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Items: 1 to 50 of 135

1.

Quantitative HLA-class-II/Factor VIII (FVIII) Peptidomic Variation in Dendritic Cells Correlates with the Immunogenic Potential of Therapeutic FVIII Proteins in Hemophilia A.

Diego VP, Luu BW, Hofmann M, Dinh LV, Almeida M, Powell JS, Rajalingam R, Peralta JM, Kumar S, Curran JE, Sauna ZE, Kellerman R, Park Y, Key NS, Escobar MA, Huynh H, Verhagen AM, Williams-Blangero S, Lehmann PV, Maraskovsky E, Blangero J, Howard TE.

J Thromb Haemost. 2019 Sep 25. doi: 10.1111/jth.14647. [Epub ahead of print]

PMID:
31556206
2.

Comprehensive Evaluation of the Expressed CD8+ T Cell Epitope Space Using High-Throughput Epitope Mapping.

Lehmann PV, Suwansaard M, Zhang T, Roen DR, Kirchenbaum GA, Karulin AY, Lehmann A, Reche PA.

Front Immunol. 2019 Apr 26;10:655. doi: 10.3389/fimmu.2019.00655. eCollection 2019.

3.

Natural T cell autoreactivity to melanoma antigens: clonally expanded melanoma-antigen specific CD8 + memory T cells can be detected in healthy humans.

Przybyla A, Zhang T, Li R, Roen DR, Mackiewicz A, Lehmann PV.

Cancer Immunol Immunother. 2019 May;68(5):709-720. doi: 10.1007/s00262-018-02292-7. Epub 2019 Feb 19.

PMID:
30783693
4.

Multi-Color FLUOROSPOT Counting Using ImmunoSpot® Fluoro-X™ Suite.

Megyesi Z, Lehmann PV, Karulin AY.

Methods Mol Biol. 2018;1808:115-131. doi: 10.1007/978-1-4939-8567-8_10.

PMID:
29956178
5.

Multiplexing T- and B-Cell FLUOROSPOT Assays: Experimental Validation of the Multi-Color ImmunoSpot® Software Based on Center of Mass Distance Algorithm.

Karulin AY, Megyesi Z, Caspell R, Hanson J, Lehmann PV.

Methods Mol Biol. 2018;1808:95-113. doi: 10.1007/978-1-4939-8567-8_9.

PMID:
29956177
6.

Detecting all Immunoglobulin Classes and Subclasses in a Multiplex 7 Color ImmunoSpot® Assay.

Caspell R, Lehmann PV.

Methods Mol Biol. 2018;1808:85-94. doi: 10.1007/978-1-4939-8567-8_8.

PMID:
29956176
7.

Multiplex ImmunoSpot® Assays for the Study of Functional B Cell Subpopulations.

Roen DR, Hanson J, Lehmann PV.

Methods Mol Biol. 2018;1808:73-83. doi: 10.1007/978-1-4939-8567-8_7.

PMID:
29956175
8.

Four Color ImmunoSpot® Assays for Identification of Effector T-Cell Lineages.

Hanson J, Roen DR, Lehmann PV.

Methods Mol Biol. 2018;1808:51-62. doi: 10.1007/978-1-4939-8567-8_5.

PMID:
29956173
9.

B Cells and B Cell Blasts Withstand Cryopreservation While Retaining Their Functionality for Producing Antibody.

Fecher P, Caspell R, Naeem V, Karulin AY, Kuerten S, Lehmann PV.

Cells. 2018 May 31;7(6). pii: E50. doi: 10.3390/cells7060050.

10.

Direct Detection of T- and B-Memory Lymphocytes by ImmunoSpot® Assays Reveals HCMV Exposure that Serum Antibodies Fail to Identify.

Terlutter F, Caspell R, Nowacki TM, Lehmann A, Li R, Zhang T, Przybyla A, Kuerten S, Lehmann PV.

Cells. 2018 May 19;7(5). pii: E45. doi: 10.3390/cells7050045.

11.

High-Throughput GLP-Capable Target Cell Visualization Assay for Measuring Cell-Mediated Cytotoxicity.

Welter A, Sundararaman S, Li R, Zhang T, Karulin AY, Lehmann A, Naeem V, Roen DR, Kuerten S, Lehmann PV.

Cells. 2018 Apr 24;7(5). pii: E35. doi: 10.3390/cells7050035.

12.

Secondhand Smoke Induces Inflammation and Impairs Immunity to Respiratory Infections.

