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Enchondromas and atypical cartilaginous tumors at the proximal humerus treated with intralesional resection and bone cement filling with or without osteosynthesis: retrospective analysis of 42 cases with 6 years mean follow-up.

Omlor GW, Lohnherr V, Lange J, Gantz S, Merle C, Fellenberg J, Raiss P, Lehner B.

World J Surg Oncol. 2018 Jul 13;16(1):139. doi: 10.1186/s12957-018-1437-z.


Systematic discovery of germline cancer predisposition genes through the identification of somatic second hits.

Park S, Supek F, Lehner B.

Nat Commun. 2018 Jul 4;9(1):2601. doi: 10.1038/s41467-018-04900-7.


Host-Pathogen Interaction Reconstituted in Three-Dimensional Cocultures of Mucosa and Candida albicans.

Buchs R, Lehner B, Meuwly P, Schnyder B.

Tissue Eng Part C Methods. 2018 Jul;24(7):412-417. doi: 10.1089/ten.TEC.2018.0042.


Pairwise and higher-order genetic interactions during the evolution of a tRNA.

Domingo J, Diss G, Lehner B.

Nature. 2018 Jun;558(7708):117-121. doi: 10.1038/s41586-018-0170-7. Epub 2018 May 30.


The genetic landscape of a physical interaction.

Diss G, Lehner B.

Elife. 2018 Apr 11;7. pii: e32472. doi: 10.7554/eLife.32472.


[Infections after reconstructive spinal interventions : How do I deal with them?]

Lehner B, Akbar M, Beckmann NA.

Orthopade. 2018 Apr;47(4):288-295. doi: 10.1007/s00132-018-3557-0. Review. German.


Modelling crop land use change derived from influencing factors selected and ranked by farmers in North temperate agricultural regions.

Mehdi B, Lehner B, Ludwig R.

Sci Total Environ. 2018 Aug 1;631-632:407-420. doi: 10.1016/j.scitotenv.2018.03.014. Epub 2018 Mar 16.


[Metastatic breast cancer in the spine : Molecular predictors for choosing adequate treatment strategies].

Adler D, Kriegsmann M, Sinn P, Schneeweiss A, Almansour H, Lehner B, Akbar M.

Orthopade. 2018 Jul;47(7):594-603. doi: 10.1007/s00132-018-3540-9. German.


Integrative genomic and transcriptomic analysis of leiomyosarcoma.

Chudasama P, Mughal SS, Sanders MA, Hübschmann D, Chung I, Deeg KI, Wong SH, Rabe S, Hlevnjak M, Zapatka M, Ernst A, Kleinheinz K, Schlesner M, Sieverling L, Klink B, Schröck E, Hoogenboezem RM, Kasper B, Heilig CE, Egerer G, Wolf S, von Kalle C, Eils R, Stenzinger A, Weichert W, Glimm H, Gröschel S, Kopp HG, Omlor G, Lehner B, Bauer S, Schimmack S, Ulrich A, Mechtersheimer G, Rippe K, Brors B, Hutter B, Renner M, Hohenberger P, Scholl C, Fröhling S.

Nat Commun. 2018 Jan 10;9(1):144. doi: 10.1038/s41467-017-02602-0.


Maternal age generates phenotypic variation in Caenorhabditis elegans.

Perez MF, Francesconi M, Hidalgo-Carcedo C, Lehner B.

Nature. 2017 Dec 7;552(7683):106-109. doi: 10.1038/nature25012. Epub 2017 Nov 29.


Systematic Analysis of the Determinants of Gene Expression Noise in Embryonic Stem Cells.

Faure AJ, Schmiedel JM, Lehner B.

Cell Syst. 2017 Nov 22;5(5):471-484.e4. doi: 10.1016/j.cels.2017.10.003. Epub 2017 Nov 1.


MiR-127 and miR-376a act as tumor suppressors by in vivo targeting of COA1 and PDIA6 in giant cell tumor of bone.

Herr I, Sähr H, Zhao Z, Yin L, Omlor G, Lehner B, Fellenberg J.

Cancer Lett. 2017 Nov 28;409:49-55. doi: 10.1016/j.canlet.2017.08.029. Epub 2017 Sep 1.


Impaired DNA replication derepresses chromatin and generates a transgenerationally inherited epigenetic memory.

Klosin A, Reis K, Hidalgo-Carcedo C, Casas E, Vavouri T, Lehner B.

