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Items: 1 to 50 of 276

1.

Is there a single porcine protegrin gene?

Lehrer RI.

FEBS J. 2014 Dec;281(24):5418-9. doi: 10.1111/febs.13143. Epub 2014 Nov 26. No abstract available.

2.

Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets.

Chu H, Pazgier M, Jung G, Nuccio SP, Castillo PA, de Jong MF, Winter MG, Winter SE, Wehkamp J, Shen B, Salzman NH, Underwood MA, Tsolis RM, Young GM, Lu W, Lehrer RI, Bäumler AJ, Bevins CL.

Science. 2012 Jul 27;337(6093):477-81. doi: 10.1126/science.1218831. Epub 2012 Jun 21.

3.

θ-Defensins: cyclic peptides with endless potential.

Lehrer RI, Cole AM, Selsted ME.

J Biol Chem. 2012 Aug 3;287(32):27014-9. doi: 10.1074/jbc.R112.346098. Epub 2012 Jun 14.

4.

Hapivirins and diprovirins: novel θ-defensin analogs with potent activity against influenza A virus.

Doss M, Ruchala P, Tecle T, Gantz D, Verma A, Hartshorn A, Crouch EC, Luong H, Micewicz ED, Lehrer RI, Hartshorn KL.

J Immunol. 2012 Mar 15;188(6):2759-68. doi: 10.4049/jimmunol.1101335. Epub 2012 Feb 15.

5.

Sometimes it takes two to tango: contributions of dimerization to functions of human α-defensin HNP1 peptide.

Pazgier M, Wei G, Ericksen B, Jung G, Wu Z, de Leeuw E, Yuan W, Szmacinski H, Lu WY, Lubkowski J, Lehrer RI, Lu W.

J Biol Chem. 2012 Mar 16;287(12):8944-53. doi: 10.1074/jbc.M111.332205. Epub 2012 Jan 23.

6.

α-Defensins in human innate immunity.

Lehrer RI, Lu W.

Immunol Rev. 2012 Jan;245(1):84-112. doi: 10.1111/j.1600-065X.2011.01082.x. Review.

PMID:
22168415
7.

Humanized theta-defensins (retrocyclins) enhance macrophage performance and protect mice from experimental anthrax infections.

Welkos S, Cote CK, Hahn U, Shastak O, Jedermann J, Bozue J, Jung G, Ruchala P, Pratikhya P, Tang T, Lehrer RI, Beyer W.

Antimicrob Agents Chemother. 2011 Sep;55(9):4238-50. doi: 10.1128/AAC.00267-11. Epub 2011 Jul 18.

8.

Immunology: Peptide gets in shape for self-defence.

Lehrer RI.

Nature. 2011 Jan 20;469(7330):309-10. doi: 10.1038/469309a. No abstract available.

PMID:
21248835
9.

Inerolysin, a cholesterol-dependent cytolysin produced by Lactobacillus iners.

Rampersaud R, Planet PJ, Randis TM, Kulkarni R, Aguilar JL, Lehrer RI, Ratner AJ.

J Bacteriol. 2011 Mar;193(5):1034-41. doi: 10.1128/JB.00694-10. Epub 2010 Dec 17.

10.

Defensins enable macrophages to inhibit the intracellular proliferation of Listeria monocytogenes.

Arnett E, Lehrer RI, Pratikhya P, Lu W, Seveau S.

Cell Microbiol. 2011 Apr;13(4):635-51. doi: 10.1111/j.1462-5822.2010.01563.x. Epub 2011 Jan 13.

PMID:
21143570
11.

The formulated microbicide RC-101 was safe and antivirally active following intravaginal application in pigtailed macaques.

Cole AM, Patton DL, Rohan LC, Cole AL, Cosgrove-Sweeney Y, Rogers NA, Ratner D, Sassi AB, Lackman-Smith C, Tarwater P, Ramratnam B, Ruchala P, Lehrer RI, Waring AJ, Gupta P.

PLoS One. 2010 Nov 29;5(11):e15111. doi: 10.1371/journal.pone.0015111.

12.

Oxpholipin 11D: an anti-inflammatory peptide that binds cholesterol and oxidized phospholipids.

Ruchala P, Navab M, Jung CL, Hama-Levy S, Micewicz ED, Luong H, Reyles JE, Sharma S, Waring AJ, Fogelman AM, Lehrer RI.

PLoS One. 2010 Apr 14;5(4):e10181. doi: 10.1371/journal.pone.0010181.

13.

