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Repeatability and variation of the flow independent nitric oxide parameters.

Karvonen T, Lehtimäki L.

J Breath Res. 2019 Sep 24. doi: 10.1088/1752-7163/ab4784. [Epub ahead of print]


Understanding Dry Powder Inhalers: Key Technical and Patient Preference Attributes.

Levy ML, Carroll W, Izquierdo Alonso JL, Keller C, Lavorini F, Lehtimäki L.

Adv Ther. 2019 Oct;36(10):2547-2557. doi: 10.1007/s12325-019-01066-6. Epub 2019 Sep 2.


Association of air humidity with incidence of exercise-induced bronchoconstriction in children.

Tikkakoski AP, Tikkakoski A, Kivistö JE, Huhtala H, Sipilä K, Karjalainen J, Kähönen M, Lehtimäki L.

Pediatr Pulmonol. 2019 Nov;54(11):1830-1836. doi: 10.1002/ppul.24471. Epub 2019 Aug 8.


In vitro drug delivery performance of five valved holding chambers with and without facemasks.

Csonka P, Lehtimäki L.

Pediatr Pulmonol. 2019 Sep;54(9):1457-1465. doi: 10.1002/ppul.24425. Epub 2019 Jun 29.


Observational cross-sectional study on Symptoms Associated to Moisture DAmage at Workplace: the SAMDAW study protocol.

Nynäs P, Vilpas S, Kankare E, Karjalainen J, Lehtimäki L, Numminen J, Tikkakoski A, Kleemola L, Uitti J.

BMJ Open. 2019 Jun 25;9(6):e026485. doi: 10.1136/bmjopen-2018-026485.


Flow-independent nitric oxide parameters in asthma: a systematic review and meta-analysis.

Karvonen T, Lehtimäki L.

J Breath Res. 2019 Jul 18;13(4):044001. doi: 10.1088/1752-7163/ab2c99.


Age- and gender-specific incidence of new asthma diagnosis from childhood to late adulthood.

Honkamäki J, Hisinger-Mölkänen H, Ilmarinen P, Piirilä P, Tuomisto LE, Andersén H, Huhtala H, Sovijärvi A, Backman H, Lundbäck B, Rönmark E, Lehtimäki L, Kankaanranta H.

Respir Med. 2019 Jul - Aug;154:56-62. doi: 10.1016/j.rmed.2019.06.003. Epub 2019 Jun 8.


Converting FENO by different flows to standard flow FENO.

Lassmann-Klee PG, Lehtimäki L, Lindholm T, Malmberg LP, Sovijärvi ARA, Piirilä PL.

Clin Physiol Funct Imaging. 2019 Sep;39(5):315-321. doi: 10.1111/cpf.12574. Epub 2019 Jun 3.


Cumulative effect of smoking on disease burden and multimorbidity in adult-onset asthma.

Tommola M, Ilmarinen P, Tuomisto LE, Lehtimäki L, Niemelä O, Nieminen P, Kankaanranta H.

Eur Respir J. 2019 Sep 5;54(3). pii: 1801580. doi: 10.1183/13993003.01580-2018. Print 2019 Sep. No abstract available.


Predictors of Impaired Survival in Subjects With Long-Term Oxygen Therapy.

Rantala HA, Leivo-Korpela S, Lehtimäki L, Lehto JT.

Respir Care. 2019 Mar 26. pii: respcare.06615. doi: 10.4187/respcare.06615. [Epub ahead of print]


Basic characteristics and clinical value of FeNO in smoking asthmatics-a systematic review.

Ahovuo-Saloranta A, Csonka P, Lehtimäki L.

J Breath Res. 2019 May 3;13(3):034003. doi: 10.1088/1752-7163/ab0ece.


Valved holding chamber drug delivery is dependent on breathing pattern and device design.

Csonka P, Lehtimäki L.

ERJ Open Res. 2019 Feb 4;5(1). pii: 00158-2018. doi: 10.1183/23120541.00158-2018. eCollection 2019 Feb.


