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Reply to DS Ludwig et al.

Hall KD, Guo J, Chen KY, Leibel RL, Reitman ML, Rosenbaum M, Smith SR, Ravussin E.

Am J Clin Nutr. 2019 Nov 1;110(5):1255-1256. doi: 10.1093/ajcn/nqz157. No abstract available.


Auto-Regulation of Leptin Neurobiology.

LeDuc CA, Leibel RL.

Cell Metab. 2019 Oct 1;30(4):614-616. doi: 10.1016/j.cmet.2019.09.006.


Functional genomic characterization of the FTO locus in African Americans.

Gill R, Stratigopoulos G, Lee JH, Leibel RL.

Physiol Genomics. 2019 Nov 1;51(11):517-528. doi: 10.1152/physiolgenomics.00057.2019. Epub 2019 Sep 18.


The FTO Gene and Measured Food Intake in 5- to 10-Year-Old Children Without Obesity.

Ranzenhofer LM, Mayer LES, Davis HA, Mielke-Maday HK, McInerney H, Korn R, Gupta N, Brown AJ, Schebendach J, Tanofsky-Kraff M, Thaker V, Chung WK, Leibel RL, Walsh BT, Rosenbaum M.

Obesity (Silver Spring). 2019 Jun;27(6):1023-1029. doi: 10.1002/oby.22464.


Glucose and Lipid Homeostasis and Inflammation in Humans Following an Isocaloric Ketogenic Diet.

Rosenbaum M, Hall KD, Guo J, Ravussin E, Mayer LS, Reitman ML, Smith SR, Walsh BT, Leibel RL.

Obesity (Silver Spring). 2019 Jun;27(6):971-981. doi: 10.1002/oby.22468. Epub 2019 May 8.


Methodologic considerations for measuring energy expenditure differences between diets varying in carbohydrate using the doubly labeled water method.

Hall KD, Guo J, Chen KY, Leibel RL, Reitman ML, Rosenbaum M, Smith SR, Ravussin E.

Am J Clin Nutr. 2019 May 1;109(5):1328-1334. doi: 10.1093/ajcn/nqy390.


Transgenic substitution with Greater Amberjack Seriola dumerili fish insulin 2 in NOD mice reduces beta cell immunogenicity.

Foo KS, Skowronski AA, Baum D, Firdessa-Fite R, Thams S, Shang L, Creusot RJ, LeDuc CA, Egli D, Leibel RL.

Sci Rep. 2019 Mar 21;9(1):4965. doi: 10.1038/s41598-019-40768-3.


A role for foregut tyrosine metabolism in glucose tolerance.

Korner J, Cline GW, Slifstein M, Barba P, Rayat GR, Febres G, Leibel RL, Maffei A, Harris PE.

Mol Metab. 2019 May;23:37-50. doi: 10.1016/j.molmet.2019.02.008. Epub 2019 Feb 27.


Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development.

Wang L, De Solis AJ, Goffer Y, Birkenbach KE, Engle SE, Tanis R, Levenson JM, Li X, Rausch R, Purohit M, Lee JY, Tan J, De Rosa MC, Doege CA, Aaron HL, Martins GJ, Brüning JC, Egli D, Costa R, Berbari N, Leibel RL, Stratigopoulos G.

JCI Insight. 2019 Feb 7;4(3). pii: 123337. doi: 10.1172/jci.insight.123337. [Epub ahead of print]


Resistance Training Reduces Skeletal Muscle Work Efficiency in Weight-Reduced and Non-Weight-Reduced Subjects.

Rosenbaum M, Heaner M, Goldsmith RL, Christian Schulze P, Shukla A, Shen W, Shane EJ, Naor E, Leibel RL, Aronne LJ.

Obesity (Silver Spring). 2018 Oct;26(10):1576-1583. doi: 10.1002/oby.22274. Epub 2018 Sep 27.


Pancreatic Beta Cell Differentiation From Human Pluripotent Stem Cells.

Sui L, Leibel RL, Egli D.

Curr Protoc Hum Genet. 2018 Oct;99(1):e68. doi: 10.1002/cphg.68. Epub 2018 Sep 7.


Physiological responses to leptin levels in lipodystrophy: a model for other hypoleptinemias?

Rosenbaum M, Leibel RL.

J Clin Invest. 2018 Aug 1;128(8):3237-3239. doi: 10.1172/JCI122042. Epub 2018 Jul 16.


