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Items: 33

1.

Distinct expression of the neurotoxic microRNA family let-7 in the cerebrospinal fluid of patients with Alzheimer's disease.

Derkow K, Rössling R, Schipke C, Krüger C, Bauer J, Fähling M, Stroux A, Schott E, Ruprecht K, Peters O, Lehnardt S.

PLoS One. 2018 Jul 16;13(7):e0200602. doi: 10.1371/journal.pone.0200602. eCollection 2018.

2.

TLR2 controls random motility, while TLR7 regulates chemotaxis of microglial cells via distinct pathways.

Ifuku M, Buonfiglioli A, Jordan P, Lehnardt S, Kettenmann H.

Brain Behav Immun. 2016 Nov;58:338-347. doi: 10.1016/j.bbi.2016.08.003. Epub 2016 Aug 21.

PMID:
27554518
3.

Glioma Stem Cells but Not Bulk Glioma Cells Upregulate IL-6 Secretion in Microglia/Brain Macrophages via Toll-like Receptor 4 Signaling.

Dzaye O, Hu F, Derkow K, Haage V, Euskirchen P, Harms C, Lehnardt S, Synowitz M, Wolf SA, Kettenmann H.

J Neuropathol Exp Neurol. 2016 May;75(5):429-40. doi: 10.1093/jnen/nlw016. Epub 2016 Mar 30.

4.

The Role of Regulatory CD4 T Cells in Maintaining Tolerance in a Mouse Model of Autoimmune Hepatitis.

An Haack I, Derkow K, Riehn M, Rentinck MN, Kühl AA, Lehnardt S, Schott E.

PLoS One. 2015 Nov 24;10(11):e0143715. doi: 10.1371/journal.pone.0143715. eCollection 2015.

5.

Microglia Induce Neurotoxic IL-17+ γδ T Cells Dependent on TLR2, TLR4, and TLR9 Activation.

Derkow K, Krüger C, Dembny P, Lehnardt S.

PLoS One. 2015 Aug 19;10(8):e0135898. doi: 10.1371/journal.pone.0135898. eCollection 2015.

6.

Intrathecal heat shock protein 60 mediates neurodegeneration and demyelination in the CNS through a TLR4- and MyD88-dependent pathway.

Rosenberger K, Dembny P, Derkow K, Engel O, Krüger C, Wolf SA, Kettenmann H, Schott E, Meisel A, Lehnardt S.

Mol Neurodegener. 2015 Feb 26;10:5. doi: 10.1186/s13024-015-0003-1.

7.

Glioma-derived versican promotes tumor expansion via glioma-associated microglial/macrophages Toll-like receptor 2 signaling.

Hu F, Dzaye O, Hahn A, Yu Y, Scavetta RJ, Dittmar G, Kaczmarek AK, Dunning KR, Ricciardelli C, Rinnenthal JL, Heppner FL, Lehnardt S, Synowitz M, Wolf SA, Kettenmann H.

Neuro Oncol. 2015 Feb;17(2):200-10. doi: 10.1093/neuonc/nou324. Epub 2014 Dec 1.

8.

The impact of single and pairwise Toll-like receptor activation on neuroinflammation and neurodegeneration.

Rosenberger K, Derkow K, Dembny P, Krüger C, Schott E, Lehnardt S.

J Neuroinflammation. 2014 Sep 20;11:166. doi: 10.1186/s12974-014-0166-7.

9.

Glioma-associated microglial MMP9 expression is upregulated by TLR2 signaling and sensitive to minocycline.

Hu F, Ku MC, Markovic D, Dzaye O, Lehnardt S, Synowitz M, Wolf SA, Kettenmann H.

Int J Cancer. 2014 Dec 1;135(11):2569-78. doi: 10.1002/ijc.28908. Epub 2014 May 9.

10.

Influence of CD8 T cell priming in liver and gut on the enterohepatic circulation.

Eickmeier I, Seidel D, Grün JR, Derkow K, Lehnardt S, Kühl AA, Hamann A, Schott E.

J Hepatol. 2014 Jun;60(6):1143-50. doi: 10.1016/j.jhep.2014.02.011. Epub 2014 Feb 19.

PMID:
24560659
11.

Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansion.

