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Items: 1 to 50 of 160

1.

Temporal proteomic analysis of BK polyomavirus infection reveals virus-induced G2 arrest and highly effective evasion of innate immune sensing.

Caller LG, Davies CTR, Antrobus R, Lehner PJ, Weekes MP, Crump CM.

J Virol. 2019 May 29. pii: JVI.00595-19. doi: 10.1128/JVI.00595-19. [Epub ahead of print]

2.

Promiscuous Targeting of Cellular Proteins by Vpr Drives Systems-Level Proteomic Remodeling in HIV-1 Infection.

Greenwood EJD, Williamson JC, Sienkiewicz A, Naamati A, Matheson NJ, Lehner PJ.

Cell Rep. 2019 Apr 30;27(5):1579-1596.e7. doi: 10.1016/j.celrep.2019.04.025.

3.

Functional proteomic atlas of HIV infection in primary human CD4+ T cells.

Naamati A, Williamson JC, Greenwood EJ, Marelli S, Lehner PJ, Matheson NJ.

Elife. 2019 Mar 12;8. pii: e41431. doi: 10.7554/eLife.41431.

4.

Monocytes Latently Infected with Human Cytomegalovirus Evade Neutrophil Killing.

Elder E, Krishna B, Williamson J, Aslam Y, Farahi N, Wood A, Romashova V, Roche K, Murphy E, Chilvers E, Lehner PJ, Sinclair J, Poole E.

iScience. 2019 Feb 22;12:13-26. doi: 10.1016/j.isci.2019.01.007. Epub 2019 Jan 8.

5.

An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles.

Ortiz A, Gui J, Zahedi F, Yu P, Cho C, Bhattacharya S, Carbone CJ, Yu Q, Katlinski KV, Katlinskaya YV, Handa S, Haas V, Volk SW, Brice AK, Wals K, Matheson NJ, Antrobus R, Ludwig S, Whiteside TL, Sander C, Tarhini AA, Kirkwood JM, Lehner PJ, Guo W, Rui H, Minn AJ, Koumenis C, Diehl JA, Fuchs SY.

Cancer Cell. 2019 Jan 14;35(1):33-45.e6. doi: 10.1016/j.ccell.2018.12.001.

PMID:
30645975
6.

The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1.

Menzies SA, Volkmar N, van den Boomen DJ, Timms RT, Dickson AS, Nathan JA, Lehner PJ.

Elife. 2018 Dec 13;7. pii: e40009. doi: 10.7554/eLife.40009.

7.

Differential viral accessibility (DIVA) identifies alterations in chromatin architecture through large-scale mapping of lentiviral integration sites.

Timms RT, Tchasovnikarova IA, Lehner PJ.

Nat Protoc. 2019 Jan;14(1):153-170. doi: 10.1038/s41596-018-0087-5.

PMID:
30518911
8.

Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia.

Mangolini M, Götte F, Moore A, Ammon T, Oelsner M, Lutzny-Geier G, Klein-Hitpass L, Williamson JC, Lehner PJ, Dürig J, Möllmann M, Rásó-Barnett L, Hughes K, Santoro A, Méndez-Ferrer S, Oostendorp RAJ, Zimber-Strobl U, Peschel C, Hodson DJ, Schmidt-Supprian M, Ringshausen I.

Nat Commun. 2018 Sep 21;9(1):3839. doi: 10.1038/s41467-018-06069-5.

9.

The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes.

Robbez-Masson L, Tie CHC, Conde L, Tunbak H, Husovsky C, Tchasovnikarova IA, Timms RT, Herrero J, Lehner PJ, Rowe HM.

Genome Res. 2018 Jun;28(6):836-845. doi: 10.1101/gr.228171.117. Epub 2018 May 4.

10.

Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses.

