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Grafted Neural Progenitor Cells Persist in the Injured Site and Differentiate Neuronally in a Rodent Model of Cardiac Arrest-Induced Global Brain Ischemia.

Meyer P, Grandgirard D, Lehner M, Haenggi M, Leib SL.

Stem Cells Dev. 2020 Feb 19. doi: 10.1089/scd.2019.0190. [Epub ahead of print]


Antimicrobial resistance classification using MALDI-TOF-MS is not that easy: lessons from vancomycin-resistant Enterococcus faecium.

Brackmann M, Leib SL, Tonolla M, Schürch N, Wittwer M.

Clin Microbiol Infect. 2020 Mar;26(3):391-393. doi: 10.1016/j.cmi.2019.10.027. Epub 2019 Nov 1. No abstract available.


Rapid and Cost-Efficient Enterovirus Genotyping from Clinical Samples Using Flongle Flow Cells.

Grädel C, Terrazos Miani MA, Barbani MT, Leib SL, Suter-Riniker F, Ramette A.

Genes (Basel). 2019 Aug 29;10(9). pii: E659. doi: 10.3390/genes10090659.


Metformin mediates neuroprotection and attenuates hearing loss in experimental pneumococcal meningitis.

Muri L, Le ND, Zemp J, Grandgirard D, Leib SL.

J Neuroinflammation. 2019 Jul 27;16(1):156. doi: 10.1186/s12974-019-1549-6.


Bacteriophages Improve Outcomes in Experimental Staphylococcus aureus Ventilator-associated Pneumonia.

Prazak J, Iten M, Cameron DR, Save J, Grandgirard D, Resch G, Goepfert C, Leib SL, Takala J, Jakob SM, Que YA, Haenggi M.

Am J Respir Crit Care Med. 2019 Nov 1;200(9):1126-1133. doi: 10.1164/rccm.201812-2372OC.


Anti-inflammatory and Oto-Protective Effect of the Small Heat Shock Protein Alpha B-Crystallin (HspB5) in Experimental Pneumococcal Meningitis.

Erni ST, Fernandes G, Buri M, Perny M, Rutten RJ, van Noort JM, Senn P, Grandgirard D, Roccio M, Leib SL.

Front Neurol. 2019 Jun 10;10:570. doi: 10.3389/fneur.2019.00570. eCollection 2019.


MMPs and ADAMs in neurological infectious diseases and multiple sclerosis.

Muri L, Leppert D, Grandgirard D, Leib SL.

Cell Mol Life Sci. 2019 Aug;76(16):3097-3116. doi: 10.1007/s00018-019-03174-6. Epub 2019 Jun 6. Review.


Pneumolysin and the bacterial capsule of Streptococcus pneumoniae cooperatively inhibit taxis and motility of microglia.

Hupp S, Grandgirard D, Mitchell TJ, Leib SL, Hathaway LJ, Iliev AI.

J Neuroinflammation. 2019 May 18;16(1):105. doi: 10.1186/s12974-019-1491-7.


Combining Ceftriaxone with Doxycycline and Daptomycin Reduces Mortality, Neuroinflammation, Brain Damage, and Hearing Loss in Infant Rat Pneumococcal Meningitis.

Muri L, Perny M, Zemp J, Grandgirard D, Leib SL.

Antimicrob Agents Chemother. 2019 Jun 24;63(7). pii: e00220-19. doi: 10.1128/AAC.00220-19. Print 2019 Jul.


Testing bioresorbable stent feasibility in a rat aneurysm model.

Grüter BE, Täschler D, Strange F, Rey J, von Gunten M, Grandgirard D, Leib SL, Remonda L, Widmer HR, Nevzati E, Fandino J, Marbacher S, Coluccia D.

J Neurointerv Surg. 2019 Oct;11(10):1050-1054. doi: 10.1136/neurintsurg-2018-014697. Epub 2019 Mar 9.


Virulence Traits of a Serogroup C Meningococcus and Isogenic cssA Mutant, Defective in Surface-Exposed Sialic Acid, in a Murine Model of Meningitis.

Colicchio R, Pagliuca C, Ricci S, Scaglione E, Grandgirard D, Masouris I, Farina F, Pagliarulo C, Mantova G, Paragliola L, Leib SL, Koedel U, Pozzi G, Alifano P, Salvatore P.

Infect Immun. 2019 Mar 25;87(4). pii: e00688-18. doi: 10.1128/IAI.00688-18. Print 2019 Apr.


Pulmonary nocardiosis in Western Europe-Clinical evaluation of 43 patients and population-based estimates of hospitalization rates.

Ott SR, Meier N, Kolditz M, Bauer TT, Rohde G, Presterl E, Schürmann D, Lepper PM, Ringshausen FC, Flick H, Leib SL, Pletz MW; OPINION Study Group.