Sci Adv. 2017 Aug 16;3(8):e1701143. doi: 10.1126/sciadv.1701143. eCollection 2017 Aug.


Bacterial Infection and Implant Loosening in Hip and Knee Arthroplasty: Evaluation of 209 Cases.

Dapunt U, Radzuweit-Mihaljevic S, Lehner B, Haensch GM, Ewerbeck V.

Materials (Basel). 2016 Oct 26;9(11). pii: E871. doi: 10.3390/ma9110871.


Clustered Mutation Signatures Reveal that Error-Prone DNA Repair Targets Mutations to Active Genes.

Supek F, Lehner B.

Cell. 2017 Jul 27;170(3):534-547.e23. doi: 10.1016/j.cell.2017.07.003.


A Transcriptome Survey Spanning Life Stages and Sexes of the Harlequin Bug, Murgantia histrionica.

Sparks ME, Rhoades JH, Nelson DR, Kuhar D, Lancaster J, Lehner B, Tholl D, Weber DC, Gundersen-Rindal DE.

Insects. 2017 May 25;8(2). pii: E55. doi: 10.3390/insects8020055.


[Diagnostics and treatment of benign spinal tumors].

Lehner B, Rehnitz C, Geisbüsch A, Akbar M, Omlor GW.

Orthopade. 2017 Jun;46(6):505-509. doi: 10.1007/s00132-017-3432-4. German.


Transgenerational transmission of environmental information in C. elegans.

Klosin A, Casas E, Hidalgo-Carcedo C, Vavouri T, Lehner B.

Science. 2017 Apr 21;356(6335):320-323. doi: 10.1126/science.aah6412.


3D structures of individual mammalian genomes studied by single-cell Hi-C.

Stevens TJ, Lando D, Basu S, Atkinson LP, Cao Y, Lee SF, Leeb M, Wohlfahrt KJ, Boucher W, O'Shaughnessy-Kirwan A, Cramard J, Faure AJ, Ralser M, Blanco E, Morey L, Sansó M, Palayret MGS, Lehner B, Di Croce L, Wutz A, Hendrich B, Klenerman D, Laue ED.

Nature. 2017 Apr 6;544(7648):59-64. doi: 10.1038/nature21429. Epub 2017 Mar 13.


A Straightforward Approach for 3D Bacterial Printing.

Lehner BAE, Schmieden DT, Meyer AS.

ACS Synth Biol. 2017 Jul 21;6(7):1124-1130. doi: 10.1021/acssynbio.6b00395. Epub 2017 Mar 1.


Structural changes in the thigh muscles following trans-femoral amputation.

Putz C, Block J, Gantz S, Heitzmann DWW, Dreher T, Lehner B, Alimusaj M, Wolf SI, Müller S.

Eur J Orthop Surg Traumatol. 2017 Aug;27(6):829-835. doi: 10.1007/s00590-017-1929-5. Epub 2017 Feb 21.


[Mazabraud and McCune-Albright syndromes in association : A case of two very rare orthopaedic tumour entities].

Schwarze M, Weber MA, Mechtersheimer G, Lehner B, Renker EK.

Orthopade. 2017 Sep;46(9):776-780. doi: 10.1007/s00132-017-3399-1. German.


Estimating the volume and age of water stored in global lakes using a geo-statistical approach.

Messager ML, Lehner B, Grill G, Nedeva I, Schmitt O.

Nat Commun. 2016 Dec 15;7:13603. doi: 10.1038/ncomms13603.


The rules and impact of nonsense-mediated mRNA decay in human cancers.

Lindeboom RG, Supek F, Lehner B.

Nat Genet. 2016 Oct;48(10):1112-8. doi: 10.1038/ng.3664. Epub 2016 Sep 12.


Compensatory Cell Movements Confer Robustness to Mechanical Deformation during Embryonic Development.

Jelier R, Kruger A, Swoger J, Zimmermann T, Lehner B.

Cell Syst. 2016 Aug;3(2):160-171. doi: 10.1016/j.cels.2016.07.005. Epub 2016 Aug 11.


MUFFINN: cancer gene discovery via network analysis of somatic mutation data.

Cho A, Shim JE, Kim E, Supek F, Lehner B, Lee I.

Genome Biol. 2016 Jun 23;17(1):129. doi: 10.1186/s13059-016-0989-x.


A Concentration-Dependent Liquid Phase Separation Can Cause Toxicity upon Increased Protein Expression.

