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Items: 38


The decidua of preeclamptic-like BPH/5 mice exhibits an exaggerated inflammatory response during early pregnancy.

Heyward CY, Sones JL, Lob HE, Yuen LC, Abbott KE, Huang W, Begun ZR, Butler SD, August A, Leifer CA, Davisson RL.

J Reprod Immunol. 2017 Apr;120:27-33. doi: 10.1016/j.jri.2017.04.002. Epub 2017 Apr 10.


The effect of cell debris within biologic scaffolds upon the macrophage response.

Londono R, Dziki JL, Haljasmaa E, Turner NJ, Leifer CA, Badylak SF.

J Biomed Mater Res A. 2017 Aug;105(8):2109-2118. doi: 10.1002/jbm.a.36055. Epub 2017 Apr 12.


Safe Recombinant Outer Membrane Vesicles that Display M2e Elicit Heterologous Influenza Protection.

Watkins HC, Rappazzo CG, Higgins JS, Sun X, Brock N, Chau A, Misra A, Cannizzo JPB, King MR, Maines TR, Leifer CA, Whittaker GR, DeLisa MP, Putnam D.

Mol Ther. 2017 Apr 5;25(4):989-1002. doi: 10.1016/j.ymthe.2017.01.010. Epub 2017 Feb 16.


Dendritic cells in host response to biologic scaffolds.

Leifer CA.

Semin Immunol. 2017 Feb;29:41-48. doi: 10.1016/j.smim.2017.01.001. Epub 2017 Feb 14. Review.


Molecular mechanisms of regulation of Toll-like receptor signaling.

Leifer CA, Medvedev AE.

J Leukoc Biol. 2016 Nov;100(5):927-941. Epub 2016 Jun 24. Review.


Complex Negative Regulation of TLR9 by Multiple Proteolytic Cleavage Events.

Sinha SS, Cameron J, Brooks JC, Leifer CA.

J Immunol. 2016 Aug 15;197(4):1343-52. doi: 10.4049/jimmunol.1502357. Epub 2016 Jul 15.


TLR9 stability and signaling are regulated by phosphorylation and cell stress.

Hasan M, Gruber E, Cameron J, Leifer CA.

J Leukoc Biol. 2016 Sep;100(3):525-33. doi: 10.1189/jlb.2A0815-337R. Epub 2016 Mar 8.


Recombinant M2e outer membrane vesicle vaccines protect against lethal influenza A challenge in BALB/c mice.

Rappazzo CG, Watkins HC, Guarino CM, Chau A, Lopez JL, DeLisa MP, Leifer CA, Whittaker GR, Putnam D.

Vaccine. 2016 Mar 4;34(10):1252-8. doi: 10.1016/j.vaccine.2016.01.028. Epub 2016 Jan 29.


Electrostatically self-assembled biodegradable microparticles from pseudoproteins and polysaccharide: fabrication, characterization, and biological properties.

Potuck AN, Weed BL, Leifer CA, Chu CC.

Biomacromolecules. 2015 Feb 9;16(2):564-77. doi: 10.1021/bm5016255. Epub 2015 Jan 17.


Linking genetic variation in human Toll-like receptor 5 genes to the gut microbiome's potential to cause inflammation.

Leifer CA, McConkey C, Li S, Chassaing B, Gewirtz AT, Ley RE.

Immunol Lett. 2014 Dec;162(2 Pt A):3-9. doi: 10.1016/j.imlet.2014.07.017. Epub 2014 Oct 2. Review.


Discordant results obtained with Francisella tularensis during in vitro and in vivo immunological studies are attributable to compromised bacterial structural integrity.

Singh A, Rahman T, Malik M, Hickey AJ, Leifer CA, Hazlett KR, Sellati TJ.

PLoS One. 2013;8(3):e58513. doi: 10.1371/journal.pone.0058513. Epub 2013 Mar 12.


Participation of MyD88 and interleukin-33 as innate drivers of Th2 immunity to Trichinella spiralis.

Scalfone LK, Nel HJ, Gagliardo LF, Cameron JL, Al-Shokri S, Leifer CA, Fallon PG, Appleton JA.

