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Items: 35

1.

Inhibition of transport across the hepatocyte canalicular membrane by the antibiotic fusidate.

Bode KA, Donner MG, Leier I, Keppler D.

Biochem Pharmacol. 2002 Jul 1;64(1):151-8.

PMID:
12106615
2.
3.

Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6.

Cui Y, König J, Leier I, Buchholz U, Keppler D.

J Biol Chem. 2001 Mar 30;276(13):9626-30. Epub 2000 Dec 27.

4.

Localization, substrate specificity, and drug resistance conferred by conjugate export pumps of the MRP family.

Keppler D, Kamisako T, Leier I, Cui Y, Nies AT, Tsujii H, König J.

Adv Enzyme Regul. 2000;40:339-49. No abstract available.

PMID:
10828358
5.

ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2.

Leier I, Hummel-Eisenbeiss J, Cui Y, Keppler D.

Kidney Int. 2000 Apr;57(4):1636-42.

6.

Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance.

König J, Nies AT, Cui Y, Leier I, Keppler D.

Biochim Biophys Acta. 1999 Dec 6;1461(2):377-94. Review.

7.

Export pumps for anionic conjugates encoded by MRP genes.

Keppler D, Cui Y, König J, Leier I, Nies A.

Adv Enzyme Regul. 1999;39:237-46.

PMID:
10470375
8.

Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2.

Kamisako T, Leier I, Cui Y, König J, Buchholz U, Hummel-Eisenbeiss J, Keppler D.

Hepatology. 1999 Aug;30(2):485-90.

PMID:
10421658
9.
10.

Expression of the apical conjugate export pump, Mrp2, in the polarized hepatoma cell line, WIF-B.

Nies AT, Cantz T, Brom M, Leier I, Keppler D.

Hepatology. 1998 Nov;28(5):1332-40.

PMID:
9794919
11.

Transport function and substrate specificity of multidrug resistance protein.

Keppler D, Jedlitschky G, Leier I.

Methods Enzymol. 1998;292:607-16. No abstract available.

PMID:
9711586
12.

ATP-dependent transport of glutathione S-conjugates by the multidrug resistance protein MRP1 and its apical isoform MRP2.

Keppler D, Leier I, Jedlitschky G, König J.

Chem Biol Interact. 1998 Apr 24;111-112:153-61. Review.

PMID:
9679551
13.

Multidrug resistance protein-mediated transport of chlorambucil and melphalan conjugated to glutathione.

Barnouin K, Leier I, Jedlitschky G, Pourtier-Manzanedo A, König J, Lehmann WD, Keppler D.

Br J Cancer. 1998;77(2):201-9.

14.

ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2.

Jedlitschky G, Leier I, Buchholz U, Hummel-Eisenbeiss J, Burchell B, Keppler D.

Biochem J. 1997 Oct 1;327 ( Pt 1):305-10.

15.

Transport of glutathione conjugates and glucuronides by the multidrug resistance proteins MRP1 and MRP2.

Keppler D, Leier I, Jedlitschky G.

Biol Chem. 1997 Aug;378(8):787-91. Review.

PMID:
9377473
16.

Identification of the biosynthetic leukotriene C4 export pump in murine mastocytoma cells as a homolog of the multidrug-resistance protein.

Leier I, Jedlitschky G, Büchler M, Buchholz U, Brom M, Keppler D.

Eur J Biochem. 1996 Dec 1;242(2):201-5.

17.

Identification of the multidrug-resistance protein (MRP) as the glutathione-S-conjugate export pump of erythrocytes.

Pulaski L, Jedlitschky G, Leier I, Buchholz U, Keppler D.

Eur J Biochem. 1996 Oct 15;241(2):644-8.

18.

ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump.

Leier I, Jedlitschky G, Buchholz U, Center M, Cole SP, Deeley RG, Keppler D.

Biochem J. 1996 Mar 1;314 ( Pt 2):433-7.

19.

Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump.

Jedlitschky G, Leier I, Buchholz U, Barnouin K, Kurz G, Keppler D.

Cancer Res. 1996 Mar 1;56(5):988-94.