Bhat TA, Kalathil SG, Bogner PN, Miller A, Lehmann PV, Thatcher TH, Phipps RP, Sime PJ, Thanavala Y.

J Immunol. 2018 Apr 15;200(8):2927-2940. doi: 10.4049/jimmunol.1701417. Epub 2018 Mar 19.

13.

Reagent Tracker Dyes Permit Quality Control for Verifying Plating Accuracy in ELISPOT Tests.

Lehmann A, Megyesi Z, Przybyla A, Lehmann PV.

Cells. 2018 Jan 3;7(1). pii: E3. doi: 10.3390/cells7010003.

14.

A Positive Control for Detection of Functional CD4 T Cells in PBMC: The CPI Pool.

Schiller A, Zhang T, Li R, Duechting A, Sundararaman S, Przybyla A, Kuerten S, Lehmann PV.

Cells. 2017 Dec 7;6(4). pii: E47. doi: 10.3390/cells6040047.

15.

Delayed Activation Kinetics of Th2- and Th17 Cells Compared to Th1 Cells.

Duechting A, Przybyla A, Kuerten S, Lehmann PV.

Cells. 2017 Sep 12;6(3). pii: E29. doi: 10.3390/cells6030029.

16.

The enteric nervous system is a potential autoimmune target in multiple sclerosis.

Wunsch M, Jabari S, Voussen B, Enders M, Srinivasan S, Cossais F, Wedel T, Boettner M, Schwarz A, Weyer L, Göcer O, Schroeter M, Maeurer M, Woenckhaus M, Pollok K, Radbruch H, Klotz L, Scholz CJ, Nickel J, Friebe A, Addicks K, Ergün S, Lehmann PV, Kuerten S.

Acta Neuropathol. 2017 Aug;134(2):281-295. doi: 10.1007/s00401-017-1742-6. Epub 2017 Jun 15.

PMID:
28620692
17.

The Correlation between the Virus- and Brain Antigen-Specific B Cell Response in the Blood of Patients with Multiple Sclerosis.

Wunsch M, Hohmann C, Milles B, Rostermund C, Lehmann PV, Schroeter M, Bayas A, Ulzheimer J, Mäurer M, Ergün S, Kuerten S.

Viruses. 2016 Apr 23;8(4):105. doi: 10.3390/v8040105.

18.

How frequently are predicted peptides actually recognized by CD8 cells?

Moldovan I, Targoni O, Zhang W, Sundararaman S, Lehmann PV.

Cancer Immunol Immunother. 2016 Jul;65(7):847-55. doi: 10.1007/s00262-016-1840-7. Epub 2016 Apr 23. Review.

19.

Characterization of the HCMV-Specific CD4 T Cell Responses that Are Associated with Protective Immunity.

Wunsch M, Zhang W, Hanson J, Caspell R, Karulin AY, Recks MS, Kuerten S, Sundararaman S, Lehmann PV.

Viruses. 2015 Aug 6;7(8):4414-37. doi: 10.3390/v7082828.

20.

The autoimmune pathogenesis of multiple sclerosis.

Lehmann PV, Rottlaender A, Kuerten S.

Pharmazie. 2015 Jan;70(1):5-11. Review.

PMID:
25975091
21.
22.

ELISPOT Assays in 384-Well Format: Up to 30 Data Points with One Million Cells.

Hanson J, Sundararaman S, Caspell R, Karacsony E, Karulin AY, Lehmann PV.

Cells. 2015 Jan 29;4(1):71-83. doi: 10.3390/cells4010071.

23.

ELISPOTs Produced by CD8 and CD4 Cells Follow Log Normal Size Distribution Permitting Objective Counting.

Karulin AY, Karacsony K, Zhang W, Targoni OS, Moldovan I, Dittrich M, Sundararaman S, Lehmann PV.

Cells. 2015 Jan 20;4(1):56-70. doi: 10.3390/cells4010056.

24.

Categorization of multiple sclerosis relapse subtypes by B cell profiling in the blood.

Hohmann C, Milles B, Schinke M, Schroeter M, Ulzheimer J, Kraft P, Kleinschnitz C, Lehmann PV, Kuerten S.

Acta Neuropathol Commun. 2014 Sep 16;2:138. doi: 10.1186/s40478-014-0138-2.

25.

Serial Measurements of Apoptotic Cell Numbers Provide Better Acceptance Criterion for PBMC Quality than a Single Measurement Prior to the T Cell Assay.

