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Items: 1 to 50 of 72

1.

High tissue MMP14 expression predicts worse survival in gastric cancer, particularly with a low PROX1.

Kasurinen A, Gramolelli S, Hagström J, Laitinen A, Kokkola A, Miki Y, Lehti K, Yashiro M, Ojala PM, Böckelman C, Haglund C.

Cancer Med. 2019 Sep 27. doi: 10.1002/cam4.2576. [Epub ahead of print]

2.

MMP14 in Sarcoma: A Regulator of Tumor Microenvironment Communication in Connective Tissues.

Gonzalez-Molina J, Gramolelli S, Liao Z, Carlson JW, Ojala PM, Lehti K.

Cells. 2019 Aug 28;8(9). pii: E991. doi: 10.3390/cells8090991. Review.

3.

A novel mutation in the matrix metallopeptidase 2 coding gene associated with intrafamilial variability of multicentric osteolysis, nodulosis, and arthropathy.

Kröger L, Löppönen T, Ala-Kokko L, Kröger H, Jauhonen HM, Lehti K, Jääskeläinen J.

Mol Genet Genomic Med. 2019 Aug;7(8):e802. doi: 10.1002/mgg3.802. Epub 2019 Jul 3.

4.

Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization.

Le Joncour V, Filppu P, Hyvönen M, Holopainen M, Turunen SP, Sihto H, Burghardt I, Joensuu H, Tynninen O, Jääskeläinen J, Weller M, Lehti K, Käkelä R, Laakkonen P.

EMBO Mol Med. 2019 Jun;11(6). pii: e9034. doi: 10.15252/emmm.201809034.

5.

FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis.

Turunen SP, von Nandelstadh P, Öhman T, Gucciardo E, Seashore-Ludlow B, Martins B, Rantanen V, Li H, Höpfner K, Östling P, Varjosalo M, Lehti K.

Cell Death Differ. 2019 Mar 22. doi: 10.1038/s41418-019-0321-x. [Epub ahead of print]

PMID:
30903103
6.

An Ex Vivo Tissue Culture Model for Fibrovascular Complications in Proliferative Diabetic Retinopathy.

Gucciardo E, Loukovaara S, Korhonen A, Lehti K.

J Vis Exp. 2019 Jan 25;(143). doi: 10.3791/59090.

PMID:
30735169
7.

Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage.

Zeiner J, Loukovaara S, Losenkova K, Zuccarini M, Korhonen AM, Lehti K, Kauppinen A, Kaarniranta K, Müller CE, Jalkanen S, Yegutkin GG.

J Mol Med (Berl). 2019 Mar;97(3):341-354. doi: 10.1007/s00109-018-01734-0. Epub 2019 Jan 7.

8.

Integrated Molecular Analysis of Undifferentiated Uterine Sarcomas Reveals Clinically Relevant Molecular Subtypes.

Binzer-Panchal A, Hardell E, Viklund B, Ghaderi M, Bosse T, Nucci MR, Lee CH, Hollfelder N, Corcoran P, Gonzalez-Molina J, Moyano-Galceran L, Bell DA, Schoolmeester JK, Måsbäck A, Kristensen GB, Davidson B, Lehti K, Isaksson A, Carlson JW.

Clin Cancer Res. 2019 Apr 1;25(7):2155-2165. doi: 10.1158/1078-0432.CCR-18-2792. Epub 2019 Jan 7.

PMID:
30617134
9.

Lymphatic Vascular Structures: A New Aspect in Proliferative Diabetic Retinopathy.

Gucciardo E, Loukovaara S, Salven P, Lehti K.

Int J Mol Sci. 2018 Dec 13;19(12). pii: E4034. doi: 10.3390/ijms19124034. Review.

10.

Liprin-α1 modulates cancer cell signaling by transmembrane protein CD82 in adhesive membrane domains linked to cytoskeleton.

