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Sarcoplasmic reticulum calcium leak contributes to arrhythmia but not to heart failure progression.

Mohamed BA, Hartmann N, Tirilomis P, Sekeres K, Li W, Neef S, Richter C, Zeisberg EM, Kattner L, Didié M, Guan K, Schmitto JD, Lehnart SE, Luther S, Voigt N, Seidler T, Sossalla S, Hasenfuss G, Toischer K.

Sci Transl Med. 2018 Sep 12;10(458). pii: eaan0724. doi: 10.1126/scitranslmed.aan0724.


Differential multivariable risk prediction of appropriate shock versus competing mortality - A prospective cohort study to estimate benefits from ICD therapy.

Bergau L, Willems R, Sprenkeler DJ, Fischer TH, Flevari P, Hasenfuß G, Katsaras D, Kirova A, Lehnart SE, Lüthje L, Röver C, Seegers J, Sossalla S, Dunnink A, Sritharan R, Tuinenburg AE, Vandenberk B, Vos MA, Wijers SC, Friede T, Zabel M.

Int J Cardiol. 2018 Jun 28. pii: S0167-5273(18)32262-9. doi: 10.1016/j.ijcard.2018.06.103. [Epub ahead of print]


Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy.

Richter KN, Revelo NH, Seitz KJ, Helm MS, Sarkar D, Saleeb RS, D'Este E, Eberle J, Wagner E, Vogl C, Lazaro DF, Richter F, Coy-Vergara J, Coceano G, Boyden ES, Duncan RR, Hell SW, Lauterbach MA, Lehnart SE, Moser T, Outeiro TF, Rehling P, Schwappach B, Testa I, Zapiec B, Rizzoli SO.

EMBO J. 2018 Jan 4;37(1):139-159. doi: 10.15252/embj.201695709. Epub 2017 Nov 16.


High-Affinity Functional Fluorescent Ligands for Human β-Adrenoceptors.

Mitronova GY, Lukinavičius G, Butkevich AN, Kohl T, Belov VN, Lehnart SE, Hell SW.

Sci Rep. 2017 Sep 26;7(1):12319. doi: 10.1038/s41598-017-12468-3.


Impaired calcium homeostasis is associated with sudden cardiac death and arrhythmias in a genetic equivalent mouse model of the human HRC-Ser96Ala variant.

Tzimas C, Johnson DM, Santiago DJ, Vafiadaki E, Arvanitis DA, Davos CH, Varela A, Athanasiadis NC, Dimitriou C, Katsimpoulas M, Sonntag S, Kryzhanovska M, Shmerling D, Lehnart SE, Sipido KR, Kranias EG, Sanoudou D.

Cardiovasc Res. 2017 Sep 1;113(11):1403-1417. doi: 10.1093/cvr/cvx113.


Negative Adrenergic Feedback Specific to Phospholamban.

Hasenfuss G, Lehnart SE.

JACC Basic Transl Sci. 2017 Apr 24;2(2):181-183. doi: 10.1016/j.jacbts.2017.02.001. eCollection 2017 Apr. No abstract available.


A protocol for registration and correction of multicolour STED superresolution images.

Hebisch E, Wagner E, Westphal V, Sieber JJ, Lehnart SE.

J Microsc. 2017 Aug;267(2):160-175. doi: 10.1111/jmi.12556. Epub 2017 Apr 3.


Axial tubule junctions control rapid calcium signaling in atria.

Brandenburg S, Kohl T, Williams GS, Gusev K, Wagner E, Rog-Zielinska EA, Hebisch E, Dura M, Didié M, Gotthardt M, Nikolaev VO, Hasenfuss G, Kohl P, Ward CW, Lederer WJ, Lehnart SE.

J Clin Invest. 2016 Oct 3;126(10):3999-4015. doi: 10.1172/JCI88241. Epub 2016 Sep 19.