Wang ECY, Pjechova M, Nightingale K, Vlahava VM, Patel M, Ruckova E, Forbes SK, Nobre L, Antrobus R, Roberts D, Fielding CA, Seirafian S, Davies J, Murrell I, Lau B, Wilkie GS, Suárez NM, Stanton RJ, Vojtesek B, Davison A, Lehner PJ, Weekes MP, Wilkinson GWG, Tomasec P.

Proc Natl Acad Sci U S A. 2018 May 8;115(19):4998-5003. doi: 10.1073/pnas.1720950115. Epub 2018 Apr 24.

11.

Gene expression of terminal oxidases in two marine bacterial strains exposed to nanomolar oxygen concentrations.

Gong X, Garcia-Robledo E, Lund MB, Lehner P, Borisov SM, Klimant I, Revsbech NP, Schramm A.

FEMS Microbiol Ecol. 2018 Jul 1;94(7). doi: 10.1093/femsec/fiy072.

PMID:
29688454
12.

Regulation of Human γδ T Cells by BTN3A1 Protein Stability and ATP-Binding Cassette Transporters.

Rhodes DA, Chen HC, Williamson JC, Hill A, Yuan J, Smith S, Rhodes H, Trowsdale J, Lehner PJ, Herrmann T, Eberl M.

Front Immunol. 2018 Apr 4;9:662. doi: 10.3389/fimmu.2018.00662. eCollection 2018.

13.

MARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins.

Stefanovic-Barrett S, Dickson AS, Burr SP, Williamson JC, Lobb IT, van den Boomen DJ, Lehner PJ, Nathan JA.

EMBO Rep. 2018 May;19(5). pii: e45603. doi: 10.15252/embr.201745603. Epub 2018 Mar 8.

14.

Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms.

Douse CH, Bloor S, Liu Y, Shamin M, Tchasovnikarova IA, Timms RT, Lehner PJ, Modis Y.

Nat Commun. 2018 Feb 13;9(1):651. doi: 10.1038/s41467-018-03045-x.

15.

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity.

Burr ML, Sparbier CE, Chan YC, Williamson JC, Woods K, Beavis PA, Lam EYN, Henderson MA, Bell CC, Stolzenburg S, Gilan O, Bloor S, Noori T, Morgens DW, Bassik MC, Neeson PJ, Behren A, Darcy PK, Dawson SJ, Voskoboinik I, Trapani JA, Cebon J, Lehner PJ, Dawson MA.

Nature. 2017 Sep 7;549(7670):101-105. doi: 10.1038/nature23643. Epub 2017 Aug 16.

16.

A genome-wide CRISPR screen reconciles the role of N-linked glycosylation in galectin-3 transport to the cell surface.

Stewart SE, Menzies SA, Popa SJ, Savinykh N, Petrunkina Harrison A, Lehner PJ, Moreau K.

J Cell Sci. 2017 Oct 1;130(19):3234-3247. doi: 10.1242/jcs.206425. Epub 2017 Aug 3.

17.

Multiple E2 ubiquitin-conjugating enzymes regulate human cytomegalovirus US2-mediated immunoreceptor downregulation.

van de Weijer ML, Schuren ABC, van den Boomen DJH, Mulder A, Claas FHJ, Lehner PJ, Lebbink RJ, Wiertz EJHJ.

J Cell Sci. 2017 Sep 1;130(17):2883-2892. doi: 10.1242/jcs.206839. Epub 2017 Jul 25.

18.

Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.

Tchasovnikarova IA, Timms RT, Douse CH, Roberts RC, Dougan G, Kingston RE, Modis Y, Lehner PJ.

Nat Genet. 2017 Jul;49(7):1035-1044. doi: 10.1038/ng.3878. Epub 2017 Jun 5.

19.

MARCH9-mediated ubiquitination regulates MHC I export from the TGN.

De Angelis Rigotti F, De Gassart A, Pforr C, Cano F, N'Guessan P, Combes A, Camossetto V, Lehner PJ, Pierre P, Gatti E.