Bolognesi B, Lorenzo Gotor N, Dhar R, Cirillo D, Baldrighi M, Tartaglia GG, Lehner B.

Cell Rep. 2016 Jun 28;16(1):222-231. doi: 10.1016/j.celrep.2016.05.076. Epub 2016 Jun 16.


The complete local genotype-phenotype landscape for the alternative splicing of a human exon.

Julien P, Miñana B, Baeza-Centurion P, Valcárcel J, Lehner B.

Nat Commun. 2016 May 10;7:11558. doi: 10.1038/ncomms11558.


Mechanisms, timescales and principles of trans-generational epigenetic inheritance in animals.

Klosin A, Lehner B.

Curr Opin Genet Dev. 2016 Feb;36:41-9. doi: 10.1016/j.gde.2016.04.001. Epub 2016 Apr 30. Review.


Moving the mandible in orthognathic surgery - A multicenter analysis.

Thiele OC, Kreppel M, Bittermann G, Bonitz L, Desmedt M, Dittes C, Dörre A, Dunsche A, Eckert AW, Ehrenfeld M, Fleiner B, Frerich B, Gaggl A, Gerressen M, Gmelin L, Hammacher A, Haßfeld S, Heiland M, Hemprich A, Hidding J, Hölzle F, Howaldt HP, Iizuka T, Kater W, Klein C, Klein M, Köhnke RH, Kolk A, Kübler AC, Kübler NR, Kunkel M, Kuttenberger JJ, Kreusch T, Landes C, Lehner B, Mischkowski RA, Mokros S, Neff A, Nkenke E, Palm F, Paulus GW, Piesold JU, Rasse M, Rodemer H, Rothamel D, Rustemeyer J, Sader R, Scheer M, Scheffler B, Schippers C, Schliephake H, Schmelzeisen R, Schramm A, Spitzer WJ, Stoll C, Terheyden H, Weingart D, Wiltfang J, Wolff KD, Ziegler CM, Zöller JE.

J Craniomaxillofac Surg. 2016 May;44(5):579-83. doi: 10.1016/j.jcms.2016.01.024. Epub 2016 Feb 3.


Elevated ratio of MMP2/MMP9 activity is associated with poor response to chemotherapy in osteosarcoma.

Kunz P, Sähr H, Lehner B, Fischer C, Seebach E, Fellenberg J.

BMC Cancer. 2016 Mar 15;16:223. doi: 10.1186/s12885-016-2266-5.


The Blood Group A Genotype Determines the Level of Expression of the Blood Group A on Platelets But Not the Anti-B Isotiter.

Lehner B, Eichelberger B, Jungbauer C, Panzer S.

Transfus Med Hemother. 2015 Nov;42(6):366-71. doi: 10.1159/000432414. Epub 2015 Jun 18.


CT-Guided Biopsy in Suspected Spondylodiscitis--The Association of Paravertebral Inflammation with Microbial Pathogen Detection.

Spira D, Germann T, Lehner B, Hemmer S, Akbar M, Jesser J, Weber MA, Rehnitz C.

PLoS One. 2016 Jan 4;11(1):e0146399. doi: 10.1371/journal.pone.0146399. eCollection 2016.


Intraoperative electron radiation therapy combined with external beam radiation therapy and limb sparing surgery in extremity soft tissue sarcoma: a retrospective single center analysis of 183 cases.

Roeder F, Lehner B, Saleh-Ebrahimi L, Hensley FW, Ulrich A, Alldinger I, Mechtersheimer G, Huber PE, Krempien R, Bischof M, Debus J, Uhl M.

Radiother Oncol. 2016 Apr;119(1):22-9. doi: 10.1016/j.radonc.2015.11.014. Epub 2015 Dec 1.


Risk assessment of down-the-drain chemicals at large spatial scales: Model development and application to contaminants originating from urban areas in the Saint Lawrence River Basin.

Grill G, Khan U, Lehner B, Nicell J, Ariwi J.

Sci Total Environ. 2016 Jan 15;541:825-838. doi: 10.1016/j.scitotenv.2015.09.100. Epub 2015 Oct 2. Erratum in: Sci Total Environ. 2016 May 1;551-552:753-4.


Reconstructing and analysing cellular states, space and time from gene expression profiles of many cells and single cells.

Francesconi M, Lehner B.

Mol Biosyst. 2015 Oct;11(10):2690-8. doi: 10.1039/c5mb00339c. Review.