Trp-26 imparts functional versatility to human alpha-defensin HNP1.

Wei G, Pazgier M, de Leeuw E, Rajabi M, Li J, Zou G, Jung G, Yuan W, Lu WY, Lehrer RI, Lu W.

J Biol Chem. 2010 May 21;285(21):16275-85. doi: 10.1074/jbc.M110.102749. Epub 2010 Mar 10.

14.

De novo sequencing of two new cyclic theta-defensins from baboon (Papio hamadryas) leukocytes by matrix-assisted laser desorption/ionization mass spectrometry.

Stegemann C, Tsvetkova EV, Aleshina GM, Lehrer RI, Kokryakov VN, Hoffmann R.

Rapid Commun Mass Spectrom. 2010 Mar 15;24(5):599-604. doi: 10.1002/rcm.4424.

PMID:
20155756
15.

Antimicrobial mechanism of pore-forming protegrin peptides: 100 pores to kill E. coli.

Bolintineanu D, Hazrati E, Davis HT, Lehrer RI, Kaznessis YN.

Peptides. 2010 Jan;31(1):1-8. doi: 10.1016/j.peptides.2009.11.010. Epub 2009 Nov 30.

16.

Through the looking glass, mechanistic insights from enantiomeric human defensins.

Wei G, de Leeuw E, Pazgier M, Yuan W, Zou G, Wang J, Ericksen B, Lu WY, Lehrer RI, Lu W.

J Biol Chem. 2009 Oct 16;284(42):29180-92. doi: 10.1074/jbc.M109.018085. Epub 2009 Jul 29.

17.

Antimicrobial host defense peptides in an arteriviral infection: differential peptide expression and virus inactivation.

Sang Y, Ruchala P, Lehrer RI, Ross CR, Rowland RR, Blecha F.

Viral Immunol. 2009 Jul;22(4):235-42. doi: 10.1089/vim.2009.0005.

18.

Human alpha-defensins inhibit hemolysis mediated by cholesterol-dependent cytolysins.

Lehrer RI, Jung G, Ruchala P, Wang W, Micewicz ED, Waring AJ, Gillespie EJ, Bradley KA, Ratner AJ, Rest RF, Lu W.

Infect Immun. 2009 Sep;77(9):4028-40. doi: 10.1128/IAI.00232-09. Epub 2009 Jul 6.

19.

Multivalent binding of carbohydrates by the human alpha-defensin, HD5.

Lehrer RI, Jung G, Ruchala P, Andre S, Gabius HJ, Lu W.

J Immunol. 2009 Jul 1;183(1):480-90. doi: 10.4049/jimmunol.0900244.

20.

Interactions of alpha-, beta-, and theta-defensins with influenza A virus and surfactant protein D.

Doss M, White MR, Tecle T, Gantz D, Crouch EC, Jung G, Ruchala P, Waring AJ, Lehrer RI, Hartshorn KL.

J Immunol. 2009 Jun 15;182(12):7878-87. doi: 10.4049/jimmunol.0804049.

21.

Reawakening retrocyclins: ancestral human defensins active against HIV-1.

Venkataraman N, Cole AL, Ruchala P, Waring AJ, Lehrer RI, Stuchlik O, Pohl J, Cole AM.

PLoS Biol. 2009 Apr 28;7(4):e95. doi: 10.1371/journal.pbio.1000095.

22.

Retrocyclin-2: a potent anti-HIV theta-defensin that forms a cyclic cystine ladder structural motif.

Daly NL, Chen YK, Rosengren KJ, Marx UC, Phillips ML, Waring AJ, Wang W, Lehrer RI, Craik DJ.

Adv Exp Med Biol. 2009;611:577-8. No abstract available.

PMID:
19400321
23.

A novel method for oral delivery of apolipoprotein mimetic peptides synthesized from all L-amino acids.

Navab M, Ruchala P, Waring AJ, Lehrer RI, Hama S, Hough G, Palgunachari MN, Anantharamaiah GM, Fogelman AM.

J Lipid Res. 2009 Aug;50(8):1538-47. doi: 10.1194/jlr.M800539-JLR200. Epub 2009 Feb 18.

24.

Induction of group A Streptococcus virulence by a human antimicrobial peptide.

Gryllos I, Tran-Winkler HJ, Cheng MF, Chung H, Bolcome R 3rd, Lu W, Lehrer RI, Wessels MR.

Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16755-60. doi: 10.1073/pnas.0803815105. Epub 2008 Oct 20.

25.

