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Atropselective Disposition of 2,2',3,4',6-Pentachlorobiphenyl (PCB 91) and Identification of Its Metabolites in Mice with Liver-Specific Deletion of Cytochrome P450 Reductase.

Wu X, Zhai G, Schnoor JL, Lehmler HJ.

Chem Res Toxicol. 2019 Aug 26. doi: 10.1021/acs.chemrestox.9b00255. [Epub ahead of print]


A semi-target analytical method for quantification of OH-PCBs in environmental samples.

Saktrakulkla P, Dhakal RC, Lehmler HJ, Hornbuckle KC.

Environ Sci Pollut Res Int. 2019 Jul 29. doi: 10.1007/s11356-019-05775-x. [Epub ahead of print]


Atropselective Oxidation of 2,2',3,3',4,6'-Hexachlorobiphenyl (PCB 132) to Hydroxylated Metabolites by Human Liver Microsomes and Its Implications for PCB 132 Neurotoxicity.

Uwimana E, Cagle B, Yeung C, Li X, Patterson EV, Doorn JA, Lehmler HJ.

Toxicol Sci. 2019 Jul 3. pii: kfz150. doi: 10.1093/toxsci/kfz150. [Epub ahead of print]


Levels of tin and organotin compounds in human urine samples from Iowa, United States.

Gadogbe M, Bao W, Wels BR, Dai SY, Santillan DA, Santillan MK, Lehmler HJ.

J Environ Sci Health A Tox Hazard Subst Environ Eng. 2019;54(9):884-890. doi: 10.1080/10934529.2019.1605779. Epub 2019 May 6.


Comparative Analyses of the 12 Most Abundant PCB Congeners Detected in Human Maternal Serum for Activity at the Thyroid Hormone Receptor and Ryanodine Receptor.

Sethi S, Morgan RK, Feng W, Lin Y, Li X, Luna C, Koch M, Bansal R, Duffel MW, Puschner B, Zoeller RT, Lehmler HJ, Pessah IN, Lein PJ.

Environ Sci Technol. 2019 Apr 2;53(7):3948-3958. doi: 10.1021/acs.est.9b00535. Epub 2019 Mar 19.


Association of Bisphenol A and Its Substitutes, Bisphenol F and Bisphenol S, with Obesity in United States Children and Adolescents.

Liu B, Lehmler HJ, Sun Y, Xu G, Sun Q, Snetselaar LG, Wallace RB, Bao W.

Diabetes Metab J. 2019 Feb;43(1):59-75. doi: 10.4093/dmj.2018.0045.


Toxicokinetics of Chiral PCB 136 and Its Hydroxylated Metabolites in Mice with a Liver-Specific Deletion of Cytochrome P450 Reductase.

Li X, Wu X, Kelly KM, Veng-Pedersen P, Lehmler HJ.

Chem Res Toxicol. 2019 Apr 15;32(4):727-736. doi: 10.1021/acs.chemrestox.8b00389. Epub 2019 Feb 20.


Human CYP2A6, CYP2B6, AND CYP2E1 Atropselectively Metabolize Polychlorinated Biphenyls to Hydroxylated Metabolites.

Uwimana E, Ruiz P, Li X, Lehmler HJ.

Environ Sci Technol. 2019 Feb 19;53(4):2114-2123. doi: 10.1021/acs.est.8b05250. Epub 2019 Feb 8.


Gut Microbiota Modulates Interactions Between Polychlorinated Biphenyls and Bile Acid Homeostasis.

Cheng SL, Li X, Lehmler HJ, Phillips B, Shen D, Cui JY.

Toxicol Sci. 2018 Dec 1;166(2):269-287. doi: 10.1093/toxsci/kfy208.


Hundreds of Unrecognized Halogenated Contaminants Discovered in Polar Bear Serum.

Liu Y, Richardson ES, Derocher AE, Lunn NJ, Lehmler HJ, Li X, Zhang Y, Cui JY, Cheng L, Martin JW.

