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Bifidobacterium animalis subsp. lactis 420 for Metabolic Health: Review of the Research.

Uusitupa HM, Rasinkangas P, Lehtinen MJ, Mäkelä SM, Airaksinen K, Anglenius H, Ouwehand AC, Maukonen J.

Nutrients. 2020 Mar 25;12(4). pii: E892. doi: 10.3390/nu12040892. Review.


Age-specific vaccination coverage estimates for influenza, human papillomavirus and measles containing vaccines from seven population-based healthcare databases from four EU countries - The ADVANCE project.

Braeye T, Emborg HD, Llorente-García A, Huerta C, Martín-Merino E, Duarte-Salles T, Danieli G, Tramontan L, Weibel D, McGee C, Villa M, Gini R, Lehtinen M, Titievsky L, Sturkenboom M.

Vaccine. 2020 Mar 11. pii: S0264-410X(20)30326-1. doi: 10.1016/j.vaccine.2020.02.082. [Epub ahead of print]


Vaccination with moderate coverage eradicates oncogenic human papillomaviruses if a gender-neutral strategy is applied.

Vänskä S, Luostarinen T, Bausssano I, Apter D, Eriksson T, Natunen K, Nieminen P, Paavonen J, Pimenoff VN, Pukkala E, Söderlund-Strand A, Dubin G, Garnett G, Dillner J, Lehtinen M.

J Infect Dis. 2020 Mar 11. pii: jiaa099. doi: 10.1093/infdis/jiaa099. [Epub ahead of print]


Peak neutralizing and cross-neutralizing antibody levels to human papillomavirus types 6/16/18/31/33/45/52/58 induced by bivalent and quadrivalent HPV vaccines.

Mariz FC, Bender N, Anantharaman D, Basu P, Bhatla N, Pillai MR, Prabhu PR, Sankaranarayanan R, Eriksson T, Pawlita M, Prager K, Sehr P, Waterboer T, Müller M, Lehtinen M.

NPJ Vaccines. 2020 Feb 14;5:14. doi: 10.1038/s41541-020-0165-x. eCollection 2020.


Emergence and Developmental Roles of the Cerebrospinal Fluid System.

Fame RM, Lehtinen MK.

Dev Cell. 2020 Feb 10;52(3):261-275. doi: 10.1016/j.devcel.2020.01.027. Review.


Human papillomavirus genotype replacement: still too early to tell?

Man I, Vänskä S, Lehtinen M, Bogaards JA.

J Infect Dis. 2020 Jan 27. pii: jiaa032. doi: 10.1093/infdis/jiaa032. [Epub ahead of print]


T-bet+ Memory B Cells Link to Local Cross-Reactive IgG upon Human Rhinovirus Infection.

Eccles JD, Turner RB, Kirk NA, Muehling LM, Borish L, Steinke JW, Payne SC, Wright PW, Thacker D, Lahtinen SJ, Lehtinen MJ, Heymann PW, Woodfolk JA.

Cell Rep. 2020 Jan 14;30(2):351-366.e7. doi: 10.1016/j.celrep.2019.12.027.


Safety of the AS04-adjuvanted human papillomavirus (HPV)-16/18 vaccine in adolescents aged 12-15 years: end-of-study results from a community-randomized study up to 6.5 years.

Bi D, Apter D, Eriksson T, Hokkanen M, Zima J, Damaso S, Soila M, Dubin G, Lehtinen M, Struyf F.

Hum Vaccin Immunother. 2019 Dec 12:1-12. doi: 10.1080/21645515.2019.1692557. [Epub ahead of print]


The Prevalence of HSV, HHV-6, HPV and Mycoplasma genitalium in Chlamydia trachomatis positive and Chlamydia trachomatis Negative Urogenital Samples among Young Women in Finland.

Korhonen S, Hokynar K, Eriksson T, Natunen K, Paavonen J, Lehtinen M, Puolakkainen M.

Pathogens. 2019 Dec 1;8(4). pii: E276. doi: 10.3390/pathogens8040276.


Strain specific stress-modulating effects of candidate probiotics: A systematic screening in a mouse model of chronic restraint stress.

Stenman LK, Patterson E, Meunier J, Roman FJ, Lehtinen MJ.

