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DNA methylation-based profiling of uterine neoplasms: a novel tool to improve gynecologic cancer diagnostics.

Kommoss FKF, Stichel D, Schrimpf D, Kriegsmann M, Tessier-Cloutier B, Talhouk A, McAlpine JN, Chang KTE, Sturm D, Pfister SM, Romero-Pérez L, Kirchner T, Grünewald TGP, Buslei R, Sinn HP, Mechtersheimer G, Schirmacher P, Schmidt D, Lehr HA, Sahm F, Huntsman DG, Gilks CB, Kommoss F, von Deimling A, Koelsche C.

J Cancer Res Clin Oncol. 2020 Jan;146(1):97-104. doi: 10.1007/s00432-019-03093-w. Epub 2019 Nov 25.


[Sex cord-stromal tumors of the ovary : Current aspects with a focus on granulosa cell tumors, Sertoli-Leydig cell tumors, and gynandroblastomas].

Kommoss F, Lehr HA.

Pathologe. 2019 Feb;40(1):61-72. doi: 10.1007/s00292-018-0562-3. Review. German.


Robustness of biomarker determination in breast cancer by RT-qPCR: impact of tumor cell content, DCIS and non-neoplastic breast tissue.

Hartmann K, Schlombs K, Laible M, Gürtler C, Schmidt M, Sahin U, Lehr HA.

Diagn Pathol. 2018 Oct 20;13(1):83. doi: 10.1186/s13000-018-0760-6.


Nlrp3-dependent IL-1β inhibits CD103+ dendritic cell differentiation in the gut.

Mak'Anyengo R, Duewell P, Reichl C, Hörth C, Lehr HA, Fischer S, Clavel T, Denk G, Hohenester S, Kobold S, Endres S, Schnurr M, Bauer C.

JCI Insight. 2018 Mar 8;3(5). pii: 96322. doi: 10.1172/jci.insight.96322.


Risk factors for positive resection margins of breast cancer tumorectomy specimen following breast-conserving surgery.

Heiss N, Rousson V, Ifticene-Treboux A, Lehr HA, Delaloye JF.

Horm Mol Biol Clin Investig. 2017 Dec 9;32(2). pii: /j/hmbci.2017.32.issue-2/hmbci-2017-0023/hmbci-2017-0023.xml. doi: 10.1515/hmbci-2017-0023.


Rectal Delivery of a DNAzyme That Specifically Blocks the Transcription Factor GATA3 and Reduces Colitis in Mice.

Popp V, Gerlach K, Mott S, Turowska A, Garn H, Atreya R, Lehr HA, Ho IC, Renz H, Weigmann B, Neurath MF.

Gastroenterology. 2017 Jan;152(1):176-192.e5. doi: 10.1053/j.gastro.2016.09.005. Epub 2016 Sep 14.


TIE-2-expressing monocytes are lymphangiogenic and associate specifically with lymphatics of human breast cancer.

Bron S, Henry L, Faes-Van't Hull E, Turrini R, Vanhecke D, Guex N, Ifticene-Treboux A, Marina Iancu E, Semilietof A, Rufer N, Lehr HA, Xenarios I, Coukos G, Delaloye JF, Doucey MA.

Oncoimmunology. 2015 Aug 20;5(2):e1073882. eCollection 2016 Feb.


System Characterization of a Highly Integrated Preclinical Hybrid MPI-MRI Scanner.

Franke J, Heinen U, Lehr H, Weber A, Jaspard F, Ruhm W, Heidenreich M, Schulz V.

IEEE Trans Med Imaging. 2016 Sep;35(9):1993-2004. doi: 10.1109/TMI.2016.2542041. Epub 2016 Mar 14.


Quality in pathology: how good is good? An introduction.

Bosman FT, Lehr HA.

Virchows Arch. 2016 Jan;468(1):1-4. doi: 10.1007/s00428-015-1896-3. No abstract available.


IRAK1 Drives Intestinal Inflammation by Promoting the Generation of Effector Th Cells with Optimal Gut-Homing Capacity.

Heiseke AF, Jeuk BH, Markota A, Straub T, Lehr HA, Reindl W, Krug AB.