Pehkonen H, Lento M, von Nandelstadh P, Filippou A, Grénman R, Lehti K, Monni O.

Cell Commun Signal. 2018 Jul 13;16(1):41. doi: 10.1186/s12964-018-0253-y.

11.

PROX1 is a transcriptional regulator of MMP14.

Gramolelli S, Cheng J, Martinez-Corral I, Vähä-Koskela M, Elbasani E, Kaivanto E, Rantanen V, Tuohinto K, Hautaniemi S, Bower M, Haglund C, Alitalo K, Mäkinen T, Petrova TV, Lehti K, Ojala PM.

Sci Rep. 2018 Jun 22;8(1):9531. doi: 10.1038/s41598-018-27739-w.

12.

Fibroblasts in the Tumor Microenvironment: Shield or Spear?

Alkasalias T, Moyano-Galceran L, Arsenian-Henriksson M, Lehti K.

Int J Mol Sci. 2018 May 21;19(5). pii: E1532. doi: 10.3390/ijms19051532. Review.

13.

A Functional Homologous Recombination Assay Predicts Primary Chemotherapy Response and Long-Term Survival in Ovarian Cancer Patients.

Tumiati M, Hietanen S, Hynninen J, Pietilä E, Färkkilä A, Kaipio K, Roering P, Huhtinen K, Alkodsi A, Li Y, Lehtonen R, Erkan EP, Tuominen MM, Lehti K, Hautaniemi SK, Vähärautio A, Grénman S, Carpén O, Kauppi L.

Clin Cancer Res. 2018 Sep 15;24(18):4482-4493. doi: 10.1158/1078-0432.CCR-17-3770. Epub 2018 Jun 1.

14.

Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation.

Pekkonen P, Alve S, Balistreri G, Gramolelli S, Tatti-Bugaeva O, Paatero I, Niiranen O, Tuohinto K, Perälä N, Taiwo A, Zinovkina N, Repo P, Icay K, Ivaska J, Saharinen P, Hautaniemi S, Lehti K, Ojala PM.

Elife. 2018 May 1;7. pii: e32490. doi: 10.7554/eLife.32490.

15.

The microenvironment of proliferative diabetic retinopathy supports lymphatic neovascularization.

Gucciardo E, Loukovaara S, Korhonen A, Repo P, Martins B, Vihinen H, Jokitalo E, Lehti K.

J Pathol. 2018 Jun;245(2):172-185. doi: 10.1002/path.5070. Epub 2018 Apr 6.

PMID:
29536540
16.

Gremlin-1 is a key regulator of the invasive cell phenotype in mesothelioma.

Yin M, Tissari M, Tamminen J, Ylivinkka I, Rönty M, von Nandelstadh P, Lehti K, Hyytiäinen M, Myllärniemi M, Koli K.

Oncotarget. 2017 Oct 6;8(58):98280-98297. doi: 10.18632/oncotarget.21550. eCollection 2017 Nov 17.

17.

Membrane-type matrix metalloproteases as diverse effectors of cancer progression.

Turunen SP, Tatti-Bugaeva O, Lehti K.

Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt A):1974-1988. doi: 10.1016/j.bbamcr.2017.04.002. Epub 2017 Apr 5. Review.

18.

RhoA knockout fibroblasts lose tumor-inhibitory capacity in vitro and promote tumor growth in vivo.

Alkasalias T, Alexeyenko A, Hennig K, Danielsson F, Lebbink RJ, Fielden M, Turunen SP, Lehti K, Kashuba V, Madapura HS, Bozoky B, Lundberg E, Balland M, Guvén H, Klein G, Gad AK, Pavlova T.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1413-E1421. doi: 10.1073/pnas.1621161114. Epub 2017 Feb 7.

19.

Somatic MED12 Nonsense Mutation Escapes mRNA Decay and Reveals a Motif Required for Nuclear Entry.