Int J Infect Dis. 2019 Apr;81:140-148. doi: 10.1016/j.ijid.2018.12.010. Epub 2019 Jan 15. Review.


Comparison of Four Commercial IgG-Enzyme-Linked Immunosorbent Assays for the Detection of Tick-Borne Encephalitis Virus Antibodies.

Ackermann-Gäumann R, Eyer C, Leib SL, Niederhauser C.

Vector Borne Zoonotic Dis. 2019 May;19(5):358-364. doi: 10.1089/vbz.2018.2359. Epub 2018 Dec 4.


Fatal bronchopneumonia caused by skunk adenovirus 1 in an African pygmy hedgehog.

Needle DB, Selig MK, Jackson KA, Delwart E, Tighe E, Leib SL, Seuberlich T, Pesavento PA.

J Vet Diagn Invest. 2019 Jan;31(1):103-106. doi: 10.1177/1040638718812123. Epub 2018 Nov 26.


Limited Correlation of Shotgun Metagenomics Following Host Depletion and Routine Diagnostics for Viruses and Bacteria in Low Concentrated Surrogate and Clinical Samples.

Oechslin CP, Lenz N, Liechti N, Ryter S, Agyeman P, Bruggmann R, Leib SL, Beuret CM.

Front Cell Infect Microbiol. 2018 Oct 23;8:375. doi: 10.3389/fcimb.2018.00375. eCollection 2018.


Evaluation of antivirals against tick-borne encephalitis virus in organotypic brain slices of rat cerebellum.

Lenz N, Engler O, Grandgirard D, Leib SL, Ackermann-Gäumann R.

PLoS One. 2018 Oct 9;13(10):e0205294. doi: 10.1371/journal.pone.0205294. eCollection 2018.


Is Penicillin Plus Gentamicin Synergistic Against Sessile Group B Streptococcal Isolates? An in Vivo Study With an Experimental Model of Foreign-Body Infection.

Ruppen C, Mercier T, Grandgirard D, Leib SL, El Haj C, Murillo O, Decosterd L, Sendi P.

Front Microbiol. 2018 May 15;9:919. doi: 10.3389/fmicb.2018.00919. eCollection 2018.


Foreign peptide triggers boost in pneumococcal metabolism and growth.

Nasher F, Förster S, Yildirim EC, Grandgirard D, Leib SL, Heller M, Hathaway LJ.

BMC Microbiol. 2018 Mar 27;18(1):23. doi: 10.1186/s12866-018-1167-y.


DNA repair protein APE1 is involved in host response during pneumococcal meningitis and its expression can be modulated by vitamin B6.

Coutinho LG, de Oliveira AHS, Witwer M, Leib SL, Agnez-Lima LF.

J Neuroinflammation. 2017 Dec 12;14(1):243. doi: 10.1186/s12974-017-1020-5.


A transcribed enhancer dictates mesendoderm specification in pluripotency.

Alexanian M, Maric D, Jenkinson SP, Mina M, Friedman CE, Ting CC, Micheletti R, Plaisance I, Nemir M, Maison D, Kernen J, Pezzuto I, Villeneuve D, Burdet F, Ibberson M, Leib SL, Palpant NJ, Hernandez N, Ounzain S, Pedrazzini T.

Nat Commun. 2017 Nov 27;8(1):1806. doi: 10.1038/s41467-017-01804-w.


Prevalence of tick-borne pathogens in questing Ixodes ricinus ticks in urban and suburban areas of Switzerland.

Oechslin CP, Heutschi D, Lenz N, Tischhauser W, Péter O, Rais O, Beuret CM, Leib SL, Bankoul S, Ackermann-Gäumann R.

Parasit Vectors. 2017 Nov 9;10(1):558. doi: 10.1186/s13071-017-2500-2.


Novel and preclinical treatment strategies in pneumococcal meningitis.

Bewersdorf JP, Grandgirard D, Koedel U, Leib SL.

Curr Opin Infect Dis. 2018 Feb;31(1):85-92. doi: 10.1097/QCO.0000000000000416. Review.


Neuroprotection with the P53-Inhibitor Pifithrin-μ after Cardiac Arrest in a Rodent Model.

Glas M, Frick T, Springe D, Putzu A, Zuercher P, Grandgirard D, Leib SL, Jakob SM, Takala J, Haenggi M.

Shock. 2018 Feb;49(2):229-234. doi: 10.1097/SHK.0000000000000917.


Streptococcus pneumoniae-induced ototoxicity in organ of Corti explant cultures.

Perny M, Solyga M, Grandgirard D, Roccio M, Leib SL, Senn P.