Behav Brain Res. 2020 Feb 3;379:112376. doi: 10.1016/j.bbr.2019.112376. Epub 2019 Nov 22.


Baseline findings and safety of infrequent vs. frequent screening of human papillomavirus vaccinated women.

Louvanto K, Eriksson T, Gray P, Apter D, Baussano I, Bly A, Harjula K, Heikkilä K, Hokkanen M, Huhtinen L, Ikonen M, Karttunen H, Nummela M, Söderlund-Strand A, Veivo U, Dillner J, Elfstöm M, Nieminen P, Lehtinen M.

Int J Cancer. 2019 Nov 20. doi: 10.1002/ijc.32802. [Epub ahead of print]


Effectiveness of the AS04-adjuvanted HPV-16/18 vaccine in reducing oropharyngeal HPV infections in young females-Results from a community-randomized trial.

Lehtinen M, Apter D, Eriksson T, Harjula K, Hokkanen M, Lehtinen T, Natunen K, Damaso S, Soila M, Bi D, Struyf F.

Int J Cancer. 2019 Nov 17. doi: 10.1002/ijc.32791. [Epub ahead of print]


A concerted metabolic shift in early forebrain alters the CSF proteome and depends on MYC downregulation for mitochondrial maturation.

Fame RM, Shannon ML, Chau KF, Head JP, Lehtinen MK.

Development. 2019 Oct 24;146(20). pii: dev182857. doi: 10.1242/dev.182857.


Spatiotemporal Gradient of Cortical Neuron Death Contributes to Microcephaly in Knock-In Mouse Model of Ligase 4 Syndrome.

Lun MP, Shannon ML, Keles S, Reisli I, Luche N, Ryan D, Capuder K, Notarangelo LD, Lehtinen MK.

Am J Pathol. 2019 Dec;189(12):2440-2449. doi: 10.1016/j.ajpath.2019.08.010. Epub 2019 Sep 18.


Effect of Phytase on in Vitro Hydrolysis of Phytate and the Formation of myo-Inositol Phosphate Esters in Various Feed Materials.

Hirvonen J, Liljavirta J, Saarinen MT, Lehtinen MJ, Ahonen I, Nurminen P.

J Agric Food Chem. 2019 Oct 16;67(41):11396-11402. doi: 10.1021/acs.jafc.9b03919. Epub 2019 Oct 3.


Is the risk of cervical atypia associated with the interval between menarche and the start of sexual activity? A population-based cohort study.

Adhikari I, Eriksson T, Luostarinen T, Apter D, Lehtinen M.

BMJ Open. 2019 Sep 11;9(9):e030091. doi: 10.1136/bmjopen-2019-030091.


Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models.

Orefice LL, Mosko JR, Morency DT, Wells MF, Tasnim A, Mozeika SM, Ye M, Chirila AM, Emanuel AJ, Rankin G, Fame RM, Lehtinen MK, Feng G, Ginty DD.

Cell. 2019 Aug 8;178(4):867-886.e24. doi: 10.1016/j.cell.2019.07.024.


Xylitol's Health Benefits beyond Dental Health: A Comprehensive Review.

Salli K, Lehtinen MJ, Tiihonen K, Ouwehand AC.

Nutrients. 2019 Aug 6;11(8). pii: E1813. doi: 10.3390/nu11081813. Review.


Age-specific HPV type distribution in high-grade cervical disease in screened and unvaccinated women.

Aro K, Nieminen P, Louvanto K, Jakobsson M, Virtanen S, Lehtinen M, Dillner J, Kalliala I.

Gynecol Oncol. 2019 Aug;154(2):354-359. doi: 10.1016/j.ygyno.2019.05.024. Epub 2019 Jun 5.


Sister, Sister: Ependymal Cells and Adult Neural Stem Cells Are Separated at Birth by Geminin Family Members.

Fame RM, Lehtinen MK.

Neuron. 2019 Apr 17;102(2):278-279. doi: 10.1016/j.neuron.2019.02.040.


Short-term probiotic supplementation enhances cellular immune function in healthy elderly: systematic review and meta-analysis of controlled studies.

Miller LE, Lehtoranta L, Lehtinen MJ.

Nutr Res. 2019 Apr;64:1-8. doi: 10.1016/j.nutres.2018.12.011. Epub 2018 Dec 28. Review.


