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A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response.

Fermaintt CS, Sano K, Liu Z, Ishii N, Seino J, Dobbs N, Suzuki T, Fu YX, Lehrman MA, Matsuo I, Yan N.

Nat Commun. 2019 May 30;10(1):2377. doi: 10.1038/s41467-019-10319-5.


Targeting STT3A-oligosaccharyltransferase with NGI-1 causes herpes simplex virus 1 dysfunction.

Lu H, Cherepanova NA, Gilmore R, Contessa JN, Lehrman MA.

FASEB J. 2019 Jun;33(6):6801-6812. doi: 10.1096/fj.201802044RR. Epub 2019 Feb 27.


The Lec5 glycosylation mutant links homeobox genes with cholesterol and lipid-linked oligosaccharides.

Lu H, Sathe AA, Xing C, Lehrman MA.

Glycobiology. 2019 Feb 1;29(2):106-109. doi: 10.1093/glycob/cwy103.


Mammalian STT3A/B oligosaccharyltransferases segregate N-glycosylation at the translocon from lipid-linked oligosaccharide hydrolysis.

Lu H, Fermaintt CS, Cherepanova NA, Gilmore R, Yan N, Lehrman MA.

Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9557-9562. doi: 10.1073/pnas.1806034115. Epub 2018 Sep 4.


Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells.

Lopez-Sambrooks C, Shrimal S, Khodier C, Flaherty DP, Rinis N, Charest JC, Gao N, Zhao P, Wells L, Lewis TA, Lehrman MA, Gilmore R, Golden JE, Contessa JN.

Nat Chem Biol. 2016 Dec;12(12):1023-1030. doi: 10.1038/nchembio.2194. Epub 2016 Oct 3.


trappc11 is required for protein glycosylation in zebrafish and humans.

DeRossi C, Vacaru A, Rafiq R, Cinaroglu A, Imrie D, Nayar S, Baryshnikova A, Milev MP, Stanga D, Kadakia D, Gao N, Chu J, Freeze HH, Lehrman MA, Sacher M, Sadler KC.

Mol Biol Cell. 2016 Apr 15;27(8):1220-34. doi: 10.1091/mbc.E15-08-0557. Epub 2016 Feb 24.


Flipping a Lipid-Linked Oligosaccharide? You Must Whip It!

Lehrman MA.

Trends Biochem Sci. 2015 Dec;40(12):715-717. doi: 10.1016/j.tibs.2015.10.001. Epub 2015 Oct 17.


Mcl-1 downregulation leads to the heightened sensitivity exhibited by BCR-ABL positive ALL to induction of energy and ER-stress.

Leclerc GJ, DeSalvo J, Du J, Gao N, Leclerc GM, Lehrman MA, Lampidis TJ, Barredo JC.

Leuk Res. 2015 Aug 20. pii: S0145-2126(15)30360-X. doi: 10.1016/j.leukres.2015.08.007. [Epub ahead of print]


Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation.

Hasan M, Fermaintt CS, Gao N, Sakai T, Miyazaki T, Jiang S, Li QZ, Atkinson JP, Morse HC 3rd, Lehrman MA, Yan N.

Immunity. 2015 Sep 15;43(3):463-74. doi: 10.1016/j.immuni.2015.07.022. Epub 2015 Aug 25.


Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway.

Wang ZV, Deng Y, Gao N, Pedrozo Z, Li DL, Morales CR, Criollo A, Luo X, Tan W, Jiang N, Lehrman MA, Rothermel BA, Lee AH, Lavandero S, Mammen PPA, Ferdous A, Gillette TG, Scherer PE, Hill JA.

Cell. 2014 Mar 13;156(6):1179-1192. doi: 10.1016/j.cell.2014.01.014.


Increased sensitivity to glucose starvation correlates with downregulation of glycogen phosphorylase isoform PYGB in tumor cell lines resistant to 2-deoxy-D-glucose.

Philips KB, Kurtoglu M, Leung HJ, Liu H, Gao N, Lehrman MA, Murray TG, Lampidis TJ.

Cancer Chemother Pharmacol. 2014 Feb;73(2):349-61. doi: 10.1007/s00280-013-2358-8. Epub 2013 Dec 1.


