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Items: 42

1.

FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster.

Wang H, Shi H, Rajan M, Canarie ER, Hong S, Simoneschi D, Pagano M, Bush MF, Stoll S, Leibold EA, Zheng N.

Mol Cell. 2020 Feb 25. pii: S1097-2765(20)30081-2. doi: 10.1016/j.molcel.2020.02.011. [Epub ahead of print]

PMID:
32126207
2.

Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification.

Santos MCFD, Anderson CP, Neschen S, Zumbrennen-Bullough KB, Romney SJ, Kahle-Stephan M, Rathkolb B, Gailus-Durner V, Fuchs H, Wolf E, Rozman J, de Angelis MH, Cai WM, Rajan M, Hu J, Dedon PC, Leibold EA.

Nat Commun. 2020 Jan 15;11(1):296. doi: 10.1038/s41467-019-14004-5.

3.

NHR-14 loss of function couples intestinal iron uptake with innate immunity in C. elegans through PQM-1 signaling.

Rajan M, Anderson CP, Rindler PM, Romney SJ, Ferreira Dos Santos MC, Gertz J, Leibold EA.

Elife. 2019 Sep 18;8. pii: e44674. doi: 10.7554/eLife.44674.

4.

Mechanisms of iron metabolism in Caenorhabditis elegans.

Anderson CP, Leibold EA.

Front Pharmacol. 2014 May 21;5:113. doi: 10.3389/fphar.2014.00113. eCollection 2014. Review.

5.

Abnormal brain iron metabolism in Irp2 deficient mice is associated with mild neurological and behavioral impairments.

Zumbrennen-Bullough KB, Becker L, Garrett L, Hölter SM, Calzada-Wack J, Mossbrugger I, Quintanilla-Fend L, Racz I, Rathkolb B, Klopstock T, Wurst W, Zimmer A, Wolf E, Fuchs H, Gailus-Durner V, de Angelis MH, Romney SJ, Leibold EA.

PLoS One. 2014 Jun 4;9(6):e98072. doi: 10.1371/journal.pone.0098072. eCollection 2014.

6.

Mammalian iron metabolism and its control by iron regulatory proteins.

Anderson CP, Shen M, Eisenstein RS, Leibold EA.

Biochim Biophys Acta. 2012 Sep;1823(9):1468-83. doi: 10.1016/j.bbamcr.2012.05.010. Epub 2012 May 17. Review.

7.

HIF-1 regulates iron homeostasis in Caenorhabditis elegans by activation and inhibition of genes involved in iron uptake and storage.

Romney SJ, Newman BS, Thacker C, Leibold EA.

PLoS Genet. 2011 Dec;7(12):e1002394. doi: 10.1371/journal.pgen.1002394. Epub 2011 Dec 15.

8.

Control of iron homeostasis by an iron-regulated ubiquitin ligase.

Vashisht AA, Zumbrennen KB, Huang X, Powers DN, Durazo A, Sun D, Bhaskaran N, Persson A, Uhlen M, Sangfelt O, Spruck C, Leibold EA, Wohlschlegel JA.

Science. 2009 Oct 30;326(5953):718-21. doi: 10.1126/science.1176333. Epub 2009 Sep 17.

9.

Cysteine oxidation regulates the RNA-binding activity of iron regulatory protein 2.

Zumbrennen KB, Wallander ML, Romney SJ, Leibold EA.

Mol Cell Biol. 2009 Apr;29(8):2219-29. doi: 10.1128/MCB.00004-09. Epub 2009 Feb 17.

10.

Iron-independent phosphorylation of iron regulatory protein 2 regulates ferritin during the cell cycle.

Wallander ML, Zumbrennen KB, Rodansky ES, Romney SJ, Leibold EA.

J Biol Chem. 2008 Aug 29;283(35):23589-98. doi: 10.1074/jbc.M803005200. Epub 2008 Jun 23.

11.

An iron enhancer element in the FTN-1 gene directs iron-dependent expression in Caenorhabditis elegans intestine.

Romney SJ, Thacker C, Leibold EA.

J Biol Chem. 2008 Jan 11;283(2):716-25. Epub 2007 Nov 16.

12.

HOIL-1 is not required for iron-mediated IRP2 degradation in HEK293 cells.

Zumbrennen KB, Hanson ES, Leibold EA.

Biochim Biophys Acta. 2008 Feb;1783(2):246-52. Epub 2007 Aug 9.

13.

Alteration of iron regulatory proteins (IRP1 and IRP2) and ferritin in the brains of scrapie-infected mice.

Kim BH, Jun YC, Jin JK, Kim JI, Kim NH, Leibold EA, Connor JR, Choi EK, Carp RI, Kim YS.

Neurosci Lett. 2007 Jul 18;422(3):158-63. Epub 2007 Jun 14.

14.

Molecular control of vertebrate iron homeostasis by iron regulatory proteins.

Wallander ML, Leibold EA, Eisenstein RS.

