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Items: 1 to 50 of 92

1.

PI3K links NKG2D signaling to a CrkL pathway involved in natural killer cell adhesion, polarity, and granule secretion.

Segovis CM, Schoon RA, Dick CJ, Nacusi LP, Leibson PJ, Billadeau DD.

J Immunol. 2009 Jun 1;182(11):6933-42. doi: 10.4049/jimmunol.0803840.

2.

TREM-2 mediated signaling induces antigen uptake and retention in mature myeloid dendritic cells.

Radhakrishnan S, Arneson LN, Upshaw JL, Howe CL, Felts SJ, Colonna M, Leibson PJ, Rodriguez M, Pease LR.

J Immunol. 2008 Dec 1;181(11):7863-72. Retraction in: Arneson LN, Upshaw JL, Howe CL, Felts SJ, Rodriguez M, Pease LR, Colonna M. J Immunol. 2010 Jun 1;184(11):6557.

3.

Dynamin 2 regulates granule exocytosis during NK cell-mediated cytotoxicity.

Arneson LN, Segovis CM, Gomez TS, Schoon RA, Dick CJ, Lou Z, Billadeau DD, Leibson PJ.

J Immunol. 2008 Nov 15;181(10):6995-7001.

4.

Signal transduction during natural killer cell activation.

Chini CC, Leibson PJ.

Curr Protoc Cytom. 2001 May;Chapter 9:Unit 9.16. doi: 10.1002/0471142956.cy0916s14.

PMID:
18770753
5.

Signal transduction during natural killer cell activation.

Chini CC, Leibson PJ.

Curr Protoc Immunol. 2001 May;Chapter 11:Unit 11.9B. doi: 10.1002/0471142735.im1109bs35. Review.

PMID:
18432709
6.

Cutting edge: syntaxin 11 regulates lymphocyte-mediated secretion and cytotoxicity.

Arneson LN, Brickshawana A, Segovis CM, Schoon RA, Dick CJ, Leibson PJ.

J Immunol. 2007 Sep 15;179(6):3397-401.

7.

Differential regulation of human NK cell-mediated cytotoxicity by the tyrosine kinase Itk.

Khurana D, Arneson LN, Schoon RA, Dick CJ, Leibson PJ.

J Immunol. 2007 Mar 15;178(6):3575-82.

8.

Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse.

Gomez TS, Kumar K, Medeiros RB, Shimizu Y, Leibson PJ, Billadeau DD.

Immunity. 2007 Feb;26(2):177-90.

9.

NKG2D-mediated activation of cytotoxic lymphocytes: unique signaling pathways and distinct functional outcomes.

Upshaw JL, Leibson PJ.

Semin Immunol. 2006 Jun;18(3):167-75. Epub 2006 May 24. Review.

PMID:
16723257
10.

NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells.

Upshaw JL, Arneson LN, Schoon RA, Dick CJ, Billadeau DD, Leibson PJ.

Nat Immunol. 2006 May;7(5):524-32. Epub 2006 Apr 2.

PMID:
16582911
11.

The isoforms of phospholipase C-gamma are differentially used by distinct human NK activating receptors.

Upshaw JL, Schoon RA, Dick CJ, Billadeau DD, Leibson PJ.

J Immunol. 2005 Jul 1;175(1):213-8.

12.

Stimulatory killer Ig-like receptors modulate T cell activation through DAP12-dependent and DAP12-independent mechanisms.

Snyder MR, Nakajima T, Leibson PJ, Weyand CM, Goronzy JJ.

J Immunol. 2004 Sep 15;173(6):3725-31.

13.

The regulation of lymphocyte activation by inhibitory receptors.

Leibson PJ.

Curr Opin Immunol. 2004 Jun;16(3):328-36. Review.

PMID:
15134782
14.

Having it both ways: MHC recognition in cis and trans.

Leibson PJ, Pease LR.

Nat Immunol. 2004 Mar;5(3):237-8. No abstract available.

PMID:
14985707
15.

Vav1 dephosphorylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicity.

Stebbins CC, Watzl C, Billadeau DD, Leibson PJ, Burshtyn DN, Long EO.

Mol Cell Biol. 2003 Sep;23(17):6291-9.

16.

NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway.

Billadeau DD, Upshaw JL, Schoon RA, Dick CJ, Leibson PJ.

Nat Immunol. 2003 Jun;4(6):557-64. Epub 2003 May 11.

