.05.030. Epub 2017 May 17.


Human β-defensin-2 production upon viral and bacterial co-infection is attenuated in COPD.

Arnason JW, Murphy JC, Kooi C, Wiehler S, Traves SL, Shelfoon C, Maciejewski B, Dumonceaux CJ, Lewenza WS, Proud D, Leigh R.

PLoS One. 2017 May 10;12(5):e0175963. doi: 10.1371/journal.pone.0175963. eCollection 2017.


Recovery of orthographic processing after stroke: A longitudinal fMRI study.

Purcell J, Sebastian R, Leigh R, Jarso S, Davis C, Posner J, Wright A, Hillis AE.

Cortex. 2017 Jul;92:103-118. doi: 10.1016/j.cortex.2017.03.022. Epub 2017 Apr 8.


Perfusion Deficits and Association with Clinical Outcome in Patients with Anterior Choroidal Artery Stroke.

Alqahtani SA, Luby M, Nadareishvili Z, Benson RT, Hsia AW, Leigh R, Lynch JK.

J Stroke Cerebrovasc Dis. 2017 Aug;26(8):1755-1759. doi: 10.1016/j.jstrokecerebrovasdis.2017.04.001. Epub 2017 Apr 27.


The association between air pollution and type 2 diabetes in a large cross-sectional study in Leicester: The CHAMPIONS Study.

O'Donovan G, Chudasama Y, Grocock S, Leigh R, Dalton AM, Gray LJ, Yates T, Edwardson C, Hill S, Henson J, Webb D, Khunti K, Davies MJ, Jones AP, Bodicoat DH, Wells A.

Environ Int. 2017 Jul;104:41-47. doi: 10.1016/j.envint.2017.03.027. Epub 2017 Apr 13.


Imaging the physiological evolution of the ischemic penumbra in acute ischemic stroke.

Leigh R, Knutsson L, Zhou J, van Zijl PC.

J Cereb Blood Flow Metab. 2018 Sep;38(9):1500-1516. doi: 10.1177/0271678X17700913. Epub 2017 Mar 27.


Ranking current and prospective NO2 pollution mitigation strategies: An environmental and economic modelling investigation in Oxford Street, London.

Jeanjean APR, Gallagher J, Monks PS, Leigh RJ.

Environ Pollut. 2017 Jun;225:587-597. doi: 10.1016/j.envpol.2017.03.027. Epub 2017 Mar 21.


Rhinovirus-bacteria coexposure synergistically induces CCL20 production from human bronchial epithelial cells.

Maciejewski BA, Jamieson KC, Arnason JW, Kooi C, Wiehler S, Traves SL, Leigh R, Proud D.

Am J Physiol Lung Cell Mol Physiol. 2017 May 1;312(5):L731-L740. doi: 10.1152/ajplung.00362.2016. Epub 2017 Mar 10.


Human Rhinovirus Infection of Epithelial Cells Modulates Airway Smooth Muscle Migration.

Shariff S, Shelfoon C, Holden NS, Traves SL, Wiehler S, Kooi C, Proud D, Leigh R.

Am J Respir Cell Mol Biol. 2017 Jun;56(6):796-803. doi: 10.1165/rcmb.2016-0252OC.


Ocular stability and set-point adaptation.

Zee DS, Jareonsettasin P, Leigh RJ.

Philos Trans R Soc Lond B Biol Sci. 2017 Apr 19;372(1718). pii: 20160199. doi: 10.1098/rstb.2016.0199. Review.


An inhaled dose of budesonide induces genes involved in transcription and signaling in the human airways: enhancement of anti- and proinflammatory effector genes.

Leigh R, Mostafa MM, King EM, Rider CF, Shah S, Dumonceaux C, Traves SL, McWhae A, Kolisnik T, Kooi C, Slater DM, Kelly MM, Bieda M, Miller-Larsson A, Newton R.

Pharmacol Res Perspect. 2016 Jul 12;4(4):e00243. doi: 10.1002/prp2.243. eCollection 2016 Aug.


Stuttering lacunar infarction captured on serial MRIs.

Tahsili-Fahadan P, Simpkins AN, Leigh R, Merino JG.

Neurol Clin Pract. 2016 Oct;6(5):e37-e39. No abstract available.