Immunol Cell Biol. 2017 Oct;95(9):753-764. doi: 10.1038/icb.2017.44. Epub 2017 May 31.

PMID:
28559542
20.

Increased light-use efficiency sustains net primary productivity of shaded coffee plants in agroforestry system.

Charbonnier F, Roupsard O, le Maire G, Guillemot J, Casanoves F, Lacointe A, Vaast P, Allinne C, Audebert L, Cambou A, Clément-Vidal A, Defrenet E, Duursma RA, Jarri L, Jourdan C, Khac E, Leandro P, Medlyn BE, Saint-André L, Thaler P, Van Den Meersche K, Barquero Aguilar A, Lehner P, Dreyer E.

Plant Cell Environ. 2017 Aug;40(8):1592-1608. doi: 10.1111/pce.12964. Epub 2017 Jun 20.

PMID:
28382683
21.

Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation.

Fielding CA, Weekes MP, Nobre LV, Ruckova E, Wilkie GS, Paulo JA, Chang C, Suárez NM, Davies JA, Antrobus R, Stanton RJ, Aicheler RJ, Nichols H, Vojtesek B, Trowsdale J, Davison AJ, Gygi SP, Tomasec P, Lehner PJ, Wilkinson GW.

Elife. 2017 Feb 10;6. pii: e22206. doi: 10.7554/eLife.22206.

22.

Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions.

Burr SP, Costa AS, Grice GL, Timms RT, Lobb IT, Freisinger P, Dodd RB, Dougan G, Lehner PJ, Frezza C, Nathan JA.

Cell Metab. 2016 Nov 8;24(5):740-752. doi: 10.1016/j.cmet.2016.09.015. Epub 2016 Oct 27.

23.

Temporal proteomic analysis of HIV infection reveals remodelling of the host phosphoproteome by lentiviral Vif variants.

Greenwood EJ, Matheson NJ, Wals K, van den Boomen DJ, Antrobus R, Williamson JC, Lehner PJ.

Elife. 2016 Sep 30;5. pii: e18296. doi: 10.7554/eLife.18296.

24.

ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex.

Timms RT, Tchasovnikarova IA, Antrobus R, Dougan G, Lehner PJ.

Cell Rep. 2016 Oct 11;17(3):653-659. doi: 10.1016/j.celrep.2016.09.050.

25.

NOTCH1 mediates a switch between two distinct secretomes during senescence.

Hoare M, Ito Y, Kang TW, Weekes MP, Matheson NJ, Patten DA, Shetty S, Parry AJ, Menon S, Salama R, Antrobus R, Tomimatsu K, Howat W, Lehner PJ, Zender L, Narita M.

Nat Cell Biol. 2016 Sep;18(9):979-92. doi: 10.1038/ncb3397. Epub 2016 Aug 15.

26.

Manipulation of immunometabolism by HIV-accessories to the crime?

Matheson NJ, Greenwood EJ, Lehner PJ.

Curr Opin Virol. 2016 Aug;19:65-70. doi: 10.1016/j.coviro.2016.06.014. Epub 2016 Jul 21. Review.

PMID:
27448768
27.

Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens.

Timms RT, Menzies SA, Tchasovnikarova IA, Christensen LC, Williamson JC, Antrobus R, Dougan G, Ellgaard L, Lehner PJ.

Nat Commun. 2016 Jun 10;7:11786. doi: 10.1038/ncomms11786.

28.

A Genetic Screen Identifies a Critical Role for the WDR81-WDR91 Complex in the Trafficking and Degradation of Tetherin.

Rapiteanu R, Davis LJ, Williamson JC, Timms RT, Paul Luzio J, Lehner PJ.

Traffic. 2016 Aug;17(8):940-58. doi: 10.1111/tra.12409. Epub 2016 May 25.

29.

Human Cytomegalovirus Infection Upregulates the Mitochondrial Transcription and Translation Machineries.

