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Items: 1 to 50 of 82

1.

Waterlogging and soil freezing during dormancy affected root and shoot phenology and growth of Scots pine saplings.

Roitto M, Sutinen S, Wang AF, Domisch T, Lehto T, Repo T.

Tree Physiol. 2019 Feb 7. doi: 10.1093/treephys/tpz003. [Epub ahead of print]

PMID:
30753688
2.

Whole-plant frost hardiness of mycorrhizal (Hebeloma sp. or Suillus luteus) and non-mycorrhizal Scots pine seedlings.

Korhonen A, Lehto T, Heinonen J, Repo T.

Tree Physiol. 2018 Oct 29. doi: 10.1093/treephys/tpy105. [Epub ahead of print]

PMID:
30371901
3.

Effective in vivo gene delivery with reduced toxicity, achieved by charge and fatty acid -modified cell penetrating peptide.

Kurrikoff K, Veiman KL, Künnapuu K, Peets EM, Lehto T, Pärnaste L, Arukuusk P, Langel Ü.

Sci Rep. 2017 Dec 6;7(1):17056. doi: 10.1038/s41598-017-17316-y.

4.

Simultaneous membrane interaction of amphipathic peptide monomers, self-aggregates and cargo complexes detected by fluorescence correlation spectroscopy.

Vasconcelos L, Lehto T, Madani F, Radoi V, Hällbrink M, Vukojević V, Langel Ü.

Biochim Biophys Acta Biomembr. 2018 Feb;1860(2):491-504. doi: 10.1016/j.bbamem.2017.09.024. Epub 2017 Sep 28.

5.

Systemic Delivery of Folate-PEG siRNA Lipopolyplexes with Enhanced Intracellular Stability for In Vivo Gene Silencing in Leukemia.

Lee DJ, Kessel E, Lehto T, Liu X, Yoshinaga N, Padari K, Chen YC, Kempter S, Uchida S, Rädler JO, Pooga M, Sheu MT, Kataoka K, Wagner E.

Bioconjug Chem. 2017 Sep 20;28(9):2393-2409. doi: 10.1021/acs.bioconjchem.7b00383. Epub 2017 Aug 24.

PMID:
28772071
6.

Photosynthesis, nutrient accumulation and growth of two Betula species exposed to waterlogging in late dormancy and in the early growing season.

Wang AF, Roitto M, Lehto T, Sutinen S, Heinonen J, Zhang G, Repo T.

Tree Physiol. 2017 Jun 1;37(6):767-778. doi: 10.1093/treephys/tpx021.

PMID:
28338895
7.

Delivery is key: lessons learnt from developing splice-switching antisense therapies.

Godfrey C, Desviat LR, Smedsrød B, Piétri-Rouxel F, Denti MA, Disterer P, Lorain S, Nogales-Gadea G, Sardone V, Anwar R, El Andaloussi S, Lehto T, Khoo B, Brolin C, van Roon-Mom WM, Goyenvalle A, Aartsma-Rus A, Arechavala-Gomeza V.

EMBO Mol Med. 2017 May;9(5):545-557. doi: 10.15252/emmm.201607199. Review.

8.

Saturated Fatty Acid Analogues of Cell-Penetrating Peptide PepFect14: Role of Fatty Acid Modification in Complexation and Delivery of Splice-Correcting Oligonucleotides.

Lehto T, Vasconcelos L, Margus H, Figueroa R, Pooga M, Hällbrink M, Langel Ü.

Bioconjug Chem. 2017 Mar 15;28(3):782-792. doi: 10.1021/acs.bioconjchem.6b00680. Epub 2017 Mar 2.

PMID:
28209057
9.

Peptides for nucleic acid delivery.

Lehto T, Ezzat K, Wood MJA, El Andaloussi S.

Adv Drug Deliv Rev. 2016 Nov 15;106(Pt A):172-182. doi: 10.1016/j.addr.2016.06.008. Epub 2016 Jun 25. Review.

10.

The effectiveness of email-based exercises in promoting psychological wellbeing and healthy lifestyle: a two-year follow-up study.

Torniainen-Holm M, Pankakoski M, Lehto T, Saarelma O, Mustonen P, Joutsenniemi K, Suvisaari J.

BMC Psychol. 2016 May 17;4(1):21. doi: 10.1186/s40359-016-0125-4.

11.

Dual antitumoral potency of EG5 siRNA nanoplexes armed with cytotoxic bifunctional glutamyl-methotrexate targeting ligand.

Lee DJ, Kessel E, Edinger D, He D, Klein PM, Voith von Voithenberg L, Lamb DC, Lächelt U, Lehto T, Wagner E.

Biomaterials. 2016 Jan;77:98-110. doi: 10.1016/j.biomaterials.2015.11.004. Epub 2015 Nov 5.