J Immunol. 2015 Dec 15;195(12):5787-94. doi: 10.4049/jimmunol.1501874. Epub 2015 Nov 11.


Communication skills in diagnostic pathology.

Lehr HA, Bosman FT.

Virchows Arch. 2016 Jan;468(1):61-7. doi: 10.1007/s00428-015-1848-y. Epub 2015 Oct 19.


Standardization for Ki-67 assessment in moderately differentiated breast cancer. A retrospective analysis of the SAKK 28/12 study.

Varga Z, Cassoly E, Li Q, Oehlschlegel C, Tapia C, Lehr HA, Klingbiel D, Thürlimann B, Ruhstaller T.

PLoS One. 2015 Apr 17;10(4):e0123435. doi: 10.1371/journal.pone.0123435. eCollection 2015.


Angiogenic activity of breast cancer patients' monocytes reverted by combined use of systems modeling and experimental approaches.

Guex N, Crespo I, Bron S, Ifticene-Treboux A, Faes-Van't Hull E, Kharoubi S, Liechti R, Werffeli P, Ibberson M, Majo F, Nicolas M, Laurent J, Garg A, Zaman K, Lehr HA, Stevenson BJ, Rüegg C, Coukos G, Delaloye JF, Xenarios I, Doucey MA.

PLoS Comput Biol. 2015 Mar 13;11(3):e1004050. doi: 10.1371/journal.pcbi.1004050. eCollection 2015 Mar.


Proapoptotic and antiapoptotic proteins of the Bcl-2 family regulate sensitivity of pancreatic cancer cells toward gemcitabine and T-cell-mediated cytotoxicity.

Bauer C, Hees C, Sterzik A, Bauernfeind F, Mak'Anyengo R, Duewell P, Lehr HA, Noessner E, Wank R, Trauzold A, Endres S, Dauer M, Schnurr M.

J Immunother. 2015 Apr;38(3):116-26. doi: 10.1097/CJI.0000000000000073.


Role of Tyk-2 in Th9 and Th17 cells in allergic asthma.

Übel C, Graser A, Koch S, Rieker RJ, Lehr HA, Müller M, Finotto S.

Sci Rep. 2014 Aug 11;4:5865. doi: 10.1038/srep05865.


TH9 cells that express the transcription factor PU.1 drive T cell-mediated colitis via IL-9 receptor signaling in intestinal epithelial cells.

Gerlach K, Hwang Y, Nikolaev A, Atreya R, Dornhoff H, Steiner S, Lehr HA, Wirtz S, Vieth M, Waisman A, Rosenbauer F, McKenzie AN, Weigmann B, Neurath MF.

Nat Immunol. 2014 Jul;15(7):676-86. doi: 10.1038/ni.2920. Epub 2014 Jun 8. Erratum in: Nat Immunol. 2015 Feb;16(2):214.


In vitro and in vivo repair activities of undifferentiated and classically and alternatively activated macrophages.

Enderlin Vaz da Silva Z, Lehr HA, Velin D.

Pathobiology. 2014;81(2):86-93. doi: 10.1159/000357306. Epub 2014 Jan 23.


Instruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1-ETO mouse model.

Cabezas-Wallscheid N, Eichwald V, de Graaf J, Löwer M, Lehr HA, Kreft A, Eshkind L, Hildebrandt A, Abassi Y, Heck R, Dehof AK, Ohngemach S, Sprengel R, Wörtge S, Schmitt S, Lotz J, Meyer C, Kindler T, Zhang DE, Kaina B, Castle JC, Trumpp A, Sahin U, Bockamp E.

EMBO Mol Med. 2013 Dec;5(12):1804-20. doi: 10.1002/emmm.201302661. Epub 2013 Oct 4.


TIE-2 and VEGFR kinase activities drive immunosuppressive function of TIE-2-expressing monocytes in human breast tumors.

Ibberson M, Bron S, Guex N, Faes-van't Hull E, Ifticene-Treboux A, Henry L, Lehr HA, Delaloye JF, Coukos G, Xenarios I, Doucey MA.

Clin Cancer Res. 2013 Jul 1;19(13):3439-49. doi: 10.1158/1078-0432.CCR-12-3181. Epub 2013 May 6.