The Carbohydrate-Insulin Model of Obesity Is Difficult to Reconcile With Current Evidence.

Hall KD, Guyenet SJ, Leibel RL.

JAMA Intern Med. 2018 Aug 1;178(8):1103-1105. doi: 10.1001/jamainternmed.2018.2920. No abstract available.


FTO mediates cell-autonomous effects on adipogenesis and adipocyte lipid content by regulating gene expression via 6mA DNA modifications.

Martin Carli JF, LeDuc CA, Zhang Y, Stratigopoulos G, Leibel RL.

J Lipid Res. 2018 Aug;59(8):1446-1460. doi: 10.1194/jlr.M085555. Epub 2018 Jun 22.


Triiodothyronine and leptin repletion in humans similarly reverse weight-loss-induced changes in skeletal muscle.

Rosenbaum M, Goldsmith RL, Haddad F, Baldwin KM, Smiley R, Gallagher D, Leibel RL.

Am J Physiol Endocrinol Metab. 2018 Nov 1;315(5):E771-E779. doi: 10.1152/ajpendo.00116.2018. Epub 2018 Jun 19.


DMSO increases efficiency of genome editing at two non-coding loci.

Stratigopoulos G, De Rosa MC, LeDuc CA, Leibel RL, Doege CA.

PLoS One. 2018 Jun 4;13(6):e0198637. doi: 10.1371/journal.pone.0198637. eCollection 2018.


ILDR2 has a negligible role in hepatic steatosis.

Millings EJ, De Rosa MC, Fleet S, Watanabe K, Rausch R, Egli D, Li G, Leduc CA, Zhang Y, Fischer SG, Leibel RL.

PLoS One. 2018 May 30;13(5):e0197548. doi: 10.1371/journal.pone.0197548. eCollection 2018.


FTO genotype impacts food intake and corticolimbic activation.

Melhorn SJ, Askren MK, Chung WK, Kratz M, Bosch TA, Tyagi V, Webb MF, De Leon MRB, Grabowski TJ, Leibel RL, Schur EA.

Am J Clin Nutr. 2018 Feb 1;107(2):145-154. doi: 10.1093/ajcn/nqx029.


The role of Rpgrip1l, a component of the primary cilium, in adipocyte development and function.

Carli JFM, LeDuc CA, Zhang Y, Stratigopoulos G, Leibel RL.

FASEB J. 2018 Jul;32(7):3946-3956. doi: 10.1096/fj.201701216R. Epub 2018 Feb 21.


Pathophysiology of drug induced weight and metabolic effects: findings from an RCT in healthy volunteers treated with olanzapine, iloperidone, or placebo.

Ballon JS, Pajvani UB, Mayer LE, Freyberg Z, Freyberg R, Contreras I, Rosenbaum M, Leibel RL, Lieberman JA.

J Psychopharmacol. 2018 May;32(5):533-540. doi: 10.1177/0269881118754708. Epub 2018 Feb 15.


Energy homeostasis in leptin deficient Lepob/ob mice.

Skowronski AA, Ravussin Y, Leibel RL, LeDuc CA.

PLoS One. 2017 Dec 20;12(12):e0189784. doi: 10.1371/journal.pone.0189784. eCollection 2017.


Loss of the imprinted, non-coding Snord116 gene cluster in the interval deleted in the Prader Willi syndrome results in murine neuronal and endocrine pancreatic developmental phenotypes.

Burnett LC, Hubner G, LeDuc CA, Morabito MV, Carli JFM, Leibel RL.

Hum Mol Genet. 2017 Dec 1;26(23):4606-4616. doi: 10.1093/hmg/ddx342.


β-Cell Replacement in Mice Using Human Type 1 Diabetes Nuclear Transfer Embryonic Stem Cells.

Sui L, Danzl N, Campbell SR, Viola R, Williams D, Xing Y, Wang Y, Phillips N, Poffenberger G, Johannesson B, Oberholzer J, Powers AC, Leibel RL, Chen X, Sykes M, Egli D.

Diabetes. 2018 Jan;67(1):26-35. doi: 10.2337/db17-0120. Epub 2017 Sep 20.


Obesity Pathogenesis: An Endocrine Society Scientific Statement.

Schwartz MW, Seeley RJ, Zeltser LM, Drewnowski A, Ravussin E, Redman LM, Leibel RL.

