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Items: 1 to 50 of 351

1.

Gain-of-function CEBPE mutation causes non-canonical autoinflammatory inflammasomopathy.

Göös H, Fogarty CL, Sahu B, Plagnol V, Rajamäki K, Nurmi K, Liu X, Einarsdottir E, Jouppila A, Pettersson T, Vihinen H, Krjutskov K, Saavalainen P, Järvinen A, Muurinen M, Greco D, Scala G, Curtis J, Nordström D, Flaumenhaft R, Vaarala O, Kovanen PE, Keskitalo S, Ranki A, Kere J, Lehto M, Notarangelo LD, Nejentsev S, Eklund KK, Varjosalo M, Taipale J, Seppänen MR.

J Allergy Clin Immunol. 2019 Jun 12. pii: S0091-6749(19)30762-6. doi: 10.1016/j.jaci.2019.06.003. [Epub ahead of print]

2.

Continuous 4-week ECG monitoring with adhesive electrodes reveals AF in patients with recent embolic stroke of undetermined source.

Lumikari TJ, Putaala J, Kerola A, Sibolt G, Pirinen J, Pakarinen S, Lehto M, Nieminen T.

Ann Noninvasive Electrocardiol. 2019 May 2:e12649. doi: 10.1111/anec.12649. [Epub ahead of print]

PMID:
31045315
3.

Poor Quality of Warfarin Treatment Increases the Risk of All Types of Intracranial Hemorrhage in Atrial Fibrillation.

Tiili P, Putaala J, Mehtälä J, Khanfir H, Niiranen J, Korhonen P, Raatikainen P, Lehto M.

Circ J. 2019 Feb 25;83(3):540-547. doi: 10.1253/circj.CJ-18-0975. Epub 2019 Jan 25.

4.

Use of antihypertensive medication after ischemic stroke in young adults and its association with long-term outcome.

van Dongen MME, Aarnio K, Martinez-Majander N, Pirinen J, Sinisalo J, Lehto M, Kaste M, Tatlisumak T, de Leeuw FE, Putaala J.

Ann Med. 2019 Feb;51(1):68-77. doi: 10.1080/07853890.2018.1564358. Epub 2019 Feb 14.

PMID:
30592437
5.

The Gut-Kidney Axis: Putative Interconnections Between Gastrointestinal and Renal Disorders.

Lehto M, Groop PH.

Front Endocrinol (Lausanne). 2018 Sep 19;9:553. doi: 10.3389/fendo.2018.00553. eCollection 2018. Review.

6.

Soil exposure modifies the gut microbiota and supports immune tolerance in a mouse model.

Ottman N, Ruokolainen L, Suomalainen A, Sinkko H, Karisola P, Lehtimäki J, Lehto M, Hanski I, Alenius H, Fyhrquist N.

J Allergy Clin Immunol. 2019 Mar;143(3):1198-1206.e12. doi: 10.1016/j.jaci.2018.06.024. Epub 2018 Aug 7.

PMID:
30097187
7.

Differences in the risk of stroke, bleeding events, and mortality between female and male patients with atrial fibrillation during warfarin therapy.

Penttilä T, Lehto M, Niiranen J, Mehtälä J, Khanfir H, Lassila R, Raatikainen P.

Eur Heart J Cardiovasc Pharmacother. 2019 Jan 1;5(1):29-36. doi: 10.1093/ehjcvp/pvy026.

PMID:
30052822
8.

Association of circulating metabolites with healthy diet and risk of cardiovascular disease: analysis of two cohort studies.

Akbaraly T, Würtz P, Singh-Manoux A, Shipley MJ, Haapakoski R, Lehto M, Desrumaux C, Kähönen M, Lehtimäki T, Mikkilä V, Hingorani A, Humphries SE, Kangas AJ, Soininen P, Raitakari O, Ala-Korpela M, Kivimäki M.

Sci Rep. 2018 Jun 5;8(1):8620. doi: 10.1038/s41598-018-26441-1.

9.

Optimal timing for cardioversion in patients with atrial fibrillation.

Hellman T, Kiviniemi T, Nuotio I, Biancari F, Vasankari T, Hartikainen J, Lehto M, Airaksinen KE; FinCV Investigators.

Clin Cardiol. 2018 Jul;41(7):966-971. doi: 10.1002/clc.22986. Epub 2018 Jul 23.

10.

Nasal mucosa and blood cell transcriptome profiles do not reflect respiratory symptoms associated with moisture damage.