IL-6 activated integrated BATF/IRF4 functions in lymphocytes are T-bet-independent and reversed by subcutaneous immunotherapy.

Koch S, Mousset S, Graser A, Reppert S, Übel C, Reinhardt C, Zimmermann T, Rieker R, Lehr HA, Finotto S.

Sci Rep. 2013;3:1754. doi: 10.1038/srep01754.


Effects of an interleukin-15 antagonist on systemic and skeletal alterations in mice with DSS-induced colitis.

Brounais-Le Royer B, Pierroz DD, Velin D, Frossard C, Zheng XX, Lehr HA, Ferrari-Lacraz S, Ferrari SL.

Am J Pathol. 2013 Jun;182(6):2155-67. doi: 10.1016/j.ajpath.2013.02.033. Epub 2013 Apr 10.


Microfluidic processor allows rapid HER2 immunohistochemistry of breast carcinomas and significantly reduces ambiguous (2+) read-outs.

Ciftlik AT, Lehr HA, Gijs MA.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5363-8. doi: 10.1073/pnas.1211273110. Epub 2013 Mar 11.


The selective phosphodiesterase 4 inhibitor roflumilast and phosphodiesterase 3/4 inhibitor pumafentrine reduce clinical score and TNF expression in experimental colitis in mice.

Rieder F, Siegmund B, Bundschuh DS, Lehr HA, Endres S, Eigler A.

PLoS One. 2013;8(2):e56867. doi: 10.1371/journal.pone.0056867. Epub 2013 Feb 28.


Protective and aggravating effects of Nlrp3 inflammasome activation in IBD models: influence of genetic and environmental factors.

Bauer C, Duewell P, Lehr HA, Endres S, Schnurr M.

Dig Dis. 2012;30 Suppl 1:82-90. doi: 10.1159/000341681. Epub 2012 Oct 11.


Mitotic figure counts are significantly overestimated in resection specimens of invasive breast carcinomas.

Lehr HA, Rochat C, Schaper C, Nobile A, Shanouda S, Vijgen S, Gauthier A, Obermann E, Leuba S, Schmidt M, C CR, Delaloye JF, Simiantonaki N, Schaefer SC.

Mod Pathol. 2013 Mar;26(3):336-42. doi: 10.1038/modpathol.2012.140. Epub 2012 Oct 5.


Potassium restores vasorelaxation of resistance arterioles in non-hypertensive DOCA/salt fed mice.

Wyss C, Wang Q, Golshayan D, Nussberger J, Burnier M, Lehr HA, Schaefer SC.

Microvasc Res. 2012 Nov;84(3):340-4. doi: 10.1016/j.mvr.2012.09.005. Epub 2012 Sep 23.


Tumor architecture exerts no bias on nuclear grading in breast cancer diagnosis.

Mora B, Bombari D, Schaefer SC, Schmidt M, Delaloye JF, Mast F, Lehr HA.

Virchows Arch. 2012 Oct;461(4):399-403. doi: 10.1007/s00428-012-1304-1. Epub 2012 Aug 31.


Transcription factor NFATc2 controls the emergence of colon cancer associated with IL-6-dependent colitis.

Gerlach K, Daniel C, Lehr HA, Nikolaev A, Gerlach T, Atreya R, Rose-John S, Neurath MF, Weigmann B.

Cancer Res. 2012 Sep 1;72(17):4340-50. doi: 10.1158/0008-5472.CAN-11-4155. Epub 2012 Jun 27.


Board examination for anatomical pathology in Switzerland: two intense days to verify professional competence.

Lehr HA, Moch H, Christen B, Safret A, Gugger M, Rössle M, von Gunten M, Lemoine R, Kurt AM, Caduff R, Walter A, Singer G, Luscieti P, Bannwart F, Genton CY.

Virchows Arch. 2012 Jul;461(1):87-92. doi: 10.1007/s00428-012-1262-7. Epub 2012 Jun 21.


What was I thinking? Eye-tracking experiments underscore the bias that architecture exerts on nuclear grading in prostate cancer.

Bombari D, Mora B, Schaefer SC, Mast FW, Lehr HA.