"Reduced" Coumarin Dyes with an O-Phosphorylated 2,2-Dimethyl-4-(hydroxymethyl)-1,2,3,4-tetrahydroquinoline Fragment: Synthesis, Spectra, and STED Microscopy.

Nizamov S, Sednev MV, Bossi ML, Hebisch E, Frauendorf H, Lehnart SE, Belov VN, Hell SW.

Chemistry. 2016 Aug 8;22(33):11631-42. doi: 10.1002/chem.201601252. Epub 2016 Jul 7.


Exercise training prevents ventricular tachycardia in CPVT1 due to reduced CaMKII-dependent arrhythmogenic Ca2+ release.

Manotheepan R, Danielsen TK, Sadredini M, Anderson ME, Carlson CR, Lehnart SE, Sjaastad I, Stokke MK.

Cardiovasc Res. 2016 Aug 1;111(3):295-306. doi: 10.1093/cvr/cvw095. Epub 2016 May 8.


Optogenetic Light Crafting Tools for the Control of Cardiac Arrhythmias.

Richter C, Christoph J, Lehnart SE, Luther S.

Methods Mol Biol. 2016;1408:293-302. doi: 10.1007/978-1-4939-3512-3_20.


Intensity matters: Ryanodine receptor regulation during exercise.

Kohl T, Weninger G, Zalk R, Eaton P, Lehnart SE.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15271-2. doi: 10.1073/pnas.1521051112. Epub 2015 Dec 2. No abstract available.


The molecular and functional identities of atrial cardiomyocytes in health and disease.

Brandenburg S, Arakel EC, Schwappach B, Lehnart SE.

Biochim Biophys Acta. 2016 Jul;1863(7 Pt B):1882-93. doi: 10.1016/j.bbamcr.2015.11.025. Epub 2015 Nov 24. Review.


On the Adjacency Matrix of RyR2 Cluster Structures.

Walker MA, Kohl T, Lehnart SE, Greenstein JL, Lederer WJ, Winslow RL.

PLoS Comput Biol. 2015 Nov 6;11(11):e1004521. doi: 10.1371/journal.pcbi.1004521. eCollection 2015 Nov.


Ca(2+) signaling in the myocardium by (redox) regulation of PKA/CaMKII.

Johnston AS, Lehnart SE, Burgoyne JR.

Front Pharmacol. 2015 Aug 10;6:166. doi: 10.3389/fphar.2015.00166. eCollection 2015. Review.


Optogenetic determination of the myocardial requirements for extrasystoles by cell type-specific targeting of ChannelRhodopsin-2.

Zaglia T, Pianca N, Borile G, Da Broi F, Richter C, Campione M, Lehnart SE, Luther S, Corrado D, Miquerol L, Mongillo M.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):E4495-504. doi: 10.1073/pnas.1509380112. Epub 2015 Jul 23.


Sensing Cardiac Electrical Activity With a Cardiac Myocyte--Targeted Optogenetic Voltage Indicator.

Chang Liao ML, de Boer TP, Mutoh H, Raad N, Richter C, Wagner E, Downie BR, Unsöld B, Arooj I, Streckfuss-Bömeke K, Döker S, Luther S, Guan K, Wagner S, Lehnart SE, Maier LS, Stühmer W, Wettwer E, van Veen T, Morlock MM, Knöpfel T, Zimmermann WH.

Circ Res. 2015 Aug 14;117(5):401-12. doi: 10.1161/CIRCRESAHA.117.306143. Epub 2015 Jun 15.


Physiologic force-frequency response in engineered heart muscle by electromechanical stimulation.

Godier-Furnémont AF, Tiburcy M, Wagner E, Dewenter M, Lämmle S, El-Armouche A, Lehnart SE, Vunjak-Novakovic G, Zimmermann WH.

Biomaterials. 2015 Aug;60:82-91. doi: 10.1016/j.biomaterials.2015.03.055. Epub 2015 May 15.