Ndika J, Suojalehto H, Täubel M, Lehto M, Karvala K, Pallasaho P, Sund J, Auvinen P, Järvi K, Pekkanen J, Kinaret P, Greco D, Hyvärinen A, Alenius H.

Indoor Air. 2018 May 4. doi: 10.1111/ina.12472. [Epub ahead of print]

PMID:
29729044
11.

The quality of warfarin therapy and CHA2DS2-VASc score associate with the incidence of myocardial infarction and cardiovascular outcome in patients with atrial fibrillation: data from the nationwide FinWAF Registry.

Raatikainen MJP, Penttilä T, Korhonen P, Mehtälä J, Lassila R, Lehto M.

Eur Heart J Cardiovasc Pharmacother. 2018 Oct 1;4(4):211-219. doi: 10.1093/ehjcvp/pvy009.

PMID:
29514184
12.

A novel glycocluster molecule prevents timothy-induced allergic airway inflammation in mice.

Lehto M, Wolff H, Leino R, Alenius H, Savolainen J.

Allergy. 2018 Aug;73(8):1700-1706. doi: 10.1111/all.13419. Epub 2018 Feb 13.

PMID:
29377154
13.

Noninvasive mapping reveals recurrent and suddenly changing patterns in atrial fibrillation-a magnetocardiographic study.

Mäntynen V, Lehto M, Parikka H, Montonen J.

Physiol Meas. 2018 Feb 26;39(2):025006. doi: 10.1088/1361-6579/aaa3bb.

PMID:
29271352
14.

Embolic strokes of undetermined source in young adults: baseline characteristics and long-term outcome.

Martinez-Majander N, Aarnio K, Pirinen J, Lumikari T, Nieminen T, Lehto M, Sinisalo J, Kaste M, Tatlisumak T, Putaala J.

Eur J Neurol. 2018 Mar;25(3):535-541. doi: 10.1111/ene.13540. Epub 2018 Jan 19.

PMID:
29218790
15.

Improving autocoding performance of rare categories in injury classification: Is more training data or filtering the solution?

Nanda G, Vallmuur K, Lehto M.

Accid Anal Prev. 2018 Jan;110:115-127. doi: 10.1016/j.aap.2017.10.020. Epub 2017 Nov 8.

PMID:
29127808
16.

Non-vitamin K antagonist oral anticoagulants in atrial fibrillation patients undergoing elective cardioversion.

Itäinen S, Lehto M, Vasankari T, Mustonen P, Kotamäki M, Numminen A, Lahtela H, Bah A, Hartikainen J, Hekkala AM, Airaksinen JKE.

Europace. 2018 Apr 1;20(4):565-568. doi: 10.1093/europace/eux116.

PMID:
29016758
17.

Antiarrhythmic drug therapy among patients presenting to emergency department with symptomatic atrial fibrillation - a prospective nationwide cohort.

Penttilä T, Mäkynen H, Hartikainen J, Hyppölä H, Lauri T, Lehto M, Lund J, Raatikainen MJP; FinFib2 investigators.

Scand J Trauma Resusc Emerg Med. 2017 Aug 15;25(1):81. doi: 10.1186/s13049-017-0424-7.

18.

Dietary patterns reflecting healthy food choices are associated with lower serum LPS activity.

Ahola AJ, Lassenius MI, Forsblom C, Harjutsalo V, Lehto M, Groop PH.

Sci Rep. 2017 Jul 26;7(1):6511. doi: 10.1038/s41598-017-06885-7.

19.

ECG markers associated with ischemic stroke at young age - a case-control study.

Pirinen J, Eranti A, Knekt P, Lehto M, Martinez-Majander N, Aro AL, Rissanen H, Heliövaara M, Kaste M, Tatlisumak T, Huikuri H, Putaala J.

Ann Med. 2017 Nov;49(7):562-568. doi: 10.1080/07853890.2017.1348620. Epub 2017 Jul 14.

PMID:
28657357
20.

Searching for Explanations for Cryptogenic Stroke in the Young: Revealing the Triggers, Causes, and Outcome (SECRETO): Rationale and design.