20.

The function of the multidrug resistance proteins (MRP and cMRP) in drug conjugate transport and hepatobiliary excretion.

Keppler D, Leier I, Jedlitschky G, Mayer R, Büchler M.

Adv Enzyme Regul. 1996;36:17-29.

PMID:
8869738
21.
22.

The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.

Leier I, Jedlitschky G, Buchholz U, Cole SP, Deeley RG, Keppler D.

J Biol Chem. 1994 Nov 11;269(45):27807-10.

23.

Hepatobiliary elimination of the peroxisome proliferator nafenopin by conjugation and subsequent ATP-dependent transport across the canalicular membrane.

Jedlitschky G, Leier I, Böhme M, Buchholz U, Bar-Tana J, Keppler D.

Biochem Pharmacol. 1994 Sep 15;48(6):1113-20.

PMID:
7945404
24.

ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein.

Jedlitschky G, Leier I, Buchholz U, Center M, Keppler D.

Cancer Res. 1994 Sep 15;54(18):4833-6.

25.

Cholestasis caused by inhibition of the adenosine triphosphate-dependent bile salt transport in rat liver.

Böhme M, Müller M, Leier I, Jedlitschky G, Keppler D.

Gastroenterology. 1994 Jul;107(1):255-65.

PMID:
8020669
26.

Characterization of the ATP-dependent leukotriene C4 export carrier in mastocytoma cells.

Leier I, Jedlitschky G, Buchholz U, Keppler D.

Eur J Biochem. 1994 Mar 1;220(2):599-606.

27.

ATP-dependent export pumps and their inhibition by cyclosporins.

Böhme M, Jedlitschky G, Leier I, Büchler M, Keppler D.

Adv Enzyme Regul. 1994;34:371-80.

PMID:
7942282
28.

Transport and metabolism of leukotrienes.

Keppler D, Jedlitschky G, Leier I.

Adv Prostaglandin Thromboxane Leukot Res. 1994;22:83-9. Review. No abstract available.

PMID:
7771352
29.

Leukotriene uptake by hepatocytes and hepatoma cells.

Leier I, Müller M, Jedlitschky G, Keppler D.

Eur J Biochem. 1992 Oct 1;209(1):281-9.

30.

Transport and in vivo elimination of cysteinyl leukotrienes.

Keppler D, Müller M, Klünemann C, Guhlmann A, Krauss K, Müller J, Berger U, Leier I, Mayatepek E.

Adv Enzyme Regul. 1992;32:107-16.

PMID:
1496913
31.

Peroxisomal degradation of leukotrienes by beta-oxidation from the omega-end.

Jedlitschky G, Huber M, Völkl A, Müller M, Leier I, Müller J, Lehmann WD, Fahimi HD, Keppler D.

J Biol Chem. 1991 Dec 25;266(36):24763-72.

32.

Photoaffinity labeling of leukotriene binding sites in hepatocytes and hepatoma cells.

Müller M, Falk E, Sandbrink R, Berger U, Leier I, Jedlitschky G, Huber M, Kurz G, Keppler D.

Adv Prostaglandin Thromboxane Leukot Res. 1991;21A:395-8.

PMID:
1847774
33.

Metabolism of cysteinyl leukotrienes in monkey and man.

Huber M, Müller J, Leier I, Jedlitschky G, Ball HA, Moore KP, Taylor GW, Williams R, Keppler D.

Eur J Biochem. 1990 Nov 26;194(1):309-15.

34.

Inhibition of leukotriene omega-oxidation by omega-trifluoro analogs of leukotrienes.

Jedlitschky G, Leier I, Huber M, Mayer D, Keppler D.

Arch Biochem Biophys. 1990 Nov 1;282(2):333-9.

PMID:
2173482
35.

Leukotrienes in shock syndromes: metabolism and detection in vivo.

Keppler D, Guhlmann A, Huber M, Ball HA, Leier I, Jedlitschky G.

Adv Prostaglandin Thromboxane Leukot Res. 1990;20:179-86. Review. No abstract available.

PMID:
2144690

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