Karniely S, Weekes MP, Antrobus R, Rorbach J, van Haute L, Umrania Y, Smith DL, Stanton RJ, Minczuk M, Lehner PJ, Sinclair JH.

MBio. 2016 Mar 29;7(2):e00029. doi: 10.1128/mBio.00029-16.

30.

Position-effect variegation revisited: HUSHing up heterochromatin in human cells.

Timms RT, Tchasovnikarova IA, Lehner PJ.

Bioessays. 2016 Apr;38(4):333-43. doi: 10.1002/bies.201500184. Epub 2016 Feb 8. Review.

PMID:
26853531
31.

A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.

Cano F, Rapiteanu R, Sebastiaan Winkler G, Lehner PJ.

Nat Commun. 2015 Oct 16;6:8670. doi: 10.1038/ncomms9670.

32.

Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef.

Matheson NJ, Sumner J, Wals K, Rapiteanu R, Weekes MP, Vigan R, Weinelt J, Schindler M, Antrobus R, Costa AS, Frezza C, Clish CB, Neil SJ, Lehner PJ.

Cell Host Microbe. 2015 Oct 14;18(4):409-23. doi: 10.1016/j.chom.2015.09.003. Epub 2015 Oct 1.

33.

Effect of UBE2L3 genotype on regulation of the linear ubiquitin chain assembly complex in systemic lupus erythematosus.

Lewis M, Vyse S, Shields A, Boeltz S, Gordon P, Spector T, Lehner P, Walczak H, Vyse T.

Lancet. 2015 Feb 26;385 Suppl 1:S9. doi: 10.1016/S0140-6736(15)60324-5.

PMID:
26312912
34.

Antagonism of aminoacid transport in primary CD4 T cells by HIV-1 Vpu.

Matheson N, Wals K, Weekes M, Rapiteanu R, Vigan R, Antrobus R, Smith D, Neil S, Lehner P.

Lancet. 2015 Feb 26;385 Suppl 1:S66. doi: 10.1016/S0140-6736(15)60381-6.

PMID:
26312888
35.

A non-canonical ESCRT pathway, including histidine domain phosphotyrosine phosphatase (HD-PTP), is used for down-regulation of virally ubiquitinated MHC class I.

Parkinson MD, Piper SC, Bright NA, Evans JL, Boname JM, Bowers K, Lehner PJ, Luzio JP.

Biochem J. 2015 Oct 1;471(1):79-88. doi: 10.1042/BJ20150336. Epub 2015 Jul 28.

36.

Identifying the ERAD ubiquitin E3 ligases for viral and cellular targeting of MHC class I.

van den Boomen DJ, Lehner PJ.

Mol Immunol. 2015 Dec;68(2 Pt A):106-11. doi: 10.1016/j.molimm.2015.07.005. Epub 2015 Jul 22. Review.

37.

TRIM5α requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription.

Fletcher AJ, Christensen DE, Nelson C, Tan CP, Schaller T, Lehner PJ, Sundquist WI, Towers GJ.

EMBO J. 2015 Aug 4;34(15):2078-95. doi: 10.15252/embj.201490361. Epub 2015 Jun 22.

38.

LUMOS--A Sensitive and Reliable Optode System for Measuring Dissolved Oxygen in the Nanomolar Range.

Lehner P, Larndorfer C, Garcia-Robledo E, Larsen M, Borisov SM, Revsbech NP, Glud RN, Canfield DE, Klimant I.

PLoS One. 2015 Jun 1;10(6):e0128125. doi: 10.1371/journal.pone.0128125. eCollection 2015.

39.

GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.

Tchasovnikarova IA, Timms RT, Matheson NJ, Wals K, Antrobus R, Göttgens B, Dougan G, Dawson MA, Lehner PJ.

Science. 2015 Jun 26;348(6242):1481-1485. doi: 10.1126/science.aaa7227. Epub 2015 May 28.

40.

Human cytomegalovirus: taking the strain.