Putaala J, Martinez-Majander N, Saeed S, Yesilot N, Jäkälä P, Nerg O, Tsivgoulis G, Numminen H, Gordin D, von Sarnowski B, Waje-Andreassen U, Ylikotila P, Roine RO, Zedde M, Huhtakangas J, Fonseca C, Redfors P, de Leeuw FE, Pezzini A, Kõrv J, Schneider S, Tanislav C, Enzinger C, Jatuzis D, Siegerink B, Martínez-Sánchez P, Grau AJ, Palm F, Groop PH, Lanthier S, Ten Cate H, Pussinen P, Paju S, Sinisalo J, Lehto M, Lindgren A, Ferro J, Kittner S, Fazekas F, Gerdts E, Tatlisumak T.

Eur Stroke J. 2017 Jun;2(2):116-125. doi: 10.1177/2396987317703210. Epub 2017 Apr 4.

21.

Intestinal alkaline phosphatase at the crossroad of intestinal health and disease - a putative role in type 1 diabetes.

Lassenius MI, Fogarty CL, Blaut M, Haimila K, Riittinen L, Paju A, Kirveskari J, Järvelä J, Ahola AJ, Gordin D, Härma MA, Kumar A, Hamarneh SR, Hodin RA, Sorsa T, Tervahartiala T, Hörkkö S, Pussinen PJ, Forsblom C, Jauhiainen M, Taskinen MR, Groop PH, Lehto M; FinnDiane Study Group.

J Intern Med. 2017 Jun;281(6):586-600. doi: 10.1111/joim.12607. Epub 2017 Apr 10.

22.

Quality of warfarin therapy and risk of stroke, bleeding, and mortality among patients with atrial fibrillation: results from the nationwide FinWAF Registry.

Lehto M, Niiranen J, Korhonen P, Mehtälä J, Khanfir H, Hoti F, Lassila R, Raatikainen P.

Pharmacoepidemiol Drug Saf. 2017 Jun;26(6):657-665. doi: 10.1002/pds.4194. Epub 2017 Mar 19.

PMID:
28317274
23.

Twelve-lead electrocardiogram and mortality in young adults after ischaemic stroke.

Pirinen J, Putaala J, Aarnio K, Aro AL, Mustanoja S, Sinisalo J, Kaste M, Haapaniemi E, Tatlisumak T, Lehto M.

Eur Stroke J. 2017 Mar;2(1):77-86. doi: 10.1177/2396987316684706. Epub 2017 Mar 1.

24.

Septin 7 reduces nonmuscle myosin IIA activity in the SNAP23 complex and hinders GLUT4 storage vesicle docking and fusion.

Wasik AA, Dumont V, Tienari J, Nyman TA, Fogarty CL, Forsblom C, Lehto M, Lehtonen E, Groop PH, Lehtonen S.

Exp Cell Res. 2017 Jan 15;350(2):336-348. doi: 10.1016/j.yexcr.2016.12.010. Epub 2016 Dec 20.

25.

Endotoxins are associated with visceral fat mass in type 1 diabetes.

Lassenius MI, Ahola AJ, Harjutsalo V, Forsblom C, Groop PH, Lehto M.

Sci Rep. 2016 Dec 13;6:38887. doi: 10.1038/srep38887.

26.

Combined immunodeficiency and hypoglycemia associated with mutations in hypoxia upregulated 1.

Haapaniemi EM, Fogarty CL, Keskitalo S, Katayama S, Vihinen H, Ilander M, Mustjoki S, Krjutškov K, Lehto M, Hautala T, Eriksson O, Jokitalo E, Velagapudi V, Varjosalo M, Seppänen M, Kere J.

J Allergy Clin Immunol. 2017 Apr;139(4):1391-1393.e11. doi: 10.1016/j.jaci.2016.09.050. Epub 2016 Nov 29. No abstract available.

27.

Classifying injury narratives of large administrative databases for surveillance-A practical approach combining machine learning ensembles and human review.

Marucci-Wellman HR, Corns HL, Lehto MR.

Accid Anal Prev. 2017 Jan;98:359-371. doi: 10.1016/j.aap.2016.10.014. Epub 2016 Nov 15.

28.

Are 12-lead ECG findings associated with the risk of cardiovascular events after ischemic stroke in young adults?

Pirinen J, Putaala J, Aarnio K, Aro AL, Sinisalo J, Kaste M, Haapaniemi E, Tatlisumak T, Lehto M.

Ann Med. 2016 Nov;48(7):532-540. Epub 2016 Sep 29.

PMID:
27684300
29.

Biochemical pathways of breath ammonia (NH3) generation in patients with end-stage renal disease undergoing hemodialysis.

Chen W, Laiho S, Vaittinen O, Halonen L, Ortiz F, Forsblom C, Groop PH, Lehto M, Metsälä M.