Complete Atrioventricular Septal Defect: Evolution of Results in a Single Center During 50 Years.

Airaksinen R, Mattila I, Jokinen E, Salminen J, Puntila J, Lehtinen ML, Ojala T, Rautiainen P, Rahkonen O, Suominen P, Pätilä T.

Ann Thorac Surg. 2019 Jun;107(6):1824-1830. doi: 10.1016/j.athoracsur.2019.01.020. Epub 2019 Feb 13.


Premedication with intranasal dexmedetomidine decreases barbiturate requirement in pediatric patients sedated for magnetic resonance imaging: a retrospective study.

Uusalo P, Lehtinen M, Löyttyniemi E, Manner T, Scheinin M, Saari TI.

BMC Anesthesiol. 2019 Feb 13;19(1):22. doi: 10.1186/s12871-019-0690-1.


Occurrence of human papillomavirus (HPV) type replacement by sexual risk-taking behaviour group: Post-hoc analysis of a community randomized clinical trial up to 9 years after vaccination (IV).

Gray P, Luostarinen T, Vänskä S, Eriksson T, Lagheden C, Man I, Palmroth J, Pimenoff VN, Söderlund-Strand A, Dillner J, Lehtinen M.

Int J Cancer. 2019 Aug 1;145(3):785-796. doi: 10.1002/ijc.32189. Epub 2019 Feb 28.


Fast approximate computation of cervical cancer screening outcomes by a deterministic multiple-type HPV progression model.

Vänskä S, Bogaards JA, Auranen K, Lehtinen M, Berkhof J.

Math Biosci. 2019 Mar;309:92-106. doi: 10.1016/j.mbs.2019.01.006. Epub 2019 Jan 16.


Eradication of human papillomavirus and elimination of HPV-related diseases - scientific basis for global public health policies.

Lehtinen M, Baussano I, Paavonen J, Vänskä S, Dillner J.

Expert Rev Vaccines. 2019 Feb;18(2):153-160. doi: 10.1080/14760584.2019.1568876. Epub 2019 Feb 7. Review.


Superselective endovascular tissue access using trans-vessel wall technique: feasibility study for treatment applications in heart, pancreas and kidney in swine.

Grankvist R, Jensen-Urstad M, Clarke J, Lehtinen M, Little P, Lundberg J, Arnberg F, Jonsson S, Chien KR, Holmin S.

J Intern Med. 2019 Apr;285(4):398-406. doi: 10.1111/joim.12841. Epub 2018 Oct 28.


Long-term Antibody Response to Human Papillomavirus Vaccines: Up to 12 Years of Follow-up in the Finnish Maternity Cohort.

Artemchuk H, Eriksson T, Poljak M, Surcel HM, Dillner J, Lehtinen M, Faust H.

J Infect Dis. 2019 Jan 29;219(4):582-589. doi: 10.1093/infdis/jiy545.


Sodium Channel SCN3A (NaV1.3) Regulation of Human Cerebral Cortical Folding and Oral Motor Development.

Smith RS, Kenny CJ, Ganesh V, Jang A, Borges-Monroy R, Partlow JN, Hill RS, Shin T, Chen AY, Doan RN, Anttonen AK, Ignatius J, Medne L, Bönnemann CG, Hecht JL, Salonen O, Barkovich AJ, Poduri A, Wilke M, de Wit MCY, Mancini GMS, Sztriha L, Im K, Amrom D, Andermann E, Paetau R, Lehesjoki AE, Walsh CA, Lehtinen MK.

Neuron. 2018 Sep 5;99(5):905-913.e7. doi: 10.1016/j.neuron.2018.07.052. Epub 2018 Aug 23.


Which human papillomavirus vaccine and vaccination strategy for national programs?

Lehtinen M.

Acta Obstet Gynecol Scand. 2018 Sep;97(9):1049-1050. doi: 10.1111/aogs.13424. No abstract available.


Nasal microbiota clusters associate with inflammatory response, viral load, and symptom severity in experimental rhinovirus challenge.

Lehtinen MJ, Hibberd AA, Männikkö S, Yeung N, Kauko T, Forssten S, Lehtoranta L, Lahtinen SJ, Stahl B, Lyra A, Turner RB.