Vinnakota K, Hu F, Ku MC, Georgieva PB, Szulzewsky F, Pohlmann A, Waiczies S, Waiczies H, Niendorf T, Lehnardt S, Hanisch UK, Synowitz M, Markovic D, Wolf SA, Glass R, Kettenmann H.

Neuro Oncol. 2013 Nov;15(11):1457-68. doi: 10.1093/neuonc/not115. Epub 2013 Sep 5.

12.

Multiple sclerosis: modulation of toll-like receptor (TLR) expression by interferon-β includes upregulation of TLR7 in plasmacytoid dendritic cells.

Derkow K, Bauer JM, Hecker M, Paap BK, Thamilarasan M, Koczan D, Schott E, Deuschle K, Bellmann-Strobl J, Paul F, Zettl UK, Ruprecht K, Lehnardt S.

PLoS One. 2013 Aug 12;8(8):e70626. doi: 10.1371/journal.pone.0070626. eCollection 2013.

13.

Elevation in type I interferons inhibits HCN1 and slows cortical neuronal oscillations.

Stadler K, Bierwirth C, Stoenica L, Battefeld A, Reetz O, Mix E, Schuchmann S, Velmans T, Rosenberger K, Bräuer AU, Lehnardt S, Nitsch R, Budt M, Wolff T, Kole MH, Strauss U.

Cereb Cortex. 2014 Jan;24(1):199-210. doi: 10.1093/cercor/bhs305. Epub 2012 Oct 4.

PMID:
23042740
14.

Extracellularly delivered single-stranded viral RNA causes neurodegeneration dependent on TLR7.

Lehmann SM, Rosenberger K, Krüger C, Habbel P, Derkow K, Kaul D, Rybak A, Brandt C, Schott E, Wulczyn FG, Lehnardt S.

J Immunol. 2012 Aug 1;189(3):1448-58. doi: 10.4049/jimmunol.1201078. Epub 2012 Jun 27.

15.

Expression of Toll-like receptors in the developing brain.

Kaul D, Habbel P, Derkow K, Krüger C, Franzoni E, Wulczyn FG, Bereswill S, Nitsch R, Schott E, Veh R, Naumann T, Lehnardt S.

PLoS One. 2012;7(5):e37767. doi: 10.1371/journal.pone.0037767. Epub 2012 May 30.

16.

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration.

Lehmann SM, Krüger C, Park B, Derkow K, Rosenberger K, Baumgart J, Trimbuch T, Eom G, Hinz M, Kaul D, Habbel P, Kälin R, Franzoni E, Rybak A, Nguyen D, Veh R, Ninnemann O, Peters O, Nitsch R, Heppner FL, Golenbock D, Schott E, Ploegh HL, Wulczyn FG, Lehnardt S.

Nat Neurosci. 2012 Jun;15(6):827-35. doi: 10.1038/nn.3113.

PMID:
22610069
17.

In vivo imaging of partially reversible th17 cell-induced neuronal dysfunction in the course of encephalomyelitis.

Siffrin V, Radbruch H, Glumm R, Niesner R, Paterka M, Herz J, Leuenberger T, Lehmann SM, Luenstedt S, Rinnenthal JL, Laube G, Luche H, Lehnardt S, Fehling HJ, Griesbeck O, Zipp F.

Immunity. 2010 Sep 24;33(3):424-36. doi: 10.1016/j.immuni.2010.08.018.

18.
19.

Exaggerated inflammatory response of primary human myeloid dendritic cells to lipopolysaccharide in patients with inflammatory bowel disease.

Baumgart DC, Thomas S, Przesdzing I, Metzke D, Bielecki C, Lehmann SM, Lehnardt S, Dörffel Y, Sturm A, Scheffold A, Schmitz J, Radbruch A.

Clin Exp Immunol. 2009 Sep;157(3):423-36. doi: 10.1111/j.1365-2249.2009.03981.x.

20.

Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion.

Markovic DS, Vinnakota K, Chirasani S, Synowitz M, Raguet H, Stock K, Sliwa M, Lehmann S, Kälin R, van Rooijen N, Holmbeck K, Heppner FL, Kiwit J, Matyash V, Lehnardt S, Kaminska B, Glass R, Kettenmann H.

Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12530-5. doi: 10.1073/pnas.0804273106. Epub 2009 Jul 15.

21.