Letter to the Glycoforum: Improved protocols for preparing lipid-linked and related saccharides for Fluorophore-Assisted Carbohydrate Electrophoresis (FACE).

Gao N, Holmes J, Lehrman MA.

Glycobiology. 2013 Oct;23(10):1111. doi: 10.1093/glycob/cwt067. No abstract available.


Mannose-6-phosphate: a regulator of LLO destruction.

Gao N, Lehrman MA.

Methods Mol Biol. 2013;1022:277-82. doi: 10.1007/978-1-62703-465-4_20.


Glycoprotein biosynthesis in a eukaryote lacking the membrane protein Rft1.

Jelk J, Gao N, Serricchio M, Signorell A, Schmidt RS, Bangs JD, Acosta-Serrano A, Lehrman MA, Bütikofer P, Menon AK.

J Biol Chem. 2013 Jul 12;288(28):20616-23. doi: 10.1074/jbc.M113.479642. Epub 2013 May 28.


The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism.

Deng Y, Wang ZV, Tao C, Gao N, Holland WL, Ferdous A, Repa JJ, Liang G, Ye J, Lehrman MA, Hill JA, Horton JD, Scherer PE.

J Clin Invest. 2013 Jan;123(1):455-68. doi: 10.1172/JCI62819. Epub 2012 Dec 21.


A zebrafish model of PMM2-CDG reveals altered neurogenesis and a substrate-accumulation mechanism for N-linked glycosylation deficiency.

Cline A, Gao N, Flanagan-Steet H, Sharma V, Rosa S, Sonon R, Azadi P, Sadler KC, Freeze HH, Lehrman MA, Steet R.

Mol Biol Cell. 2012 Nov;23(21):4175-87. doi: 10.1091/mbc.E12-05-0411. Epub 2012 Sep 5.


A zebrafish model of congenital disorders of glycosylation with phosphomannose isomerase deficiency reveals an early opportunity for corrective mannose supplementation.

Chu J, Mir A, Gao N, Rosa S, Monson C, Sharma V, Steet R, Freeze HH, Lehrman MA, Sadler KC.

Dis Model Mech. 2013 Jan;6(1):95-105. doi: 10.1242/dmm.010116. Epub 2012 Aug 16.


5-thiomannosides block the biosynthesis of dolichol-linked oligosaccharides and mimic class I congenital disorders of glycosylation.

Zandberg WF, Gao N, Kumarasamy J, Lehrman MA, Seidah NG, Pinto BM.

Chembiochem. 2012 Feb 13;13(3):392-401. doi: 10.1002/cbic.201100647. Epub 2012 Jan 19.


Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides.

Gao N, Shang J, Huynh D, Manthati VL, Arias C, Harding HP, Kaufman RJ, Mohr I, Ron D, Falck JR, Lehrman MA.

Mol Biol Cell. 2011 Sep;22(17):2994-3009. doi: 10.1091/mbc.E11-04-0286. Epub 2011 Jul 7.


Nogo-B receptor is necessary for cellular dolichol biosynthesis and protein N-glycosylation.

Harrison KD, Park EJ, Gao N, Kuo A, Rush JS, Waechter CJ, Lehrman MA, Sessa WC.

EMBO J. 2011 May 13;30(12):2490-500. doi: 10.1038/emboj.2011.147.


Antiangiogenic activity of 2-deoxy-D-glucose.

Merchan JR, Kovács K, Railsback JW, Kurtoglu M, Jing Y, Piña Y, Gao N, Murray TG, Lehrman MA, Lampidis TJ.

PLoS One. 2010 Oct 27;5(10):e13699. doi: 10.1371/journal.pone.0013699.


Suppression of Rft1 expression does not impair the transbilayer movement of Man5GlcNAc2-P-P-dolichol in sealed microsomes from yeast.

Rush JS, Gao N, Lehrman MA, Matveev S, Waechter CJ.

J Biol Chem. 2009 Jul 24;284(30):19835-42. doi: 10.1074/jbc.M109.000893. Epub 2009 Jun 3.


