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Early Quantitative Partial Weight-bearing Exercise after Periarticular Fractures of the Tibia Using a Lower-Body Positive-Pressure Treadmill: A Case Series.

Kim JC, Leigh JH, Jang JY, Kim JK, Cho JW, Oh JK, Nam HS, Chung SG, Chang YH, Lee SH.

Am J Phys Med Rehabil. 2019 Jun 26. doi: 10.1097/PHM.0000000000001257. [Epub ahead of print]


Assessment of Dysarthria Using One-Word Speech Recognition with Hidden Markov Models.

Lee SH, Kim M, Seo HG, Oh BM, Lee G, Leigh JH.

J Korean Med Sci. 2019 Apr 8;34(13):e108. doi: 10.3346/jkms.2019.34.e108.


Use of coronary artery calcium testing to improve coronary heart disease risk assessment in a lung cancer screening population: The Multi-Ethnic Study of Atherosclerosis (MESA).

Garg PK, Jorgensen NW, McClelland RL, Leigh JA, Greenland P, Blaha MJ, Yoon AJ, Wong ND, Yeboah J, Budoff MJ.

J Cardiovasc Comput Tomogr. 2018 Nov - Dec;12(6):493-499. doi: 10.1016/j.jcct.2018.10.001. Epub 2018 Oct 2.


Smoking intensity and duration is associated with cardiac structure and function: the ECHOcardiographic Study of Hispanics/Latinos.

Leigh JA, Kaplan RC, Swett K, Balfour P, Kansal MM, Talavera GA, Perreira K, Blaha MJ, Benjamin EJ, Robertson R, Bhartnagar A, Rodriguez CJ.

Open Heart. 2017 Jun 14;4(2):e000614. doi: 10.1136/openhrt-2017-000614. eCollection 2017.


Defining the ABC of gene essentiality in streptococci.

Charbonneau ARL, Forman OP, Cain AK, Newland G, Robinson C, Boursnell M, Parkhill J, Leigh JA, Maskell DJ, Waller AS.

BMC Genomics. 2017 May 31;18(1):426. doi: 10.1186/s12864-017-3794-3.


Exploring Hydrogenotrophic Methanogenesis: a Genome Scale Metabolic Reconstruction of Methanococcus maripaludis.

Richards MA, Lie TJ, Zhang J, Ragsdale SW, Leigh JA, Price ND.

J Bacteriol. 2016 Nov 18;198(24):3379-3390. Print 2016 Dec 15.


Electrocardiographic Left Ventricular Hypertrophy as a Predictor of Cardiovascular Disease Independent of Left Ventricular Anatomy in Subjects Aged ≥65 Years.

Leigh JA, O'Neal WT, Soliman EZ.

Am J Cardiol. 2016 Jun 1;117(11):1831-5. doi: 10.1016/j.amjcard.2016.03.020. Epub 2016 Mar 19.


Ethnic Minorities and Coronary Heart Disease: an Update and Future Directions.

Leigh JA, Alvarez M, Rodriguez CJ.

Curr Atheroscler Rep. 2016 Feb;18(2):9. doi: 10.1007/s11883-016-0559-4. Review.


Streptococcus uberis strains isolated from the bovine mammary gland evade immune recognition by mammary epithelial cells, but not of macrophages.

Günther J, Czabanska A, Bauer I, Leigh JA, Holst O, Seyfert HM.

Vet Res. 2016 Jan 7;47:13. doi: 10.1186/s13567-015-0287-8.


Comparison of Echocardiographic Measures in a Hispanic/Latino Population With the 2005 and 2015 American Society of Echocardiography Reference Limits (The Echocardiographic Study of Latinos).

Qureshi WT, Leigh JA, Swett K, Dharod A, Allison MA, Cai J, Gonzalez F 2nd, Hurwitz BE, Shah SJ, Desai AA, Spevack DM, Rodriguez CJ.

Circ Cardiovasc Imaging. 2016 Jan;9(1). pii: e003597. doi: 10.1161/CIRCIMAGING.115.003597.


Will Ebola change the game? Ten essential reforms before the next pandemic. The report of the Harvard-LSHTM Independent Panel on the Global Response to Ebola.

Moon S, Sridhar D, Pate MA, Jha AK, Clinton C, Delaunay S, Edwin V, Fallah M, Fidler DP, Garrett L, Goosby E, Gostin LO, Heymann DL, Lee K, Leung GM, Morrison JS, Saavedra J, Tanner M, Leigh JA, Hawkins B, Woskie LR, Piot P.

