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Items: 1 to 50 of 213

1.

Resolving the Combinatorial Complexity of Smad Protein Complex Formation and Its Link to Gene Expression.

Lucarelli P, Schilling M, Kreutz C, Vlasov A, Boehm ME, Iwamoto N, Steiert B, Lattermann S, Wäsch M, Stepath M, Matter MS, Heikenwälder M, Hoffmann K, Deharde D, Damm G, Seehofer D, Muciek M, Gretz N, Lehmann WD, Timmer J, Klingmüller U.

Cell Syst. 2018 Jan 24;6(1):75-89.e11. doi: 10.1016/j.cels.2017.11.010. Epub 2017 Dec 13.

2.

Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib.

Sobotta S, Raue A, Huang X, Vanlier J, Jünger A, Bohl S, Albrecht U, Hahnel MJ, Wolf S, Mueller NS, D'Alessandro LA, Mueller-Bohl S, Boehm ME, Lucarelli P, Bonefas S, Damm G, Seehofer D, Lehmann WD, Rose-John S, van der Hoeven F, Gretz N, Theis FJ, Ehlting C, Bode JG, Timmer J, Schilling M, Klingmüller U.

Front Physiol. 2017 Oct 9;8:775. doi: 10.3389/fphys.2017.00775. eCollection 2017.

3.

IL-1β-induced and p38MAPK-dependent activation of the mitogen-activated protein kinase-activated protein kinase 2 (MK2) in hepatocytes: Signal transduction with robust and concentration-independent signal amplification.

Kulawik A, Engesser R, Ehlting C, Raue A, Albrecht U, Hahn B, Lehmann WD, Gaestel M, Klingmüller U, Häussinger D, Timmer J, Bode JG.

J Biol Chem. 2017 Apr 14;292(15):6291-6302. doi: 10.1074/jbc.M117.775023. Epub 2017 Feb 21.

4.

Microquantification of phospholipid classes by stable isotope dilution and nanoESI mass spectrometry.

Safian MF, Zinn N, Seidler J, Lehmann WD.

Anal Bioanal Chem. 2016 Nov;408(27):7663-7667. Epub 2016 Aug 11.

PMID:
27515797
5.

Identification of Cell Type-Specific Differences in Erythropoietin Receptor Signaling in Primary Erythroid and Lung Cancer Cells.

Merkle R, Steiert B, Salopiata F, Depner S, Raue A, Iwamoto N, Schelker M, Hass H, Wäsch M, Böhm ME, Mücke O, Lipka DB, Plass C, Lehmann WD, Kreutz C, Timmer J, Schilling M, Klingmüller U.

PLoS Comput Biol. 2016 Aug 5;12(8):e1005049. doi: 10.1371/journal.pcbi.1005049. eCollection 2016 Aug.

6.

A timeline of stable isotopes and mass spectrometry in the life sciences.

Lehmann WD.

Mass Spectrom Rev. 2017 Jan;36(1):58-85. doi: 10.1002/mas.21497. Epub 2016 Feb 25. Review.

PMID:
26919394
7.

Context-specific flow through the MEK/ERK module produces cell- and ligand-specific patterns of ERK single and double phosphorylation.

Iwamoto N, D'Alessandro LA, Depner S, Hahn B, Kramer BA, Lucarelli P, Vlasov A, Stepath M, Böhm ME, Deharde D, Damm G, Seehofer D, Lehmann WD, Klingmüller U, Schilling M.

Sci Signal. 2016 Feb 2;9(413):ra13. doi: 10.1126/scisignal.aab1967.

PMID:
26838549
8.

Ca(2+) -complex stability of GAPAGPLIVPY peptide in gas and aqueous phase, investigated by affinity capillary electrophoresis and molecular dynamics simulations and compared to mass spectrometric results.

Nachbar M, El Deeb S, Mozafari M, Alhazmi HA, Preu L, Redweik S, Lehmann WD, Wätzig H.

Electrophoresis. 2016 Mar;37(5-6):744-51. doi: 10.1002/elps.201500403. Epub 2016 Jan 12.

PMID:
26627117
9.

Immunosuppression and Aberrant T Cell Development in the Absence of N-Myristoylation.

Rampoldi F, Bonrouhi M, Boehm ME, Lehmann WD, Popovic ZV, Kaden S, Federico G, Brunk F, Gröne HJ, Porubsky S.

J Immunol. 2015 Nov 1;195(9):4228-43. doi: 10.4049/jimmunol.1500622. Epub 2015 Sep 30.

10.

"All proteins all the time"--a comment on visions, claims, and wording in mass spectrometry-based proteomics.

Lehmann WD.

Anal Bioanal Chem. 2015 Apr;407(10):2659-63. doi: 10.1007/s00216-014-8438-8. Epub 2015 Feb 25. No abstract available.

