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Items: 1 to 50 of 105

1.

Author Correction: Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening.

Machutta CA, Kollmann CS, Lind KE, Bai X, Chan PF, Huang J, Ballell L, Belyanskaya S, Besra GS, Barros-Aguirre D, Bates RH, Centrella PA, Chang SS, Chai J, Choudhry AE, Coffin A, Davie CP, Deng H, Deng J, Ding Y, Dodson JW, Fosbenner DT, Gao EN, Graham TL, Graybill TL, Ingraham K, Johnson WP, King BW, Kwiatkowski CR, Lelièvre J, Li Y, Liu X, Lu Q, Lehr R, Mendoza-Losana A, Martin J, McCloskey L, McCormick P, O'Keefe HP, O'Keeffe T, Pao C, Phelps CB, Qi H, Rafferty K, Scavello GS, Steiginga MS, Sundersingh FS, Sweitzer SM, Szewczuk LM, Taylor A, Fern Toh M, Wang J, Wang M, Wilkins DJ, Xia B, Yao G, Zhang J, Zhou J, Donahue CP, Messer JA, Holmes D, Arico-Muendel CC, Pope AJ, Gross JW, Evindar G.

Nat Commun. 2018 Jul 13;9:16227. doi: 10.1038/ncomms16227.

2.

Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening.

Machutta CA, Kollmann CS, Lind KE, Bai X, Chan PF, Huang J, Ballell L, Belyanskaya S, Besra GS, Barros-Aguirre D, Bates RH, Centrella PA, Chang SS, Chai J, Choudhry AE, Coffin A, Davie CP, Deng H, Deng J, Ding Y, Dodson JW, Fosbenner DT, Gao EN, Graham TL, Graybill TL, Ingraham K, Johnson WP, King BW, Kwiatkowski CR, Lelièvre J, Li Y, Liu X, Lu Q, Lehr R, Mendoza-Losana A, Martin J, McCloskey L, McCormick P, O'Keefe HP, O'Keeffe T, Pao C, Phelps CB, Qi H, Rafferty K, Scavello GS, Steiginga MS, Sundersingh FS, Sweitzer SM, Szewczuk LM, Taylor A, Toh MF, Wang J, Wang M, Wilkins DJ, Xia B, Yao G, Zhang J, Zhou J, Donahue CP, Messer JA, Holmes D, Arico-Muendel CC, Pope AJ, Gross JW, Evindar G.

Nat Commun. 2017 Jul 17;8:16081. doi: 10.1038/ncomms16081. Erratum in: Nat Commun. 2018 Jul 13;9:16227.

3.

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.

Harris PA, Berger SB, Jeong JU, Nagilla R, Bandyopadhyay D, Campobasso N, Capriotti CA, Cox JA, Dare L, Dong X, Eidam PM, Finger JN, Hoffman SJ, Kang J, Kasparcova V, King BW, Lehr R, Lan Y, Leister LK, Lich JD, MacDonald TT, Miller NA, Ouellette MT, Pao CS, Rahman A, Reilly MA, Rendina AR, Rivera EJ, Schaeffer MC, Sehon CA, Singhaus RR, Sun HH, Swift BA, Totoritis RD, Vossenkämper A, Ward P, Wisnoski DD, Zhang D, Marquis RW, Gough PJ, Bertin J.

J Med Chem. 2017 Feb 23;60(4):1247-1261. doi: 10.1021/acs.jmedchem.6b01751. Epub 2017 Feb 10.

PMID:
28151659
4.

Observational registry of sorafenib use in clinical practice across Child-Pugh subgroups: The GIDEON study.

Marrero JA, Kudo M, Venook AP, Ye SL, Bronowicki JP, Chen XP, Dagher L, Furuse J, Geschwind JH, de Guevara LL, Papandreou C, Takayama T, Sanyal AJ, Yoon SK, Nakajima K, Lehr R, Heldner S, Lencioni R.