Wunsch M, Caspell R, Kuerten S, Lehmann PV, Sundararaman S.

Cells. 2015 Jan 9;4(1):40-55. doi: 10.3390/cells4010040.

26.

High Reproducibility of ELISPOT Counts from Nine Different Laboratories.

Sundararaman S, Karulin AY, Ansari T, BenHamouda N, Gottwein J, Laxmanan S, Levine SM, Loffredo JT, McArdle S, Neudoerfl C, Roen D, Silina K, Welch M, Lehmann PV.

Cells. 2015 Jan 9;4(1):21-39. doi: 10.3390/cells4010021.

27.

Identification of a B cell-dependent subpopulation of multiple sclerosis by measurements of brain-reactive B cells in the blood.

Kuerten S, Pommerschein G, Barth SK, Hohmann C, Milles B, Sammer FW, Duffy CE, Wunsch M, Rovituso DM, Schroeter M, Addicks K, Kaiser CC, Lehmann PV.

Clin Immunol. 2014 May-Jun;152(1-2):20-4. doi: 10.1016/j.clim.2014.02.014. Epub 2014 Mar 5.

28.

Longitudinal T cell-derived IFN-γ/IL-17 balances do not correlate with the disease course in two mouse models of experimental autoimmune encephalomyelitis.

Kuerten S, Wunsch M, Lehmann PV.

J Immunol Methods. 2013 Dec 15;398-399:68-75. doi: 10.1016/j.jim.2013.09.010. Epub 2013 Sep 25.

PMID:
24076090
29.

The complement system contributes to the pathology of experimental autoimmune encephalomyelitis by triggering demyelination and modifying the antigen-specific T and B cell response.

Hundgeburth LC, Wunsch M, Rovituso D, Recks MS, Addicks K, Lehmann PV, Kuerten S.

Clin Immunol. 2013 Mar;146(3):155-64. doi: 10.1016/j.clim.2012.12.007. Epub 2012 Dec 22.

PMID:
23352967
30.

An Enhanced ELISPOT Assay for Sensitive Detection of Antigen-Specific T Cell Responses to Borrelia burgdorferi.

Jin C, Roen DR, Lehmann PV, Kellermann GH.

Cells. 2013 Sep 13;2(3):607-20. doi: 10.3390/cells2030607.

31.

How much of virus-specific CD8 T cell reactivity is detected with a peptide pool when compared to individual peptides?

Zhang W, Moldovan I, Targoni OS, Subbramanian RA, Lehmann PV.

Viruses. 2012 Oct 29;4(11):2636-49. doi: 10.3390/v4112636.

32.

Tertiary lymphoid organ development coincides with determinant spreading of the myelin-specific T cell response.

Kuerten S, Schickel A, Kerkloh C, Recks MS, Addicks K, Ruddle NH, Lehmann PV.

Acta Neuropathol. 2012 Dec;124(6):861-73. doi: 10.1007/s00401-012-1023-3. Epub 2012 Jul 28.

PMID:
22842876
33.

Assessment of the innate and adaptive immune system in proliferative vitreoretinopathy.

Zhang W, Tan J, Liu Y, Li W, Gao Q, Lehmann PV.

Eye (Lond). 2012 Jun;26(6):872-81. doi: 10.1038/eye.2012.52. Epub 2012 Mar 30.

34.

The magnitude of the antigen-specific T cell response is separated from the severity of spinal cord histopathology in remitting-relapsing experimental autoimmune encephalomyelitis.

Batoulis H, Uhl M, Addicks K, Lehmann PV, Kuerten S.

Glia. 2012 May;60(5):794-805. doi: 10.1002/glia.22309. Epub 2012 Feb 8.

PMID:
22319015
36.

Resting of Cryopreserved PBMC Does Not Generally Benefit the Performance of Antigen-Specific T Cell ELISPOT Assays.

Kuerten S, Batoulis H, Recks MS, Karacsony E, Zhang W, Subbramanian RA, Lehmann PV.

Cells. 2012 Jul 30;1(3):409-27. doi: 10.3390/cells1030409.

37.

Optimal thawing of cryopreserved peripheral blood mononuclear cells for use in high-throughput human immune monitoring studies.

Ramachandran H, Laux J, Moldovan I, Caspell R, Lehmann PV, Subbramanian RA.

Cells. 2012 Jul 25;1(3):313-24. doi: 10.3390/cells1030313.

38.

Dissecting the T Cell Response: Proliferation Assays vs. Cytokine Signatures by ELISPOT.