Asthma diagnosed in late adulthood is linked to work disability and poor employment status.

Taponen S, Uitti J, Karvala K, Luukkonen R, Lehtimäki L.

Respir Med. 2019 Feb;147:76-78. doi: 10.1016/j.rmed.2019.01.004. Epub 2019 Jan 17.


Transient Receptor Potential Ankyrin 1 Enhances Ovalbumin-Induced Acute Allergic Inflammation in Murine Models.

Moilanen LJ, Hämäläinen M, Ilmarinen P, Kankaanranta H, Nieminen RM, Moilanen E, Lehtimäki L.

Int Arch Allergy Immunol. 2019;178(3):238-247. doi: 10.1159/000494932. Epub 2019 Jan 30.


Immediate bronchodilator response in FEV1 as a diagnostic criterion for adult asthma.

Tuomisto LE, Ilmarinen P, Lehtimäki L, Tommola M, Kankaanranta H.

Eur Respir J. 2019 Feb 14;53(2). pii: 1800904. doi: 10.1183/13993003.00904-2018. Print 2019 Feb. Review.


Daily physical activity and lung function decline in adult-onset asthma: a 12-year follow-up study.

Loponen J, Ilmarinen P, Tuomisto LE, Niemelä O, Tommola M, Nieminen P, Lehtimäki L, Kankaanranta H.

Eur Clin Respir J. 2018 Oct 24;5(1):1533753. doi: 10.1080/20018525.2018.1533753. eCollection 2018.


Influence of mouthwashes on extended exhaled nitric oxide (FENO) analysis.

Lassmann-Klee PG, Lehtimäki L, Lindholm T, Malmberg LP, Sovijärvi ARA, Piirilä P.

Scand J Clin Lab Invest. 2018 Oct;78(6):450-455. doi: 10.1080/00365513.2018.1497802. Epub 2018 Oct 22.


Development of the International Severe Asthma Registry (ISAR): A Modified Delphi Study.

Bulathsinhala L, Eleangovan N, Heaney LG, Menzies-Gow A, Gibson PG, Peters M, Hew M, van Boven JFM, Lehtimäki L, van Ganse E, Belhassen M, Harvey ES, Perez de Llano L, Maitland-van der Zee AH, Papadopoulos NG, FitzGerald JM, Porsbjerg C, Canonica GW, Backer V, Rhee CK, Verhamme KMC, Buhl R, Cosio BG, Carter V, Price C, Le T, Stagno d'Alcontres M, Gopalan G, Tran TN, Price D.

J Allergy Clin Immunol Pract. 2019 Feb;7(2):578-588.e2. doi: 10.1016/j.jaip.2018.08.016. Epub 2018 Sep 1.


Asthma trigger perceptions are associated with work disability.

Karvala K, Uitti J, Taponen S, Luukkonen R, Lehtimäki L.

Respir Med. 2018 Jun;139:19-26. doi: 10.1016/j.rmed.2018.04.010. Epub 2018 Apr 19.


Nordic consensus statement on the systematic assessment and management of possible severe asthma in adults.

Porsbjerg C, Ulrik C, Skjold T, Backer V, Laerum B, Lehman S, Janson C, Sandstrøm T, Bjermer L, Dahlen B, Lundbäck B, Ludviksdottir D, Björnsdóttir U, Altraja A, Lehtimäki L, Kauppi P, Karjalainen J, Kankaanranta H.

Eur Clin Respir J. 2018 Mar 6;5(1):1440868. doi: 10.1080/20018525.2018.1440868. eCollection 2018. Review.


Employment status and changes in working career in relation to asthma: a cross-sectional survey.

Taponen S, Lehtimäki L, Karvala K, Luukkonen R, Uitti J.

J Occup Med Toxicol. 2018 Feb 14;13:8. doi: 10.1186/s12995-018-0189-6. eCollection 2018.