PMID:
26584350
12.

Evaluation of a hand-held blood gas analyzer for rapid determination of blood gases, electrolytes and metabolites in intensive care setting.

Luukkonen AA, Lehto TM, Hedberg PS, Vaskivuo TE.

Clin Chem Lab Med. 2016 Apr;54(4):585-94. doi: 10.1515/cclm-2015-0592.

PMID:
26457784
13.

Waterlogging in late dormancy and the early growth phase affected root and leaf morphology in Betula pendula and Betula pubescens seedlings.

Wang AF, Roitto M, Sutinen S, Lehto T, Heinonen J, Zhang G, Repo T.

Tree Physiol. 2016 Jan;36(1):86-98. doi: 10.1093/treephys/tpv089. Epub 2015 Sep 28.

PMID:
26420790
14.

Self-Assembly into Nanoparticles Is Essential for Receptor Mediated Uptake of Therapeutic Antisense Oligonucleotides.

Ezzat K, Aoki Y, Koo T, McClorey G, Benner L, Coenen-Stass A, O'Donovan L, Lehto T, Garcia-Guerra A, Nordin J, Saleh AF, Behlke M, Morris J, Goyenvalle A, Dugovic B, Leumann C, Gordon S, Gait MJ, El-Andaloussi S, Wood MJ.

Nano Lett. 2015 Jul 8;15(7):4364-73. doi: 10.1021/acs.nanolett.5b00490. Epub 2015 Jun 15.

15.

PEG shielded MMP sensitive CPPs for efficient and tumor specific gene delivery in vivo.

Veiman KL, Künnapuu K, Lehto T, Kiisholts K, Pärn K, Langel Ü, Kurrikoff K.

J Control Release. 2015 Jul 10;209:238-47. doi: 10.1016/j.jconrel.2015.04.038. Epub 2015 Apr 30.

16.

Sequence-defined polymers for the delivery of oligonucleotides.

Lehto T, Wagner E.

Nanomedicine (Lond). 2014 Dec;9(18):2843-59. doi: 10.2217/nnm.14.166. Review.

PMID:
25535686
17.

Peptide-based vectors: recent developments.

Cerrato CP, Lehto T, Langel Ü.

Biomol Concepts. 2014 Dec;5(6):479-88. doi: 10.1515/bmc-2014-0024. Review.

PMID:
25429600
18.

Frost hardiness of mycorrhizal and non-mycorrhizal Scots pine under two fertilization treatments.

Korhonen A, Lehto T, Repo T.

Mycorrhiza. 2015 Jul;25(5):377-86. doi: 10.1007/s00572-014-0618-z. Epub 2014 Nov 18.

PMID:
25404213
19.

A new crystal structure fragment-based pharmacophore method for G protein-coupled receptors.

Fidom K, Isberg V, Hauser AS, Mordalski S, Lehto T, Bojarski AJ, Gloriam DE.

Methods. 2015 Jan;71:104-12. doi: 10.1016/j.ymeth.2014.09.009. Epub 2014 Oct 5.

PMID:
25286328
20.

Sequence-defined oligoaminoamides for the delivery of siRNAs.

Lee DJ, Wagner E, Lehto T.

Methods Mol Biol. 2015;1206:15-27. doi: 10.1007/978-1-4939-1369-5_2.

PMID:
25240883
21.

Cellular trafficking determines the exon skipping activity of Pip6a-PMO in mdx skeletal and cardiac muscle cells.

Lehto T, Castillo Alvarez A, Gauck S, Gait MJ, Coursindel T, Wood MJ, Lebleu B, Boisguerin P.

Nucleic Acids Res. 2014 Mar;42(5):3207-17. doi: 10.1093/nar/gkt1220. Epub 2013 Dec 23.

22.

Sensitive and rapid detection of Chlamydia trachomatis by recombinase polymerase amplification directly from urine samples.

Krõlov K, Frolova J, Tudoran O, Suhorutsenko J, Lehto T, Sibul H, Mäger I, Laanpere M, Tulp I, Langel Ü.

J Mol Diagn. 2014 Jan;16(1):127-35. doi: 10.1016/j.jmoldx.2013.08.003.

PMID:
24331366
23.

Transfection of infectious RNA and DNA/RNA layered vectors of semliki forest virus by the cell-penetrating peptide based reagent PepFect6.

Pärn K, Viru L, Lehto T, Oskolkov N, Langel Ü, Merits A.

PLoS One. 2013 Jul 8;8(7):e69659. doi: 10.1371/journal.pone.0069659. Print 2013.

24.

Frost hardiness of mycorrhizal (Hebeloma sp.) and non-mycorrhizal Scots pine roots.

Korhonen A, Lehto T, Repo T.