Endocr Rev. 2017 Aug 1;38(4):267-296. doi: 10.1210/er.2017-00111. Review.


Corrigendum: MC4R-dependent suppression of appetite by bone-derived lipocalin 2.

Mosialou I, Shikhel S, Liu JM, Maurizi A, Luo N, He Z, Huang Y, Zong H, Friedman RA, Barasch J, Lanzano P, Deng L, Leibel RL, Rubin M, Nickolas T, Chung W, Zeltser LM, Williams KW, Pessin JE, Kousteni S.

Nature. 2017 Jun 14;546(7658):440. doi: 10.1038/nature22808.


MC4R-dependent suppression of appetite by bone-derived lipocalin 2.

Mosialou I, Shikhel S, Liu JM, Maurizi A, Luo N, He Z, Huang Y, Zong H, Friedman RA, Barasch J, Lanzano P, Deng L, Leibel RL, Rubin M, Nickolas T, Chung W, Zeltser LM, Williams KW, Pessin JE, Kousteni S.

Nature. 2017 Mar 16;543(7645):385-390. doi: 10.1038/nature21697. Epub 2017 Mar 8. Erratum in: Nature. 2017 Jun 14;546(7658):440.


PC1/3 Deficiency Impacts Pro-opiomelanocortin Processing in Human Embryonic Stem Cell-Derived Hypothalamic Neurons.

Wang L, Sui L, Panigrahi SK, Meece K, Xin Y, Kim J, Gromada J, Doege CA, Wardlaw SL, Egli D, Leibel RL.

Stem Cell Reports. 2017 Feb 14;8(2):264-277. doi: 10.1016/j.stemcr.2016.12.021. Epub 2017 Jan 26.


Weight Perturbation Alters Leptin Signal Transduction in a Region-Specific Manner throughout the Brain.

Morabito MV, Ravussin Y, Mueller BR, Skowronski AA, Watanabe K, Foo KS, Lee SX, Lehmann A, Hjorth S, Zeltser LM, LeDuc CA, Leibel RL.

PLoS One. 2017 Jan 20;12(1):e0168226. doi: 10.1371/journal.pone.0168226. eCollection 2017.


iPSC-derived β cells model diabetes due to glucokinase deficiency.

Hua H, Shang L, Martinez H, Freeby M, Gallagher MP, Ludwig T, Deng L, Greenberg E, LeDuc C, Chung WK, Goland R, Leibel RL, Egli D.

J Clin Invest. 2017 Mar 1;127(3):1115. doi: 10.1172/JCI92775. Epub 2017 Jan 17. No abstract available.


Determination of the half-life of circulating leptin in the mouse.

Burnett LC, Skowronski AA, Rausch R, LeDuc CA, Leibel RL.

Int J Obes (Lond). 2017 Mar;41(3):355-359. doi: 10.1038/ijo.2016.238. Epub 2016 Dec 27.


Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome.

Burnett LC, LeDuc CA, Sulsona CR, Paull D, Rausch R, Eddiry S, Carli JF, Morabito MV, Skowronski AA, Hubner G, Zimmer M, Wang L, Day R, Levy B, Fennoy I, Dubern B, Poitou C, Clement K, Butler MG, Rosenbaum M, Salles JP, Tauber M, Driscoll DJ, Egli D, Leibel RL.

J Clin Invest. 2017 Jan 3;127(1):293-305. doi: 10.1172/JCI88648. Epub 2016 Dec 12.


Reply to DS Ludwig and CB Ebbeling.

Hall KD, Chen KY, Guo J, Leibel RL, Mayer LE, Reitman ML, Rosenbaum M, Smith SR, Walsh BT, Ravussin E.

Am J Clin Nutr. 2016 Nov;104(5):1488-1490. No abstract available.


Induced pluripotent stem cells (iPSC) created from skin fibroblasts of patients with Prader-Willi syndrome (PWS) retain the molecular signature of PWS.

Burnett LC, LeDuc CA, Sulsona CR, Paull D, Eddiry S, Levy B, Salles JP, Tauber M, Driscoll DJ, Egli D, Leibel RL.

Stem Cell Res. 2016 Nov;17(3):526-530. doi: 10.1016/j.scr.2016.08.008. Epub 2016 Aug 16.


Models of energy homeostasis in response to maintenance of reduced body weight.

Rosenbaum M, Leibel RL.

Obesity (Silver Spring). 2016 Aug;24(8):1620-9. doi: 10.1002/oby.21559.