Correlates of employment status in individuals with asthma: a cross-sectional survey.

Taponen S, Lehtimäki L, Karvala K, Luukkonen R, Uitti J.

J Occup Med Toxicol. 2017 Jul 24;12:19. doi: 10.1186/s12995-017-0165-6. eCollection 2017.


Comparison of feasibility and estimates of central and peripheral nitric oxide parameters by different mathematical models.

Karvonen T, Kankaanranta H, Saarelainen S, Moilanen E, Lehtimäki L.

J Breath Res. 2017 Sep 13;11(4):047102. doi: 10.1088/1752-7163/aa7cc0.


Effects of growth and aging on the reference values of pulmonary nitric oxide dynamics in healthy subjects.

Högman M, Thornadtsson A, Liv P, Hua-Huy T, Dinh-Xuan AT, Tufvesson E, Dressel H, Janson C, Koskela K, Oksa P, Sauni R, Uitti J, Moilanen E, Lehtimäki L.

J Breath Res. 2017 Sep 13;11(4):047103. doi: 10.1088/1752-7163/aa7957.


Glycoprotein YKL-40 Levels in Plasma Are Associated with Fibrotic Changes on HRCT in Asbestos-Exposed Subjects.

Väänänen T, Lehtimäki L, Vuolteenaho K, Hämäläinen M, Oksa P, Vierikko T, Järvenpää R, Uitti J, Kankaanranta H, Moilanen E.

Mediators Inflamm. 2017;2017:1797512. doi: 10.1155/2017/1797512. Epub 2017 May 14.


Differences between asthma-COPD overlap syndrome and adult-onset asthma.

Tommola M, Ilmarinen P, Tuomisto LE, Lehtimäki L, Haanpää J, Niemelä O, Kankaanranta H.

Eur Respir J. 2017 May 1;49(5). pii: 1602383. doi: 10.1183/13993003.02383-2016. Print 2017 May.


A European Respiratory Society technical standard: exhaled biomarkers in lung disease.

Horváth I, Barnes PJ, Loukides S, Sterk PJ, Högman M, Olin AC, Amann A, Antus B, Baraldi E, Bikov A, Boots AW, Bos LD, Brinkman P, Bucca C, Carpagnano GE, Corradi M, Cristescu S, de Jongste JC, Dinh-Xuan AT, Dompeling E, Fens N, Fowler S, Hohlfeld JM, Holz O, Jöbsis Q, Van De Kant K, Knobel HH, Kostikas K, Lehtimäki L, Lundberg J, Montuschi P, Van Muylem A, Pennazza G, Reinhold P, Ricciardolo FLM, Rosias P, Santonico M, van der Schee MP, van Schooten FJ, Spanevello A, Tonia T, Vink TJ.

Eur Respir J. 2017 Apr 26;49(4). pii: 1600965. doi: 10.1183/13993003.00965-2016. Print 2017 Apr.


Utilising exhaled nitric oxide information to enhance diagnosis and therapy of respiratory disease - current evidence for clinical practice and proposals to improve the methodology.

Högman M, Lehtimäki L, Dinh-Xuan AT.

Expert Rev Respir Med. 2017 Feb;11(2):101-109. doi: 10.1080/17476348.2017.1281746. Epub 2017 Jan 20. Review.


Predictive value of exhaled nitric oxide in the management of asthma: a systematic review.

Lehtimäki L, Csonka P, Mäkinen E, Isojärvi J, Hovi SL, Ahovuo-Saloranta A.

Eur Respir J. 2016 Sep;48(3):706-14. doi: 10.1183/13993003.00699-2016. Epub 2016 Aug 4. Review.


Monosodium iodoacetate-induced inflammation and joint pain are reduced in TRPA1 deficient mice--potential role of TRPA1 in osteoarthritis.

Moilanen LJ, Hämäläinen M, Nummenmaa E, Ilmarinen P, Vuolteenaho K, Nieminen RM, Lehtimäki L, Moilanen E.