Hear Res. 2017 Jul;350:100-109. doi: 10.1016/j.heares.2017.04.012. Epub 2017 Apr 25.


Embryonic Stem Cell-Derived Neurons Grown on Multi-Electrode Arrays as a Novel In vitro Bioassay for the Detection of Clostridium botulinum Neurotoxins.

Jenkinson SP, Grandgirard D, Heidemann M, Tscherter A, Avondet MA, Leib SL.

Front Pharmacol. 2017 Feb 23;8:73. doi: 10.3389/fphar.2017.00073. eCollection 2017.


The Severity of Infection Determines the Localization of Damage and Extent of Sensorineural Hearing Loss in Experimental Pneumococcal Meningitis.

Perny M, Roccio M, Grandgirard D, Solyga M, Senn P, Leib SL.

J Neurosci. 2016 Jul 20;36(29):7740-9. doi: 10.1523/JNEUROSCI.0554-16.2016.


Clinical Streptococcus pneumoniae isolates induce differing CXCL8 responses from human nasopharyngeal epithelial cells which are reduced by liposomes.

Baumgartner D, Aebi S, Grandgirard D, Leib SL, Draeger A, Babiychuk E, Hathaway LJ.

BMC Microbiol. 2016 Jul 19;16(1):154. doi: 10.1186/s12866-016-0777-5.


Multiple adaptive routes of Salmonella enterica Typhimurium to biocide and antibiotic exposure.

Curiao T, Marchi E, Grandgirard D, León-Sampedro R, Viti C, Leib SL, Baquero F, Oggioni MR, Martinez JL, Coque TM.

BMC Genomics. 2016 Jul 13;17:491. doi: 10.1186/s12864-016-2778-z.


ESCMID guideline: diagnosis and treatment of acute bacterial meningitis.

van de Beek D, Cabellos C, Dzupova O, Esposito S, Klein M, Kloek AT, Leib SL, Mourvillier B, Ostergaard C, Pagliano P, Pfister HW, Read RC, Sipahi OR, Brouwer MC; ESCMID Study Group for Infections of the Brain (ESGIB).

Clin Microbiol Infect. 2016 May;22 Suppl 3:S37-62. doi: 10.1016/j.cmi.2016.01.007. Epub 2016 Apr 7. No abstract available.


A randomized trial of the effects of the noble gases helium and argon on neuroprotection in a rodent cardiac arrest model.

Zuercher P, Springe D, Grandgirard D, Leib SL, Grossholz M, Jakob S, Takala J, Haenggi M.

BMC Neurol. 2016 Apr 4;16:43. doi: 10.1186/s12883-016-0565-8.


Streptococcus pneumoniae capsule determines disease severity in experimental pneumococcal meningitis.

Hathaway LJ, Grandgirard D, Valente LG, Täuber MG, Leib SL.

Open Biol. 2016 Mar;6(3). pii: 150269. doi: 10.1098/rsob.150269.


Microglial Cells Prevent Hemorrhage in Neonatal Focal Arterial Stroke.

Fernández-López D, Faustino J, Klibanov AL, Derugin N, Blanchard E, Simon F, Leib SL, Vexler ZS.

J Neurosci. 2016 Mar 9;36(10):2881-93. doi: 10.1523/JNEUROSCI.0140-15.2016.


Inhibition of Hippocampal Regeneration by Adjuvant Dexamethasone in Experimental Infant Rat Pneumococcal Meningitis.

Bally L, Grandgirard D, Leib SL.

Antimicrob Agents Chemother. 2016 Jan 11;60(3):1841-6. doi: 10.1128/AAC.02429-15.


Inflammatory markers in pediatric stroke: An attempt to better understanding the pathophysiology.

Buerki SE, Grandgirard D, Datta AN, Hackenberg A, Martin F, Schmitt-Mechelke T, Leib SL, Steinlin M; Swiss Neuropediatric Stroke Registry Study Group.

Eur J Paediatr Neurol. 2016 Mar;20(2):252-260. doi: 10.1016/j.ejpn.2015.12.006. Epub 2015 Dec 23.


In Vitro Activity of the Novel Antimicrobial Peptide Dendrimer G3KL against Multidrug-Resistant Acinetobacter baumannii and Pseudomonas aeruginosa.

Pires J, Siriwardena TN, Stach M, Tinguely R, Kasraian S, Luzzaro F, Leib SL, Darbre T, Reymond JL, Endimiani A.

Antimicrob Agents Chemother. 2015 Dec;59(12):7915-8. doi: 10.1128/AAC.01853-15. Epub 2015 Oct 12.


An improved simple rat model for global cerebral ischaemia by induced cardiac arrest.

Frick T, Springe D, Grandgirard D, Leib SL, Haenggi M.

