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Items: 22

1.

Discovery of a Novel Inhaled PI3Kδ Inhibitor for the Treatment of Respiratory Diseases.

Erra M, Taltavull J, Bernal FJ, Caturla JF, Carrascal M, Pagès L, Mir M, Espinosa S, Gràcia J, Domínguez M, Sabaté M, Paris S, Maldonado M, Hernández B, Bravo M, Calama E, Miralpeix M, Lehner MD, Calbet M.

J Med Chem. 2018 Nov 8;61(21):9551-9567. doi: 10.1021/acs.jmedchem.8b00873. Epub 2018 Oct 29.

PMID:
30351000
2.

In vivo and in vitro investigation of anti-inflammatory and mucus-regulatory activities of a fixed combination of thyme and primula extracts.

Seibel J, Kryshen K, Pongrácz JE, Lehner MD.

Pulm Pharmacol Ther. 2018 Aug;51:10-17. doi: 10.1016/j.pupt.2018.04.009. Epub 2018 Apr 24.

PMID:
29698781
3.

4-Amino-7,8-dihydro-1,6-naphthyridin-5(6 H)-ones as Inhaled Phosphodiesterase Type 4 (PDE4) Inhibitors: Structural Biology and Structure-Activity Relationships.

Roberts RS, Sevilla S, Ferrer M, Taltavull J, Hernández B, Segarra V, Gràcia J, Lehner MD, Gavaldà A, Andrés M, Cabedo J, Vilella D, Eichhorn P, Calama E, Carcasona C, Miralpeix M.

J Med Chem. 2018 Mar 22;61(6):2472-2489. doi: 10.1021/acs.jmedchem.7b01751. Epub 2018 Mar 13.

PMID:
29502405
4.

Discovery of a Potent, Selective, and Orally Available PI3Kδ Inhibitor for the Treatment of Inflammatory Diseases.

Erra M, Taltavull J, Gréco A, Bernal FJ, Caturla JF, Gràcia J, Domínguez M, Sabaté M, Paris S, Soria S, Hernández B, Armengol C, Cabedo J, Bravo M, Calama E, Miralpeix M, Lehner MD.

ACS Med Chem Lett. 2016 Nov 30;8(1):118-123. doi: 10.1021/acsmedchemlett.6b00438. eCollection 2017 Jan 12.

5.

Biphenyl Pyridazinone Derivatives as Inhaled PDE4 Inhibitors: Structural Biology and Structure-Activity Relationships.

Gràcia J, Buil MA, Castro J, Eichhorn P, Ferrer M, Gavaldà A, Hernández B, Segarra V, Lehner MD, Moreno I, Pagès L, Roberts RS, Serrat J, Sevilla S, Taltavull J, Andrés M, Cabedo J, Vilella D, Calama E, Carcasona C, Miralpeix M.

J Med Chem. 2016 Dec 8;59(23):10479-10497. Epub 2016 Nov 17.

PMID:
27933955
6.

Anti-inflammatory potential of PI3Kδ and JAK inhibitors in asthma patients.

Southworth T, Plumb J, Gupta V, Pearson J, Ramis I, Lehner MD, Miralpeix M, Singh D.

Respir Res. 2016 Oct 4;17(1):124.

7.

Bronchipret® syrup containing thyme and ivy extracts suppresses bronchoalveolar inflammation and goblet cell hyperplasia in experimental bronchoalveolitis.

Seibel J, Pergola C, Werz O, Kryshen K, Wosikowski K, Lehner MD, Haunschild J.

Phytomedicine. 2015 Dec 1;22(13):1172-7. doi: 10.1016/j.phymed.2015.09.001. Epub 2015 Oct 1.

PMID:
26598916
8.

Combined anti CXC receptors 1 and 2 therapy is a promising anti-inflammatory treatment for respiratory diseases by reducing neutrophil migration and activation.

Planagumà A, Domènech T, Pont M, Calama E, García-González V, López R, Aulí M, López M, Fonquerna S, Ramos I, de Alba J, Nueda A, Prats N, Segarra V, Miralpeix M, Lehner MD.

Pulm Pharmacol Ther. 2015 Oct;34:37-45. doi: 10.1016/j.pupt.2015.08.002. Epub 2015 Aug 10. Review.