J Hepatol. 2016 Dec;65(6):1140-1147. doi: 10.1016/j.jhep.2016.07.020. Epub 2016 Jul 25.

PMID:
27469901
5.

Molecular impacts of perfluorinated chemicals (PFASs) in the liver and testis of male largemouth bass (Micropterus salmoides) in Minnesota Lakes.

Collí-Dulá RC, Martyniuk CJ, Streets S, Denslow ND, Lehr R.

Comp Biochem Physiol Part D Genomics Proteomics. 2016 Sep;19:129-139. doi: 10.1016/j.cbd.2016.02.001. Epub 2016 Feb 6.

PMID:
26907229
6.

Regional differences in sorafenib-treated patients with hepatocellular carcinoma: GIDEON observational study.

Kudo M, Lencioni R, Marrero JA, Venook AP, Bronowicki JP, Chen XP, Dagher L, Furuse J, Geschwind JF, Ladrón de Guevara L, Papandreou C, Sanyal AJ, Takayama T, Yoon SK, Nakajima K, Lehr R, Heldner S, Ye SL.

Liver Int. 2016 Aug;36(8):1196-205. doi: 10.1111/liv.13096. Epub 2016 Apr 1.

PMID:
26901163
7.

DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors.

Harris PA, King BW, Bandyopadhyay D, Berger SB, Campobasso N, Capriotti CA, Cox JA, Dare L, Dong X, Finger JN, Grady LC, Hoffman SJ, Jeong JU, Kang J, Kasparcova V, Lakdawala AS, Lehr R, McNulty DE, Nagilla R, Ouellette MT, Pao CS, Rendina AR, Schaeffer MC, Summerfield JD, Swift BA, Totoritis RD, Ward P, Zhang A, Zhang D, Marquis RW, Bertin J, Gough PJ.

J Med Chem. 2016 Mar 10;59(5):2163-78. doi: 10.1021/acs.jmedchem.5b01898. Epub 2016 Feb 23.

PMID:
26854747
8.

TACE Treatment in Patients with Sorafenib-treated Unresectable Hepatocellular Carcinoma in Clinical Practice: Final Analysis of GIDEON.

Geschwind JF, Kudo M, Marrero JA, Venook AP, Chen XP, Bronowicki JP, Dagher L, Furuse J, Ladrón de Guevara L, Papandreou C, Sanyal AJ, Takayama T, Ye SL, Yoon SK, Nakajima K, Lehr R, Heldner S, Lencioni R.

Radiology. 2016 May;279(2):630-40. doi: 10.1148/radiol.2015150667. Epub 2016 Jan 8.

PMID:
26744927
9.

High throughput screening identifies ATP-competitive inhibitors of the NLRP1 inflammasome.

Harris PA, Duraiswami C, Fisher DT, Fornwald J, Hoffman SJ, Hofmann G, Jiang M, Lehr R, McCormick PM, Nickels L, Schwartz B, Wu Z, Zhang G, Marquis RW, Bertin J, Gough PJ.

Bioorg Med Chem Lett. 2015 Jul 15;25(14):2739-43. doi: 10.1016/j.bmcl.2015.05.032. Epub 2015 May 19.

PMID:
26022841
10.

Discovery of a Potent Class of PI3Kα Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT).

Yang H, Medeiros PF, Raha K, Elkins P, Lind KE, Lehr R, Adams ND, Burgess JL, Schmidt SJ, Knight SD, Auger KR, Schaber MD, Franklin GJ, Ding Y, DeLorey JL, Centrella PA, Mataruse S, Skinner SR, Clark MA, Cuozzo JW, Evindar G.

ACS Med Chem Lett. 2015 Mar 20;6(5):531-6. doi: 10.1021/acsmedchemlett.5b00025. eCollection 2015 May 14.

11.

Catch and Release: Photocleavable Cationic Diblock Copolymers as a Potential Platform for Nucleic Acid Delivery.

Green MD, Foster AA, Greco CT, Roy R, Lehr RM, Epps TH 3rd, Sullivan MO.

