Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 164

1.

Fatty Liver Due to Increased de novo Lipogenesis: Alterations in the Hepatic Peroxisomal Proteome.

Knebel B, Fahlbusch P, Dille M, Wahlers N, Hartwig S, Jacob S, Kettel U, Schiller M, Herebian D, Koellmer C, Lehr S, Müller-Wieland D, Kotzka J.

Front Cell Dev Biol. 2019 Oct 25;7:248. doi: 10.3389/fcell.2019.00248. eCollection 2019.

2.

Successful combination therapy of systemic checkpoint inhibitors and intralesional interleukin-2 in patients with metastatic melanoma with primary therapeutic resistance to checkpoint inhibitors alone.

Rafei-Shamsabadi D, Lehr S, von Bubnoff D, Meiss F.

Cancer Immunol Immunother. 2019 Sep;68(9):1417-1428. doi: 10.1007/s00262-019-02377-x. Epub 2019 Aug 17.

PMID:
31422446
3.

Identification of the Secreted Proteins Originated from Primary Human Hepatocytes and HepG2 Cells.

Franko A, Hartwig S, Kotzka J, Ruoß M, Nüssler AK, Königsrainer A, Häring HU, Lehr S, Peter A.

Nutrients. 2019 Aug 3;11(8). pii: E1795. doi: 10.3390/nu11081795.

4.

Decreased M1 macrophage polarization in dabigatran-treated Ldlr-deficient mice: Implications for atherosclerosis and adipose tissue inflammation.

Feldmann K, Grandoch M, Kohlmorgen C, Valentin B, Gerfer S, Nagy N, Hartwig S, Lehr S, Fender AC, Fischer JW.

Atherosclerosis. 2019 Aug;287:81-88. doi: 10.1016/j.atherosclerosis.2019.06.897. Epub 2019 Jun 8.

PMID:
31233979
5.

Adipokinome Signatures in Obese Mouse Models Reflect Adipose Tissue Health and Are Associated with Serum Lipid Composition.

Knebel B, Fahlbusch P, Poschmann G, Dille M, Wahlers N, Stühler K, Hartwig S, Lehr S, Schiller M, Jacob S, Kettel U, Müller-Wieland D, Kotzka J.

Int J Mol Sci. 2019 May 24;20(10). pii: E2559. doi: 10.3390/ijms20102559.

6.

Cardiac Hyaluronan Synthesis Is Critically Involved in the Cardiac Macrophage Response and Promotes Healing After Ischemia Reperfusion Injury.

Petz A, Grandoch M, Gorski DJ, Abrams M, Piroth M, Schneckmann R, Homann S, Müller J, Hartwig S, Lehr S, Yamaguchi Y, Wight TN, Gorressen S, Ding Z, Kötter S, Krüger M, Heinen A, Kelm M, Gödecke A, Flögel U, Fischer JW.

Circ Res. 2019 May 10;124(10):1433-1447. doi: 10.1161/CIRCRESAHA.118.313285.

PMID:
30916618
7.

Abscisic Acid Receptors and Coreceptors Modulate Plant Water Use Efficiency and Water Productivity.

Yang Z, Liu J, Poree F, Schaeufele R, Helmke H, Frackenpohl J, Lehr S, von Koskull-Döring P, Christmann A, Schnyder H, Schmidhalter U, Grill E.

Plant Physiol. 2019 Jun;180(2):1066-1080. doi: 10.1104/pp.18.01238. Epub 2019 Mar 18.

8.

The WNT10B Network Is Associated with Survival and Metastases in Chemoresistant Triple-Negative Breast Cancer.

El Ayachi I, Fatima I, Wend P, Alva-Ornelas JA, Runke S, Kuenzinger WL, Silva J, Silva W, Gray JK, Lehr S, Barch HC, Krutilina RI, White AC, Cardiff R, Yee LD, Yang L, O'Regan RM, Lowry WE, Seagroves TN, Seewaldt V, Krum SA, Miranda-Carboni GA.

Cancer Res. 2019 Mar 1;79(5):982-993. doi: 10.1158/0008-5472.CAN-18-1069. Epub 2018 Dec 18.

PMID:
30563890
9.

Exosomal proteins constitute an essential part of the human adipose tissue secretome.

Hartwig S, De Filippo E, Göddeke S, Knebel B, Kotzka J, Al-Hasani H, Roden M, Lehr S, Sell H.

Biochim Biophys Acta Proteins Proteom. 2019 Dec;1867(12):140172. doi: 10.1016/j.bbapap.2018.11.009. Epub 2018 Nov 28.