PMID:
26271598
9.

2-(1H-Pyrazol-1-yl)acetic acids as chemoattractant receptor-homologous molecule expressed on Th2 lymphocytes (CRTh2) antagonists.

Andrés M, Bravo M, Buil MA, Calbet M, Castillo M, Castro J, Eichhorn P, Ferrer M, Lehner MD, Moreno I, Roberts RS, Sevilla S.

Eur J Med Chem. 2014 Jan;71:168-84. doi: 10.1016/j.ejmech.2013.10.072. Epub 2013 Nov 9.

PMID:
24292338
10.

2-(1H-Pyrazol-4-yl)acetic acids as CRTh2 antagonists.

Andrés M, Bravo M, Buil MA, Calbet M, Castro J, Domènech T, Eichhorn P, Ferrer M, Gómez E, Lehner MD, Moreno I, Roberts RS, Sevilla S.

Bioorg Med Chem Lett. 2013 Jun 1;23(11):3349-53. doi: 10.1016/j.bmcl.2013.03.093. Epub 2013 Apr 2.

PMID:
23601708
11.

PDE4 inhibitors: a review of current developments (2005 - 2009).

Pagès L, Gavaldà A, Lehner MD.

Expert Opin Ther Pat. 2009 Nov;19(11):1501-19. doi: 10.1517/13543770903313753. Review.

PMID:
19832118
12.

Inhibition of inducible nitric oxide synthase in respiratory diseases.

Hesslinger C, Strub A, Boer R, Ulrich WR, Lehner MD, Braun C.

Biochem Soc Trans. 2009 Aug;37(Pt 4):886-91. doi: 10.1042/BST0370886. Review.

PMID:
19614613
13.

In vivo characterization of the novel imidazopyridine BYK191023 [2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine], a potent and highly selective inhibitor of inducible nitric-oxide synthase.

Lehner MD, Marx D, Boer R, Strub A, Hesslinger C, Eltze M, Ulrich WR, Schwoebel F, Schermuly RT, Barsig J.

J Pharmacol Exp Ther. 2006 Apr;317(1):181-7. Epub 2005 Dec 20.

PMID:
16368897
14.

The novel imidazopyridine 2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine (BYK191023) is a highly selective inhibitor of the inducible nitric-oxide synthase.

Strub A, Ulrich WR, Hesslinger C, Eltze M, Fuchss T, Strassner J, Strand S, Lehner MD, Boer R.

Mol Pharmacol. 2006 Jan;69(1):328-37. Epub 2005 Oct 13.

PMID:
16223957
15.

Differential effects of CpG-DNA in Toll-like receptor-2/-4/-9 tolerance and cross-tolerance.

Dalpke AH, Lehner MD, Hartung T, Heeg K.

Immunology. 2005 Oct;116(2):203-12.

16.

Methotrexate treatment suppresses local cytokine and chemokine production in rat adjuvant arthritis.

Barsig J, Yam G, Lehner MD, Beume R.

Drugs Exp Clin Res. 2005;31(1):7-11.

PMID:
15921024
17.

Endotoxin tolerance-mechanisms and beneficial effects in bacterial infection.

Lehner MD, Hartung T.

Rev Physiol Biochem Pharmacol. 2002;144:95-141. Review. No abstract available.

PMID:
11987826
18.

Mitogen-activated protein kinase-activated protein kinase 2-deficient mice show increased susceptibility to Listeria monocytogenes infection.

Lehner MD, Schwoebel F, Kotlyarov A, Leist M, Gaestel M, Hartung T.

J Immunol. 2002 May 1;168(9):4667-73.

19.

Inhibition of cyclooxygenase-2 by natriuretic peptides.

Kiemer AK, Lehner MD, Hartung T, Vollmar AM.

Endocrinology. 2002 Mar;143(3):846-52.

PMID:
11861506
20.

Cytokine induction by purified lipoteichoic acids from various bacterial species--role of LBP, sCD14, CD14 and failure to induce IL-12 and subsequent IFN-gamma release.

Hermann C, Spreitzer I, Schröder NW, Morath S, Lehner MD, Fischer W, Schütt C, Schumann RR, Hartung T.

Eur J Immunol. 2002 Feb;32(2):541-51.

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