Mycorrhiza. 2013 Oct;23(7):551-9. doi: 10.1007/s00572-013-0497-8. Epub 2013 Apr 5.

PMID:
23558517
25.

PepFect14 peptide vector for efficient gene delivery in cell cultures.

Veiman KL, Mäger I, Ezzat K, Margus H, Lehto T, Langel K, Kurrikoff K, Arukuusk P, Suhorutšenko J, Padari K, Pooga M, Lehto T, Langel Ü.

Mol Pharm. 2013 Jan 7;10(1):199-210. doi: 10.1021/mp3003557. Epub 2012 Dec 14.

PMID:
23186360
26.

Relationship between cognitive and motor performance in physically well-recovered men with traumatic brain injury.

Sarajuuri J, Pasanen M, Rinne M, Vartiainen M, Lehto T, Alaranta H.

J Rehabil Med. 2013 Jan;45(1):38-46. doi: 10.2340/16501977-1060.

27.

Solid formulation of cell-penetrating peptide nanocomplexes with siRNA and their stability in simulated gastric conditions.

Ezzat K, Zaghloul EM, El Andaloussi S, Lehto T, El-Sayed R, Magdy T, Smith CI, Langel U.

J Control Release. 2012 Aug 20;162(1):1-8. doi: 10.1016/j.jconrel.2012.06.006. Epub 2012 Jun 12.

PMID:
22698942
28.

Cell-penetrating peptides for the delivery of nucleic acids.

Lehto T, Kurrikoff K, Langel Ü.

Expert Opin Drug Deliv. 2012 Jul;9(7):823-36. doi: 10.1517/17425247.2012.689285. Epub 2012 May 17. Review.

PMID:
22594635
29.

The role of endocytosis on the uptake kinetics of luciferin-conjugated cell-penetrating peptides.

Mäger I, Langel K, Lehto T, Eiríksdóttir E, Langel U.

Biochim Biophys Acta. 2012 Mar;1818(3):502-11. doi: 10.1016/j.bbamem.2011.11.020. Epub 2011 Dec 1.

30.

Peptide nanoparticles for oligonucleotide delivery.

Lehto T, Ezzat K, Langel U.

Prog Mol Biol Transl Sci. 2011;104:397-426. doi: 10.1016/B978-0-12-416020-0.00010-3. Review.

PMID:
22093225
31.

Boron nutrition affects the carbon metabolism of silver birch seedlings.

Ruuhola T, Keinänen M, Keski-Saari S, Lehto T.

Tree Physiol. 2011 Nov;31(11):1251-61. doi: 10.1093/treephys/tpr109.

PMID:
22084021
32.

Persuasive features in web-based alcohol and smoking interventions: a systematic review of the literature.

Lehto T, Oinas-Kukkonen H.

J Med Internet Res. 2011 Jul 22;13(3):e46. doi: 10.2196/jmir.1559. Review.

33.

Novel viral vectors utilizing intron splice-switching to activate genome rescue, expression and replication in targeted cells.

Viru L, Heller G, Lehto T, Pärn K, El Andaloussi S, Langel Ü, Merits A.

Virol J. 2011 May 19;8:243. doi: 10.1186/1743-422X-8-243.

34.

Insights into the cellular trafficking of splice redirecting oligonucleotides complexed with chemically modified cell-penetrating peptides.

Hassane FS, Abes R, El Andaloussi S, Lehto T, Sillard R, Langel U, Lebleu B.

J Control Release. 2011 Jul 30;153(2):163-72. doi: 10.1016/j.jconrel.2011.04.013. Epub 2011 Apr 20.

PMID:
21536086
35.

Boron fertilization enhances the induced defense of silver birch.

Ruuhola T, Leppänen T, Julkunen-Tiitto R, Rantala MJ, Lehto T.

J Chem Ecol. 2011 May;37(5):460-71. doi: 10.1007/s10886-011-9948-x. Epub 2011 Apr 13.

PMID:
21487920
36.

PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation.

Ezzat K, Andaloussi SE, Zaghloul EM, Lehto T, Lindberg S, Moreno PM, Viola JR, Magdy T, Abdo R, Guterstam P, Sillard R, Hammond SM, Wood MJ, Arzumanov AA, Gait MJ, Smith CI, Hällbrink M, Langel Ü.

Nucleic Acids Res. 2011 Jul;39(12):5284-98. doi: 10.1093/nar/gkr072. Epub 2011 Feb 23.

37.

A peptide-based vector for efficient gene transfer in vitro and in vivo.

Lehto T, Simonson OE, Mäger I, Ezzat K, Sork H, Copolovici DM, Viola JR, Zaghloul EM, Lundin P, Moreno PM, Mäe M, Oskolkov N, Suhorutšenko J, Smith CI, Andaloussi SE.

