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Items: 1 to 50 of 119

1.

The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes.

Robbez-Masson L, Tie CHC, Conde L, Tunbak H, Husovsky C, Tchasovnikarova IA, Timms RT, Herrero J, Lehner PJ, Rowe HM.

Genome Res. 2018 Jun;28(6):836-845. doi: 10.1101/gr.228171.117. Epub 2018 May 4.

2.

Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses.

Wang ECY, Pjechova M, Nightingale K, Vlahava VM, Patel M, Ruckova E, Forbes SK, Nobre L, Antrobus R, Roberts D, Fielding CA, Seirafian S, Davies J, Murrell I, Lau B, Wilkie GS, Suárez NM, Stanton RJ, Vojtesek B, Davison A, Lehner PJ, Weekes MP, Wilkinson GWG, Tomasec P.

Proc Natl Acad Sci U S A. 2018 May 8;115(19):4998-5003. doi: 10.1073/pnas.1720950115. Epub 2018 Apr 24.

PMID:
29691324
3.

Regulation of Human γδ T Cells by BTN3A1 Protein Stability and ATP-Binding Cassette Transporters.

Rhodes DA, Chen HC, Williamson JC, Hill A, Yuan J, Smith S, Rhodes H, Trowsdale J, Lehner PJ, Herrmann T, Eberl M.

Front Immunol. 2018 Apr 4;9:662. doi: 10.3389/fimmu.2018.00662. eCollection 2018.

4.

MARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins.

Stefanovic-Barrett S, Dickson AS, Burr SP, Williamson JC, Lobb IT, van den Boomen DJ, Lehner PJ, Nathan JA.

EMBO Rep. 2018 May;19(5). pii: e45603. doi: 10.15252/embr.201745603. Epub 2018 Mar 8.

5.

Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms.

Douse CH, Bloor S, Liu Y, Shamin M, Tchasovnikarova IA, Timms RT, Lehner PJ, Modis Y.

Nat Commun. 2018 Feb 13;9(1):651. doi: 10.1038/s41467-018-03045-x.

6.

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity.

Burr ML, Sparbier CE, Chan YC, Williamson JC, Woods K, Beavis PA, Lam EYN, Henderson MA, Bell CC, Stolzenburg S, Gilan O, Bloor S, Noori T, Morgens DW, Bassik MC, Neeson PJ, Behren A, Darcy PK, Dawson SJ, Voskoboinik I, Trapani JA, Cebon J, Lehner PJ, Dawson MA.

Nature. 2017 Sep 7;549(7670):101-105. doi: 10.1038/nature23643. Epub 2017 Aug 16.

7.

A genome-wide CRISPR screen reconciles the role of N-linked glycosylation in galectin-3 transport to the cell surface.

Stewart SE, Menzies SA, Popa SJ, Savinykh N, Petrunkina Harrison A, Lehner PJ, Moreau K.

J Cell Sci. 2017 Oct 1;130(19):3234-3247. doi: 10.1242/jcs.206425. Epub 2017 Aug 3.

8.

Multiple E2 ubiquitin-conjugating enzymes regulate human cytomegalovirus US2-mediated immunoreceptor downregulation.

van de Weijer ML, Schuren ABC, van den Boomen DJH, Mulder A, Claas FHJ, Lehner PJ, Lebbink RJ, Wiertz EJHJ.

J Cell Sci. 2017 Sep 1;130(17):2883-2892. doi: 10.1242/jcs.206839. Epub 2017 Jul 25.

9.

Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.

Tchasovnikarova IA, Timms RT, Douse CH, Roberts RC, Dougan G, Kingston RE, Modis Y, Lehner PJ.

Nat Genet. 2017 Jul;49(7):1035-1044. doi: 10.1038/ng.3878. Epub 2017 Jun 5.

10.

MARCH9-mediated ubiquitination regulates MHC I export from the TGN.

De Angelis Rigotti F, De Gassart A, Pforr C, Cano F, N'Guessan P, Combes A, Camossetto V, Lehner PJ, Pierre P, Gatti E.

Immunol Cell Biol. 2017 Oct;95(9):753-764. doi: 10.1038/icb.2017.44. Epub 2017 May 31.

PMID:
28559542
11.

Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation.

Fielding CA, Weekes MP, Nobre LV, Ruckova E, Wilkie GS, Paulo JA, Chang C, Suárez NM, Davies JA, Antrobus R, Stanton RJ, Aicheler RJ, Nichols H, Vojtesek B, Trowsdale J, Davison AJ, Gygi SP, Tomasec P, Lehner PJ, Wilkinson GW.

Elife. 2017 Feb 10;6. pii: e22206. doi: 10.7554/eLife.22206.

12.

Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions.