PMID:
30502511
10.

AKT and AMP-activated protein kinase regulate TBC1D1 through phosphorylation and its interaction with the cytosolic tail of insulin-regulated aminopeptidase IRAP.

Mafakheri S, Flörke RR, Kanngießer S, Hartwig S, Espelage L, De Wendt C, Schönberger T, Hamker N, Lehr S, Chadt A, Al-Hasani H.

J Biol Chem. 2018 Nov 16;293(46):17853-17862. doi: 10.1074/jbc.RA118.005040. Epub 2018 Oct 1.

11.

Dissociation of Fatty Liver and Insulin Resistance in I148M PNPLA3 Carriers: Differences in Diacylglycerol (DAG) FA18:1 Lipid Species as a Possible Explanation.

Franko A, Merkel D, Kovarova M, Hoene M, Jaghutriz BA, Heni M, Königsrainer A, Papan C, Lehr S, Häring HU, Peter A.

Nutrients. 2018 Sep 17;10(9). pii: E1314. doi: 10.3390/nu10091314.

12.

Aβ Oligomer Elimination Restores Cognition in Transgenic Alzheimer's Mice with Full-blown Pathology.

Schemmert S, Schartmann E, Zafiu C, Kass B, Hartwig S, Lehr S, Bannach O, Langen KJ, Shah NJ, Kutzsche J, Willuweit A, Willbold D.

Mol Neurobiol. 2019 Mar;56(3):2211-2223. doi: 10.1007/s12035-018-1209-3. Epub 2018 Jul 12.

13.

FGF21 regulates insulin sensitivity following long-term chronic stress.

Jelenik T, Dille M, Müller-Lühlhoff S, Kabra DG, Zhou Z, Binsch C, Hartwig S, Lehr S, Chadt A, Peters EMJ, Kruse J, Roden M, Al-Hasani H, Castañeda TR.

Mol Metab. 2018 Oct;16:126-138. doi: 10.1016/j.molmet.2018.06.012. Epub 2018 Jun 20.

14.

Inactivation of SREBP-1a Phosphorylation Prevents Fatty Liver Disease in Mice: Identification of Related Signaling Pathways by Gene Expression Profiles in Liver and Proteomes of Peroxisomes.

Knebel B, Hartwig S, Jacob S, Kettel U, Schiller M, Passlack W, Koellmer C, Lehr S, Müller-Wieland D, Kotzka J.

Int J Mol Sci. 2018 Mar 25;19(4). pii: E980. doi: 10.3390/ijms19040980.

15.

Activation of neutrophils by Chlamydia trachomatis-infected epithelial cells is modulated by the chlamydial plasmid.

Lehr S, Vier J, Häcker G, Kirschnek S.

Microbes Infect. 2018 May;20(5):284-292. doi: 10.1016/j.micinf.2018.02.007. Epub 2018 Mar 2.

PMID:
29499390
16.

CDH13 abundance interferes with adipocyte differentiation and is a novel biomarker for adipose tissue health.

Göddeke S, Knebel B, Fahlbusch P, Hörbelt T, Poschmann G, van de Velde F, Benninghoff T, Al-Hasani H, Jacob S, Van Nieuwenhove Y, Lapauw B, Lehr S, Ouwens DM, Kotzka J.

Int J Obes (Lond). 2018 Jun;42(5):1039-1050. doi: 10.1038/s41366-018-0022-4. Epub 2018 Feb 21.

PMID:
29467502
17.

Absence of the kinase S6k1 mimics the effect of chronic endurance exercise on glucose tolerance and muscle oxidative stress.

Binsch C, Jelenik T, Pfitzer A, Dille M, Müller-Lühlhoff S, Hartwig S, Karpinski S, Lehr S, Kabra DG, Chadt A, Roden M, Al-Hasani H, Castañeda TR.

Mol Metab. 2017 Nov;6(11):1443-1453. doi: 10.1016/j.molmet.2017.08.008. Epub 2017 Aug 25.

18.

Alteration of Liver Peroxisomal and Mitochondrial Functionality in the NZO Mouse Model of Metabolic Syndrome.

Knebel B, Göddeke S, Hartwig S, Hörbelt T, Fahlbusch P, Al-Hasani H, Jacob S, Koellmer C, Nitzgen U, Schiller M, Lehr S, Kotzka J.

Proteomics Clin Appl. 2018 Jan;12(1). doi: 10.1002/prca.201700028. Epub 2017 Dec 11.