Mol Ther. 2011 Aug;19(8):1457-67. doi: 10.1038/mt.2011.10. Epub 2011 Feb 22.

38.

Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo.

Andaloussi SE, Lehto T, Mäger I, Rosenthal-Aizman K, Oprea II, Simonson OE, Sork H, Ezzat K, Copolovici DM, Kurrikoff K, Viola JR, Zaghloul EM, Sillard R, Johansson HJ, Said Hassane F, Guterstam P, Suhorutšenko J, Moreno PM, Oskolkov N, Hälldin J, Tedebark U, Metspalu A, Lebleu B, Lehtiö J, Smith CI, Langel U.

Nucleic Acids Res. 2011 May;39(9):3972-87. doi: 10.1093/nar/gkq1299. Epub 2011 Jan 17.

39.

Ectomycorrhizas and water relations of trees: a review.

Lehto T, Zwiazek JJ.

Mycorrhiza. 2011 Feb;21(2):71-90. doi: 10.1007/s00572-010-0348-9. Epub 2010 Dec 8. Review.

PMID:
21140277
40.

Application of PepFect peptides for the delivery of splice-correcting oligonucleotides.

Andaloussi SE, Lehto T, Lundin P, Langel U.

Methods Mol Biol. 2011;683:361-73. doi: 10.1007/978-1-60761-919-2_26.

PMID:
21053143
41.

Analysis of the willow root system by electrical impedance spectroscopy.

Cao Y, Repo T, Silvennoinen R, Lehto T, Pelkonen P.

J Exp Bot. 2011 Jan;62(1):351-8. doi: 10.1093/jxb/erq276. Epub 2010 Aug 26.

42.

Cellular internalization kinetics of (luciferin-)cell-penetrating peptide conjugates.

Eiríksdóttir E, Mäger I, Lehto T, El Andaloussi S, Langel U.

Bioconjug Chem. 2010 Sep 15;21(9):1662-72. doi: 10.1021/bc100174y.

PMID:
20684543
43.

Boron and other elements in sporophores of ectomycorrhizal and saprotrophic fungi.

Lavola A, Aphalo PJ, Lehto T.

Mycorrhiza. 2011 Apr;21(3):155-65. doi: 10.1007/s00572-010-0321-7. Epub 2010 Jun 5.

PMID:
20526634
44.

An appraisal of the electrical resistance method for assessing root surface area.

Cao Y, Repo T, Silvennoinen R, Lehto T, Pelkonen P.

J Exp Bot. 2010 May;61(9):2491-7. doi: 10.1093/jxb/erq078. Epub 2010 Apr 2.

45.

Chemically modified cell-penetrating peptides for the delivery of nucleic acids.

Mäe M, Andaloussi SE, Lehto T, Langel U.

Expert Opin Drug Deliv. 2009 Nov;6(11):1195-205. doi: 10.1517/17425240903213688. Review.

PMID:
19831582
46.

Delivery of nucleic acids with a stearylated (RxR)4 peptide using a non-covalent co-incubation strategy.

Lehto T, Abes R, Oskolkov N, Suhorutsenko J, Copolovici DM, Mäger I, Viola JR, Simonson OE, Ezzat K, Guterstam P, Eriste E, Smith CI, Lebleu B, Samir El Andaloussi, Langel U.

J Control Release. 2010 Jan 4;141(1):42-51. doi: 10.1016/j.jconrel.2009.08.028. Epub 2009 Sep 8.

PMID:
19744531
47.

Performance evaluation of Abbott CELL-DYN Ruby for routine use.

Lehto T, Hedberg P.

Int J Lab Hematol. 2008 Oct;30(5):400-7. doi: 10.1111/j.1751-553X.2007.00971.x.

PMID:
19046315
48.

Delayed soil thawing affects root and shoot functioning and growth in Scots pine.

Repo T, Lehto T, Finér L.

Tree Physiol. 2008 Oct;28(10):1583-91.

PMID:
18708340
49.

Freezing tolerance of ectomycorrhizal fungi in pure culture.

Lehto T, Brosinsky A, Heinonen-Tanski H, Repo T.

Mycorrhiza. 2008 Oct;18(8):385-392. doi: 10.1007/s00572-008-0190-5. Epub 2008 Aug 8.

PMID:
18688659
50.

HDL2 of heavy alcohol drinkers enhances cholesterol efflux from raw macrophages via phospholipid-rich HDL 2b particles.

Mäkelä SM, Jauhiainen M, Ala-Korpela M, Metso J, Lehto TM, Savolainen MJ, Hannuksela ML.

Alcohol Clin Exp Res. 2008 Jun;32(6):991-1000. doi: 10.1111/j.1530-0277.2008.00660.x.

PMID:
18498551

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