PLoS One. 2012;7(5):e38023. doi: 10.1371/journal.pone.0038023. Epub 2012 May 30.


How reliable is Ki-67 immunohistochemistry in grade 2 breast carcinomas? A QA study of the Swiss Working Group of Breast- and Gynecopathologists.

Varga Z, Diebold J, Dommann-Scherrer C, Frick H, Kaup D, Noske A, Obermann E, Ohlschlegel C, Padberg B, Rakozy C, Sancho Oliver S, Schobinger-Clement S, Schreiber-Facklam H, Singer G, Tapia C, Wagner U, Mastropasqua MG, Viale G, Lehr HA.

PLoS One. 2012;7(5):e37379. doi: 10.1371/journal.pone.0037379. Epub 2012 May 25.


[Giant cell arteritis: etiological knowledge and diagnostic challenge for pathologists].

Schaefer SC, Lehr HA.

Pathologe. 2012 May;33(3):228-35. doi: 10.1007/s00292-011-1555-7. German.


Intravital microscopy reveals endothelial dysfunction in resistance arterioles in Angiotensin II-induced hypertension.

Schäfer SC, Pellegrin M, Wyss C, Aubert JF, Nussberger J, Hayoz D, Lehr HA, Mazzolai L.

Hypertens Res. 2012 Aug;35(8):855-61. doi: 10.1038/hr.2012.58. Epub 2012 May 10.


Mesenteric fat - control site for bacterial translocation in colitis?

Batra A, Heimesaat MM, Bereswill S, Fischer A, Glauben R, Kunkel D, Scheffold A, Erben U, Kühl A, Loddenkemper C, Lehr HA, Schumann M, Schulzke JD, Zeitz M, Siegmund B.

Mucosal Immunol. 2012 Sep;5(5):580-91. doi: 10.1038/mi.2012.33. Epub 2012 May 9.


Impact of salt on cardiac differential gene expression and coronary lesion in normotensive mineralocorticoid-treated mice.

Wang Q, Domenighetti AA, Schäfer SC, Weber J, Simon A, Maillard MP, Pedrazzini T, Chen J, Lehr HA, Burnier M.

Am J Physiol Regul Integr Comp Physiol. 2012 May;302(9):R1025-33. doi: 10.1152/ajpregu.00387.2011. Epub 2012 Mar 7.


A comprehensive analysis of human gene expression profiles identifies stromal immunoglobulin κ C as a compatible prognostic marker in human solid tumors.

Schmidt M, Hellwig B, Hammad S, Othman A, Lohr M, Chen Z, Boehm D, Gebhard S, Petry I, Lebrecht A, Cadenas C, Marchan R, Stewart JD, Solbach C, Holmberg L, Edlund K, Kultima HG, Rody A, Berglund A, Lambe M, Isaksson A, Botling J, Karn T, Müller V, Gerhold-Ay A, Cotarelo C, Sebastian M, Kronenwett R, Bojar H, Lehr HA, Sahin U, Koelbl H, Gehrmann M, Micke P, Rahnenführer J, Hengstler JG.

Clin Cancer Res. 2012 May 1;18(9):2695-703. doi: 10.1158/1078-0432.CCR-11-2210. Epub 2012 Feb 20.


Photodynamic drug delivery enhancement in tumours does not depend on leukocyte-endothelial interaction in a human mesothelioma xenograft model.

Wang Y, Perentes JY, Schäfer SC, Gonzalez M, Debefve E, Lehr HA, van den Bergh H, Krueger T.

Eur J Cardiothorac Surg. 2012 Aug;42(2):348-54. doi: 10.1093/ejcts/ezr294. Epub 2012 Jan 27.


Informed consent: Biobank donors should have a say.

Spencer B, Koutaissoff D, Lehr HA.

Nature. 2012 Jan 25;481(7382):443. doi: 10.1038/481443c. No abstract available.


Allergen-induced IgE-dependent gut inflammation in a human PBMC-engrafted murine model of allergy.

Weigmann B, Schughart N, Wiebe C, Sudowe S, Lehr HA, Jonuleit H, Vogel L, Becker C, Neurath MF, Grabbe S, Saloga J, Bellinghausen I.