PMID:
29068532
19.

Hyaluronan synthase 3 promotes plaque inflammation and atheroprogression.

Homann S, Grandoch M, Kiene LS, Podsvyadek Y, Feldmann K, Rabausch B, Nagy N, Lehr S, Kretschmer I, Oberhuber A, Bollyky P, Fischer JW.

Matrix Biol. 2018 Mar;66:67-80. doi: 10.1016/j.matbio.2017.09.005. Epub 2017 Oct 5.

20.

EB1 protein alteration characterizes sporadic but not ulcerative colitis associated colorectal cancer.

Gemoll T, Kollbeck SL, Karstens KF, Hò GG, Hartwig S, Strohkamp S, Schillo K, Thorns C, Oberländer M, Kalies K, Lehr S, Habermann JK.

Oncotarget. 2017 Jul 4;8(33):54939-54950. doi: 10.18632/oncotarget.18978. eCollection 2017 Aug 15.

21.

Characterization of the Epicardial Adipose Tissue in Decellularized Human-Scaled Whole Hearts: Implications for the Whole-Heart Tissue Engineering.

Akhyari P, Oberle F, Hülsmann J, Heid H, Lehr S, Barbian A, Nakanishi S, Aubin H, Jenke A, Lichtenberg A.

Tissue Eng Part A. 2018 Apr;24(7-8):682-693. doi: 10.1089/ten.tea.2017.0107. Epub 2018 Mar 13.

PMID:
28895502
22.

Novel Insights into the Adipokinome of Obese and Obese/Diabetic Mouse Models.

Knebel B, Goeddeke S, Poschmann G, Markgraf DF, Jacob S, Nitzgen U, Passlack W, Preuss C, Dicken HD, Stühler K, Hartwig S, Lehr S, Kotzka J.

Int J Mol Sci. 2017 Sep 8;18(9). pii: E1928. doi: 10.3390/ijms18091928.

23.

Protein levels of clusterin and glutathione synthetase in platelets allow for early detection of colorectal cancer.

Strohkamp S, Gemoll T, Humborg S, Hartwig S, Lehr S, Freitag-Wolf S, Becker S, Franzén B, Pries R, Wollenberg B, Roblick UJ, Bruch HP, Keck T, Auer G, Habermann JK.

Cell Mol Life Sci. 2018 Jan;75(2):323-334. doi: 10.1007/s00018-017-2631-9. Epub 2017 Aug 28.

PMID:
28849249
24.

Long-Term Cold Adaptation Does Not Require FGF21 or UCP1.

Keipert S, Kutschke M, Ost M, Schwarzmayr T, van Schothorst EM, Lamp D, Brachthäuser L, Hamp I, Mazibuko SE, Hartwig S, Lehr S, Graf E, Plettenburg O, Neff F, Tschöp MH, Jastroch M.

Cell Metab. 2017 Aug 1;26(2):437-446.e5. doi: 10.1016/j.cmet.2017.07.016.

25.

The Inverted Heart Model for Interstitial Transudate Collection from the Isolated Rat Heart.

Tan K, Ding Z, Steckel B, Hartwig S, Lehr S, Deng X, Schrader J.

J Vis Exp. 2017 Jun 20;(124). doi: 10.3791/55849.

26.

Mechanisms of Insulin Resistance in Primary and Secondary Nonalcoholic Fatty Liver.

Jelenik T, Kaul K, Séquaris G, Flögel U, Phielix E, Kotzka J, Knebel B, Fahlbusch P, Hörbelt T, Lehr S, Reinbeck AL, Müller-Wieland D, Esposito I, Shulman GI, Szendroedi J, Roden M.

Diabetes. 2017 Aug;66(8):2241-2253. doi: 10.2337/db16-1147. Epub 2017 May 10.

27.

Differential Patterns of Impaired Cardiorespiratory Fitness and Cardiac Autonomic Dysfunction in Recently Diagnosed Type 1 and Type 2 Diabetes.

Röhling M, Strom A, Bönhof G, Püttgen S, Bódis K, Müssig K, Szendrödi J, Markgraf D, Lehr S, Roden M, Ziegler D; German Diabetes Study Group.

Diabetes Care. 2017 Feb;40(2):246-252. doi: 10.2337/dc16-1898. Epub 2016 Nov 29.

PMID:
27899499
28.

Association between copy-number variation on metabolic phenotypes and HDL-C levels in patients with polycystic ovary syndrome.

Knebel B, Lehr S, Janssen OE, Hahn S, Jacob S, Nitzgen U, Müller-Wieland D, Kotzka J.