Neurol Res. 2016 Apr;38(4):373-80. doi: 10.1179/1743132815Y.0000000090. Epub 2016 Apr 20.


Genetic polymorphisms associated with the inflammatory response in bacterial meningitis.

Fontes FL, de Araújo LF, Coutinho LG, Leib SL, Agnez-Lima LF.

BMC Med Genet. 2015 Aug 28;16:70. doi: 10.1186/s12881-015-0218-6.


Bacterial meningitis: insights into pathogenesis and evaluation of new treatment options: a perspective from experimental studies.

Liechti FD, Grandgirard D, Leib SL.

Future Microbiol. 2015;10(7):1195-213. doi: 10.2217/fmb.15.43. Epub 2015 Jun 29. Review.


Do different anesthesia regimes affect hippocampal apoptosis and neurologic deficits in a rodent cardiac arrest model?

Bendel S, Springe D, Pereira A, Grandgirard D, Leib SL, Putzu A, Schlickeiser J, Jakob SM, Takala J, Haenggi M.

BMC Anesthesiol. 2015 Jan 15;15:2. doi: 10.1186/1471-2253-15-2.


Deletion of Fibrinogen-like Protein 2 (FGL-2), a Novel CD4+ CD25+ Treg Effector Molecule, Leads to Improved Control of Echinococcus multilocularis Infection in Mice.

Wang J, Vuitton DA, Müller N, Hemphill A, Spiliotis M, Blagosklonov O, Grandgirard D, Leib SL, Shalev I, Levy G, Lu X, Lin R, Wen H, Gottstein B.

PLoS Negl Trop Dis. 2015 May 8;9(5):e0003755. doi: 10.1371/journal.pntd.0003755. eCollection 2015 May.


Mutations upstream of fabI in triclosan resistant Staphylococcus aureus strains are associated with elevated fabI gene expression.

Grandgirard D, Furi L, Ciusa ML, Baldassarri L, Knight DR, Morrissey I, Largiadèr CR, Leib SL, Oggioni MR.

BMC Genomics. 2015 Apr 30;16:345. doi: 10.1186/s12864-015-1544-y.


The matrix metalloproteinase inhibitor RS-130830 attenuates brain injury in experimental pneumococcal meningitis.

Liechti FD, Bächtold F, Grandgirard D, Leppert D, Leib SL.

J Neuroinflammation. 2015 Mar 4;12:43. doi: 10.1186/s12974-015-0257-0.


The antidepressant fluoxetine protects the hippocampus from brain damage in experimental pneumococcal meningitis.

Liechti FD, Grandgirard D, Leib SL.

Neuroscience. 2015 Jun 25;297:89-94. doi: 10.1016/j.neuroscience.2015.03.056. Epub 2015 Apr 1.


Inhibition of matrix metalloproteinases attenuates brain damage in experimental meningococcal meningitis.

Ricci S, Grandgirard D, Wenzel M, Braccini T, Salvatore P, Oggioni MR, Leib SL, Koedel U.

BMC Infect Dis. 2014 Dec 31;14:726. doi: 10.1186/s12879-014-0726-6.


Endogenous and synthetic MMP inhibitors in CNS physiopathology.

Baranger K, Rivera S, Liechti FD, Grandgirard D, Bigas J, Seco J, Tarrago T, Leib SL, Khrestchatisky M.

Prog Brain Res. 2014;214:313-51. doi: 10.1016/B978-0-444-63486-3.00014-1. Review.


The mood-stabilizer lithium prevents hippocampal apoptosis and improves spatial memory in experimental meningitis.

Liechti FD, Stüdle N, Theurillat R, Grandgirard D, Thormann W, Leib SL.

PLoS One. 2014 Nov 19;9(11):e113607. doi: 10.1371/journal.pone.0113607. eCollection 2014.


A tick-borne encephalitis model in infant rats infected with langat virus.

Maffioli C, Grandgirard D, Engler O, Leib SL.

J Neuropathol Exp Neurol. 2014 Dec;73(12):1107-15. doi: 10.1097/NEN.0000000000000131.


The kynurenine pathway is involved in bacterial meningitis.

Coutinho LG, Christen S, Bellac CL, Fontes FL, Souza FR, Grandgirard D, Leib SL, Agnez-Lima LF.

J Neuroinflammation. 2014 Oct 2;11:169. doi: 10.1186/s12974-014-0169-4.


Increase in hippocampal water diffusion and volume during experimental pneumococcal meningitis is aggravated by bacteremia.

Holler JG, Brandt CT, Leib SL, Rowland IJ, Østergaard C.

BMC Infect Dis. 2014 May 6;14:240. doi: 10.1186/1471-2334-14-240.

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