J Breath Res. 2016 Aug 12;10(3):036011. doi: 10.1088/1752-7155/10/3/036011.

PMID:
27516572
30.

Local TNF causes NFATc1-dependent cholesterol-mediated podocyte injury.

Pedigo CE, Ducasa GM, Leclercq F, Sloan A, Mitrofanova A, Hashmi T, Molina-David J, Ge M, Lassenius MI, Forsblom C, Lehto M, Groop PH, Kretzler M, Eddy S, Martini S, Reich H, Wahl P, Ghiggeri G, Faul C, Burke GW 3rd, Kretz O, Huber TB, Mendez AJ, Merscher S, Fornoni A.

J Clin Invest. 2016 Sep 1;126(9):3336-50. doi: 10.1172/JCI85939. Epub 2016 Aug 2.

31.

Acute-Phase Blood Pressure Levels Correlate With a High Risk of Recurrent Strokes in Young-Onset Ischemic Stroke.

Mustanoja S, Putaala J, Gordin D, Tulkki L, Aarnio K, Pirinen J, Surakka I, Sinisalo J, Lehto M, Tatlisumak T.

Stroke. 2016 Jun;47(6):1593-8. doi: 10.1161/STROKEAHA.116.012944. Epub 2016 May 5.

PMID:
27217509
32.

Bayesian decision support for coding occupational injury data.

Nanda G, Grattan KM, Chu MT, Davis LK, Lehto MR.

J Safety Res. 2016 Jun;57:71-82. doi: 10.1016/j.jsr.2016.03.001. Epub 2016 Mar 15.

PMID:
27178082
33.

Cardiovascular events after ischemic stroke in young adults: A prospective follow-up study.

Aarnio K, Siegerink B, Pirinen J, Sinisalo J, Lehto M, Haapaniemi E, Nave AH, Kaste M, Tatlisumak T, Putaala J.

Neurology. 2016 May 17;86(20):1872-9. doi: 10.1212/WNL.0000000000002689. Epub 2016 Apr 20.

PMID:
27164672
35.

Anticoagulation therapy among patients presenting to the emergency department with symptomatic atrial fibrillation - the FinFib2 study.

Penttilä T, Mäkynen H, Hartikainen J, Lauri T, Lehto M, Lund J, Mäkijärvi M, Raatikainen P.

Eur J Emerg Med. 2017 Oct;24(5):347-352. doi: 10.1097/MEJ.0000000000000402.

PMID:
27097066
36.

Detection of hydrogen cyanide from oral anaerobes by cavity ring down spectroscopy.

Chen W, Roslund K, Fogarty CL, Pussinen PJ, Halonen L, Groop PH, Metsälä M, Lehto M.

Sci Rep. 2016 Mar 4;6:22577. doi: 10.1038/srep22577.

37.

Cyclin-dependent kinase 2 protects podocytes from apoptosis.

Saurus P, Kuusela S, Dumont V, Lehtonen E, Fogarty CL, Lassenius MI, Forsblom C, Lehto M, Saleem MA, Groop PH, Lehtonen S.

Sci Rep. 2016 Feb 15;6:21664. doi: 10.1038/srep21664.

38.

Harnessing information from injury narratives in the 'big data' era: understanding and applying machine learning for injury surveillance.

Vallmuur K, Marucci-Wellman HR, Taylor JA, Lehto M, Corns HL, Smith GS.

Inj Prev. 2016 Apr;22 Suppl 1:i34-42. doi: 10.1136/injuryprev-2015-041813. Epub 2016 Jan 4.

39.

Quality of prior warfarin therapy in ischemic stroke patients with a pre-stroke diagnosis of atrial fibrillation.

Tiili P, Lehto M, Meretoja A, Nieminen T, Pakarinen S, Tatlisumak T, Putaala J.

Duodecim. 2016;132(15):1366-74.

PMID:
29160645
40.

A practical tool for public health surveillance: Semi-automated coding of short injury narratives from large administrative databases using Naïve Bayes algorithms.

Marucci-Wellman HR, Lehto MR, Corns HL.

Accid Anal Prev. 2015 Nov;84:165-76. doi: 10.1016/j.aap.2015.06.014. Epub 2015 Sep 26.

41.

A novel mannoside-glycocluster adjuvant: Compared in vitro to CpG ODN and MPL and tested in vivo in mouse asthma model.