Sci Rep. 2018 Jul 30;8(1):11411. doi: 10.1038/s41598-018-29793-w.


The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles.

Coulter ME, Dorobantu CM, Lodewijk GA, Delalande F, Cianferani S, Ganesh VS, Smith RS, Lim ET, Xu CS, Pang S, Wong ET, Lidov HGW, Calicchio ML, Yang E, Gonzalez DM, Schlaeger TM, Mochida GH, Hess H, Lee WA, Lehtinen MK, Kirchhausen T, Haussler D, Jacobs FMJ, Gaudin R, Walsh CA.

Cell Rep. 2018 Jul 24;24(4):973-986.e8. doi: 10.1016/j.celrep.2018.06.100.


Gender-neutral vaccination provides improved control of human papillomavirus types 18/31/33/35 through herd immunity: Results of a community randomized trial (III).

Lehtinen M, Luostarinen T, Vänskä S, Söderlund-Strand A, Eriksson T, Natunen K, Apter D, Baussano I, Harjula K, Hokkanen M, Kuortti M, Palmroth J, Petäjä T, Pukkala E, Rekonen S, Siitari-Mattila M, Surcel HM, Tuomivaara L, Paavonen J, Nieminen P, Dillner J, Dubin G, Garnett G.

Int J Cancer. 2018 Nov 1;143(9):2299-2310. doi: 10.1002/ijc.31618. Epub 2018 Aug 10.


Downregulation of ribosome biogenesis during early forebrain development.

Chau KF, Shannon ML, Fame RM, Fonseca E, Mullan H, Johnson MB, Sendamarai AK, Springel MW, Laurent B, Lehtinen MK.

Elife. 2018 May 10;7. pii: e36998. doi: 10.7554/eLife.36998.


Estimating effectiveness of HPV vaccination against HPV infection from post-vaccination data in the absence of baseline data.

Vänskä S, Söderlund-Strand A, Uhnoo I, Lehtinen M, Dillner J.

Vaccine. 2018 May 31;36(23):3239-3246. doi: 10.1016/j.vaccine.2018.04.073. Epub 2018 Apr 30.


Potential occupational exposures in diagnostic and interventional radiology: statistical modeling based on Finnish national dose registry data.

Pekkarinen A, Siiskonen T, Lehtinen M, Savolainen S, Kortesniemi M.

Acta Radiol. 2019 Jan;60(1):68-77. doi: 10.1177/0284185118770902. Epub 2018 Apr 17.


Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction.

Foo KS, Lehtinen ML, Leung CY, Lian X, Xu J, Keung W, Geng L, Kolstad TRS, Thams S, Wong AO, Wong N, Bylund K, Zhou C, He X, Jin SB, Clarke J, Lendahl U, Li RA, Louch WE, Chien KR.

Mol Ther. 2018 Jul 5;26(7):1644-1659. doi: 10.1016/j.ymthe.2018.02.012. Epub 2018 Feb 17.


Mice Expressing Myc in Neural Precursors Develop Choroid Plexus and Ciliary Body Tumors.

Shannon ML, Fame RM, Chau KF, Dani N, Calicchio ML, Géléoc GS, Lidov HGW, Alexandrescu S, Lehtinen MK.

Am J Pathol. 2018 Jun;188(6):1334-1344. doi: 10.1016/j.ajpath.2018.02.009. Epub 2018 Mar 13.


The risk of cervical atypia in oral contraceptive users.

Adhikari I, Eriksson T, Luostarinen T, Lehtinen M, Apter D.

Eur J Contracept Reprod Health Care. 2018 Feb;23(1):12-17. doi: 10.1080/13625187.2018.1431214. Epub 2018 Feb 7.


Evaluation of HPV type-replacement in unvaccinated and vaccinated adolescent females-Post-hoc analysis of a community-randomized clinical trial (II).

Gray P, Palmroth J, Luostarinen T, Apter D, Dubin G, Garnett G, Eriksson T, Natunen K, Merikukka M, Pimenoff V, Söderlund-Strand A, Vänskä S, Paavonen J, Pukkala E, Dillner J, Lehtinen M.

Int J Cancer. 2018 Jun 15;142(12):2491-2500. doi: 10.1002/ijc.31281. Epub 2018 Feb 12.