Energy expenditure and body composition changes after an isocaloric ketogenic diet in overweight and obese men.

Hall KD, Chen KY, Guo J, Lam YY, Leibel RL, Mayer LE, Reitman ML, Rosenbaum M, Smith SR, Walsh BT, Ravussin E.

Am J Clin Nutr. 2016 Aug;104(2):324-33. doi: 10.3945/ajcn.116.133561. Epub 2016 Jul 6.


Efficient Generation of Hypothalamic Neurons from Human Pluripotent Stem Cells.

Wang L, Egli D, Leibel RL.

Curr Protoc Hum Genet. 2016 Jul 1;90:21.5.1-21.5.14. doi: 10.1002/cphg.3.


ZNF70, a novel ILDR2-interacting protein, contributes to the regulation of HES1 gene expression.

Watanabe K, Nakayama K, Ohta S, Tago K, Boonvisut S, Millings EJ, Fischer SG, LeDuc CA, Leibel RL, Iwamoto S.

Biochem Biophys Res Commun. 2016 Sep 2;477(4):712-716. doi: 10.1016/j.bbrc.2016.06.124. Epub 2016 Jun 25.


Hypomorphism of Fto and Rpgrip1l causes obesity in mice.

Stratigopoulos G, Burnett LC, Rausch R, Gill R, Penn DB, Skowronski AA, LeDuc CA, Lanzano AJ, Zhang P, Storm DR, Egli D, Leibel RL.

J Clin Invest. 2016 May 2;126(5):1897-910. doi: 10.1172/JCI85526. Epub 2016 Apr 11.


Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.

Kilpeläinen TO, Carli JF, Skowronski AA, Sun Q, Kriebel J, Feitosa MF, Hedman ÅK, Drong AW, Hayes JE, Zhao J, Pers TH, Schick U, Grarup N, Kutalik Z, Trompet S, Mangino M, Kristiansson K, Beekman M, Lyytikäinen LP, Eriksson J, Henneman P, Lahti J, Tanaka T, Luan J, Del Greco M F, Pasko D, Renström F, Willems SM, Mahajan A, Rose LM, Guo X, Liu Y, Kleber ME, Pérusse L, Gaunt T, Ahluwalia TS, Ju Sung Y, Ramos YF, Amin N, Amuzu A, Barroso I, Bellis C, Blangero J, Buckley BM, Böhringer S, I Chen YD, de Craen AJ, Crosslin DR, Dale CE, Dastani Z, Day FR, Deelen J, Delgado GE, Demirkan A, Finucane FM, Ford I, Garcia ME, Gieger C, Gustafsson S, Hallmans G, Hankinson SE, Havulinna AS, Herder C, Hernandez D, Hicks AA, Hunter DJ, Illig T, Ingelsson E, Ioan-Facsinay A, Jansson JO, Jenny NS, Jørgensen ME, Jørgensen T, Karlsson M, Koenig W, Kraft P, Kwekkeboom J, Laatikainen T, Ladwig KH, LeDuc CA, Lowe G, Lu Y, Marques-Vidal P, Meisinger C, Menni C, Morris AP, Myers RH, Männistö S, Nalls MA, Paternoster L, Peters A, Pradhan AD, Rankinen T, Rasmussen-Torvik LJ, Rathmann W, Rice TK, Brent Richards J, Ridker PM, Sattar N, Savage DB, Söderberg S, Timpson NJ, Vandenput L, van Heemst D, Uh HW, Vohl MC, Walker M, Wichmann HE, Widén E, Wood AR, Yao J, Zeller T, Zhang Y, Meulenbelt I, Kloppenburg M, Astrup A, Sørensen TI, Sarzynski MA, Rao DC, Jousilahti P, Vartiainen E, Hofman A, Rivadeneira F, Uitterlinden AG, Kajantie E, Osmond C, Palotie A, Eriksson JG, Heliövaara M, Knekt PB, Koskinen S, Jula A, Perola M, Huupponen RK, Viikari JS, Kähönen M, Lehtimäki T, Raitakari OT, Mellström D, Lorentzon M, Casas JP, Bandinelli S, März W, Isaacs A, van Dijk KW, van Duijn CM, Harris TB, Bouchard C, Allison MA, Chasman DI, Ohlsson C, Lind L, Scott RA, Langenberg C, Wareham NJ, Ferrucci L, Frayling TM, Pramstaller PP, Borecki IB, Waterworth DM, Bergmann S, Waeber G, Vollenweider P, Vestergaard H, Hansen T, Pedersen O, Hu FB, Eline Slagboom P, Grallert H, Spector TD, Jukema JW, Klein RJ, Schadt EE, Franks PW, Lindgren CM, Leibel RL, Loos RJ.