Osteoarthritis Cartilage. 2015 Nov;23(11):2017-26. doi: 10.1016/j.joca.2015.09.008.


Pinosylvin Inhibits TRPA1-Induced Calcium Influx In Vitro and TRPA1-Mediated Acute Paw Inflammation In Vivo.

Moilanen LJ, Hämäläinen M, Lehtimäki L, Nieminen RM, Muraki K, Moilanen E.

Basic Clin Pharmacol Toxicol. 2016 Mar;118(3):238-42. doi: 10.1111/bcpt.12485. Epub 2015 Oct 7. No abstract available.


Prevalence of asthma-COPD overlap syndrome among primary care asthmatics with a smoking history: a cross-sectional study.

Kiljander T, Helin T, Venho K, Jaakkola A, Lehtimäki L.

NPJ Prim Care Respir Med. 2015 Jul 16;25:15047. doi: 10.1038/npjpcrm.2015.47.


Annual costs of chronic obstructive pulmonary disease in Finland during 1996-2006 and a prediction model for 2007-2030.

Herse F, Kiljander T, Lehtimäki L.

NPJ Prim Care Respir Med. 2015 Mar 26;25:15015. doi: 10.1038/npjpcrm.2015.15.


Urate crystal induced inflammation and joint pain are reduced in transient receptor potential ankyrin 1 deficient mice--potential role for transient receptor potential ankyrin 1 in gout.

Moilanen LJ, Hämäläinen M, Lehtimäki L, Nieminen RM, Moilanen E.

PLoS One. 2015 Feb 6;10(2):e0117770. doi: 10.1371/journal.pone.0117770. eCollection 2015.


Pulmonary inflammation in foundry workers.

Koskela K, Oksa P, Sauni R, Linnainmaa M, Toivio P, Lehtimäki L, Moilanen E, Nieminen R, Luukkonen R, Uitti J.

J Occup Environ Med. 2015 Feb;57(2):124-8. doi: 10.1097/JOM.0000000000000390.


Diagnosis and pharmacotherapy of stable chronic obstructive pulmonary disease: the finnish guidelines.

Kankaanranta H, Harju T, Kilpeläinen M, Mazur W, Lehto JT, Katajisto M, Peisa T, Meinander T, Lehtimäki L.

Basic Clin Pharmacol Toxicol. 2015 Apr;116(4):291-307. doi: 10.1111/bcpt.12366. Epub 2015 Jan 22. Review.


How to assess alveolar nitric oxide: a quest of the grail?

Lehtimäki L, Cristescu SM, Van Muylem A, Högman M, Dinh-Xuan AT.

Chest. 2014 Dec;146(6):e234-e235. doi: 10.1378/chest.14-1189. No abstract available.


Very low birthweight bronchopulmonary dysplasia survivors show no substantial association between lung function and current inflammatory markers.

Suursalmi P, Kopeli T, Korhonen P, Lehtimäki L, Nieminen R, Luukkaala T, Moilanen E, Korppi M, Paassilta M, Tammela O.

Acta Paediatr. 2015 Mar;104(3):264-8. doi: 10.1111/apa.12837. Epub 2014 Nov 17.


[Update on current care guideline: chronic obstructive pulmonary disease (COPD)].

Harju T, Kankaanranta H, Katajisto M, Kilpeläinen M, Lehtimäki L, Lehto J, Mazur W, Meinander T, Peisa T.

Duodecim. 2014;130(17):1774-6. Finnish.


Adipokines NUCB2/nesfatin-1 and visfatin as novel inflammatory factors in chronic obstructive pulmonary disease.

Leivo-Korpela S, Lehtimäki L, Hämälainen M, Vuolteenaho K, Kööbi L, Järvenpää R, Kankaanranta H, Saarelainen S, Moilanen E.

Mediators Inflamm. 2014;2014:232167. doi: 10.1155/2014/232167. Epub 2014 May 6.