Biochim Biophys Acta. 2006 Jul;1763(7):668-89. Epub 2006 May 17. Review.

15.

Influence of gestational age and fetal iron status on IRP activity and iron transporter protein expression in third-trimester human placenta.

Bradley J, Leibold EA, Harris ZL, Wobken JD, Clarke S, Zumbrennen KB, Eisenstein RS, Georgieff MK.

Am J Physiol Regul Integr Comp Physiol. 2004 Oct;287(4):R894-901. Epub 2004 Jun 3.

16.

Oxygen and iron regulation of iron regulatory protein 2.

Hanson ES, Rawlins ML, Leibold EA.

J Biol Chem. 2003 Oct 10;278(41):40337-42. Epub 2003 Jul 29.

17.

Effects of iron regulatory protein regulation on iron homeostasis during hypoxia.

Schneider BD, Leibold EA.

Blood. 2003 Nov 1;102(9):3404-11. Epub 2003 Jul 10.

PMID:
12855587
18.

Iron deficiency alters iron regulatory protein and iron transport protein expression in the perinatal rat brain.

Siddappa AJ, Rao RB, Wobken JD, Casperson K, Leibold EA, Connor JR, Georgieff MK.

Pediatr Res. 2003 May;53(5):800-7. Epub 2003 Mar 5.

PMID:
12621119
19.

Cytosolic aconitase and ferritin are regulated by iron in Caenorhabditis elegans.

Gourley BL, Parker SB, Jones BJ, Zumbrennen KB, Leibold EA.

J Biol Chem. 2003 Jan 31;278(5):3227-34. Epub 2002 Nov 15.

20.

Developmental changes in the expression of iron regulatory proteins and iron transport proteins in the perinatal rat brain.

Siddappa AJ, Rao RB, Wobken JD, Leibold EA, Connor JR, Georgieff MK.

J Neurosci Res. 2002 Jun 15;68(6):761-75.

PMID:
12111837
21.

Immunolocalization of iron regulatory protein expression in the murine central nervous system.

Leibold EA, Gahring LC, Rogers SW.

Histochem Cell Biol. 2001 Mar;115(3):195-203.

PMID:
11326747
22.

Regulation of mammalian iron homeostasis.

Schneider BD, Leibold EA.

Curr Opin Clin Nutr Metab Care. 2000 Jul;3(4):267-73. Review.

PMID:
10929672
23.
24.

Iron metabolism.

Aisen P, Wessling-Resnick M, Leibold EA.

Curr Opin Chem Biol. 1999 Apr;3(2):200-6. Review.

PMID:
10226041
25.

Hypoxia post-translationally activates iron-regulatory protein 2.

Hanson ES, Foot LM, Leibold EA.

J Biol Chem. 1999 Feb 19;274(8):5047-52.

26.

Increased placental iron regulatory protein-1 expression in diabetic pregnancies complicated by fetal iron deficiency.

Georgieff MK, Berry SA, Wobken JD, Leibold EA.

Placenta. 1999 Jan;20(1):87-93.

PMID:
9950149
27.
28.

Regulation of iron regulatory protein 1 during hypoxia and hypoxia/reoxygenation.

Hanson ES, Leibold EA.

J Biol Chem. 1998 Mar 27;273(13):7588-93.

29.

Expression and biochemical characterization of iron regulatory proteins 1 and 2 in Saccharomyces cerevisiae.

Phillips JD, Guo B, Yu Y, Brown FM, Leibold EA.

Biochemistry. 1996 Dec 10;35(49):15704-14.

PMID:
8961933
30.

Differential regulation of IRP1 and IRP2 by nitric oxide in rat hepatoma cells.

Phillips JD, Kinikini DV, Yu Y, Guo B, Leibold EA.

Blood. 1996 Apr 1;87(7):2983-92.

PMID:
8639920
31.

Iron regulates the intracellular degradation of iron regulatory protein 2 by the proteasome.

Guo B, Phillips JD, Yu Y, Leibold EA.

J Biol Chem. 1995 Sep 15;270(37):21645-51.

32.
33.
34.

The iron-responsive element binding protein. Purification, cloning, and regulation in rat liver.

Yu Y, Radisky E, Leibold EA.

J Biol Chem. 1992 Sep 15;267(26):19005-10.

35.

Iron-dependent regulation of ferritin and transferrin receptor expression by the iron-responsive element binding protein.

Leibold EA, Guo B.

Annu Rev Nutr. 1992;12:345-68. Review. No abstract available.

PMID:
1323982
38.

The ferritin genes: structure, expression, and regulation.

Munro HN, Aziz N, Leibold EA, Murray M, Rogers J, Vass JK, White K.

Ann N Y Acad Sci. 1988;526:113-23. Review. No abstract available.

PMID:
3291676
40.

Structure of human ferritin light subunit messenger RNA: comparison with heavy subunit message and functional implications.

Dörner MH, Salfeld J, Will H, Leibold EA, Vass JK, Munro HN.

Proc Natl Acad Sci U S A. 1985 May;82(10):3139-43.

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