Polym Chem. 2014 Jun. doi: 10.1039/C4PY00638K.

12.

Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis.

Harris PA, Bandyopadhyay D, Berger SB, Campobasso N, Capriotti CA, Cox JA, Dare L, Finger JN, Hoffman SJ, Kahler KM, Lehr R, Lich JD, Nagilla R, Nolte RT, Ouellette MT, Pao CS, Schaeffer MC, Smallwood A, Sun HH, Swift BA, Totoritis RD, Ward P, Marquis RW, Bertin J, Gough PJ.

ACS Med Chem Lett. 2013 Nov 4;4(12):1238-43. doi: 10.1021/ml400382p. eCollection 2013 Dec 12.

13.

GIDEON (Global Investigation of therapeutic DEcisions in hepatocellular carcinoma and Of its treatment with sorafeNib): second interim analysis.

Lencioni R, Kudo M, Ye SL, Bronowicki JP, Chen XP, Dagher L, Furuse J, Geschwind JF, de Guevara LL, Papandreou C, Takayama T, Yoon SK, Nakajima K, Lehr R, Heldner S, Sanyal AJ.

Int J Clin Pract. 2014 May;68(5):609-17. doi: 10.1111/ijcp.12352. Epub 2013 Nov 28.

14.

Gadobutrol in the central nervous system at three doses: results from a phase II, randomized, multicenter trial.

Breuer J, Gutierrez J, Latchaw R, Lehr R, Sorensen AG.

J Magn Reson Imaging. 2014 Feb;39(2):410-8. doi: 10.1002/jmri.24180. Epub 2013 May 16.

PMID:
23681501
15.

On the catalytic mechanism of human ATP citrate lyase.

Fan F, Williams HJ, Boyer JG, Graham TL, Zhao H, Lehr R, Qi H, Schwartz B, Raushel FM, Meek TD.

Biochemistry. 2012 Jun 26;51(25):5198-211. doi: 10.1021/bi300611s. Epub 2012 Jun 15.

PMID:
22657152
16.

Kinetic mechanism and rate-limiting steps of focal adhesion kinase-1.

Schneck JL, Briand J, Chen S, Lehr R, McDevitt P, Zhao B, Smallwood A, Concha N, Oza K, Kirkpatrick R, Yan K, Villa JP, Meek TD, Thrall SH.

Biochemistry. 2010 Aug 24;49(33):7151-63. doi: 10.1021/bi100824v.

PMID:
20597513
17.

Baculovirus production of fully-active phosphoinositide 3-kinase alpha as a p85alpha-p110alpha fusion for X-ray crystallographic analysis with ATP competitive enzyme inhibitors.

Sinnamon RH, McDevitt P, Pietrak BL, Leydon VR, Xue Y, Lehr R, Qi H, Burns M, Elkins P, Ward P, Vincentini G, Fisher D, Grimes M, Brandt M, Auger KR, Ho T, Johanson K, Jones CS, Schwartz B, Sweitzer TD, Kirkpatrick RB.

Protein Expr Purif. 2010 Oct;73(2):167-76. doi: 10.1016/j.pep.2010.05.002. Epub 2010 May 10.

PMID:
20457255
18.

Characterization of PI3K class IA isoforms with regulatory subunit p55alpha using a scintillation proximity assay.

Van Aller GS, Carson JD, Fernandes C, Lehr R, Sinnamon RH, Kirkpatrick RB, Tummino PJ, Luo L.

Anal Biochem. 2008 Dec 15;383(2):311-5. doi: 10.1016/j.ab.2008.08.037. Epub 2008 Sep 10.

PMID:
18814837
19.

Crystal structure of the kinase domain of serum and glucocorticoid-regulated kinase 1 in complex with AMP PNP.

Zhao B, Lehr R, Smallwood AM, Ho TF, Maley K, Randall T, Head MS, Koretke KK, Schnackenberg CG.