Single-Cell Tracking Reveals a Role for Pre-Existing CCR5+ Memory Th1 Cells in the Control of Rhinovirus-A39 After Experimental Challenge in Humans.

Muehling LM, Turner RB, Brown KB, Wright PW, Patrie JT, Lahtinen SJ, Lehtinen MJ, Kwok WW, Woodfolk JA.

J Infect Dis. 2018 Jan 17;217(3):381-392. doi: 10.1093/infdis/jix514.


Vaccination protects against invasive HPV-associated cancers.

Luostarinen T, Apter D, Dillner J, Eriksson T, Harjula K, Natunen K, Paavonen J, Pukkala E, Lehtinen M.

Int J Cancer. 2018 May 15;142(10):2186-2187. doi: 10.1002/ijc.31231. Epub 2018 Jan 4. No abstract available.


Epicardial delivery of autologous atrial appendage micrografts during coronary artery bypass surgery-safety and feasibility study.

Nummi A, Nieminen T, Pätilä T, Lampinen M, Lehtinen ML, Kivistö S, Holmström M, Wilkman E, Teittinen K, Laine M, Sinisalo J, Kupari M, Kankuri E, Juvonen T, Vento A, Suojaranta R, Harjula A; AADC consortium.

Pilot Feasibility Stud. 2017 Dec 20;3:74. doi: 10.1186/s40814-017-0217-9. eCollection 2017.


The effect of an apple polyphenol extract rich in epicatechin and flavan-3-ol oligomers on brachial artery flow-mediated vasodilatory function in volunteers with elevated blood pressure.

Saarenhovi M, Salo P, Scheinin M, Lehto J, Lovró Z, Tiihonen K, Lehtinen MJ, Junnila J, Hasselwander O, Tarpila A, Raitakari OT.

Nutr J. 2017 Oct 27;16(1):73. doi: 10.1186/s12937-017-0291-0.


Cancer Registry follow-up for 17 million person-years of a nationwide maternity cohort.

Lehtinen M, Surcel HM, Natunen K, Pukkala E, Dillner J.

Cancer Med. 2017 Dec;6(12):3060-3064. doi: 10.1002/cam4.1222. Epub 2017 Oct 25.


Impact of gender-neutral or girls-only vaccination against human papillomavirus-Results of a community-randomized clinical trial (I).

Lehtinen M, Söderlund-Strand A, Vänskä S, Luostarinen T, Eriksson T, Natunen K, Apter D, Baussano I, Harjula K, Hokkanen M, Kuortti M, Palmroth J, Petäjä T, Pukkala E, Rekonen S, Siitari-Mattila M, Surcel HM, Tuomivaara L, Paavonen J, Dillner J, Dubin G, Garnett G.

Int J Cancer. 2018 Mar 1;142(5):949-958. doi: 10.1002/ijc.31119. Epub 2017 Nov 9.


Human Papillomavirus (HPV) Prevalence in Male Adolescents 4 Years After HPV-16/18 Vaccination.

Lehtinen T, Söderlund-Strand A, Petäjä T, Eriksson T, Jokiranta S, Natunen K, Dillner J, Lehtinen M.

J Infect Dis. 2017 Nov 15;216(8):966-968. doi: 10.1093/infdis/jix415.


Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition.

Calder PC, Bosco N, Bourdet-Sicard R, Capuron L, Delzenne N, Doré J, Franceschi C, Lehtinen MJ, Recker T, Salvioli S, Visioli F.

Ageing Res Rev. 2017 Nov;40:95-119. doi: 10.1016/j.arr.2017.09.001. Epub 2017 Sep 9. Review.


Different Challenges in Eliminating HPV16 Compared to Other Types: A Modeling Study.

Baussano I, Lazzarato F, Ronco G, Lehtinen M, Dillner J, Franceschi S.

J Infect Dis. 2017 Aug 1;216(3):336-344. doi: 10.1093/infdis/jix299.


Universal Janus Filters for the Rapid Separation of Oil from Emulsions Stabilized by Ionic or Nonionic Surfactants.

Wang Z, Lehtinen M, Liu G.

Angew Chem Int Ed Engl. 2017 Oct 9;56(42):12892-12897. doi: 10.1002/anie.201706158. Epub 2017 Sep 7.


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