Mäkinen K, Mukherjee C, Leino M, Panchadhayee R, Lehto M, Wolff H, Alenius H, Leino R, Savolainen J.

Allergol Immunopathol (Madr). 2016 Jan-Feb;44(1):9-17. doi: 10.1016/j.aller.2015.04.008. Epub 2015 Sep 26.

PMID:
26395525
42.

Undetermined stroke with an embolic pattern--a common phenotype with high early recurrence risk.

Putaala J, Nieminen T, Haapaniemi E, Meretoja A, Rantanen K, Heikkinen N, Kinnunen J, Strbian D, Mustanoja S, Curtze S, Pakarinen S, Lehto M, Tatlisumak T.

Ann Med. 2015;47(5):406-13. doi: 10.3109/07853890.2015.1057612. Epub 2015 Aug 4.

PMID:
26224200
43.

Negligible respiratory irritation and inflammation potency of pigmentary TiO2 in mice.

Leppänen M, Korpi A, Yli-Pirilä P, Lehto M, Wolff H, Kosma VM, Alenius H, Pasanen P.

Inhal Toxicol. 2015;27(8):378-86. doi: 10.3109/08958378.2015.1056890. Epub 2015 Jul 15.

PMID:
26176585
44.

Resting 12-lead electrocardiogram reveals high-risk sources of cardioembolism in young adult ischemic stroke.

Pirinen J, Putaala J, Aro AL, Surakka I, Haapaniemi A, Kaste M, Haapaniemi E, Tatlisumak T, Lehto M.

Int J Cardiol. 2015 Nov 1;198:196-200. doi: 10.1016/j.ijcard.2015.06.095. Epub 2015 Jun 29.

PMID:
26163917
45.

Lymphopenia-induced proliferation in the absence of functional Autoimmune regulator (Aire) induces colitis in mice.

Kekäläinen E, Lehto MK, Smeds E, Pöntynen N, Pekkarinen PT, Ulmanen I, Miettinen A, Arstila TP.

Immunol Lett. 2015 Sep;167(1):17-22. doi: 10.1016/j.imlet.2015.06.010. Epub 2015 Jun 22.

PMID:
26112418
46.

Invariant Natural Killer T Cells Play a Role in Chemotaxis, Complement Activation and Mucus Production in a Mouse Model of Airway Hyperreactivity and Inflammation.

Karisola P, Lehto M, Kinaret P, Ahonen N, Haapakoski R, Anthoni M, Taniguchi M, Wolff H, Puustinen A, Alenius H.

PLoS One. 2015 Jun 12;10(6):e0129446. doi: 10.1371/journal.pone.0129446. eCollection 2015.

47.

A Single Aspiration of Rod-like Carbon Nanotubes Induces Asbestos-like Pulmonary Inflammation Mediated in Part by the IL-1 Receptor.

Rydman EM, Ilves M, Vanhala E, Vippola M, Lehto M, Kinaret PA, Pylkkänen L, Happo M, Hirvonen MR, Greco D, Savolainen K, Wolff H, Alenius H.

Toxicol Sci. 2015 Sep;147(1):140-55. doi: 10.1093/toxsci/kfv112. Epub 2015 Jun 5.

PMID:
26048651
48.

Podocyte apoptosis is prevented by blocking the Toll-like receptor pathway.

Saurus P, Kuusela S, Lehtonen E, Hyvönen ME, Ristola M, Fogarty CL, Tienari J, Lassenius MI, Forsblom C, Lehto M, Saleem MA, Groop PH, Holthöfer H, Lehtonen S.

Cell Death Dis. 2015 May 7;6:e1752. doi: 10.1038/cddis.2015.125.

49.

Surgical outcomes of hip and knee arthroplasties for primary osteoarthritis in patients with Alzheimer's disease: a nationwide registry-based case-controlled study.

Jämsen E, Peltola M, Puolakka T, Eskelinen A, Lehto MU.

Bone Joint J. 2015 May;97-B(5):654-61. doi: 10.1302/0301-620X.97B5.34382.

PMID:
25922460
50.

Bacterial infections in patients with type 1 diabetes: a 14-year follow-up study.

Simonsen JR, Harjutsalo V, Järvinen A, Kirveskari J, Forsblom C, Groop PH, Lehto M; FinnDiane Study Group.

BMJ Open Diabetes Res Care. 2015 Mar 5;3(1):e000067. doi: 10.1136/bmjdrc-2014-000067. eCollection 2015.

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