Infect Immun. 2013 Apr;81(4):1354-63. doi: 10.1128/IAI.01307-12. Epub 2013 Feb 12.


Traditional biochemical assays for studying toll-like receptor 9.

Leifer CA, Rose WA 2nd, Botelho F.

J Immunoassay Immunochem. 2013;34(1):1-15. doi: 10.1080/15321819.2012.666222. Review.


TLR9 is important for protection against intestinal damage and for intestinal repair.

Rose WA 2nd, Sakamoto K, Leifer CA.

Sci Rep. 2012;2:574. doi: 10.1038/srep00574. Epub 2012 Aug 14.


Multifunctional role of dextran sulfate sodium for in vivo modeling of intestinal diseases.

Rose WA 2nd, Sakamoto K, Leifer CA.

BMC Immunol. 2012 Aug 1;13:41. doi: 10.1186/1471-2172-13-41.


Heterozygous carriage of a dysfunctional Toll-like receptor 9 allele affects CpG oligonucleotide responses in B cells.

Knezević J, Pavlinić D, Rose WA 2nd, Leifer CA, Bendelja K, Gabrilovac J, Parcina M, Lauc G, Kubarenko AV, Petricevic B, Vrbanec D, Bulat-Kardum L, Bekeredjian-Ding I, Pavelić J, Dembić Z, Weber AN.

J Biol Chem. 2012 Jul 13;287(29):24544-53. doi: 10.1074/jbc.M111.337477. Epub 2012 May 21.


Heat shock protein gp96 regulates Toll-like receptor 9 proteolytic processing and conformational stability.

Brooks JC, Sun W, Chiosis G, Leifer CA.

Biochem Biophys Res Commun. 2012 May 18;421(4):780-4. doi: 10.1016/j.bbrc.2012.04.083. Epub 2012 Apr 23.


Cutting edge: a TLR9 cytoplasmic tyrosine motif is selectively required for proinflammatory cytokine production.

Chockalingam A, Rose WA 2nd, Hasan M, Ju CH, Leifer CA.

J Immunol. 2012 Jan 15;188(2):527-30. doi: 10.4049/jimmunol.1102713. Epub 2011 Dec 14. Erratum in: J Immunol. 2012 Apr 1;188(7):3551.


Antimicrobial peptides inhibit polyinosinic-polycytidylic acid-induced immune responses.

Hasan M, Ruksznis C, Wang Y, Leifer CA.

J Immunol. 2011 Dec 1;187(11):5653-9. doi: 10.4049/jimmunol.1102144. Epub 2011 Nov 2.


Negative regulation of signaling by a soluble form of toll-like receptor 9.

Chockalingam A, Cameron JL, Brooks JC, Leifer CA.

Eur J Immunol. 2011 Aug;41(8):2176-84. doi: 10.1002/eji.201041034. Epub 2011 Jul 4.


Early response of mucosal epithelial cells during Toxoplasma gondii infection.

Ju CH, Chockalingam A, Leifer CA.

J Immunol. 2009 Dec 1;183(11):7420-7. doi: 10.4049/jimmunol.0900640. Epub 2009 Nov 16.


MARCO, TLR2, and CD14 are required for macrophage cytokine responses to mycobacterial trehalose dimycolate and Mycobacterium tuberculosis.

Bowdish DM, Sakamoto K, Kim MJ, Kroos M, Mukhopadhyay S, Leifer CA, Tryggvason K, Gordon S, Russell DG.

PLoS Pathog. 2009 Jun;5(6):e1000474. doi: 10.1371/journal.ppat.1000474. Epub 2009 Jun 12.


TLR9 traffics through the Golgi complex to localize to endolysosomes and respond to CpG DNA.

Chockalingam A, Brooks JC, Cameron JL, Blum LK, Leifer CA.

Immunol Cell Biol. 2009 Mar-Apr;87(3):209-17. doi: 10.1038/icb.2008.101. Epub 2008 Dec 16.


Genetic diversity of Toxoplasma gondii isolates from chickens from Brazil.