PMID:
25711985
11.

Microquantification of inorganic and organic phosphate by negative ion electrospray tandem mass spectrometry.

Safian MF, Lehmann WD.

Anal Bioanal Chem. 2015 Apr;407(10):2933-7. doi: 10.1007/s00216-015-8542-4. Epub 2015 Feb 24.

PMID:
25709067
12.

Identification of isoform-specific dynamics in phosphorylation-dependent STAT5 dimerization by quantitative mass spectrometry and mathematical modeling.

Boehm ME, Adlung L, Schilling M, Roth S, Klingmüller U, Lehmann WD.

J Proteome Res. 2014 Dec 5;13(12):5685-94. doi: 10.1021/pr5006923. Epub 2014 Nov 7.

PMID:
25333863
13.

One-source peptide/phosphopeptide ratio standards for accurate and site-specific determination of the degree of phosphorylation.

Boehm ME, Hahn B, Lehmann WD.

Methods Mol Biol. 2014;1156:367-78. doi: 10.1007/978-1-4939-0685-7_24.

PMID:
24792001
14.

Preparation of heteroelement-incorporated and stable isotope-labeled protein standards for quantitative proteomics.

Konopka A, Zinn N, Wild C, Lehmann WD.

Methods Mol Biol. 2014;1156:337-63. doi: 10.1007/978-1-4939-0685-7_23.

PMID:
24792000
15.

Phosphorylation of multifunctional galectins by protein kinases CK1, CK2, and PKA.

Kübler D, Seidler J, André S, Kumar S, Schwartz-Albiez R, Lehmann WD, Gabius HJ.

Anal Biochem. 2014 Mar 15;449:109-17. doi: 10.1016/j.ab.2013.12.006. Epub 2013 Dec 10.

PMID:
24333252
16.

Biliary phosphatidylcholine and lysophosphatidylcholine profiles in sclerosing cholangitis.

Gauss A, Ehehalt R, Lehmann WD, Erben G, Weiss KH, Schaefer Y, Kloeters-Plachky P, Stiehl A, Stremmel W, Sauer P, Gotthardt DN.

World J Gastroenterol. 2013 Sep 7;19(33):5454-63. doi: 10.3748/wjg.v19.i33.5454.

17.

ESI hydrogen/deuterium exchange can count chemical forms of heteroatom-bound hydrogen.

Tittebrandt S, Edelson-Averbukh M, Spengler B, Lehmann WD.

Angew Chem Int Ed Engl. 2013 Aug 19;52(34):8973-5. doi: 10.1002/anie.201304249. Epub 2013 Jul 12. No abstract available.

PMID:
23852916
18.

Heterogeneous kinetics of AKT signaling in individual cells are accounted for by variable protein concentration.

Meyer R, D'Alessandro LA, Kar S, Kramer B, She B, Kaschek D, Hahn B, Wrangborg D, Karlsson J, Kvarnström M, Jirstrand M, Lehmann WD, Timmer J, Höfer T, Klingmüller U.

Front Physiol. 2012 Nov 28;3:451. doi: 10.3389/fphys.2012.00451. eCollection 2012.

19.

Cellular ERK phospho-form profiles with conserved preference for a switch-like pattern.

Hahn B, D'Alessandro LA, Depner S, Waldow K, Boehm ME, Bachmann J, Schilling M, Klingmüller U, Lehmann WD.

J Proteome Res. 2013 Feb 1;12(2):637-46. doi: 10.1021/pr3007232. Epub 2012 Dec 26.

PMID:
23210697
20.

Enzyme-cleavable tandem peptides for quantitative studies in MS-based proteomics.

Winter D, Hung CW, Jaskolla TW, Karas M, Lehmann WD.

Proteomics. 2012 Dec;12(23-24):3470-4. doi: 10.1002/pmic.201200290. Epub 2012 Nov 26.

PMID:
23090848
21.

Molecular interaction of artemisinin with translationally controlled tumor protein (TCTP) of Plasmodium falciparum.

Eichhorn T, Winter D, Büchele B, Dirdjaja N, Frank M, Lehmann WD, Mertens R, Krauth-Siegel RL, Simmet T, Granzin J, Efferth T.

Biochem Pharmacol. 2013 Jan 1;85(1):38-45. doi: 10.1016/j.bcp.2012.10.006. Epub 2012 Oct 17.

PMID:
23085438
22.

Site-specific degree of phosphorylation in proteins measured by liquid chromatography-electrospray mass spectrometry.

Boehm ME, Seidler J, Hahn B, Lehmann WD.

Proteomics. 2012 Jul;12(13):2167-78. doi: 10.1002/pmic.201100561. Review.