Heikkinen T, Kämpjärvi K, Keskitalo S, von Nandelstadh P, Liu X, Rantanen V, Pitkänen E, Kinnunen M, Kuusanmäki H, Kontro M, Turunen M, Mäkinen N, Taipale J, Heckman C, Lehti K, Mustjoki S, Varjosalo M, Vahteristo P.

Hum Mutat. 2017 Mar;38(3):269-274. doi: 10.1002/humu.23157. Epub 2017 Jan 11.

PMID:
28054750
20.

Liprin-α1 is a regulator of vimentin intermediate filament network in the cancer cell adhesion machinery.

Pehkonen H, von Nandelstadh P, Karhemo PR, Lepikhova T, Grenman R, Lehti K, Monni O.

Sci Rep. 2016 Apr 14;6:24486. doi: 10.1038/srep24486.

21.

Proactive for invasion: Reuse of matrix metalloproteinase for structural memory.

Gucciardo E, Mobashir M, Lehti K.

J Cell Biol. 2016 Apr 11;213(1):11-3. doi: 10.1083/jcb.201603066.

22.

Quantitative Proteomics Analysis of Vitreous Humor from Diabetic Retinopathy Patients.

Loukovaara S, Nurkkala H, Tamene F, Gucciardo E, Liu X, Repo P, Lehti K, Varjosalo M.

J Proteome Res. 2015 Dec 4;14(12):5131-43. doi: 10.1021/acs.jproteome.5b00900. Epub 2015 Oct 30.

PMID:
26490944
23.

A Case of Abnormal Lymphatic-Like Differentiation and Endothelial Progenitor Cell Activation in Neovascularization Associated with Hemi-Retinal Vein Occlusion.

Loukovaara S, Gucciardo E, Repo P, Lohi J, Salven P, Lehti K.

Case Rep Ophthalmol. 2015 Jul 17;6(2):228-38. doi: 10.1159/000437254. eCollection 2015 May-Aug.

24.

Indications of lymphatic endothelial differentiation and endothelial progenitor cell activation in the pathology of proliferative diabetic retinopathy.

Loukovaara S, Gucciardo E, Repo P, Vihinen H, Lohi J, Jokitalo E, Salven P, Lehti K.

Acta Ophthalmol. 2015 Sep;93(6):512-23. doi: 10.1111/aos.12741. Epub 2015 Apr 21.

25.

MMP16 Mediates a Proteolytic Switch to Promote Cell-Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma.

Tatti O, Gucciardo E, Pekkonen P, Holopainen T, Louhimo R, Repo P, Maliniemi P, Lohi J, Rantanen V, Hautaniemi S, Alitalo K, Ranki A, Ojala PM, Keski-Oja J, Lehti K.

Cancer Res. 2015 May 15;75(10):2083-94. doi: 10.1158/0008-5472.CAN-14-1923. Epub 2015 Mar 25.

26.

Identification of 33 candidate oncogenes by screening for base-specific mutations.

Tuupanen S, Hänninen UA, Kondelin J, von Nandelstadh P, Cajuso T, Gylfe AE, Katainen R, Tanskanen T, Ristolainen H, Böhm J, Mecklin JP, Järvinen H, Renkonen-Sinisalo L, Andersen CL, Taipale M, Taipale J, Vahteristo P, Lehti K, Pitkänen E, Aaltonen LA.

Br J Cancer. 2014 Oct 14;111(8):1657-62. doi: 10.1038/bjc.2014.429. Epub 2014 Aug 12.

27.

Actin-associated protein palladin promotes tumor cell invasion by linking extracellular matrix degradation to cell cytoskeleton.

von Nandelstadh P, Gucciardo E, Lohi J, Li R, Sugiyama N, Carpen O, Lehti K.

Mol Biol Cell. 2014 Sep 1;25(17):2556-70. doi: 10.1091/mbc.E13-11-0667. Epub 2014 Jul 2.

28.

Eph- and ephrin-dependent mechanisms in tumor and stem cell dynamics.