Mol Biol Rep. 2017 Feb;44(1):51-61. doi: 10.1007/s11033-016-4080-1. Epub 2016 Nov 22.

PMID:
27878529
29.

Lipidomics-Reshaping the Analysis and Perception of Type 2 Diabetes.

Markgraf DF, Al-Hasani H, Lehr S.

Int J Mol Sci. 2016 Nov 4;17(11). pii: E1841. Review.

30.

Mass spectrometry in life science research.

Lehr S, Markgraf D.

Arch Physiol Biochem. 2016 Dec;122(5):235. Epub 2016 Nov 3.

PMID:
27808565
31.

Oxygen and differentiation status modulate the effect of X-ray irradiation on physiology and mitochondrial proteome of human neuroblastoma cells.

Džinić T, Hartwig S, Lehr S, Dencher NA.

Arch Physiol Biochem. 2016 Dec;122(5):257-265. Epub 2016 Sep 10.

PMID:
27615280
32.

Impact of fibroblast growth factor 21 on the secretome of human perivascular preadipocytes and adipocytes: a targeted proteomics approach.

Berti L, Hartwig S, Irmler M, Rädle B, Siegel-Axel D, Beckers J, Lehr S, Al-Hasani H, Häring HU, Hrabě de Angelis M, Staiger H.

Arch Physiol Biochem. 2016 Dec;122(5):281-288. Epub 2016 Aug 5.

PMID:
27494767
33.

Native DIGE proteomic analysis of mitochondria from substantia nigra and striatum during neuronal degeneration and its compensation in an animal model of early Parkinson's disease.

Kuter K, Kratochwil M, Marx SH, Hartwig S, Lehr S, Sugawa MD, Dencher NA.

Arch Physiol Biochem. 2016 Dec;122(5):238-256. Epub 2016 Jul 28.

PMID:
27467289
34.

Untargeted mass spectrometric approach in metabolic healthy offspring of patients with type 2 diabetes reveals medium-chain acylcarnitine as potential biomarker for lipid induced glucose intolerance (LGIT).

Knebel B, Mack S, Lehr S, Barsch A, Schiller M, Haas J, Lange S, Fuchser J, Zurek G, Müller-Wieland D, Kotzka J.

Arch Physiol Biochem. 2016 Dec;122(5):266-280. Epub 2016 Jul 2.

PMID:
27373781
35.

Creative Strategies to Enhance Students' Classroom Learning in Mental Health.

Lehr S, Schlenger A.

J Psychosoc Nurs Ment Health Serv. 2016 May 1;54(5):41-8. doi: 10.3928/02793695-20160420-06.

PMID:
27135893
36.

Specific Metabolic Profiles and Their Relationship to Insulin Resistance in Recent-Onset Type 1 and Type 2 Diabetes.

Knebel B, Strassburger K, Szendroedi J, Kotzka J, Scheer M, Nowotny B, Müssig K, Lehr S, Pacini G, Finner H, Klüppelholz B, Giani G, Al-Hasani H, Roden M; German Diabetes Study Group.

J Clin Endocrinol Metab. 2016 May;101(5):2130-40. doi: 10.1210/jc.2015-4133. Epub 2016 Feb 1.

PMID:
26829444
37.

Deletion of Hyaluronan Synthase 3 Inhibits Neointimal Hyperplasia in Mice.

Kiene LS, Homann S, Suvorava T, Rabausch B, Müller J, Kojda G, Kretschmer I, Twarock S, Dai G, Deenen R, Hartwig S, Lehr S, Köhrer K, Savani RC, Grandoch M, Fischer JW.

Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):e9-16. doi: 10.1161/ATVBAHA.115.306607. Epub 2015 Nov 19.

38.

Increased cathepsin D protein expression is a biomarker for osteosarcomas, pulmonary metastases and other bone malignancies.

Gemoll T, Epping F, Heinrich L, Fritzsche B, Roblick UJ, Szymczak S, Hartwig S, Depping R, Bruch HP, Thorns C, Lehr S, Paech A, Habermann JK.

Oncotarget. 2015 Jun 30;6(18):16517-26.

39.

Deep serum discoveries: SDF-1α and HSA fragments in myelodysplastic syndromes.

Fröbel J, Hartwig S, Jourdain S, Fischer JC, Zilkens C, Kündgen A, Suckau D, Germing U, Czibere A, Lehr S.

Am J Hematol. 2015 Sep;90(9):E185-7. doi: 10.1002/ajh.24070. Epub 2015 Jul 27. No abstract available.