Wilkinson GW, Davison AJ, Tomasec P, Fielding CA, Aicheler R, Murrell I, Seirafian S, Wang EC, Weekes M, Lehner PJ, Wilkie GS, Stanton RJ.

Med Microbiol Immunol. 2015 Jun;204(3):273-84. doi: 10.1007/s00430-015-0411-4. Epub 2015 Apr 17. Review.

41.

Plasma membrane profiling defines an expanded class of cell surface proteins selectively targeted for degradation by HCMV US2 in cooperation with UL141.

Hsu JL, van den Boomen DJ, Tomasec P, Weekes MP, Antrobus R, Stanton RJ, Ruckova E, Sugrue D, Wilkie GS, Davison AJ, Wilkinson GW, Lehner PJ.

PLoS Pathog. 2015 Apr 14;11(4):e1004811. doi: 10.1371/journal.ppat.1004811. eCollection 2015 Apr.

42.

UBE2L3 polymorphism amplifies NF-κB activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases.

Lewis MJ, Vyse S, Shields AM, Boeltz S, Gordon PA, Spector TD, Lehner PJ, Walczak H, Vyse TJ.

Am J Hum Genet. 2015 Feb 5;96(2):221-34. doi: 10.1016/j.ajhg.2014.12.024. Epub 2015 Jan 29.

43.

Intrinsic artefacts in optical oxygen sensors--how reliable are our measurements?

Lehner P, Staudinger C, Borisov SM, Regensburger J, Klimant I.

Chemistry. 2015 Mar 2;21(10):3978-86. doi: 10.1002/chem.201406037. Epub 2015 Jan 28.

PMID:
25630306
44.

The effect of high light intensities on luminescence lifetime based oxygen sensing.

Larndorfer C, Borisov SM, Lehner P, Klimant I.

Analyst. 2014 Dec 21;139(24):6569-79. doi: 10.1039/c4an01058b.

PMID:
25364788
45.

Antibody-free magnetic cell sorting of genetically modified primary human CD4+ T cells by one-step streptavidin affinity purification.

Matheson NJ, Peden AA, Lehner PJ.

PLoS One. 2014 Oct 31;9(10):e111437. doi: 10.1371/journal.pone.0111437. eCollection 2014.

46.

Fat mass and obesity-related (FTO) shuttles between the nucleus and cytoplasm.

Gulati P, Avezov E, Ma M, Antrobus R, Lehner P, O'Rahilly S, Yeo GS.

Biosci Rep. 2014 Oct 22;34(5). pii: e00144. doi: 10.1042/BSR20140111.

47.

HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells.

Stanton RJ, Prod'homme V, Purbhoo MA, Moore M, Aicheler RJ, Heinzmann M, Bailer SM, Haas J, Antrobus R, Weekes MP, Lehner PJ, Vojtesek B, Miners KL, Man S, Wilkie GS, Davison AJ, Wang ECY, Tomasec P, Wilkinson GWG.

Cell Host Microbe. 2014 Aug 13;16(2):201-214. doi: 10.1016/j.chom.2014.07.005.

48.

Ultra-sensitive optical oxygen sensors for characterization of nearly anoxic systems.

Lehner P, Staudinger C, Borisov SM, Klimant I.

Nat Commun. 2014 Jul 21;5:4460. doi: 10.1038/ncomms5460.

49.

TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I.

van den Boomen DJ, Timms RT, Grice GL, Stagg HR, Skødt K, Dougan G, Nathan JA, Lehner PJ.

Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11425-30. doi: 10.1073/pnas.1409099111. Epub 2014 Jul 16.

50.

Cleavage by signal peptide peptidase is required for the degradation of selected tail-anchored proteins.

Boname JM, Bloor S, Wandel MP, Nathan JA, Antrobus R, Dingwell KS, Thurston TL, Smith DL, Smith JC, Randow F, Lehner PJ.

J Cell Biol. 2014 Jun 23;205(6):847-62. doi: 10.1083/jcb.201312009.

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