Gucciardo E, Sugiyama N, Lehti K.

Cell Mol Life Sci. 2014 Oct;71(19):3685-710. doi: 10.1007/s00018-014-1633-0. Epub 2014 May 4. Review.

PMID:
24794629
29.

Increased intravitreal angiopoietin-2 levels associated with rhegmatogenous retinal detachment.

Loukovaara S, Lehti K, Robciuc A, Pessi T, Holopainen JM, Koli K, Immonen I, Keski-Oja J.

Graefes Arch Clin Exp Ophthalmol. 2014 Jun;252(6):881-8. doi: 10.1007/s00417-013-2508-z. Epub 2013 Nov 12.

PMID:
24218041
30.

EphA2 bears plasticity to tumor invasion.

Sugiyama N, Gucciardo E, Lehti K.

Cell Cycle. 2013 Sep 15;12(18):2927-8. doi: 10.4161/cc.26180. Epub 2013 Aug 23. No abstract available.

31.

EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion.

Sugiyama N, Gucciardo E, Tatti O, Varjosalo M, Hyytiäinen M, Gstaiger M, Lehti K.

J Cell Biol. 2013 Apr 29;201(3):467-84. doi: 10.1083/jcb.201205176.

32.

Ang-2 upregulation correlates with increased levels of MMP-9, VEGF, EPO and TGFβ1 in diabetic eyes undergoing vitrectomy.

Loukovaara S, Robciuc A, Holopainen JM, Lehti K, Pessi T, Liinamaa J, Kukkonen KT, Jauhiainen M, Koli K, Keski-Oja J, Immonen I.

Acta Ophthalmol. 2013 Sep;91(6):531-9. doi: 10.1111/j.1755-3768.2012.02473.x. Epub 2012 Oct 26.

33.

An optimized isolation of biotinylated cell surface proteins reveals novel players in cancer metastasis.

Karhemo PR, Ravela S, Laakso M, Ritamo I, Tatti O, Mäkinen S, Goodison S, Stenman UH, Hölttä E, Hautaniemi S, Valmu L, Lehti K, Laakkonen P.

J Proteomics. 2012 Dec 21;77:87-100. doi: 10.1016/j.jprot.2012.07.009. Epub 2012 Jul 17.

34.

MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling and calvarial osteogenesis.

Chan KM, Wong HL, Jin G, Liu B, Cao R, Cao Y, Lehti K, Tryggvason K, Zhou Z.

Dev Cell. 2012 Jun 12;22(6):1176-90. doi: 10.1016/j.devcel.2012.04.014. Epub 2012 May 24.

35.

KSHV-initiated notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition.

Cheng F, Pekkonen P, Laurinavicius S, Sugiyama N, Henderson S, Günther T, Rantanen V, Kaivanto E, Aavikko M, Sarek G, Hautaniemi S, Biberfeld P, Aaltonen L, Grundhoff A, Boshoff C, Alitalo K, Lehti K, Ojala PM.

Cell Host Microbe. 2011 Dec 15;10(6):577-90. doi: 10.1016/j.chom.2011.10.011.

36.

Membrane-type-3 matrix metalloproteinase (MT3-MMP) functions as a matrix composition-dependent effector of melanoma cell invasion.

Tatti O, Arjama M, Ranki A, Weiss SJ, Keski-Oja J, Lehti K.

PLoS One. 2011;6(12):e28325. doi: 10.1371/journal.pone.0028325. Epub 2011 Dec 2.

37.

Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor.

Zheng W, Tammela T, Yamamoto M, Anisimov A, Holopainen T, Kaijalainen S, Karpanen T, Lehti K, Ylä-Herttuala S, Alitalo K.

Blood. 2011 Jul 28;118(4):1154-62. doi: 10.1182/blood-2010-11-317800. Epub 2011 May 12.

PMID:
21566091
38.

Syndecan-1 and -4 differentially regulate oncogenic K-ras dependent cell invasion into collagen through α2β1 integrin and MT1-MMP.