PMID:
22653803
23.

Improving the precision of quantitative bottom-up proteomics based on stable isotope-labeled proteins.

Konopka A, Boehm ME, Rohmer M, Baeumlisberger D, Karas M, Lehmann WD.

Anal Bioanal Chem. 2012 Sep;404(4):1079-87. doi: 10.1007/s00216-012-6007-6. Epub 2012 Apr 26.

PMID:
22535440
24.

Cdc14-dependent dephosphorylation of Inn1 contributes to Inn1-Cyk3 complex formation.

Palani S, Meitinger F, Boehm ME, Lehmann WD, Pereira G.

J Cell Sci. 2012 Jul 1;125(Pt 13):3091-6. doi: 10.1242/jcs.106021. Epub 2012 Mar 27.

25.

Impaired neurotransmission in ether lipid-deficient nerve terminals.

Brodde A, Teigler A, Brugger B, Lehmann WD, Wieland F, Berger J, Just WW.

Hum Mol Genet. 2012 Jun 15;21(12):2713-24. doi: 10.1093/hmg/dds097. Epub 2012 Mar 8.

26.

Bioinformatic and experimental fishing for artemisinin-interacting proteins from human nasopharyngeal cancer cells.

Eichhorn T, Schloissnig S, Hahn B, Wendler A, Mertens R, Lehmann WD, Krauth-Siegel RL, Efferth T.

Mol Biosyst. 2012 Apr;8(4):1311-8. doi: 10.1039/c2mb05437j. Epub 2012 Feb 6.

PMID:
22311186
27.

GCP6 is a substrate of Plk4 and required for centriole duplication.

Bahtz R, Seidler J, Arnold M, Haselmann-Weiss U, Antony C, Lehmann WD, Hoffmann I.

J Cell Sci. 2012 Jan 15;125(Pt 2):486-96. doi: 10.1242/jcs.093930. Epub 2012 Feb 2.

28.

Discrimination between peptide O-sulfo- and O-phosphotyrosine residues by negative ion mode electrospray tandem mass spectrometry.

Edelson-Averbukh M, Shevchenko A, Pipkorn R, Lehmann WD.

J Am Soc Mass Spectrom. 2011 Dec;22(12):2256-68. doi: 10.1007/s13361-011-0248-z. Epub 2011 Sep 27.

PMID:
21952787
29.

Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range.

Bachmann J, Raue A, Schilling M, Böhm ME, Kreutz C, Kaschek D, Busch H, Gretz N, Lehmann WD, Timmer J, Klingmüller U.

Mol Syst Biol. 2011 Jul 19;7:516. doi: 10.1038/msb.2011.50.

30.

Phosphorylation-dependent regulation of the F-BAR protein Hof1 during cytokinesis.

Meitinger F, Boehm ME, Hofmann A, Hub B, Zentgraf H, Lehmann WD, Pereira G.

Genes Dev. 2011 Apr 15;25(8):875-88. doi: 10.1101/gad.622411.

31.

Toward comprehensive analysis of the galectin network in chicken: unique diversity of galectin-3 and comparison of its localization profile in organs of adult animals to the other four members of this lectin family.

Kaltner H, Kübler D, López-Merino L, Lohr M, Manning JC, Lensch M, Seidler J, Lehmann WD, André S, Solís D, Gabius HJ.

Anat Rec (Hoboken). 2011 Mar;294(3):427-44. doi: 10.1002/ar.21341. Epub 2011 Feb 2.

32.

One-source peptide/phosphopeptide standards for accurate phosphorylation degree determination.

Hahn B, Böhm M, Raia V, Zinn N, Möller P, Klingmüller U, Lehmann WD.

Proteomics. 2011 Feb;11(3):490-4. doi: 10.1002/pmic.201000569. Epub 2011 Jan 13.

PMID:
21268278
33.

Dynamic mathematical modeling of IL13-induced signaling in Hodgkin and primary mediastinal B-cell lymphoma allows prediction of therapeutic targets.

Raia V, Schilling M, Böhm M, Hahn B, Kowarsch A, Raue A, Sticht C, Bohl S, Saile M, Möller P, Gretz N, Timmer J, Theis F, Lehmann WD, Lichter P, Klingmüller U.

Cancer Res. 2011 Feb 1;71(3):693-704. doi: 10.1158/0008-5472.CAN-10-2987. Epub 2010 Dec 2.

34.

Defining the structural requirements for ribose 5-phosphate-binding and intersubunit cross-talk of the malarial pyridoxal 5-phosphate synthase.

Derrer B, Windeisen V, Guédez Rodríguez G, Seidler J, Gengenbacher M, Lehmann WD, Rippe K, Sinning I, Tews I, Kappes B.