Protein Sci. 2007 Dec;16(12):2761-9. Epub 2007 Oct 26.

20.

ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism.

Luo L, Parrish CA, Nevins N, McNulty DE, Chaudhari AM, Carson JD, Sudakin V, Shaw AN, Lehr R, Zhao H, Sweitzer S, Lad L, Wood KW, Sakowicz R, Annan RS, Huang PS, Jackson JR, Dhanak D, Copeland RA, Auger KR.

Nat Chem Biol. 2007 Nov;3(11):722-6. Epub 2007 Oct 7.

PMID:
17922005
21.

Effects of oncogenic p110alpha subunit mutations on the lipid kinase activity of phosphoinositide 3-kinase.

Carson JD, Van Aller G, Lehr R, Sinnamon RH, Kirkpatrick RB, Auger KR, Dhanak D, Copeland RA, Gontarek RR, Tummino PJ, Luo L.

Biochem J. 2008 Jan 15;409(2):519-24.

PMID:
17877460
22.

Selective binding and oligomerization of the murine granulocyte colony-stimulating factor receptor by a low molecular weight, nonpeptidyl ligand.

Doyle ML, Tian SS, Miller SG, Kessler L, Baker AE, Brigham-Burke MR, Dillon SB, Duffy KJ, Keenan RM, Lehr R, Rosen J, Schneeweis LA, Trill J, Young PR, Luengo JI, Lamb P.

J Biol Chem. 2003 Mar 14;278(11):9426-34. Epub 2003 Jan 10.

23.

Electrocardiographic effects of diagnostic imaging agents.

Wiggins J, Beckmann R, Weinmann HJ, Lehr R.

Acad Radiol. 2002 Aug;9 Suppl 2:S444-6. No abstract available.

PMID:
12188303
24.

Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production.

Kumar S, Hanning CR, Brigham-Burke MR, Rieman DJ, Lehr R, Khandekar S, Kirkpatrick RB, Scott GF, Lee JC, Lynch FJ, Gao W, Gambotto A, Lotze MT.

Cytokine. 2002 Apr 21;18(2):61-71.

PMID:
12096920
25.

Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542.

Laping NJ, Grygielko E, Mathur A, Butter S, Bomberger J, Tweed C, Martin W, Fornwald J, Lehr R, Harling J, Gaster L, Callahan JF, Olson BA.

Mol Pharmacol. 2002 Jul;62(1):58-64.

PMID:
12065755
26.

Identification of novel inhibitors of the transforming growth factor beta1 (TGF-beta1) type 1 receptor (ALK5).

Callahan JF, Burgess JL, Fornwald JA, Gaster LM, Harling JD, Harrington FP, Heer J, Kwon C, Lehr R, Mathur A, Olson BA, Weinstock J, Laping NJ.

J Med Chem. 2002 Feb 28;45(5):999-1001.

PMID:
11855979
27.
28.

A modified metal-ion affinity chromatography procedure for the purification of histidine-tagged recombinant proteins expressed in Drosophila S2 cells.

Lehr RV, Elefante LC, Kikly KK, O'Brien SP, Kirkpatrick RB.

Protein Expr Purif. 2000 Aug;19(3):362-8.

PMID:
10910726
29.

Identification and initial characterization of four novel members of the interleukin-1 family.

Kumar S, McDonnell PC, Lehr R, Tierney L, Tzimas MN, Griswold DE, Capper EA, Tal-Singer R, Wells GI, Doyle ML, Young PR.

J Biol Chem. 2000 Apr 7;275(14):10308-14.

30.

The structure of ribonuclease P protein from Staphylococcus aureus reveals a unique binding site for single-stranded RNA.

Spitzfaden C, Nicholson N, Jones JJ, Guth S, Lehr R, Prescott CD, Hegg LA, Eggleston DS.

J Mol Biol. 2000 Jan 7;295(1):105-15.

PMID:
10623511
32.

Production, purification and characterization of non-myristylated human T-cell protein tyrosine kinase in a baculovirus expression system.