Nat Commun. 2016 Feb 1;7:10494. doi: 10.1038/ncomms10494.


Cross-sectional and Test-Retest Characterization of PET with [(18)F]FP-(+)-DTBZ for β Cell Mass Estimates in Diabetes.

Freeby MJ, Kringas P, Goland RS, Leibel RL, Maffei A, Divgi C, Ichise M, Harris PE.

Mol Imaging Biol. 2016 Apr;18(2):292-301. doi: 10.1007/s11307-015-0888-7. Epub 2015 Sep 14.


The gut microbiota in human energy homeostasis and obesity.

Rosenbaum M, Knight R, Leibel RL.

Trends Endocrinol Metab. 2015 Sep;26(9):493-501. doi: 10.1016/j.tem.2015.07.002. Epub 2015 Aug 7. Review.


Proopiomelanocortin, agouti-related protein, and leptin in human cerebrospinal fluid: correlations with body weight and adiposity.

Page-Wilson G, Meece K, White A, Rosenbaum M, Leibel RL, Smiley R, Wardlaw SL.

Am J Physiol Endocrinol Metab. 2015 Sep 1;309(5):E458-65. doi: 10.1152/ajpendo.00206.2015. Epub 2015 Jul 7.


Biologic Responses to Weight Loss and Weight Regain: Report From an American Diabetes Association Research Symposium.

Leibel RL, Seeley RJ, Darsow T, Berg EG, Smith SR, Ratner R.

Diabetes. 2015 Jul;64(7):2299-309. doi: 10.2337/db15-0004. Review. No abstract available.


Lessons From Rodent Models of Obesity.

Myers MG, Leibel RL.

In: Feingold KR, Anawalt B, Boyce A, Chrousos G, Dungan K, Grossman A, Hershman JM, Kaltsas G, Koch C, Kopp P, Korbonits M, McLachlan R, Morley JE, New M, Perreault L, Purnell J, Rebar R, Singer F, Trence DL, Vinik A, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA):, Inc.; 2000-.
2015 Feb 28.


Differentiation of hypothalamic-like neurons from human pluripotent stem cells.

Wang L, Meece K, Williams DJ, Lo KA, Zimmer M, Heinrich G, Martin Carli J, Leduc CA, Sun L, Zeltser LM, Freeby M, Goland R, Tsang SH, Wardlaw SL, Egli D, Leibel RL.

J Clin Invest. 2015 Feb;125(2):796-808. doi: 10.1172/JCI79220. Epub 2015 Jan 2.


Retinoic acid receptor signaling is required to maintain glucose-stimulated insulin secretion and β-cell mass.

Brun PJ, Grijalva A, Rausch R, Watson E, Yuen JJ, Das BC, Shudo K, Kagechika H, Leibel RL, Blaner WS.

FASEB J. 2015 Feb;29(2):671-83. doi: 10.1096/fj.14-256743. Epub 2014 Nov 11.


A missing link in body weight homeostasis: the catabolic signal of the overfed state.

Ravussin Y, Leibel RL, Ferrante AW Jr.

Cell Metab. 2014 Oct 7;20(4):565-72. doi: 10.1016/j.cmet.2014.09.002. Review.


Molecular pathophysiology of metabolic effects of antipsychotic medications.

Ballon JS, Pajvani U, Freyberg Z, Leibel RL, Lieberman JA.

Trends Endocrinol Metab. 2014 Nov;25(11):593-600. doi: 10.1016/j.tem.2014.07.004. Epub 2014 Sep 2. Review.


The threshold shift paradigm of obesity: evidence from surgically induced weight loss.

Ferrannini E, Rosenbaum M, Leibel RL.

Am J Clin Nutr. 2014 Oct;100(4):996-1002. doi: 10.3945/ajcn.114.090167. Epub 2014 Aug 6.


20 years of leptin: role of leptin in energy homeostasis in humans.

Rosenbaum M, Leibel RL.

J Endocrinol. 2014 Oct;223(1):T83-96. doi: 10.1530/JOE-14-0358. Epub 2014 Jul 25. Review.

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