Angew Chem Int Ed Engl. 2018 Dec 10;57(50):16401-16406. doi: 10.1002/anie.201809906. Epub 2018 Nov 15.


PCB11 Metabolite, 3,3'-Dichlorobiphenyl-4-ol, Exposure Alters the Expression of Genes Governing Fatty Acid Metabolism in the Absence of Functional Sirtuin 3: Examining the Contribution of MnSOD.

Alam S, Carter GS, Krager KJ, Li X, Lehmler HJ, Aykin-Burns N.

Antioxidants (Basel). 2018 Sep 15;7(9). pii: E121. doi: 10.3390/antiox7090121.


Hydroxylated and sulfated metabolites of commonly observed airborne polychlorinated biphenyls display selective uptake and toxicity in N27, SH-SY5Y, and HepG2 cells.

Rodriguez EA, Vanle BC, Doorn JA, Lehmler HJ, Robertson LW, Duffel MW.

Environ Toxicol Pharmacol. 2018 Sep;62:69-78. doi: 10.1016/j.etap.2018.06.010. Epub 2018 Jun 26.


Exposure to Bisphenol A, Bisphenol F, and Bisphenol S in U.S. Adults and Children: The National Health and Nutrition Examination Survey 2013-2014.

Lehmler HJ, Liu B, Gadogbe M, Bao W.

ACS Omega. 2018 Jun 30;3(6):6523-6532. doi: 10.1021/acsomega.8b00824. Epub 2018 Jun 18.


Association between urinary tin concentration and diabetes in nationally representative sample of US adults.

Liu B, Sun Y, Lehmler HJ, Bao W.

J Diabetes. 2018 Dec;10(12):977-983. doi: 10.1111/1753-0407.12798. Epub 2018 Jul 4.


Environmental tin exposure in a nationally representative sample of U.S. adults and children: The National Health and Nutrition Examination Survey 2011-2014.

Lehmler HJ, Gadogbe M, Liu B, Bao W.

Environ Pollut. 2018 Sep;240:599-606. doi: 10.1016/j.envpol.2018.05.019. Epub 2018 May 12.


Human Liver Microsomes Atropselectively Metabolize 2,2',3,4',6-Pentachlorobiphenyl (PCB 91) to a 1,2-Shift Product as the Major Metabolite.

Uwimana E, Li X, Lehmler HJ.

Environ Sci Technol. 2018 May 15;52(10):6000-6008. doi: 10.1021/acs.est.8b00612. Epub 2018 Apr 27.


In vitro profiling of toxic effects of prominent environmental lower-chlorinated PCB congeners linked with endocrine disruption and tumor promotion.

Pěnčíková K, Svržková L, Strapáčová S, Neča J, Bartoňková I, Dvořák Z, Hýžďalová M, Pivnička J, Pálková L, Lehmler HJ, Li X, Vondráček J, Machala M.

Environ Pollut. 2018 Jun;237:473-486. doi: 10.1016/j.envpol.2018.02.067. Epub 2018 Mar 15.


Hydroxylated and sulfated metabolites of commonly occurring airborne polychlorinated biphenyls inhibit human steroid sulfotransferases SULT1E1 and SULT2A1.

Parker VS, Squirewell EJ, Lehmler HJ, Robertson LW, Duffel MW.

Environ Toxicol Pharmacol. 2018 Mar;58:196-201. doi: 10.1016/j.etap.2018.01.010. Epub 2018 Feb 3.


Authentication of synthetic environmental contaminants and their (bio)transformation products in toxicology: polychlorinated biphenyls as an example.

Li X, Holland EB, Feng W, Zheng J, Dong Y, Pessah IN, Duffel MW, Robertson LW, Lehmler HJ.

Environ Sci Pollut Res Int. 2018 Jun;25(17):16508-16521. doi: 10.1007/s11356-017-1162-0. Epub 2018 Jan 10.