Anti-inflammatory apoA-I-mimetic peptides bind oxidized lipids with much higher affinity than human apoA-I.

Van Lenten BJ, Wagner AC, Jung CL, Ruchala P, Waring AJ, Lehrer RI, Watson AD, Hama S, Navab M, Anantharamaiah GM, Fogelman AM.

J Lipid Res. 2008 Nov;49(11):2302-11. doi: 10.1194/jlr.M800075-JLR200. Epub 2008 Jul 11. Erratum in: J Lipid Res. 2008 Dec;49(12):2698.

26.

Correlation between simulated physicochemical properties and hemolycity of protegrin-like antimicrobial peptides: predicting experimental toxicity.

Langham AA, Khandelia H, Schuster B, Waring AJ, Lehrer RI, Kaznessis YN.

Peptides. 2008 Jul;29(7):1085-93. doi: 10.1016/j.peptides.2008.03.018. Epub 2008 Mar 28.

27.

Dual mechanism of bacterial lethality for a cationic sequence-random copolymer that mimics host-defense antimicrobial peptides.

Epand RF, Mowery BP, Lee SE, Stahl SS, Lehrer RI, Gellman SH, Epand RM.

J Mol Biol. 2008 May 23;379(1):38-50. doi: 10.1016/j.jmb.2008.03.047. Epub 2008 Mar 28.

PMID:
18440552
28.

Effects of guanidinium-phosphate hydrogen bonding on the membrane-bound structure and activity of an arginine-rich membrane peptide from solid-state NMR spectroscopy.

Tang M, Waring AJ, Lehrer RI, Hong M.

Angew Chem Int Ed Engl. 2008;47(17):3202-5. doi: 10.1002/anie.200705993. No abstract available.

PMID:
18338418
29.

Retrocyclin RC-101 overcomes cationic mutations on the heptad repeat 2 region of HIV-1 gp41.

Fuhrman CA, Warren AD, Waring AJ, Dutz SM, Sharma S, Lehrer RI, Cole AL, Cole AM.

FEBS J. 2007 Dec;274(24):6477-87. Epub 2007 Nov 19.

30.

Evaluation of a theta-defensin in a Murine model of herpes simplex virus type 1 keratitis.

Brandt CR, Akkarawongsa R, Altmann S, Jose G, Kolb AW, Waring AJ, Lehrer RI.

Invest Ophthalmol Vis Sci. 2007 Nov;48(11):5118-24.

PMID:
17962464
31.

alpha-Defensin inhibits influenza virus replication by cell-mediated mechanism(s).

Salvatore M, Garcia-Sastre A, Ruchala P, Lehrer RI, Chang T, Klotman ME.

J Infect Dis. 2007 Sep 15;196(6):835-43. Epub 2007 Aug 10.

PMID:
17703413
32.

Retrocyclin-2: structural analysis of a potent anti-HIV theta-defensin.

Daly NL, Chen YK, Rosengren KJ, Marx UC, Phillips ML, Waring AJ, Wang W, Lehrer RI, Craik DJ.

Biochemistry. 2007 Sep 4;46(35):9920-8. Epub 2007 Aug 8.

PMID:
17685559
33.

Paradoxical effects of two theta-defensins on HIV type 1 infection.

Wang Q, Wang W, Zheng J, Tabibian S, Xie Y, Song J, Waring AJ, Chiu R, Yang OO, Chen IS, Lehrer RI, Pang S.

AIDS Res Hum Retroviruses. 2007 Apr;23(4):508-14.

PMID:
17506607
34.

Avian beta-defensin nomenclature: a community proposed update.

Lynn DJ, Higgs R, Lloyd AT, O'Farrelly C, Hervé-Grépinet V, Nys Y, Brinkman FS, Yu PL, Soulier A, Kaiser P, Zhang G, Lehrer RI.

Immunol Lett. 2007 May 15;110(1):86-9. Epub 2007 Apr 23. No abstract available.

PMID:
17467809
35.

The innate immune system: a repository for future drugs?

Sambhara S, Lehrer RI.

Expert Rev Anti Infect Ther. 2007 Feb;5(1):1-5. No abstract available.

PMID:
17266447
36.

The retrocyclin analogue RC-101 prevents human immunodeficiency virus type 1 infection of a model human cervicovaginal tissue construct.

Cole AL, Herasimtschuk A, Gupta P, Waring AJ, Lehrer RI, Cole AM.

Immunology. 2007 May;121(1):140-5. Epub 2007 Jan 23.

37.