Effects of the PDE5-inhibitor vardenafil in a mouse stroke model.

Royl G, Balkaya M, Lehmann S, Lehnardt S, Stohlmann K, Lindauer U, Endres M, Dirnagl U, Meisel A.

Brain Res. 2009 Apr 10;1265:148-57. doi: 10.1016/j.brainres.2009.01.061. Epub 2009 Feb 7.

PMID:
19368809
22.

Heterogeneous effects of distinct tocopherol analogues on NO release, cell volume, and cell death in microglial cells.

Sacha B, Zierler S, Lehnardt S, Weber JR, Kerschbaum HH.

J Neurosci Res. 2008 Dec;86(16):3526-35. doi: 10.1002/jnr.21811.

PMID:
18709655
23.

Inhibition of Rho-dependent pathways by Clostridium botulinum C3 protein induces a proinflammatory profile in microglia.

Hoffmann A, Hofmann F, Just I, Lehnardt S, Hanisch UK, Brück W, Kettenmann H, Ahnert-Hilger G, Höltje M.

Glia. 2008 Aug 15;56(11):1162-75. doi: 10.1002/glia.20687.

PMID:
18442097
24.

A vicious cycle involving release of heat shock protein 60 from injured cells and activation of toll-like receptor 4 mediates neurodegeneration in the CNS.

Lehnardt S, Schott E, Trimbuch T, Laubisch D, Krueger C, Wulczyn G, Nitsch R, Weber JR.

J Neurosci. 2008 Mar 5;28(10):2320-31. doi: 10.1523/JNEUROSCI.4760-07.2008.

25.

TLR2 and caspase-8 are essential for group B Streptococcus-induced apoptosis in microglia.

Lehnardt S, Wennekamp J, Freyer D, Liedtke C, Krueger C, Nitsch R, Bechmann I, Weber JR, Henneke P.

J Immunol. 2007 Nov 1;179(9):6134-43.

26.

Toll-like receptor 2 mediates CNS injury in focal cerebral ischemia.

Lehnardt S, Lehmann S, Kaul D, Tschimmel K, Hoffmann O, Cho S, Krueger C, Nitsch R, Meisel A, Weber JR.

J Neuroimmunol. 2007 Oct;190(1-2):28-33. Epub 2007 Sep 12.

PMID:
17854911
27.

Hypothermia suppresses inflammation via ERK signaling pathway in stimulated microglial cells.

Schmitt KR, Diestel A, Lehnardt S, Schwartlander R, Lange PE, Berger F, Ullrich O, Abdul-Khaliq H.

J Neuroimmunol. 2007 Sep;189(1-2):7-16. Epub 2007 Jul 24.

PMID:
17651818
28.

TLR2 mediates neuroinflammation and neuronal damage.

Hoffmann O, Braun JS, Becker D, Halle A, Freyer D, Dagand E, Lehnardt S, Weber JR.

J Immunol. 2007 May 15;178(10):6476-81.

29.

A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microglia.

Lehnardt S, Henneke P, Lien E, Kasper DL, Volpe JJ, Bechmann I, Nitsch R, Weber JR, Golenbock DT, Vartanian T.

J Immunol. 2006 Jul 1;177(1):583-92.

30.

Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway.

Lehnardt S, Massillon L, Follett P, Jensen FE, Ratan R, Rosenberg PA, Volpe JJ, Vartanian T.

Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8514-9. Epub 2003 Jun 24.

31.

The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS.

Lehnardt S, Lachance C, Patrizi S, Lefebvre S, Follett PL, Jensen FE, Rosenberg PA, Volpe JJ, Vartanian T.

J Neurosci. 2002 Apr 1;22(7):2478-86.

32.

Acid secretion of parietal cells is paralleled by a redistribution of NSF and alpha, beta-SNAPs and inhibited by tetanus toxin.

Lehnardt S, Ahnert-Hilger G, Bigalke H, Jöns T.

Histochem Cell Biol. 2000 Nov;114(5):387-91.

PMID:
11151408
33.

SNARE proteins and rab3A contribute to canalicular formation in parietal cells.

Jöns T, Lehnardt S, Bigalke H, Heim HK, Ahnert-Hilger G.

Eur J Cell Biol. 1999 Nov;78(11):779-86.

PMID:
10604654

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