Bisphenol A substitutes and obesity in US adults: analysis of a population-based, cross-sectional study.

Liu B, Lehmler HJ, Sun Y, Xu G, Liu Y, Zong G, Sun Q, Hu FB, Wallace RB, Bao W.

Lancet Planet Health. 2017 Jun;1(3):e114-e122. doi: 10.1016/S2542-5196(17)30049-9.


Genetic differences in the aryl hydrocarbon receptor and CYP1A2 affect sensitivity to developmental polychlorinated biphenyl exposure in mice: relevance to studies of human neurological disorders.

Klinefelter K, Hooven MK, Bates C, Colter BT, Dailey A, Infante SK, Kania-Korwel I, Lehmler HJ, López-Juárez A, Ludwig CP, Curran CP.

Mamm Genome. 2018 Feb;29(1-2):112-127. doi: 10.1007/s00335-017-9728-1. Epub 2017 Dec 2.


Metabolism and Photolysis of 2,4-Dinitroanisole in Arabidopsis.

Schroer HW, Li X, Lehmler HJ, Just CL.

Environ Sci Technol. 2017 Dec 5;51(23):13714-13722. doi: 10.1021/acs.est.7b04220. Epub 2017 Nov 13.


Atropisomers of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) exhibit stereoselective effects on activation of nuclear receptors in vitro.

Pěnčíková K, Brenerová P, Svržková L, Hrubá E, Pálková L, Vondráček J, Lehmler HJ, Machala M.

Environ Sci Pollut Res Int. 2018 Jun;25(17):16411-16419. doi: 10.1007/s11356-017-0683-x. Epub 2017 Nov 9.


Tuning the position of head groups by surfactant design in mixed micelles of cationic and carbohydrate surfactants.

Das S, Oldham ED, Lehmler HJ, Knutson BL, Rankin SE.

J Colloid Interface Sci. 2018 Feb 15;512:428-438. doi: 10.1016/j.jcis.2017.10.066. Epub 2017 Oct 18.


Identification of lipidomic markers of chronic 3,3',4,4',5-pentachlorobiphenyl (PCB 126) exposure in the male rat liver.

Kania-Korwel I, Wu X, Wang K, Lehmler HJ.

Toxicology. 2017 Sep 1;390:124-134. doi: 10.1016/j.tox.2017.09.005. Epub 2017 Sep 7.


Sources and toxicities of phenolic polychlorinated biphenyls (OH-PCBs).

Dhakal K, Gadupudi GS, Lehmler HJ, Ludewig G, Duffel MW, Robertson LW.

Environ Sci Pollut Res Int. 2018 Jun;25(17):16277-16290. doi: 10.1007/s11356-017-9694-x. Epub 2017 Jul 25.


Absolute configuration of 2,2',3,3',6-pentachlorinatedbiphenyl (PCB 84) atropisomers.

Li X, Parkin SR, Lehmler HJ.

Environ Sci Pollut Res Int. 2018 Jun;25(17):16402-16410. doi: 10.1007/s11356-017-9259-z. Epub 2017 May 23.


Detection of 3,3'-Dichlorobiphenyl in Human Maternal Plasma and Its Effects on Axonal and Dendritic Growth in Primary Rat Neurons.

Sethi S, Keil KP, Chen H, Hayakawa K, Li X, Lin Y, Lehmler HJ, Puschner B, Lein PJ.

Toxicol Sci. 2017 Aug 1;158(2):401-411. doi: 10.1093/toxsci/kfx100.


Editor's Highlight: Congener-Specific Disposition of Chiral Polychlorinated Biphenyls in Lactating Mice and Their Offspring: Implications for PCB Developmental Neurotoxicity.

Kania-Korwel I, Lukasiewicz T, Barnhart CD, Stamou M, Chung H, Kelly KM, Bandiera S, Lein PJ, Lehmler HJ.

Toxicol Sci. 2017 Jul 1;158(1):101-115. doi: 10.1093/toxsci/kfx071.