Vuoriluoto K, Högnäs G, Meller P, Lehti K, Ivaska J.

Matrix Biol. 2011 Apr;30(3):207-17. doi: 10.1016/j.matbio.2011.03.003. Epub 2011 Mar 23.

PMID:
21414405
39.

Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation.

Sugiyama N, Varjosalo M, Meller P, Lohi J, Hyytiäinen M, Kilpinen S, Kallioniemi O, Ingvarsen S, Engelholm LH, Taipale J, Alitalo K, Keski-Oja J, Lehti K.

Cancer Res. 2010 Oct 15;70(20):7851-61. doi: 10.1158/0008-5472.CAN-10-1223. Epub 2010 Sep 28.

40.

FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex.

Sugiyama N, Varjosalo M, Meller P, Lohi J, Chan KM, Zhou Z, Alitalo K, Taipale J, Keski-Oja J, Lehti K.

Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15786-91. doi: 10.1073/pnas.0914459107. Epub 2010 Aug 23.

41.

MT1-MMP promotes vascular smooth muscle dedifferentiation through LRP1 processing.

Lehti K, Rose NF, Valavaara S, Weiss SJ, Keski-Oja J.

J Cell Sci. 2009 Jan 1;122(Pt 1):126-35. doi: 10.1242/jcs.035279. Epub 2008 Dec 9.

42.

Secretion of active membrane type 1 matrix metalloproteinase (MMP-14) into extracellular space in microvesicular exosomes.

Hakulinen J, Sankkila L, Sugiyama N, Lehti K, Keski-Oja J.

J Cell Biochem. 2008 Dec 1;105(5):1211-8. doi: 10.1002/jcb.21923.

PMID:
18802920
43.

MT1-MMP releases latent TGF-beta1 from endothelial cell extracellular matrix via proteolytic processing of LTBP-1.

Tatti O, Vehviläinen P, Lehti K, Keski-Oja J.

Exp Cell Res. 2008 Aug 1;314(13):2501-14. doi: 10.1016/j.yexcr.2008.05.018. Epub 2008 Jun 6.

PMID:
18602101
44.

Further testing of a family nursing instrument (FAFHES).

Astedt-Kurki P, Tarkka MT, Rikala MR, Lehti K, Paavilainen E.

Int J Nurs Stud. 2009 Mar;46(3):350-9. doi: 10.1016/j.ijnurstu.2008.01.008. Epub 2008 Mar 10.

PMID:
18329649
45.

Epilysin (MMP-28) induces TGF-beta mediated epithelial to mesenchymal transition in lung carcinoma cells.

Illman SA, Lehti K, Keski-Oja J, Lohi J.

J Cell Sci. 2006 Sep 15;119(Pt 18):3856-65. Epub 2006 Aug 29.

46.

Family functioning assessed by family members in Finnish families of heart patients.

Paavilainen E, Lehti K, Astedt-Kurki P, Tarkka MT.

Eur J Cardiovasc Nurs. 2006 Mar;5(1):54-9. Epub 2005 Nov 16.

PMID:
16297662
47.

An MT1-MMP-PDGF receptor-beta axis regulates mural cell investment of the microvasculature.

Lehti K, Allen E, Birkedal-Hansen H, Holmbeck K, Miyake Y, Chun TH, Weiss SJ.

Genes Dev. 2005 Apr 15;19(8):979-91. Epub 2005 Apr 1.

48.

Determinants of perceived health in families of patients with heart disease.

Astedt-Kurki P, Lehti K, Tarkka MT, Paavilainen E.

J Adv Nurs. 2004 Oct;48(2):115-23.

PMID:
15369491
49.

In-hospital social support for families of heart patients.

Tarkka MT, Paavilainen E, Lehti K, Astedt-Kurki P.

J Clin Nurs. 2003 Sep;12(5):736-43.

PMID:
12919220

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