J Allergy Clin Immunol. 2012 Apr;129(4):1126-35. doi: 10.1016/j.jaci.2011.11.036. Epub 2012 Jan 10.


Gene therapy with iNOS enhances regional contractility and reduces delayed contrast enhancement in a model of postischemic congestive heart failure.

Abegunewardene N, Schmidt KH, Vosseler M, Kreitner KF, Schreiber LM, Lehr HA, Gori T, Münzel T, Horstick G.

Clin Hemorheol Microcirc. 2011;49(1-4):271-8. doi: 10.3233/CH-2011-1477.


Absence of ectopic epithelial inclusions in 3,904 axillary lymph nodes examined in sentinel technique.

Iken S, Schmidt M, Braun C, Valentino A, Lehr HA, Schaefer SC.

Breast Cancer Res Treat. 2012 Apr;132(2):621-4. doi: 10.1007/s10549-011-1923-2. Epub 2011 Dec 22.


A role for T-bet-mediated tumour immune surveillance in anti-IL-17A treatment of lung cancer.

Reppert S, Boross I, Koslowski M, Türeci Ö, Koch S, Lehr HA, Finotto S.

Nat Commun. 2011 Dec 20;2:600. doi: 10.1038/ncomms1609.


Interactions between cancer stem cells and their niche govern metastatic colonization.

Malanchi I, Santamaria-Martínez A, Susanto E, Peng H, Lehr HA, Delaloye JF, Huelsken J.

Nature. 2011 Dec 7;481(7379):85-9. doi: 10.1038/nature10694.


Leukocyte-endothelial cell interaction is necessary for photodynamic therapy induced vascular permeabilization.

Debefve E, Mithieux F, Perentes JY, Wang Y, Cheng C, Schaefer SC, Ruffieux C, Ballini JP, Gonzalez M, van den Bergh H, Ris HB, Lehr HA, Krueger T.

Lasers Surg Med. 2011 Sep;43(7):696-704. doi: 10.1002/lsm.21115.


CCL17 promotes intestinal inflammation in mice and counteracts regulatory T cell-mediated protection from colitis.

Heiseke AF, Faul AC, Lehr HA, Förster I, Schmid RM, Krug AB, Reindl W.

Gastroenterology. 2012 Feb;142(2):335-45. doi: 10.1053/j.gastro.2011.10.027. Epub 2011 Nov 2.


Inflammatory myofibroblastic tumor of the trachea with concomitant granulomatous lymph node lesions.

Koch JA, Dorn P, Rausch T, Ris HB, Lehr HA, Schäfer SC.

Case Rep Med. 2011;2011:151729. doi: 10.1155/2011/151729. Epub 2011 Sep 13.


Protein-binding microarray analysis of tumor suppressor AP2α target gene specificity.

Kerschgens J, Renaud S, Schütz F, Grasso L, Egener-Kuhn T, Delaloye JF, Lehr HA, Vogel H, Mermod N.

PLoS One. 2011;6(8):e22895. doi: 10.1371/journal.pone.0022895. Epub 2011 Aug 18.


MFG-E8/lactadherin regulates cyclins D1/D3 expression and enhances the tumorigenic potential of mammary epithelial cells.

Carrascosa C, Obula RG, Missiaglia E, Lehr HA, Delorenzi M, Frattini M, Rüegg C, Mariotti A.

Oncogene. 2012 Mar 22;31(12):1521-32. doi: 10.1038/onc.2011.356. Epub 2011 Aug 15.


Characterization of chromosomal instability in murine colitis-associated colorectal cancer.

Gerling M, Glauben R, Habermann JK, Kühl AA, Loddenkemper C, Lehr HA, Zeitz M, Siegmund B.

PLoS One. 2011;6(7):e22114. doi: 10.1371/journal.pone.0022114. Epub 2011 Jul 22.


What makes a good pathology report?

Nobile A, Treboux A, Delaloye JF, Zaman K, Jeanneret-Sozzi W, Schaefer SC, Lehr HA.

Eur J Cancer. 2011 Sep;47(14):2082-3. doi: 10.1016/j.ejca.2011.06.033. Epub 2011 Jul 19. No abstract available.


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