Antibiotic Pollution in Marine Food Webs in Laizhou Bay, North China: Trophodynamics and Human Exposure Implication.

Liu S, Zhao H, Lehmler HJ, Cai X, Chen J.

Environ Sci Technol. 2017 Feb 21;51(4):2392-2400. doi: 10.1021/acs.est.6b04556. Epub 2017 Feb 7.


Microsomal Metabolism of Prochiral Polychlorinated Biphenyls Results in the Enantioselective Formation of Chiral Metabolites.

Uwimana E, Maiers A, Li X, Lehmler HJ.

Environ Sci Technol. 2017 Feb 7;51(3):1820-1829. doi: 10.1021/acs.est.6b05387. Epub 2017 Jan 20.


Biotransformation of 2,4-dinitroanisole by a fungal Penicillium sp.

Schroer HW, Langenfeld KL, Li X, Lehmler HJ, Just CL.

Biodegradation. 2017 Feb;28(1):95-109. doi: 10.1007/s10532-016-9780-7. Epub 2016 Dec 2.


Identification of a sulfate metabolite of PCB 11 in human serum.

Grimm FA, Lehmler HJ, Koh WX, DeWall J, Teesch LM, Hornbuckle KC, Thorne PS, Robertson LW, Duffel MW.

Environ Int. 2017 Jan;98:120-128. doi: 10.1016/j.envint.2016.10.023. Epub 2016 Nov 3.


Inverted Micelle-in-Micelle Configuration in Cationic/Carbohydrate Surfactant Mixtures.

Das S, Xu W, Lehmler HJ, Miller AF, Knutson BL, Rankin SE.

Chemphyschem. 2017 Jan 4;18(1):79-86. doi: 10.1002/cphc.201600908. Epub 2016 Nov 11.


An Extended Structure-Activity Relationship of Nondioxin-Like PCBs Evaluates and Supports Modeling Predictions and Identifies Picomolar Potency of PCB 202 Towards Ryanodine Receptors.

Holland EB, Feng W, Zheng J, Dong Y, Li X, Lehmler HJ, Pessah IN.

Toxicol Sci. 2017 Jan;155(1):170-181. doi: 10.1093/toxsci/kfw189. Epub 2016 Sep 21.


3,3',4,4',5-Pentachlorobiphenyl (PCB 126) Decreases Hepatic and Systemic Ratios of Epoxide to Diol Metabolites of Unsaturated Fatty Acids in Male Rats.

Wu X, Yang J, Morisseau C, Robertson LW, Hammock B, Lehmler HJ.

Toxicol Sci. 2016 Aug;152(2):309-22. doi: 10.1093/toxsci/kfw084. Epub 2016 May 13.


Sulfation of Lower Chlorinated Polychlorinated Biphenyls Increases Their Affinity for the Major Drug-Binding Sites of Human Serum Albumin.

Rodriguez EA, Li X, Lehmler HJ, Robertson LW, Duffel MW.

Environ Sci Technol. 2016 May 17;50(10):5320-7. doi: 10.1021/acs.est.6b00484. Epub 2016 May 4.


Identification of a novel hydroxylated metabolite of 2,2',3,5',6-pentachlorobiphenyl formed in whole poplar plants.

Ma C, Zhai G, Wu H, Kania-Korwel I, Lehmler HJ, Schnoor JL.

Environ Sci Pollut Res Int. 2016 Feb;23(3):2089-98. doi: 10.1007/s11356-015-5939-8. Epub 2015 Dec 17.


Monohydroxylated Polybrominated Diphenyl Ethers (OH-PBDEs) and Dihydroxylated Polybrominated Biphenyls (Di-OH-PBBs): Novel Photoproducts of 2,6-Dibromophenol.

Zhao H, Jiang J, Wang Y, Lehmler HJ, Buettner GR, Quan X, Chen J.

Environ Sci Technol. 2015 Dec 15;49(24):14120-8. doi: 10.1021/acs.est.5b03637. Epub 2015 Nov 16.