Dubey JP, Velmurugan GV, Chockalingam A, Pena HF, de Oliveira LN, Leifer CA, Gennari SM, Bahia Oliveira LM, Su C.

Vet Parasitol. 2008 Nov 7;157(3-4):299-305. doi: 10.1016/j.vetpar.2008.07.036. Epub 2008 Aug 5.


Inhibition of TLR3 and TLR4 function and expression in human dendritic cells by helminth parasites.

Semnani RT, Venugopal PG, Leifer CA, Mostböck S, Sabzevari H, Nutman TB.

Blood. 2008 Aug 15;112(4):1290-8. doi: 10.1182/blood-2008-04-149856. Epub 2008 Jun 9.


Cytoplasmic targeting motifs control localization of toll-like receptor 9.

Leifer CA, Brooks JC, Hoelzer K, Lopez J, Kennedy MN, Mazzoni A, Segal DM.

J Biol Chem. 2006 Nov 17;281(46):35585-92. Epub 2006 Sep 21.


Dendritic cell modulation by mast cells controls the Th1/Th2 balance in responding T cells.

Mazzoni A, Siraganian RP, Leifer CA, Segal DM.

J Immunol. 2006 Sep 15;177(6):3577-81.


Induction of dendritic cell maturation by pertussis toxin and its B subunit differentially initiate Toll-like receptor 4-dependent signal transduction pathways.

Wang ZY, Yang D, Chen Q, Leifer CA, Segal DM, Su SB, Caspi RR, Howard ZO, Oppenheim JJ.

Exp Hematol. 2006 Aug;34(8):1115-24.


TLR9 is localized in the endoplasmic reticulum prior to stimulation.

Leifer CA, Kennedy MN, Mazzoni A, Lee C, Kruhlak MJ, Segal DM.

J Immunol. 2004 Jul 15;173(2):1179-83.


A complex of soluble MD-2 and lipopolysaccharide serves as an activating ligand for Toll-like receptor 4.

Kennedy MN, Mullen GE, Leifer CA, Lee C, Mazzoni A, Dileepan KN, Segal DM.

J Biol Chem. 2004 Aug 13;279(33):34698-704. Epub 2004 Jun 1.


Leucine-rich repeats and pathogen recognition in Toll-like receptors.

Bell JK, Mullen GE, Leifer CA, Mazzoni A, Davies DR, Segal DM.

Trends Immunol. 2003 Oct;24(10):528-33. Review.


Heat-killed Brucella abortus induces TNF and IL-12p40 by distinct MyD88-dependent pathways: TNF, unlike IL-12p40 secretion, is Toll-like receptor 2 dependent.

Huang LY, Aliberti J, Leifer CA, Segal DM, Sher A, Golenbock DT, Golding B.

J Immunol. 2003 Aug 1;171(3):1441-6.


Heterogeneity in the human response to immunostimulatory CpG oligodeoxynucleotides.

Leifer CA, Verthelyi D, Klinman DM.

J Immunother. 2003 Jul-Aug;26(4):313-9.


The role of disulfide bonds in the assembly and function of MD-2.

Mullen GE, Kennedy MN, Visintin A, Mazzoni A, Leifer CA, Davies DR, Segal DM.

Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3919-24. Epub 2003 Mar 17.


Cutting edge: histamine inhibits IFN-alpha release from plasmacytoid dendritic cells.

Mazzoni A, Leifer CA, Mullen GE, Kennedy MN, Klinman DM, Segal DM.

J Immunol. 2003 Mar 1;170(5):2269-73.


Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2.

Biragyn A, Ruffini PA, Leifer CA, Klyushnenkova E, Shakhov A, Chertov O, Shirakawa AK, Farber JM, Segal DM, Oppenheim JJ, Kwak LW.

Science. 2002 Nov 1;298(5595):1025-9.


Cutting edge: Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells.

Takeshita F, Leifer CA, Gursel I, Ishii KJ, Takeshita S, Gursel M, Klinman DM.

J Immunol. 2001 Oct 1;167(7):3555-8.

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