Lancet. 2015 Nov 28;386(10009):2204-21. doi: 10.1016/S0140-6736(15)00946-0. Epub 2015 Nov 23. No abstract available.


Molecular Epidemiology of Streptococcus uberis Clinical Mastitis in Dairy Herds: Strain Heterogeneity and Transmission.

Davies PL, Leigh JA, Bradley AJ, Archer SC, Emes RD, Green MJ.

J Clin Microbiol. 2016 Jan;54(1):68-74. doi: 10.1128/JCM.01583-15. Epub 2015 Oct 21.


Transposon insertion mapping with PIMMS - Pragmatic Insertional Mutation Mapping System.

Blanchard AM, Leigh JA, Egan SA, Emes RD.

Front Genet. 2015 Apr 9;6:139. doi: 10.3389/fgene.2015.00139. eCollection 2015.


Virulence related sequences; insights provided by comparative genomics of Streptococcus uberis of differing virulence.

Hossain M, Egan SA, Coffey T, Ward PN, Wilson R, Leigh JA, Emes RD.

BMC Genomics. 2015 Apr 23;16:334. doi: 10.1186/s12864-015-1512-6.


Transforming community services through the use of a multidimensional model of clinical leadership.

Leigh JA, Wild J, Hynes C, Wells S, Kurien A, Rutherford J, Rosen L, Ashcroft T, Hartley V.

J Clin Nurs. 2015 Mar;24(5-6):749-60. doi: 10.1111/jocn.12668. Epub 2014 Aug 26.


Two distinct populations of bovine IL-17⁺ T-cells can be induced and WC1⁺IL-17⁺γδ T-cells are effective killers of protozoan parasites.

Peckham RK, Brill R, Foster DS, Bowen AL, Leigh JA, Coffey TJ, Flynn RJ.

Sci Rep. 2014 Jun 25;4:5431. doi: 10.1038/srep05431.


Editorial: Reconstructing practice-based educator roles through effective practice-education partnerships.

Leigh JA.

J Clin Nurs. 2014 Jul;23(13-14):1767-9. doi: 10.1111/jocn.12381. No abstract available.


Metabolic versatility in methanogens.

Costa KC, Leigh JA.

Curr Opin Biotechnol. 2014 Oct;29:70-5. doi: 10.1016/j.copbio.2014.02.012. Epub 2014 Mar 21. Review.


A systems level predictive model for global gene regulation of methanogenesis in a hydrogenotrophic methanogen.

Yoon SH, Turkarslan S, Reiss DJ, Pan M, Burn JA, Costa KC, Lie TJ, Slagel J, Moritz RL, Hackett M, Leigh JA, Baliga NS.

Genome Res. 2013 Nov;23(11):1839-51. doi: 10.1101/gr.153916.112. Epub 2013 Oct 2.


VhuD facilitates electron flow from H2 or formate to heterodisulfide reductase in Methanococcus maripaludis.

Costa KC, Lie TJ, Xia Q, Leigh JA.

J Bacteriol. 2013 Nov;195(22):5160-5. doi: 10.1128/JB.00895-13. Epub 2013 Sep 13.


Piloting community-based medical care for survivors of sexual assault in conflict-affected Karen State of eastern Burma.

Tanabe M, Robinson K, Lee CI, Leigh JA, Htoo EM, Integer N, Krause SK.

Confl Health. 2013 May 21;7(1):12. doi: 10.1186/1752-1505-7-12.


Phenotypic evidence that the function of the [Fe]-hydrogenase Hmd in Methanococcus maripaludis requires seven hcg (hmd co-occurring genes) but not hmdII.

Lie TJ, Costa KC, Pak D, Sakesan V, Leigh JA.

FEMS Microbiol Lett. 2013 Jun;343(2):156-60. doi: 10.1111/1574-6968.12141. Epub 2013 Apr 18.


H2-independent growth of the hydrogenotrophic methanogen Methanococcus maripaludis.

Costa KC, Lie TJ, Jacobs MA, Leigh JA.

MBio. 2013 Feb 26;4(2). pii: e00062-13. doi: 10.1128/mBio.00062-13.


Effects of H2 and formate on growth yield and regulation of methanogenesis in Methanococcus maripaludis.