Anthony DD, Milkovich KA, Zhang W, Rodriguez B, Yonkers NL, Tary-Lehmann M, Lehmann PV.

Cells. 2012 May 10;1(2):127-40. doi: 10.3390/cells1020127.

39.

Cytomegalovirus (CMV)-Specific Perforin and Granzyme B ELISPOT Assays Detect Reactivation of CMV Infection in Inflammatory Bowel Disease.

Nowacki TM, Bettenworth D, Ross M, Heidemann J, Lehmann PV, Lügering A.

Cells. 2012 Apr 23;1(2):35-50. doi: 10.3390/cells1020035.

40.

Statistical analysis of ELISPOT assays.

Dittrich M, Lehmann PV.

Methods Mol Biol. 2012;792:173-83. doi: 10.1007/978-1-61779-325-7_14.

PMID:
21956510
41.

Objective, user-independent ELISPOT data analysis based on scientifically validated principles.

Zhang W, Lehmann PV.

Methods Mol Biol. 2012;792:155-71. doi: 10.1007/978-1-61779-325-7_13.

PMID:
21956509
42.

How ELISPOT morphology reflects on the productivity and kinetics of cells' secretory activity.

Karulin AY, Lehmann PV.

Methods Mol Biol. 2012;792:125-43. doi: 10.1007/978-1-61779-325-7_11.

PMID:
21956507
43.

Unique strengths of ELISPOT for T cell diagnostics.

Lehmann PV, Zhang W.

Methods Mol Biol. 2012;792:3-23. doi: 10.1007/978-1-61779-325-7_1. Review.

PMID:
21956497
44.

The immune pathogenesis of experimental autoimmune encephalomyelitis: lessons learned for multiple sclerosis?

Kuerten S, Lehmann PV.

J Interferon Cytokine Res. 2011 Dec;31(12):907-16. doi: 10.1089/jir.2011.0072. Epub 2011 Sep 21. Review.

PMID:
21936633
45.

Gene-dependent cell death in yeast.

Teng X, Cheng WC, Qi B, Yu TX, Ramachandran K, Boersma MD, Hattier T, Lehmann PV, Pineda FJ, Hardwick JM.

Cell Death Dis. 2011 Aug 4;2:e188. doi: 10.1038/cddis.2011.72.

46.

Differential patterns of spinal cord pathology induced by MP4, MOG peptide 35-55, and PLP peptide 178-191 in C57BL/6 mice.

Kuerten S, Gruppe TL, Laurentius LM, Kirch C, Tary-Lehmann M, Lehmann PV, Addicks K.

APMIS. 2011 Jun;119(6):336-46. doi: 10.1111/j.1600-0463.2011.02744.x. Epub 2011 Apr 12.

PMID:
21569091
47.

Myelin-reactive antibodies mediate the pathology of MBP-PLP fusion protein MP4-induced EAE.

Kuerten S, Pauly R, Rottlaender A, Rodi M, Gruppe TL, Addicks K, Tary-Lehmann M, Lehmann PV.

Clin Immunol. 2011 Jul;140(1):54-62. doi: 10.1016/j.clim.2011.03.009. Epub 2011 Apr 13.

PMID:
21489887
48.

The clinical course of EAE is reflected by the dynamics of the neuroantigen-specific T cell compartment in the blood.

Kuerten S, Rottlaender A, Rodi M, Velasco VB Jr, Schroeter M, Kaiser C, Addicks K, Tary-Lehmann M, Lehmann PV.

Clin Immunol. 2010 Dec;137(3):422-32. doi: 10.1016/j.clim.2010.09.004. Epub 2010 Oct 8.

PMID:
20933475
49.

Involvement of brain-derived neurotrophic factor (BDNF) in MP4-induced autoimmune encephalomyelitis.

Javeri S, Rodi M, Tary-Lehmann M, Lehmann PV, Addicks K, Kuerten S.

Clin Immunol. 2010 Nov;137(2):181-9. doi: 10.1016/j.clim.2010.08.001. Epub 2010 Aug 24.

PMID:
20797911
50.

Delineating the impact of neuroantigen vs genetic diversity on MP4-induced EAE of C57BL/6 and B6.129 mice.

Kuerten S, Rodi M, Javeri S, Gruppe TL, Tary-Lehmann M, Lehmann PV, Addicks K.

APMIS. 2009 Dec;117(12):923-35. doi: 10.1111/j.1600-0463.2009.02555.x.

PMID:
20078558

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