Inflammatory activity at school age in very low birth weight bronchopulmonary dysplasia survivors.

Korhonen PH, Suursalmi PH, Kopeli T, Nieminen R, Lehtimäki L, Luukkaala T, Korppi M, Saari A, Moilanen E, Tammela OK.

Pediatr Pulmonol. 2015 Jul;50(7):683-90. doi: 10.1002/ppul.23038. Epub 2014 Mar 26.


Adiponectin is associated with dynamic hyperinflation and a favourable response to inhaled glucocorticoids in patients with COPD.

Leivo-Korpela S, Lehtimäki L, Vuolteenaho K, Nieminen R, Kööbi L, Järvenpää R, Kankaanranta H, Saarelainen S, Moilanen E.

Respir Med. 2014 Jan;108(1):122-8. doi: 10.1016/j.rmed.2013.08.016. Epub 2013 Aug 30.


Attenuation of TNF production and experimentally induced inflammation by PDE4 inhibitor rolipram is mediated by MAPK phosphatase-1.

Korhonen R, Hömmö T, Keränen T, Laavola M, Hämäläinen M, Vuolteenaho K, Lehtimäki L, Kankaanranta H, Moilanen E.

Br J Pharmacol. 2013 Aug;169(7):1525-36. doi: 10.1111/bph.12189.


[Update on current care guidelines: asthma].

Haahtela T, Lehtimäki L, Ahonen E, Harju T, Jartti T, Kankaanranta H, Korhonen K, Mäkelä M, Puurunen M, Sovijärvi A, Valovirta E, Venho KK.

Duodecim. 2013;129(9):994-5. Review. Finnish.


Adipokine adipsin is associated with the degree of lung fibrosis in asbestos-exposed workers.

Leivo-Korpela S, Lehtimäki L, Nieminen R, Oksa P, Vierikko T, Järvenpää R, Uitti J, Moilanen E.

Respir Med. 2012 Oct;106(10):1435-40. doi: 10.1016/j.rmed.2012.07.003. Epub 2012 Jul 24.


Relation of bronchial and alveolar nitric oxide to exercise-induced bronchoconstriction in atopic children and adolescents.

Linkosalo L, Lehtimäki L, Holm K, Kaila M, Moilanen E.

Pediatr Allergy Immunol. 2012 Jun;23(4):360-6. doi: 10.1111/j.1399-3038.2011.01223.x. Epub 2011 Dec 7.


Increased alveolar nitric oxide and systemic inflammation markers in silica-exposed workers.

Sauni R, Oksa P, Lehtimäki L, Toivio P, Palmroos P, Nieminen R, Moilanen E, Uitti J.

Occup Environ Med. 2012 Apr;69(4):256-60. doi: 10.1136/oemed-2011-100347. Epub 2011 Nov 7.


Adipokine resistin predicts anti-inflammatory effect of glucocorticoids in asthma.

Leivo-Korpela S, Lehtimäki L, Vuolteenaho K, Nieminen R, Kankaanranta H, Saarelainen S, Moilanen E.

J Inflamm (Lond). 2011 May 26;8:12. doi: 10.1186/1476-9255-8-12.


Resistin is linked to inflammation, and leptin to metabolic syndrome, in women with inflammatory arthritis.

Kontunen P, Vuolteenaho K, Nieminen R, Lehtimäki L, Kautiainen H, Kesäniemi Y, Ukkola O, Kauppi M, Hakala M, Moilanen E.

Scand J Rheumatol. 2011;40(4):256-62. doi: 10.3109/03009742.2010.548827. Epub 2011 Apr 1.


Pulmonary inflammation in asbestos-exposed subjects with borderline parenchymal changes on HRCT.

Lehtimäki L, Oksa P, Järvenpää R, Vierikko T, Nieminen R, Kankaanranta H, Uitti J, Moilanen E.

Respir Med. 2010 Jul;104(7):1042-9. doi: 10.1016/j.rmed.2010.01.019. Epub 2010 Feb 16.

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