Costa KC, Yoon SH, Pan M, Burn JA, Baliga NS, Leigh JA.

J Bacteriol. 2013 Apr;195(7):1456-62. doi: 10.1128/JB.02141-12. Epub 2013 Jan 18.


Essential anaplerotic role for the energy-converting hydrogenase Eha in hydrogenotrophic methanogenesis.

Lie TJ, Costa KC, Lupa B, Korpole S, Whitman WB, Leigh JA.

Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15473-8. Epub 2012 Aug 7.


Functional responses of methanogenic archaea to syntrophic growth.

Walker CB, Redding-Johanson AM, Baidoo EE, Rajeev L, He Z, Hendrickson EL, Joachimiak MP, Stolyar S, Arkin AP, Leigh JA, Zhou J, Keasling JD, Mukhopadhyay A, Stahl DA.

ISME J. 2012 Nov;6(11):2045-55. doi: 10.1038/ismej.2012.60. Epub 2012 Jun 28.


Identification of single nucleotide polymorphisms in the bovine Toll-like receptor 1 gene and association with health traits in cattle.

Russell CD, Widdison S, Leigh JA, Coffey TJ.

Vet Res. 2012 Mar 14;43:17. doi: 10.1186/1297-9716-43-17.


Vru (Sub0144) controls expression of proven and putative virulence determinants and alters the ability of Streptococcus uberis to cause disease in dairy cattle.

Egan SA, Ward PN, Watson M, Field TR, Leigh JA.

Microbiology. 2012 Jun;158(Pt 6):1581-92. doi: 10.1099/mic.0.055863-0. Epub 2012 Mar 1.


Parallel evolution of transcriptome architecture during genome reorganization.

Yoon SH, Reiss DJ, Bare JC, Tenenbaum D, Pan M, Slagel J, Moritz RL, Lim S, Hackett M, Menon AL, Adams MW, Barnebey A, Yannone SM, Leigh JA, Baliga NS.

Genome Res. 2011 Nov;21(11):1892-904. doi: 10.1101/gr.122218.111. Epub 2011 Jul 12.


Using the patchwork text assessment as a vehicle for evaluating students' perceptions of their clinical leadership development.

Leigh JA, Rutherford J, Wild J, Cappleman J, Hynes C.

Nurse Educ Pract. 2012 Jan;12(1):46-51. doi: 10.1016/j.nepr.2011.05.006. Epub 2011 Jun 17.


Growth of methanogens under defined hydrogen conditions.

Leigh JA.

Methods Enzymol. 2011;494:111-8. doi: 10.1016/B978-0-12-385112-3.00006-8.


Genetic systems for hydrogenotrophic methanogens.

Sarmiento F, Leigh JA, Whitman WB.

Methods Enzymol. 2011;494:43-73. doi: 10.1016/B978-0-12-385112-3.00003-2.


Model organisms for genetics in the domain Archaea: methanogens, halophiles, Thermococcales and Sulfolobales.

Leigh JA, Albers SV, Atomi H, Allers T.

FEMS Microbiol Rev. 2011 Jul;35(4):577-608. doi: 10.1111/j.1574-6976.2011.00265.x. Epub 2011 Mar 7. Review.


Differential protein expression in Streptococcus uberis under planktonic and biofilm growth conditions.

Crowley RC, Leigh JA, Ward PN, Lappin-Scott HM, Bowler LD.

Appl Environ Microbiol. 2011 Jan;77(1):382-4. doi: 10.1128/AEM.01099-10. Epub 2010 Nov 12.


Structural underpinnings of nitrogen regulation by the prototypical nitrogen-responsive transcriptional factor NrpR.

Wisedchaisri G, Dranow DM, Lie TJ, Bonanno JB, Patskovsky Y, Ozyurt SA, Sauder JM, Almo SC, Wasserman SR, Burley SK, Leigh JA, Gonen T.

Structure. 2010 Nov 10;18(11):1512-21. doi: 10.1016/j.str.2010.08.014.


Interdomain conjugal transfer of DNA from bacteria to archaea.

Dodsworth JA, Li L, Wei S, Hedlund BP, Leigh JA, de Figueiredo P.

Appl Environ Microbiol. 2010 Aug;76(16):5644-7. doi: 10.1128/AEM.00967-10. Epub 2010 Jun 25.