Subacute nicotine co-exposure has no effect on 2,2',3,5',6- pentachlorobiphenyl disposition but alters hepatic cytochrome P450 expression in the male rat.

Stamou M, Uwimana E, Flannery BM, Kania-Korwel I, Lehmler HJ, Lein PJ.

Toxicology. 2015 Dec 2;338:59-68. doi: 10.1016/j.tox.2015.10.002. Epub 2015 Oct 14.


Polychlorinated Biphenyl Quinone Metabolite Promotes p53-Dependent DNA Damage Checkpoint Activation, S-Phase Cycle Arrest and Extrinsic Apoptosis in Human Liver Hepatocellular Carcinoma HepG2 Cells.

Song X, Li L, Shi Q, Lehmler HJ, Fu J, Su C, Xia X, Song E, Song Y.

Chem Res Toxicol. 2015 Nov 16;28(11):2160-9. doi: 10.1021/acs.chemrestox.5b00320. Epub 2015 Nov 9.


Toxicity Evaluation of Exposure to an Atmospheric Mixture of Polychlorinated Biphenyls by Nose-Only and Whole-Body Inhalation Regimens.

Hu X, Adamcakova-Dodd A, Lehmler HJ, Gibson-Corley K, Thorne PS.

Environ Sci Technol. 2015 Oct 6;49(19):11875-83. doi: 10.1021/acs.est.5b02865. Epub 2015 Sep 22.


Estrogenicity and androgenicity screening of PCB sulfate monoesters in human breast cancer MCF-7 cells.

Flor S, He X, Lehmler HJ, Ludewig G.

Environ Sci Pollut Res Int. 2016 Feb;23(3):2186-200. doi: 10.1007/s11356-015-5142-y. Epub 2015 Aug 25.


Effect of pregnancy on the disposition of 2,2',3,5',6-pentachlorobiphenyl (PCB 95) atropisomers and their hydroxylated metabolites in female mice.

Kania-Korwel I, Barnhart CD, Lein PJ, Lehmler HJ.

Chem Res Toxicol. 2015 Sep 21;28(9):1774-83. doi: 10.1021/acs.chemrestox.5b00241. Epub 2015 Aug 13.


Effects of thiol antioxidants on the atropselective oxidation of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) by rat liver microsomes.

Wu X, Lehmler HJ.

Environ Sci Pollut Res Int. 2016 Feb;23(3):2081-8. doi: 10.1007/s11356-015-4987-4. Epub 2015 Jul 9.


Tissue Distribution, Metabolism, and Excretion of 3,3'-Dichloro-4'-sulfooxy-biphenyl in the Rat.

Grimm FA, He X, Teesch LM, Lehmler HJ, Robertson LW, Duffel MW.

Environ Sci Technol. 2015 Jul 7;49(13):8087-95. doi: 10.1021/acs.est.5b01499. Epub 2015 Jun 18.


Toxicokinetics of chiral polychlorinated biphenyls across different species--a review.

Kania-Korwel I, Lehmler HJ.

Environ Sci Pollut Res Int. 2016 Feb;23(3):2058-80. doi: 10.1007/s11356-015-4383-0. Epub 2015 Apr 1. Review.


Cytotoxic activity of triazole-containing alkyl β-D-glucopyranosides on a human T-cell leukemia cell line.

Oldham ED, Nunes LM, Varela-Ramirez A, Rankin SE, Knutson BL, Aguilera RJ, Lehmler HJ.

Chem Cent J. 2015 Feb 1;9:3. doi: 10.1186/s13065-014-0072-1. eCollection 2015.


Chiral polychlorinated biphenyls: absorption, metabolism and excretion--a review.

Kania-Korwel I, Lehmler HJ.

Environ Sci Pollut Res Int. 2016 Feb;23(3):2042-57. doi: 10.1007/s11356-015-4150-2. Epub 2015 Feb 6. Review.

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