FEBS Lett. 2010 Oct 8;584(19):4169-74. doi: 10.1016/j.febslet.2010.09.013. Epub 2010 Sep 17.

35.

Structural and mechanistic Information on c(1) ion formation in collision-induced fragmentation of peptides.

Winter D, Seidler J, Hahn B, Lehmann WD.

J Am Soc Mass Spectrom. 2010 Oct;21(10):1814-20. doi: 10.1016/j.jasms.2010.06.020. Epub 2010 Jul 7.

36.

Uncoupling of bait-protein expression from the prey protein environment adds versatility for cell and tissue interaction proteomics and reveals a complex of CARP-1 and the PKA Cbeta1 subunit.

Erlbruch A, Hung CW, Seidler J, Borrmann K, Gesellchen F, König N, Kübler D, Herberg FW, Lehmann WD, Bossemeyer D.

Proteomics. 2010 Aug;10(16):2890-900. doi: 10.1002/pmic.200900593.

PMID:
20564261
37.

Metal ion-mobilizing additives for comprehensive detection of femtomole amounts of phosphopeptides by reversed phase LC-MS.

Seidler J, Zinn N, Haaf E, Boehm ME, Winter D, Schlosser A, Lehmann WD.

Amino Acids. 2011 Jul;41(2):311-20. doi: 10.1007/s00726-010-0647-7. Epub 2010 Jun 16.

PMID:
20552382
38.

Recombinant isotope labeled and selenium quantified proteins for absolute protein quantification.

Zinn N, Winter D, Lehmann WD.

Anal Chem. 2010 Mar 15;82(6):2334-40. doi: 10.1021/ac9025412.

PMID:
20163147
39.

Minimally permutated peptide analogs as internal standards for relative and absolute quantification of peptides and proteins.

Winter D, Seidler J, Kugelstadt D, Derrer B, Kappes B, Lehmann WD.

Proteomics. 2010 Apr;10(7):1510-4. doi: 10.1002/pmic.200900695.

PMID:
20104620
41.

Theoretical and experimental analysis links isoform-specific ERK signalling to cell fate decisions.

Schilling M, Maiwald T, Hengl S, Winter D, Kreutz C, Kolch W, Lehmann WD, Timmer J, Klingmüller U.

Mol Syst Biol. 2009;5:334. doi: 10.1038/msb.2009.91. Epub 2009 Dec 22.

42.

De novo sequencing of peptides by MS/MS.

Seidler J, Zinn N, Boehm ME, Lehmann WD.

Proteomics. 2010 Feb;10(4):634-49. doi: 10.1002/pmic.200900459. Review.

PMID:
19953542
43.

Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells.

Brenner D, Brechmann M, Röhling S, Tapernoux M, Mock T, Winter D, Lehmann WD, Kiefer F, Thome M, Krammer PH, Arnold R.

Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14508-13. doi: 10.1073/pnas.0900457106. Epub 2009 Aug 11.

44.

Phosphorus-based absolutely quantified standard peptides for quantitative proteomics.

Zinn N, Hahn B, Pipkorn R, Schwarzer D, Lehmann WD.

J Proteome Res. 2009 Oct;8(10):4870-5. doi: 10.1021/pr900494m.

PMID:
19663461
45.

Analysis of autophosphorylation sites in the recombinant catalytic subunit alpha of cAMP-dependent kinase by nano-UPLC-ESI-MS/MS.

Seidler J, Adal M, Kübler D, Bossemeyer D, Lehmann WD.

Anal Bioanal Chem. 2009 Nov;395(6):1713-20. doi: 10.1007/s00216-009-2932-4. Epub 2009 Jul 10.

PMID:
19590856
47.

Alterations of phospholipid concentration and species composition of the intestinal mucus barrier in ulcerative colitis: a clue to pathogenesis.

Braun A, Treede I, Gotthardt D, Tietje A, Zahn A, Ruhwald R, Schoenfeld U, Welsch T, Kienle P, Erben G, Lehmann WD, Fuellekrug J, Stremmel W, Ehehalt R.

Inflamm Bowel Dis. 2009 Nov;15(11):1705-20. doi: 10.1002/ibd.20993.

PMID:
19504612
48.

Gas-phase intramolecular phosphate shift in phosphotyrosine-containing peptide monoanions.

Edelson-Averbukh M, Shevchenko A, Pipkorn R, Lehmann WD.

Anal Chem. 2009 Jun 1;81(11):4369-81. doi: 10.1021/ac900244e.

PMID:
19402683
49.

Separation of peptide isomers and conformers by ultra performance liquid chromatography.

Winter D, Pipkorn R, Lehmann WD.

J Sep Sci. 2009 Apr;32(8):1111-9. doi: 10.1002/jssc.200800691.

PMID:
19360781
50.

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