Burr SP, Costa AS, Grice GL, Timms RT, Lobb IT, Freisinger P, Dodd RB, Dougan G, Lehner PJ, Frezza C, Nathan JA.

Cell Metab. 2016 Nov 8;24(5):740-752. doi: 10.1016/j.cmet.2016.09.015. Epub 2016 Oct 27.

13.

Temporal proteomic analysis of HIV infection reveals remodelling of the host phosphoproteome by lentiviral Vif variants.

Greenwood EJ, Matheson NJ, Wals K, van den Boomen DJ, Antrobus R, Williamson JC, Lehner PJ.

Elife. 2016 Sep 30;5. pii: e18296. doi: 10.7554/eLife.18296.

14.

ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex.

Timms RT, Tchasovnikarova IA, Antrobus R, Dougan G, Lehner PJ.

Cell Rep. 2016 Oct 11;17(3):653-659. doi: 10.1016/j.celrep.2016.09.050.

15.

NOTCH1 mediates a switch between two distinct secretomes during senescence.

Hoare M, Ito Y, Kang TW, Weekes MP, Matheson NJ, Patten DA, Shetty S, Parry AJ, Menon S, Salama R, Antrobus R, Tomimatsu K, Howat W, Lehner PJ, Zender L, Narita M.

Nat Cell Biol. 2016 Sep;18(9):979-92. doi: 10.1038/ncb3397. Epub 2016 Aug 15.

16.

Manipulation of immunometabolism by HIV-accessories to the crime?

Matheson NJ, Greenwood EJ, Lehner PJ.

Curr Opin Virol. 2016 Aug;19:65-70. doi: 10.1016/j.coviro.2016.06.014. Epub 2016 Jul 21. Review.

PMID:
27448768
17.

Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens.

Timms RT, Menzies SA, Tchasovnikarova IA, Christensen LC, Williamson JC, Antrobus R, Dougan G, Ellgaard L, Lehner PJ.

Nat Commun. 2016 Jun 10;7:11786. doi: 10.1038/ncomms11786.

18.

A Genetic Screen Identifies a Critical Role for the WDR81-WDR91 Complex in the Trafficking and Degradation of Tetherin.

Rapiteanu R, Davis LJ, Williamson JC, Timms RT, Paul Luzio J, Lehner PJ.

Traffic. 2016 Aug;17(8):940-58. doi: 10.1111/tra.12409. Epub 2016 May 25.

19.

Human Cytomegalovirus Infection Upregulates the Mitochondrial Transcription and Translation Machineries.

Karniely S, Weekes MP, Antrobus R, Rorbach J, van Haute L, Umrania Y, Smith DL, Stanton RJ, Minczuk M, Lehner PJ, Sinclair JH.

MBio. 2016 Mar 29;7(2):e00029. doi: 10.1128/mBio.00029-16.

20.

Position-effect variegation revisited: HUSHing up heterochromatin in human cells.

Timms RT, Tchasovnikarova IA, Lehner PJ.

Bioessays. 2016 Apr;38(4):333-43. doi: 10.1002/bies.201500184. Epub 2016 Feb 8. Review.

PMID:
26853531
21.

A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.

Cano F, Rapiteanu R, Sebastiaan Winkler G, Lehner PJ.

Nat Commun. 2015 Oct 16;6:8670. doi: 10.1038/ncomms9670.

22.

Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef.

Matheson NJ, Sumner J, Wals K, Rapiteanu R, Weekes MP, Vigan R, Weinelt J, Schindler M, Antrobus R, Costa AS, Frezza C, Clish CB, Neil SJ, Lehner PJ.

Cell Host Microbe. 2015 Oct 14;18(4):409-23. doi: 10.1016/j.chom.2015.09.003. Epub 2015 Oct 1.

23.

A non-canonical ESCRT pathway, including histidine domain phosphotyrosine phosphatase (HD-PTP), is used for down-regulation of virally ubiquitinated MHC class I.

Parkinson MD, Piper SC, Bright NA, Evans JL, Boname JM, Bowers K, Lehner PJ, Luzio JP.

Biochem J. 2015 Oct 1;471(1):79-88. doi: 10.1042/BJ20150336. Epub 2015 Jul 28.

24.

Identifying the ERAD ubiquitin E3 ligases for viral and cellular targeting of MHC class I.

van den Boomen DJ, Lehner PJ.

Mol Immunol. 2015 Dec;68(2 Pt A):106-11. doi: 10.1016/j.molimm.2015.07.005. Epub 2015 Jul 22. Review.

25.

TRIM5α requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription.

Fletcher AJ, Christensen DE, Nelson C, Tan CP, Schaller T, Lehner PJ, Sundquist WI, Towers GJ.