Lehr RV, Ma YG, Kratz D, Brake PG, Wang S, Faltynek CR, Wang XM, Stevis PE.

Gene. 1996 Mar 9;169(2):275-9.

PMID:
8647461
33.
34.

In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.

Ma S, Lin L, Raghavan R, Cohenour P, Lin PY, Bennett J, Lewis RJ, Enwall EL, Kostrzewa R, Lehr RE, et al.

J Med Chem. 1995 Sep 29;38(20):4087-97.

PMID:
7562944
35.

Damnacanthal is a highly potent, selective inhibitor of p56lck tyrosine kinase activity.

Faltynek CR, Schroeder J, Mauvais P, Miller D, Wang S, Murphy D, Lehr R, Kelley M, Maycock A, Michne W, et al.

Biochemistry. 1995 Sep 26;34(38):12404-10.

PMID:
7547985
36.

Post-acute rehabilitation outcome: relationship to case-management techniques and strategy.

Ashley MJ, Persel CS, Lehr RP Jr, Feldman B, Krych DK.

J Insur Med. 1994 Fall;26(3):348-54.

PMID:
10150511
37.

Hydrophobic interactions and the design of receptor mimetic peptides.

Martin-Moe SA, Lehr R, Cauley MD, Moe GR.

Pept Res. 1995 Mar-Apr;8(2):70-6.

PMID:
7544657
38.

p56lck interactions accelerate autophosphorylation and enhance activity toward exogenous substrates.

Wang S, Lehr R, Stevis P, Wang XM, Trevillyan J, Faltynek CR.

Arch Biochem Biophys. 1994 Nov 15;315(1):60-7.

PMID:
7979406
39.

Post-traumatic syringomyelia.

Squier MV, Lehr RP.

J Neurol Neurosurg Psychiatry. 1994 Sep;57(9):1095-8.

40.

[Freeze preservation of swine corneas with combinations of intra- and extracellular cryoprotective agents].

Lehr R, Hagenah M, Böhnke M.

Ophthalmologe. 1992 Dec;89(6):519-23. German.

PMID:
1486271
41.
42.
43.

Electromyographic study of sternocleidomastoid and scalene muscles in tetraplegic subjects during respiration.

Short DJ, Silver JR, Lehr RP.

Int Disabil Stud. 1991 Apr-Jun;13(2):46-9.

PMID:
1757404
44.

Embryological considerations of distinctive feature theory.

Ashley MJ, Lehr RP Jr.

Folia Phoniatr (Basel). 1991;43(2):93-100.

PMID:
1916551
45.

Pharmacokinetics and bioavailability of ergoloid mesylates.

Schran HF, McDonald S, Lehr R.

Biopharm Drug Dispos. 1988 Jul-Aug;9(4):349-61.

PMID:
3207855
46.

The effect of recent NLRB and court decisions on hospitals.

Lehr RI, Middlebrooks DJ.

J Health Hum Resour Adm. 1987 Summer;10(1):21-32. No abstract available.

PMID:
10285803
47.

Multiple-dose pharmacokinetics of clozapine in patients.

Choc MG, Lehr RG, Hsuan F, Honigfeld G, Smith HT, Borison R, Volavka J.

Pharm Res. 1987 Oct;4(5):402-5.

PMID:
3508549
48.

An electromyographic study of the abdominal muscles during postural and respiratory manoeuvres.

Goldman JM, Lehr RP, Millar AB, Silver JR.

J Neurol Neurosurg Psychiatry. 1987 Jul;50(7):866-9.

49.

Legal implications of employee assistance programs.

Lehr RI, Middlebrooks DJ.

Employee Relat Law J. 1986 Autumn;12(2):262-74.

PMID:
10278482
50.

An electromyographic study of the abdominal muscles of tetraplegic patients.

Goldman JM, Silver JR, Lehr RP.

Paraplegia. 1986 Aug;24(4):241-6.

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