Increased ventilatory response to carbon dioxide in COPD patients following vitamin C administration.

Hartmann SE, Kissel CK, Szabo L, Walker BL, Leigh R, Anderson TJ, Poulin MJ.

ERJ Open Res. 2015 Sep 15;1(1). pii: 00017-2015. eCollection 2015 May.


A systematic review of the effectiveness of discharge care bundles for patients with COPD.

Ospina MB, Mrklas K, Deuchar L, Rowe BH, Leigh R, Bhutani M, Stickland MK.

Thorax. 2017 Jan;72(1):31-39. doi: 10.1136/thoraxjnl-2016-208820. Epub 2016 Sep 9. Review.


Long-term Efficacy and Safety of Mepolizumab in Patients With Severe Eosinophilic Asthma: A Multi-center, Open-label, Phase IIIb Study.

Lugogo N, Domingo C, Chanez P, Leigh R, Gilson MJ, Price RG, Yancey SW, Ortega HG.

Clin Ther. 2016 Sep;38(9):2058-2070.e1. doi: 10.1016/j.clinthera.2016.07.010. Epub 2016 Aug 21.


A phase I, placebo-controlled, randomized, double-blind, single ascending dose-ranging study to evaluate the safety and tolerability of a novel biophysical bronchodilator (S-1226) administered by nebulization in healthy volunteers.

Green FH, Leigh R, Fadayomi M, Lalli G, Chiu A, Shrestha G, ElShahat SG, Nelson DE, El Mays TY, Pieron CA, Dennis JH.

Trials. 2016 Jul 28;17:361. doi: 10.1186/s13063-016-1489-8.


Identification of Reversible Disruption of the Human Blood-Brain Barrier Following Acute Ischemia.

Simpkins AN, Dias C, Leigh R; National Institutes of Health Natural History of Stroke Investigators.

Stroke. 2016 Sep;47(9):2405-8. doi: 10.1161/STROKEAHA.116.013805. Epub 2016 Jul 26.


A dual CysLT1/2 antagonist attenuates allergen-induced airway responses in subjects with mild allergic asthma.

Gauvreau GM, Boulet LP, FitzGerald JM, Cockcroft DW, Davis BE, Leigh R, Tanaka M, Fourre JA, Tanaka M, Nabata T, O'Byrne PM.

Allergy. 2016 Dec;71(12):1721-1727. doi: 10.1111/all.12987. Epub 2016 Aug 9.


A miR-335/COX-2/PTEN axis regulates the secretory phenotype of senescent cancer-associated fibroblasts.

Kabir TD, Leigh RJ, Tasena H, Mellone M, Coletta RD, Parkinson EK, Prime SS, Thomas GJ, Paterson IC, Zhou D, McCall J, Speight PM, Lambert DW.

Aging (Albany NY). 2016 Aug;8(8):1608-35. doi: 10.18632/aging.100987.


Pretreatment blood-brain barrier disruption and post-endovascular intracranial hemorrhage.

Leigh R, Christensen S, Campbell BC, Marks MP, Albers GW, Lansberg MG; DEFUSE 2 Investigators.

Neurology. 2016 Jul 19;87(3):263-9. doi: 10.1212/WNL.0000000000002862. Epub 2016 Jun 17.


Imaging Immunity in Lymph Nodes: Past, Present and Future.

Butler J, Sawtell A, Jarrett S, Cosgrove J, Leigh R, Timmis J, Coles M.

Adv Exp Med Biol. 2016;915:329-46. doi: 10.1007/978-3-319-32189-9_20. Review.


Efficacy and safety of multiple doses of QGE031 (ligelizumab) versus omalizumab and placebo in inhibiting allergen-induced early asthmatic responses.

Gauvreau GM, Arm JP, Boulet LP, Leigh R, Cockcroft DW, Davis BE, Mayers I, FitzGerald JM, Dahlen B, Killian KJ, Laviolette M, Carlsten C, Lazarinis N, Watson RM, Milot J, Swystun V, Bowen M, Hui L, Lantz AS, Meiser K, Maahs S, Lowe PJ, Skerjanec A, Drollmann A, O'Byrne PM.

J Allergy Clin Immunol. 2016 Oct;138(4):1051-1059. doi: 10.1016/j.jaci.2016.02.027. Epub 2016 Apr 7.


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