In vivo model with targeted cAMP biosensor reveals changes in receptor-microdomain communication in cardiac disease.

Sprenger JU, Perera RK, Steinbrecher JH, Lehnart SE, Maier LS, Hasenfuss G, Nikolaev VO.

Nat Commun. 2015 Apr 28;6:6965. doi: 10.1038/ncomms7965.


Calcium/calmodulin-dependent protein kinase II (CaMKII) inhibition ameliorates arrhythmias elicited by junctin ablation under stress conditions.

Tzimas C, Terrovitis J, Lehnart SE, Kranias EG, Sanoudou D.

Heart Rhythm. 2015 Jul;12(7):1599-610. doi: 10.1016/j.hrthm.2015.03.043. Epub 2015 Mar 23.


Endothelial p53 deletion improves angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice.

Gogiraju R, Xu X, Bochenek ML, Steinbrecher JH, Lehnart SE, Wenzel P, Kessel M, Zeisberg EM, Dobbelstein M, Schäfer K.

J Am Heart Assoc. 2015 Feb 24;4(2). pii: e001770. doi: 10.1161/JAHA.115.001770.


Microdomain switch of cGMP-regulated phosphodiesterases leads to ANP-induced augmentation of β-adrenoceptor-stimulated contractility in early cardiac hypertrophy.

Perera RK, Sprenger JU, Steinbrecher JH, Hübscher D, Lehnart SE, Abesser M, Schuh K, El-Armouche A, Nikolaev VO.

Circ Res. 2015 Apr 10;116(8):1304-11. doi: 10.1161/CIRCRESAHA.116.306082. Epub 2015 Feb 16.


Superresolution modeling of calcium release in the heart.

Walker MA, Williams GSB, Kohl T, Lehnart SE, Jafri MS, Greenstein JL, Lederer WJ, Winslow RL.

Biophys J. 2014 Dec 16;107(12):3018-3029. doi: 10.1016/j.bpj.2014.11.003.


Analysis of tubular membrane networks in cardiac myocytes from atria and ventricles.

Wagner E, Brandenburg S, Kohl T, Lehnart SE.

J Vis Exp. 2014 Oct 15;(92):e51823. doi: 10.3791/51823.


Toward panoramic in situ mapping of action potential propagation in transgenic hearts to investigate initiation and therapeutic control of arrhythmias.

Dura M, Schröder-Schetelig J, Luther S, Lehnart SE.

Front Physiol. 2014 Sep 8;5:337. doi: 10.3389/fphys.2014.00337. eCollection 2014.


Transgenic mice for real-time visualization of cGMP in intact adult cardiomyocytes.

Götz KR, Sprenger JU, Perera RK, Steinbrecher JH, Lehnart SE, Kuhn M, Gorelik J, Balligand JL, Nikolaev VO.

Circ Res. 2014 Apr 11;114(8):1235-45. doi: 10.1161/CIRCRESAHA.114.302437. Epub 2014 Mar 5.


Tuning the electrical properties of the heart by differential trafficking of KATP ion channel complexes.

Arakel EC, Brandenburg S, Uchida K, Zhang H, Lin YW, Kohl T, Schrul B, Sulkin MS, Efimov IR, Nichols CG, Lehnart SE, Schwappach B.

J Cell Sci. 2014 May 1;127(Pt 9):2106-19. doi: 10.1242/jcs.141440. Epub 2014 Feb 25.


Imaging T-tubules: dynamic membrane structures for deep functions.

Kohl T, Lehnart SE.

Cardiovasc Res. 2013 May 1;98(2):162-4. doi: 10.1093/cvr/cvt058. Epub 2013 Mar 14. No abstract available.


Superresolution microscopy in heart - cardiac nanoscopy.

Kohl T, Westphal V, Hell SW, Lehnart SE.