Under normoxia, 2-deoxy-D-glucose elicits cell death in select tumor types not by inhibition of glycolysis but by interfering with N-linked glycosylation.

Kurtoglu M, Gao N, Shang J, Maher JC, Lehrman MA, Wangpaichitr M, Savaraj N, Lane AN, Lampidis TJ.

Mol Cancer Ther. 2007 Nov;6(11):3049-58.


Unexpected basis for impaired Glc3Man9GlcNAc2-P-P-dolichol biosynthesis by elevated expression of GlcNAc-1-P transferase.

Gao N, Shang J, Lehrman MA.

Glycobiology. 2008 Jan;18(1):125-34. Epub 2007 Oct 3.


Teaching dolichol-linked oligosaccharides more tricks with alternatives to metabolic radiolabeling.

Lehrman MA.

Glycobiology. 2007 Aug;17(8):75R-85R. Epub 2007 Mar 23. Review.


Translation attenuation by PERK balances ER glycoprotein synthesis with lipid-linked oligosaccharide flux.

Shang J, Gao N, Kaufman RJ, Ron D, Harding HP, Lehrman MA.

J Cell Biol. 2007 Feb 26;176(5):605-16.


Stimulation of N-linked glycosylation and lipid-linked oligosaccharide synthesis by stress responses in metazoan cells.

Lehrman MA.

Crit Rev Biochem Mol Biol. 2006 Mar-Apr;41(2):51-75. Erratum in: Crit Rev Biochem Mol Biol. 2006 May-Jun;41(3):209.


Characterization of lipid-linked oligosaccharide accumulation in mouse models of Batten disease.

Cho SK, Gao N, Pearce DA, Lehrman MA, Hofmann SL.

Glycobiology. 2005 Jun;15(6):637-48. Epub 2005 Jan 12.


Discordance of UPR signaling by ATF6 and Ire1p-XBP1 with levels of target transcripts.

Shang J, Lehrman MA.

Biochem Biophys Res Commun. 2004 Apr 30;317(2):390-6.


Metformin-stimulated mannose transport in dermal fibroblasts.

Shang J, Lehrman MA.

J Biol Chem. 2004 Mar 12;279(11):9703-12. Epub 2003 Dec 17.


Expression cloning of a novel suppressor of the Lec15 and Lec35 glycosylation mutations of Chinese hamster ovary cells.

Ware FE, Lehrman MA.

J Biol Chem. 1998 May 22;273(21):13366. No abstract available.


Alternative and sources of reagents and supplies of fluorophore-assisted carbohydrate electrophoresis(FACE).

Lehrman MA, Gao N.

Glycobiology. 2003 Jan;13(1):1G-3G. No abstract available.


Rapid activation of glycogen phosphorylase by the endoplasmic reticulum unfolded protein response.

Gill A, Gao N, Lehrman MA.

J Biol Chem. 2002 Nov 22;277(47):44747-53. Epub 2002 Sep 9.


A mutation in the human MPDU1 gene causes congenital disorder of glycosylation type If (CDG-If).

Kranz C, Denecke J, Lehrman MA, Ray S, Kienz P, Kreissel G, Sagi D, Peter-Katalinic J, Freeze HH, Schmid T, Jackowski-Dohrmann S, Harms E, Marquardt T.

J Clin Invest. 2001 Dec;108(11):1613-9.


Oligosaccharide-based information in endoplasmic reticulum quality control and other biological systems.

Lehrman MA.

J Biol Chem. 2001 Mar 23;276(12):8623-6. Epub 2001 Jan 26. Review. No abstract available.


Requirement of the Lec35 gene for all known classes of monosaccharide-P-dolichol-dependent glycosyltransferase reactions in mammals.

Anand M, Rush JS, Ray S, Doucey MA, Weik J, Ware FE, Hofsteenge J, Waechter CJ, Lehrman MA.

Mol Biol Cell. 2001 Feb;12(2):487-501.


Oligosaccharide binding characteristics of the molecular chaperones calnexin and calreticulin.

Vassilakos A, Michalak M, Lehrman MA, Williams DB.

Biochemistry. 1998 Mar 10;37(10):3480-90.


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