40.

Methods for proteomics-based analysis of the human muscle secretome using an in vitro exercise model.

Scheler M, de Angelis MH, Al-Hasani H, Häring HU, Weigert C, Lehr S.

Methods Mol Biol. 2015;1295:55-64. doi: 10.1007/978-1-4939-2550-6_5.

PMID:
25820713
41.

Investigating the adipose tissue secretome: a protocol to generate high-quality samples appropriate for comprehensive proteomic profiling.

Göddeke S, Kotzka J, Lehr S.

Methods Mol Biol. 2015;1295:43-53. doi: 10.1007/978-1-4939-2550-6_4.

PMID:
25820712
42.

Peroxisomes compensate hepatic lipid overflow in mice with fatty liver.

Knebel B, Hartwig S, Haas J, Lehr S, Goeddeke S, Susanto F, Bohne L, Jacob S, Koellmer C, Nitzgen U, Müller-Wieland D, Kotzka J.

Biochim Biophys Acta. 2015 Jul;1851(7):965-76. doi: 10.1016/j.bbalip.2015.03.003. Epub 2015 Mar 17.

PMID:
25790917
43.

Deficiency in lymphotoxin β receptor protects from atherosclerosis in apoE-deficient mice.

Grandoch M, Feldmann K, Göthert JR, Dick LS, Homann S, Klatt C, Bayer JK, Waldheim JN, Rabausch B, Nagy N, Oberhuber A, Deenen R, Köhrer K, Lehr S, Homey B, Pfeffer K, Fischer JW.

Circ Res. 2015 Apr 10;116(8):e57-68. doi: 10.1161/CIRCRESAHA.116.305723. Epub 2015 Mar 4.

PMID:
25740843
44.

Isolation and quality control of functional mitochondria.

Hartwig S, Kotzka J, Lehr S.

Methods Mol Biol. 2015;1264:9-23. doi: 10.1007/978-1-4939-2257-4_2.

PMID:
25630999
45.

Preparation of "functional" mitochondria: a challenging business.

Lehr S, Hartwig S, Kotzka J.

Methods Mol Biol. 2015;1264:1-8. doi: 10.1007/978-1-4939-2257-4_1. Review.

PMID:
25630998
46.

Phosphorylation of sterol regulatory element-binding protein (SREBP)-1c by p38 kinases, ERK and JNK influences lipid metabolism and the secretome of human liver cell line HepG2.

Knebel B, Lehr S, Hartwig S, Haas J, Kaber G, Dicken HD, Susanto F, Bohne L, Jacob S, Nitzgen U, Passlack W, Muller-Wieland D, Kotzka J.

Arch Physiol Biochem. 2014 Dec;120(5):216-27. doi: 10.3109/13813455.2014.973418.

PMID:
25353341
47.

Proteomics in practice.

Lehr S.

Arch Physiol Biochem. 2014 Dec;120(5):167. doi: 10.3109/13813455.2014.973419. No abstract available.

PMID:
25353340
48.

Identification of novel adipokines differential regulated in C57BL/Ks and C57BL/6.

Hartwig S, Goeddeke S, Poschmann G, Dicken HD, Jacob S, Nitzgen U, Passlack W, Stühler K, Ouwens DM, Al-Hasani H, Knebel B, Kotzka J, Lehr S.

Arch Physiol Biochem. 2014 Dec;120(5):208-15. doi: 10.3109/13813455.2014.970197. Epub 2014 Oct 16.

PMID:
25319219
49.

Interleukin-6-dependent phenotypic modulation of cardiac fibroblasts after acute myocardial infarction.

Müller J, Gorressen S, Grandoch M, Feldmann K, Kretschmer I, Lehr S, Ding Z, Schmitt JP, Schrader J, Garbers C, Heusch G, Kelm M, Scheller J, Fischer JW.

Basic Res Cardiol. 2014;109(6):440. doi: 10.1007/s00395-014-0440-y. Epub 2014 Sep 19.

PMID:
25236954
50.

The inter-individual variability outperforms the intra-individual variability of differentially expressed proteins prior and post irradiation in lymphoblastoid cell lines.

Gürtler A, Hauptmann M, Pautz S, Kulka U, Friedl AA, Lehr S, Hornhardt S, Gomolka M.

Arch Physiol Biochem. 2014 Dec;120(5):198-207. doi: 10.3109/13813455.2014.953548. Epub 2014 Sep 1.

PMID:
25174346

Supplemental Content

Support Center