J Mol Cell Cardiol. 2013 May;58:13-21. doi: 10.1016/j.yjmcc.2012.11.016. Epub 2012 Dec 3. Review.


Understanding the physiology of heart failure through cellular and in vivo models-towards targeting of complex mechanisms.

Lehnart SE.

Exp Physiol. 2013 Mar;98(3):622-8. doi: 10.1113/expphysiol.2012.068262. Epub 2012 Oct 12. Review.


Stimulated emission depletion live-cell super-resolution imaging shows proliferative remodeling of T-tubule membrane structures after myocardial infarction.

Wagner E, Lauterbach MA, Kohl T, Westphal V, Williams GS, Steinbrecher JH, Streich JH, Korff B, Tuan HT, Hagen B, Luther S, Hasenfuss G, Parlitz U, Jafri MS, Hell SW, Lederer WJ, Lehnart SE.

Circ Res. 2012 Aug 3;111(4):402-14. doi: 10.1161/CIRCRESAHA.112.274530. Epub 2012 Jun 21.


Ablation of junctin or triadin is associated with increased cardiac injury following ischaemia/reperfusion.

Cai WF, Pritchard T, Florea S, Lam CK, Han P, Zhou X, Yuan Q, Lehnart SE, Allen PD, Kranias EG.

Cardiovasc Res. 2012 May 1;94(2):333-41. doi: 10.1093/cvr/cvs119. Epub 2012 Mar 12.


Rationale, objectives, and design of the EUTrigTreat clinical study: a prospective observational study for arrhythmia risk stratification and assessment of interrelationships among repolarization markers and genotype.

Seegers J, Vos MA, Flevari P, Willems R, Sohns C, Vollmann D, Lüthje L, Kremastinos DT, Floré V, Meine M, Tuinenburg A, Myles RC, Simon D, Brockmöller J, Friede T, Hasenfuß G, Lehnart SE, Zabel M; EUTrigTreat Clinical Study Investigators.

Europace. 2012 Mar;14(3):416-22. doi: 10.1093/europace/eur352. Epub 2011 Nov 23.


SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes.

Petitprez S, Zmoos AF, Ogrodnik J, Balse E, Raad N, El-Haou S, Albesa M, Bittihn P, Luther S, Lehnart SE, Hatem SN, Coulombe A, Abriel H.

Circ Res. 2011 Feb 4;108(3):294-304. doi: 10.1161/CIRCRESAHA.110.228312. Epub 2010 Dec 16.


Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice.

Shan J, Kushnir A, Betzenhauser MJ, Reiken S, Li J, Lehnart SE, Lindegger N, Mongillo M, Mohler PJ, Marks AR.

J Clin Invest. 2010 Dec;120(12):4388-98. doi: 10.1172/JCI32726. Epub 2010 Nov 22.


Differential cardiac remodeling in preload versus afterload.

Toischer K, Rokita AG, Unsöld B, Zhu W, Kararigas G, Sossalla S, Reuter SP, Becker A, Teucher N, Seidler T, Grebe C, Preuss L, Gupta SN, Schmidt K, Lehnart SE, Krüger M, Linke WA, Backs J, Regitz-Zagrosek V, Schäfer K, Field LJ, Maier LS, Hasenfuss G.

Circulation. 2010 Sep 7;122(10):993-1003. doi: 10.1161/CIRCULATIONAHA.110.943431. Epub 2010 Aug 23.


An antidote for calcium leak: targeting molecular arrhythmia mechanisms.

Lehnart SE, Lederer WJ.

J Mol Cell Cardiol. 2010 Feb;48(2):279-82. doi: 10.1016/j.yjmcc.2009.11.005. Epub 2009 Nov 26. No abstract available.


K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum.

Toischer K, Lehnart SE, Tenderich G, Milting H, Körfer R, Schmitto JD, Schöndube FA, Kaneko N, Loughrey CM, Smith GL, Hasenfuss G, Seidler T.