PMID:
12740575
17.

Demonstration of aberrant T-cell and natural killer-cell antigen expression in all cases of granular lymphocytic leukaemia.

Morice WG, Kurtin PJ, Leibson PJ, Tefferi A, Hanson CA.

Br J Haematol. 2003 Mar;120(6):1026-36.

PMID:
12648073
18.

Regulation of lymphocyte-mediated killing by GTP-binding proteins.

Khurana D, Leibson PJ.

J Leukoc Biol. 2003 Mar;73(3):333-8. Review.

PMID:
12629146
19.

Natural killer cell activation in mice and men: different triggers for similar weapons?

Colucci F, Di Santo JP, Leibson PJ.

Nat Immunol. 2002 Sep;3(9):807-13. Review.

PMID:
12205470
20.

ITAMs versus ITIMs: striking a balance during cell regulation.

Billadeau DD, Leibson PJ.

J Clin Invest. 2002 Jan;109(2):161-8. Review. No abstract available.

21.

A role for a RhoA/ROCK/LIM-kinase pathway in the regulation of cytotoxic lymphocytes.

Lou Z, Billadeau DD, Savoy DN, Schoon RA, Leibson PJ.

J Immunol. 2001 Nov 15;167(10):5749-57.

22.

Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2.

Jevremovic D, Billadeau DD, Schoon RA, Dick CJ, Leibson PJ.

J Immunol. 2001 Jun 15;166(12):7219-28.

23.

Natural killer cells and the syndrome of chronic natural killer cell lymphocytosis.

Morice WG, Leibson PJ, Tefferi A.

Leuk Lymphoma. 2001 Apr;41(3-4):277-84. Review.

PMID:
11378540
24.

Specific subdomains of Vav differentially affect T cell and NK cell activation.

Billadeau DD, Mackie SM, Schoon RA, Leibson PJ.

J Immunol. 2000 Apr 15;164(8):3971-81.

25.

Vav-2 controls NFAT-dependent transcription in B- but not T-lymphocytes.

Doody GM, Billadeau DD, Clayton E, Hutchings A, Berland R, McAdam S, Leibson PJ, Turner M.

EMBO J. 2000 Nov 15;19(22):6173-84.

26.

Regulation of p38 mitogen-activated protein kinase during NK cell activation.

Chini CC, Boos MD, Dick CJ, Schoon RA, Leibson PJ.

Eur J Immunol. 2000 Oct;30(10):2791-8.

27.

Direct tumor lysis by NK cells uses a Ras-independent mitogen-activated protein kinase signal pathway.

Wei S, Gilvary DL, Corliss BC, Sebti S, Sun J, Straus DB, Leibson PJ, Trapani JA, Hamilton AD, Weber MJ, Djeu JY.

J Immunol. 2000 Oct 1;165(7):3811-9.

28.

The Rho family guanine nucleotide exchange factor Vav-2 regulates the development of cell-mediated cytotoxicity.

Billadeau DD, Mackie SM, Schoon RA, Leibson PJ.

J Exp Med. 2000 Aug 7;192(3):381-92.

29.

Killer cell activating receptors function as costimulatory molecules on CD4+CD28null T cells clonally expanded in rheumatoid arthritis.

Namekawa T, Snyder MR, Yen JH, Goehring BE, Leibson PJ, Weyand CM, Goronzy JJ.

J Immunol. 2000 Jul 15;165(2):1138-45.

30.

Use of mutant Jurkat T cell lines to define human natural killer cell surface receptor signaling pathways.

Binstadt BA, Williams BL, Abraham RT, Leibson PJ.

Methods Mol Biol. 2000;121:297-304. Review. No abstract available.

PMID:
10818735
31.
33.

Cutting edge: a role for the adaptor protein LAT in human NK cell-mediated cytotoxicity.

Jevremovic D, Billadeau DD, Schoon RA, Dick CJ, Irvin BJ, Zhang W, Samelson LE, Abraham RT, Leibson PJ.

J Immunol. 1999 Mar 1;162(5):2453-6.

34.

Cytotoxic lymphocyte recognition of HLA-E: utilizing a nonclassical window to peer into classical MHC.

Leibson PJ.

Immunity. 1998 Sep;9(3):289-94. Review. No abstract available.

35.

SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptors.