Human alpha- and beta-defensins block multiple steps in herpes simplex virus infection.

Hazrati E, Galen B, Lu W, Wang W, Ouyang Y, Keller MJ, Lehrer RI, Herold BC.

J Immunol. 2006 Dec 15;177(12):8658-66.

38.

Multispecific myeloid defensins.

Lehrer RI.

Curr Opin Hematol. 2007 Jan;14(1):16-21. Review.

PMID:
17133095
39.

Membrane-dependent oligomeric structure and pore formation of a beta-hairpin antimicrobial peptide in lipid bilayers from solid-state NMR.

Mani R, Cady SD, Tang M, Waring AJ, Lehrer RI, Hong M.

Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16242-7. Epub 2006 Oct 23.

40.

Mechanism of supported membrane disruption by antimicrobial peptide protegrin-1.

Lam KL, Ishitsuka Y, Cheng Y, Chien K, Waring AJ, Lehrer RI, Lee KY.

J Phys Chem B. 2006 Oct 26;110(42):21282-6.

PMID:
17048957
41.

Insertion selectivity of antimicrobial peptide protegrin-1 into lipid monolayers: effect of head group electrostatics and tail group packing.

Ishitsuka Y, Pham DS, Waring AJ, Lehrer RI, Lee KY.

Biochim Biophys Acta. 2006 Sep;1758(9):1450-60. Epub 2006 Aug 5.

42.

alpha-Defensins from blood leukocytes of the monkey Papio hamadryas.

Tsvetkova EV, Aleshina GM, Shamova OV, Leonova LE, Lehrer RI, Kokryakov VN.

Biochemistry (Mosc). 2006 Aug;71(8):879-83.

PMID:
16978151
43.

Retrocyclins kill bacilli and germinating spores of Bacillus anthracis and inactivate anthrax lethal toxin.

Wang W, Mulakala C, Ward SC, Jung G, Luong H, Pham D, Waring AJ, Kaznessis Y, Lu W, Bradley KA, Lehrer RI.

J Biol Chem. 2006 Oct 27;281(43):32755-64. Epub 2006 Jun 21.

44.

HIV-1 adapts to a retrocyclin with cationic amino acid substitutions that reduce fusion efficiency of gp41.

Cole AL, Yang OO, Warren AD, Waring AJ, Lehrer RI, Cole AM.

J Immunol. 2006 Jun 1;176(11):6900-5.

45.

Theta-defensins prevent HIV-1 Env-mediated fusion by binding gp41 and blocking 6-helix bundle formation.

Gallo SA, Wang W, Rawat SS, Jung G, Waring AJ, Cole AM, Lu H, Yan X, Daly NL, Craik DJ, Jiang S, Lehrer RI, Blumenthal R.

J Biol Chem. 2006 Jul 7;281(27):18787-92. Epub 2006 Apr 28.

46.

Orientation of a beta-hairpin antimicrobial peptide in lipid bilayers from two-dimensional dipolar chemical-shift correlation NMR.

Tang M, Waring AJ, Lehrer RI, Hong M.

Biophys J. 2006 May 15;90(10):3616-24. Epub 2006 Feb 24.

47.

Cervicovaginal secretions contribute to innate resistance to herpes simplex virus infection.

John M, Keller MJ, Fam EH, Cheshenko N, Hogarty K, Kasowitz A, Wallenstein S, Carlucci MJ, Tuyama AC, Lu W, Klotman ME, Lehrer RI, Herold BC.

J Infect Dis. 2005 Nov 15;192(10):1731-40. Epub 2005 Oct 13.

PMID:
16235171
48.

Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus.

Mygind PH, Fischer RL, Schnorr KM, Hansen MT, Sönksen CP, Ludvigsen S, Raventós D, Buskov S, Christensen B, De Maria L, Taboureau O, Yaver D, Elvig-Jørgensen SG, Sørensen MV, Christensen BE, Kjaerulff S, Frimodt-Moller N, Lehrer RI, Zasloff M, Kristensen HH.

Nature. 2005 Oct 13;437(7061):975-80.

PMID:
16222292
49.
50.

Carbohydrate-binding molecules inhibit viral fusion and entry by crosslinking membrane glycoproteins.

Leikina E, Delanoe-Ayari H, Melikov K, Cho MS, Chen A, Waring AJ, Wang W, Xie Y, Loo JA, Lehrer RI, Chernomordik LV.

Nat Immunol. 2005 Oct;6(10):995-1001. Epub 2005 Sep 11.

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