Protein complexing in a methanogen suggests electron bifurcation and electron delivery from formate to heterodisulfide reductase.

Costa KC, Wong PM, Wang T, Lie TJ, Dodsworth JA, Swanson I, Burn JA, Hackett M, Leigh JA.

Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):11050-5. doi: 10.1073/pnas.1003653107. Epub 2010 Jun 1.


Sortase anchored proteins of Streptococcus uberis play major roles in the pathogenesis of bovine mastitis in dairy cattle.

Leigh JA, Egan SA, Ward PN, Field TR, Coffey TJ.

Vet Res. 2010 Sep-Oct;41(5):63. doi: 10.1051/vetres/2010036. Epub 2010 Jun 4.


Identification of sortase A (SrtA) substrates in Streptococcus uberis: evidence for an additional hexapeptide (LPXXXD) sorting motif.

Egan SA, Kurian D, Ward PN, Hunt L, Leigh JA.

J Proteome Res. 2010 Feb 5;9(2):1088-95. doi: 10.1021/pr901025w.


Overlapping repressor binding sites regulate expression of the Methanococcus maripaludis glnK(1) operon.

Lie TJ, Hendrickson EL, Niess UM, Moore BC, Haydock AK, Leigh JA.

Mol Microbiol. 2010 Feb;75(3):755-62. doi: 10.1111/j.1365-2958.2009.07016.x. Epub 2009 Dec 16.


Comprehensive computational analysis of Hmd enzymes and paralogs in methanogenic Archaea.

Goldman AD, Leigh JA, Samudrala R.

BMC Evol Biol. 2009 Aug 11;9:199. doi: 10.1186/1471-2148-9-199.


Quantitative proteomics of nutrient limitation in the hydrogenotrophic methanogen Methanococcus maripaludis.

Xia Q, Wang T, Hendrickson EL, Lie TJ, Hackett M, Leigh JA.

BMC Microbiol. 2009 Jul 23;9:149. doi: 10.1186/1471-2180-9-149.


Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis.

Holden MT, Hauser H, Sanders M, Ngo TH, Cherevach I, Cronin A, Goodhead I, Mungall K, Quail MA, Price C, Rabbinowitsch E, Sharp S, Croucher NJ, Chieu TB, Mai NT, Diep TS, Chinh NT, Kehoe M, Leigh JA, Ward PN, Dowson CG, Whatmore AM, Chanter N, Iversen P, Gottschalk M, Slater JD, Smith HE, Spratt BG, Xu J, Ye C, Bentley S, Barrell BG, Schultsz C, Maskell DJ, Parkhill J.

PLoS One. 2009 Jul 15;4(7):e6072. doi: 10.1371/journal.pone.0006072.


Evidence for niche adaptation in the genome of the bovine pathogen Streptococcus uberis.

Ward PN, Holden MT, Leigh JA, Lennard N, Bignell A, Barron A, Clark L, Quail MA, Woodward J, Barrell BG, Egan SA, Field TR, Maskell D, Kehoe M, Dowson CG, Chanter N, Whatmore AM, Bentley SD, Parkhill J.

BMC Genomics. 2009 Jan 28;10:54. doi: 10.1186/1471-2164-10-54.


In the absence of Lgt, lipoproteins are shed from Streptococcus uberis independently of Lsp.

Denham EL, Ward PN, Leigh JA.

Microbiology. 2009 Jan;155(Pt 1):134-41. doi: 10.1099/mic.0.022061-0.


UK registered nurse medical device education: a comparison of hospital and bank nurses.

Douglas MR, Leigh JA, Douglas CH.

Nurse Educ Pract. 2001 Jun;1(2):85-93. doi: 10.1054/nepr.2001.0015.


Formate-dependent H2 production by the mesophilic methanogen Methanococcus maripaludis.

Lupa B, Hendrickson EL, Leigh JA, Whitman WB.

Appl Environ Microbiol. 2008 Nov;74(21):6584-90. doi: 10.1128/AEM.01455-08. Epub 2008 Sep 12.


Structural consideration of the formation of the activation complex between the staphylokinase-like streptococcal plasminogen activator PadA and bovine plasminogen.

Ward PN, Abu-Median AB, Leigh JA.

J Mol Biol. 2008 Sep 5;381(3):734-47. doi: 10.1016/j.jmb.2008.06.027. Epub 2008 Jun 17.


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