Basic Res Cardiol. 2010 Mar;105(2):279-87. doi: 10.1007/s00395-009-0057-8. Epub 2009 Aug 30.


Abnormalities of calcium metabolism and myocardial contractility depression in the failing heart.

Lehnart SE, Maier LS, Hasenfuss G.

Heart Fail Rev. 2009 Dec;14(4):213-24. doi: 10.1007/s10741-009-9146-x. Review.


Inhibition of extracellular signal-regulated kinase signaling to prevent cardiomyopathy caused by mutation in the gene encoding A-type lamins.

Muchir A, Shan J, Bonne G, Lehnart SE, Worman HJ.

Hum Mol Genet. 2009 Jan 15;18(2):241-7. doi: 10.1093/hmg/ddn343. Epub 2008 Oct 16.


Arrhythmogenic right ventricular cardiomyopathy in Boxer dogs is associated with calstabin2 deficiency.

Oyama MA, Reiken S, Lehnart SE, Chittur SV, Meurs KM, Stern J, Marks AR.

J Vet Cardiol. 2008 Jun;10(1):1-10. doi: 10.1016/j.jvc.2008.04.003. Epub 2008 Jun 2.


Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice.

Lehnart SE, Mongillo M, Bellinger A, Lindegger N, Chen BX, Hsueh W, Reiken S, Wronska A, Drew LJ, Ward CW, Lederer WJ, Kass RS, Morley G, Marks AR.

J Clin Invest. 2008 Jun;118(6):2230-45. doi: 10.1172/JCI35346.


Remodeling of ryanodine receptor complex causes "leaky" channels: a molecular mechanism for decreased exercise capacity.

Bellinger AM, Reiken S, Dura M, Murphy PW, Deng SX, Landry DW, Nieman D, Lehnart SE, Samaru M, LaCampagne A, Marks AR.

Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2198-202. doi: 10.1073/pnas.0711074105. Epub 2008 Feb 11.


Inherited arrhythmias: a National Heart, Lung, and Blood Institute and Office of Rare Diseases workshop consensus report about the diagnosis, phenotyping, molecular mechanisms, and therapeutic approaches for primary cardiomyopathies of gene mutations affecting ion channel function.

Lehnart SE, Ackerman MJ, Benson DW Jr, Brugada R, Clancy CE, Donahue JK, George AL Jr, Grant AO, Groft SC, January CT, Lathrop DA, Lederer WJ, Makielski JC, Mohler PJ, Moss A, Nerbonne JM, Olson TM, Przywara DA, Towbin JA, Wang LH, Marks AR.

Circulation. 2007 Nov 13;116(20):2325-45. Erratum in: Circulation. 2008 Aug 19;118(8):e132.


Modulation of the ryanodine receptor and intracellular calcium.

Zalk R, Lehnart SE, Marks AR.

Annu Rev Biochem. 2007;76:367-85. Review.


Phosphodiesterase 4D and heart failure: a cautionary tale.

Lehnart SE, Marks AR.

Expert Opin Ther Targets. 2006 Oct;10(5):677-88. Review.


Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias.

Lehnart SE, Terrenoire C, Reiken S, Wehrens XH, Song LS, Tillman EJ, Mancarella S, Coromilas J, Lederer WJ, Kass RS, Marks AR.

Proc Natl Acad Sci U S A. 2006 May 16;103(20):7906-10. Epub 2006 May 3.


Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression.

Wehrens XH, Lehnart SE, Reiken S, Vest JA, Wronska A, Marks AR.

Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):511-8. Epub 2006 Jan 6.


Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias.

Lehnart SE, Wehrens XH, Reiken S, Warrier S, Belevych AE, Harvey RD, Richter W, Jin SL, Conti M, Marks AR.

Cell. 2005 Oct 7;123(1):25-35. Erratum in: Cell. 2005 Nov 4;123(3):535-6.

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