Slow-growing cells within isogenic populations have increased RNA polymerase error rates and DNA damage.

van Dijk D, Dhar R, Missarova AM, Espinar L, Blevins WR, Lehner B, Carey LB.

Nat Commun. 2015 Aug 13;6:7972. doi: 10.1038/ncomms8972.


Increased antibiotic release and equivalent biomechanics of a spacer cement without hard radio contrast agents.

Bitsch RG, Kretzer JP, Vogt S, Büchner H, Thomsen MN, Lehner B.

Diagn Microbiol Infect Dis. 2015 Oct;83(2):203-9. doi: 10.1016/j.diagmicrobio.2015.06.019. Epub 2015 Jul 2.


Systems biology: Network evolution hinges on history.

New AM, Lehner B.

Nature. 2015 Jul 16;523(7560):297-8. doi: 10.1038/nature14537. Epub 2015 Jul 8. No abstract available.


[Secreting and destroying infection of the foot].

Schwarze M, Weber MA, Lehner B, Maier MW.

Radiologe. 2015 Jul;55(7):588-92. doi: 10.1007/s00117-015-2865-1. German. No abstract available.


[Osteoidosteoma. From diagnosis to treatment].

Sprengel SD, Weber MA, Lehner B, Rehnitz C.

Radiologe. 2015 Jun;55(6):479-86. doi: 10.1007/s00117-014-2805-5. Review. German.


CD8+/FOXP3+-ratio in osteosarcoma microenvironment separates survivors from non-survivors: a multicenter validated retrospective study.

Fritzsching B, Fellenberg J, Moskovszky L, Sápi Z, Krenacs T, Machado I, Poeschl J, Lehner B, Szendrõi M, Bosch AL, Bernd L, Csóka M, Mechtersheimer G, Ewerbeck V, Kinscherf R, Kunz P.

Oncoimmunology. 2015 Apr 2;4(3):e990800. eCollection 2015 Mar.


Dissecting the calcium-induced differentiation of human primary keratinocytes stem cells by integrative and structural network analyses.

Toufighi K, Yang JS, Luis NM, Aznar Benitah S, Lehner B, Serrano L, Kiel C.

PLoS Comput Biol. 2015 May 6;11(5):e1004256. doi: 10.1371/journal.pcbi.1004256. eCollection 2015 May.


Establishment of a patient-derived orthotopic osteosarcoma mouse model.

Blattmann C, Thiemann M, Stenzinger A, Roth EK, Dittmar A, Witt H, Lehner B, Renker E, Jugold M, Eichwald V, Weichert W, Huber PE, Kulozik AE.

J Transl Med. 2015 Apr 30;13:136. doi: 10.1186/s12967-015-0497-x.


Clinical long-term outcome, technical success, and cost analysis of radiofrequency ablation for the treatment of osteoblastomas and spinal osteoid osteomas in comparison to open surgical resection.

Weber MA, Sprengel SD, Omlor GW, Lehner B, Wiedenhöfer B, Kauczor HU, Rehnitz C.

Skeletal Radiol. 2015 Jul;44(7):981-93. doi: 10.1007/s00256-015-2139-z. Epub 2015 Apr 25.


Differential DNA mismatch repair underlies mutation rate variation across the human genome.

Supek F, Lehner B.

Nature. 2015 May 7;521(7550):81-4. doi: 10.1038/nature14173. Epub 2015 Feb 23.


[Osteolytic diaphyseal tibial lesion with increasing constant dull tibial pain].

Glemser PA, Lehner B, Weber MA.

Radiologe. 2015 Jan;55(1):53-8. doi: 10.1007/s00117-014-2769-5. German. No abstract available.


Comprehensive single cell-resolution analysis of the role of chromatin regulators in early C. elegans embryogenesis.

Krüger AV, Jelier R, Dzyubachyk O, Zimmerman T, Meijering E, Lehner B.

Dev Biol. 2015 Feb 15;398(2):153-62. doi: 10.1016/j.ydbio.2014.10.014. Epub 2014 Oct 28.


Enrichment of c-Met+ tumorigenic stromal cells of giant cell tumor of bone and targeting by cabozantinib.

Liu L, Aleksandrowicz E, Fan P, Schönsiegel F, Zhang Y, Sähr H, Gladkich J, Mattern J, Depeweg D, Lehner B, Fellenberg J, Herr I.

Cell Death Dis. 2014 Oct 16;5:e1471. doi: 10.1038/cddis.2014.440.

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