EMBO J. 2015 Aug 4;34(15):2078-95. doi: 10.15252/embj.201490361. Epub 2015 Jun 22.

26.

GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.

Tchasovnikarova IA, Timms RT, Matheson NJ, Wals K, Antrobus R, Göttgens B, Dougan G, Dawson MA, Lehner PJ.

Science. 2015 Jun 26;348(6242):1481-1485. doi: 10.1126/science.aaa7227. Epub 2015 May 28.

27.

Human cytomegalovirus: taking the strain.

Wilkinson GW, Davison AJ, Tomasec P, Fielding CA, Aicheler R, Murrell I, Seirafian S, Wang EC, Weekes M, Lehner PJ, Wilkie GS, Stanton RJ.

Med Microbiol Immunol. 2015 Jun;204(3):273-84. doi: 10.1007/s00430-015-0411-4. Epub 2015 Apr 17. Review.

28.

Plasma membrane profiling defines an expanded class of cell surface proteins selectively targeted for degradation by HCMV US2 in cooperation with UL141.

Hsu JL, van den Boomen DJ, Tomasec P, Weekes MP, Antrobus R, Stanton RJ, Ruckova E, Sugrue D, Wilkie GS, Davison AJ, Wilkinson GW, Lehner PJ.

PLoS Pathog. 2015 Apr 14;11(4):e1004811. doi: 10.1371/journal.ppat.1004811. eCollection 2015 Apr.

29.

UBE2L3 polymorphism amplifies NF-κB activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases.

Lewis MJ, Vyse S, Shields AM, Boeltz S, Gordon PA, Spector TD, Lehner PJ, Walczak H, Vyse TJ.

Am J Hum Genet. 2015 Feb 5;96(2):221-34. doi: 10.1016/j.ajhg.2014.12.024. Epub 2015 Jan 29.

30.

Antibody-free magnetic cell sorting of genetically modified primary human CD4+ T cells by one-step streptavidin affinity purification.

Matheson NJ, Peden AA, Lehner PJ.

PLoS One. 2014 Oct 31;9(10):e111437. doi: 10.1371/journal.pone.0111437. eCollection 2014.

31.

HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells.

Stanton RJ, Prod'homme V, Purbhoo MA, Moore M, Aicheler RJ, Heinzmann M, Bailer SM, Haas J, Antrobus R, Weekes MP, Lehner PJ, Vojtesek B, Miners KL, Man S, Wilkie GS, Davison AJ, Wang ECY, Tomasec P, Wilkinson GWG.

Cell Host Microbe. 2014 Aug 13;16(2):201-214. doi: 10.1016/j.chom.2014.07.005.

32.

TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I.

van den Boomen DJ, Timms RT, Grice GL, Stagg HR, Skødt K, Dougan G, Nathan JA, Lehner PJ.

Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11425-30. doi: 10.1073/pnas.1409099111. Epub 2014 Jul 16.

33.

Cleavage by signal peptide peptidase is required for the degradation of selected tail-anchored proteins.

Boname JM, Bloor S, Wandel MP, Nathan JA, Antrobus R, Dingwell KS, Thurston TL, Smith DL, Smith JC, Randow F, Lehner PJ.

J Cell Biol. 2014 Jun 23;205(6):847-62. doi: 10.1083/jcb.201312009.

34.

Quantitative temporal viromics: an approach to investigate host-pathogen interaction.

Weekes MP, Tomasec P, Huttlin EL, Fielding CA, Nusinow D, Stanton RJ, Wang EC, Aicheler R, Murrell I, Wilkinson GW, Lehner PJ, Gygi SP.

Cell. 2014 Jun 5;157(6):1460-72. doi: 10.1016/j.cell.2014.04.028.

35.

Two novel human cytomegalovirus NK cell evasion functions target MICA for lysosomal degradation.

Fielding CA, Aicheler R, Stanton RJ, Wang EC, Han S, Seirafian S, Davies J, McSharry BP, Weekes MP, Antrobus PR, Prod'homme V, Blanchet FP, Sugrue D, Cuff S, Roberts D, Davison AJ, Lehner PJ, Wilkinson GW, Tomasec P.

PLoS Pathog. 2014 May 1;10(5):e1004058. doi: 10.1371/journal.ppat.1004058. eCollection 2014 May.

36.

Haploid genetic screens identify an essential role for PLP2 in the downregulation of novel plasma membrane targets by viral E3 ubiquitin ligases.

Timms RT, Duncan LM, Tchasovnikarova IA, Antrobus R, Smith DL, Dougan G, Weekes MP, Lehner PJ.

PLoS Pathog. 2013;9(11):e1003772. doi: 10.1371/journal.ppat.1003772. Epub 2013 Nov 21.

37.