Binstadt BA, Billadeau DD, Jevremović D, Williams BL, Fang N, Yi T, Koretzky GA, Abraham RT, Leibson PJ.

J Biol Chem. 1998 Oct 16;273(42):27518-23.

36.

IL-5 production by NK cells contributes to eosinophil infiltration in a mouse model of allergic inflammation.

Walker C, Checkel J, Cammisuli S, Leibson PJ, Gleich GJ.

J Immunol. 1998 Aug 15;161(4):1962-9.

37.

The Vav-Rac1 pathway in cytotoxic lymphocytes regulates the generation of cell-mediated killing.

Billadeau DD, Brumbaugh KM, Dick CJ, Schoon RA, Bustelo XR, Leibson PJ.

J Exp Med. 1998 Aug 3;188(3):549-59.

38.

The expression of Fas Ligand by macrophages and its upregulation by human immunodeficiency virus infection.

Dockrell DH, Badley AD, Villacian JS, Heppelmann CJ, Algeciras A, Ziesmer S, Yagita H, Lynch DH, Roche PC, Leibson PJ, Paya CV.

J Clin Invest. 1998 Jun 1;101(11):2394-405.

39.

Signal transduction during NK cell activation: balancing opposing forces.

Brumbaugh KM, Binstadt BA, Leibson PJ.

Curr Top Microbiol Immunol. 1998;230:103-22. Review.

PMID:
9586353
40.

Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line.

Williams BL, Schreiber KL, Zhang W, Wange RL, Samelson LE, Leibson PJ, Abraham RT.

Mol Cell Biol. 1998 Mar;18(3):1388-99.

41.

Functional role for Syk tyrosine kinase in natural killer cell-mediated natural cytotoxicity.

Brumbaugh KM, Binstadt BA, Billadeau DD, Schoon RA, Dick CJ, Ten RM, Leibson PJ.

J Exp Med. 1997 Dec 15;186(12):1965-74.

42.

Comparison of apoptosis in wild-type and Fas-resistant cells: chemotherapy-induced apoptosis is not dependent on Fas/Fas ligand interactions.

Eischen CM, Kottke TJ, Martins LM, Basi GS, Tung JS, Earnshaw WC, Leibson PJ, Kaufmann SH.

Blood. 1997 Aug 1;90(3):935-43.

PMID:
9242521
43.

ZAP-70 tyrosine kinase is required for the up-regulation of Fas ligand in activation-induced T cell apoptosis.

Eischen CM, Williams BL, Zhang W, Samelson LE, Lynch DH, Abraham RT, Leibson PJ.

J Immunol. 1997 Aug 1;159(3):1135-9.

PMID:
9233606
44.

Signal transduction during natural killer cell activation: inside the mind of a killer.

Leibson PJ.

Immunity. 1997 Jun;6(6):655-61. Review. No abstract available.

45.

Role for NK-cell-associated Fas ligand in cell-mediated cytotoxicity and apoptosis.

Eischen CM, Leibson PJ.

Res Immunol. 1997 Mar-Apr;148(3):164-9. Review. No abstract available.

PMID:
9255868
46.

Signal transduction by human NK cell MHC-recognizing receptors.

Binstadt BA, Brumbaugh KM, Leibson PJ.

Immunol Rev. 1997 Feb;155:197-203. Review.

PMID:
9059895
47.

The Fas pathway in apoptosis.

Eischen CM, Leibson PJ.

Adv Pharmacol. 1997;41:107-32. Review. No abstract available.

PMID:
9204143
48.

Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation.

Binstadt BA, Brumbaugh KM, Dick CJ, Scharenberg AM, Williams BL, Colonna M, Lanier LL, Kinet JP, Abraham RT, Leibson PJ.

Immunity. 1996 Dec;5(6):629-38.

49.

Clonotypic differences in signaling from CD94 (kp43) on NK cells lead to divergent cellular responses.

Brumbaugh KM, Pérez-Villar JJ, Dick CJ, Schoon RA, López-Botet M, Leibson PJ.

J Immunol. 1996 Oct 1;157(7):2804-12.

PMID:
8816383
50.

Fc receptor-induced expression of Fas ligand on activated NK cells facilitates cell-mediated cytotoxicity and subsequent autocrine NK cell apoptosis.

Eischen CM, Schilling JD, Lynch DH, Krammer PH, Leibson PJ.

J Immunol. 1996 Apr 15;156(8):2693-9.

PMID:
8609385

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