MHC class I molecules are preferentially ubiquitinated on endoplasmic reticulum luminal residues during HRD1 ubiquitin E3 ligase-mediated dislocation.

Burr ML, van den Boomen DJ, Bye H, Antrobus R, Wiertz EJ, Lehner PJ.

Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14290-5. doi: 10.1073/pnas.1303380110. Epub 2013 Aug 8.

38.

Sterol metabolism regulates neuroserpin polymer degradation in the absence of the unfolded protein response in the dementia FENIB.

Roussel BD, Newton TM, Malzer E, Simecek N, Haq I, Thomas SE, Burr ML, Lehner PJ, Crowther DC, Marciniak SJ, Lomas DA.

Hum Mol Genet. 2013 Nov 15;22(22):4616-26. doi: 10.1093/hmg/ddt310. Epub 2013 Jun 28.

39.

Latency-associated degradation of the MRP1 drug transporter during latent human cytomegalovirus infection.

Weekes MP, Tan SY, Poole E, Talbot S, Antrobus R, Smith DL, Montag C, Gygi SP, Sinclair JH, Lehner PJ.

Science. 2013 Apr 12;340(6129):199-202. doi: 10.1126/science.1235047.

40.

Tapasin-related protein TAPBPR is an additional component of the MHC class I presentation pathway.

Boyle LH, Hermann C, Boname JM, Porter KM, Patel PA, Burr ML, Duncan LM, Harbour ME, Rhodes DA, Skjødt K, Lehner PJ, Trowsdale J.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3465-70. doi: 10.1073/pnas.1222342110. Epub 2013 Feb 11.

41.

Role for the obesity-related FTO gene in the cellular sensing of amino acids.

Gulati P, Cheung MK, Antrobus R, Church CD, Harding HP, Tung YC, Rimmington D, Ma M, Ron D, Lehner PJ, Ashcroft FM, Cox RD, Coll AP, O'Rahilly S, Yeo GS.

Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2557-62. doi: 10.1073/pnas.1222796110. Epub 2013 Jan 28.

42.

Studying ubiquitination of MHC class I molecules.

Burr ML, Boname JM, Lehner PJ.

Methods Mol Biol. 2013;960:109-125. doi: 10.1007/978-1-62703-218-6_9.

PMID:
23329482
43.

A novel post-transcriptional role for ubiquitin in the differential regulation of MHC class I allotypes.

Cano F, Lehner PJ.

Mol Immunol. 2013 Sep;55(2):135-8. doi: 10.1016/j.molimm.2012.10.015. Epub 2012 Nov 7. Review.

44.

The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation.

Cano F, Bye H, Duncan LM, Buchet-Poyau K, Billaud M, Wills MR, Lehner PJ.

EMBO J. 2012 Aug 29;31(17):3596-606. doi: 10.1038/emboj.2012.218. Epub 2012 Aug 3.

45.

Fluorescence-based phenotypic selection allows forward genetic screens in haploid human cells.

Duncan LM, Timms RT, Zavodszky E, Cano F, Dougan G, Randow F, Lehner PJ.

PLoS One. 2012;7(6):e39651. doi: 10.1371/journal.pone.0039651. Epub 2012 Jun 22.

46.

Proteomic plasma membrane profiling reveals an essential role for gp96 in the cell surface expression of LDLR family members, including the LDL receptor and LRP6.

Weekes MP, Antrobus R, Talbot S, Hör S, Simecek N, Smith DL, Bloor S, Randow F, Lehner PJ.

J Proteome Res. 2012 Mar 2;11(3):1475-84. doi: 10.1021/pr201135e. Epub 2012 Feb 7.

47.

What has the study of the K3 and K5 viral ubiquitin E3 ligases taught us about ubiquitin-mediated receptor regulation?

Boname JM, Lehner PJ.

Viruses. 2011 Feb;3(2):118-31. doi: 10.3390/v3020118. Epub 2011 Jan 28. Review.

48.

Endosomal transport via ubiquitination.

Piper RC, Lehner PJ.

Trends Cell Biol. 2011 Nov;21(11):647-55. doi: 10.1016/j.tcb.2011.08.007. Epub 2011 Sep 28. Review.

49.

The dominantly expressed class I molecule of the chicken MHC is explained by coevolution with the polymorphic peptide transporter (TAP) genes.

Walker BA, Hunt LG, Sowa AK, Skjødt K, Göbel TW, Lehner PJ, Kaufman J.

Proc Natl Acad Sci U S A. 2011 May 17;108(20):8396-401. doi: 10.1073/pnas.1019496108. Epub 2011 May 2.

50.

HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation.

Burr ML, Cano F, Svobodova S, Boyle LH, Boname JM, Lehner PJ.

Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2034-9. doi: 10.1073/pnas.1016229108. Epub 2011 Jan 18.

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