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The mechanism of thin filament regulation: Models in conflict?

Geeves MA, Lehrer SS, Lehman W.

J Gen Physiol. 2019 Nov 4;151(11):1265-1271. doi: 10.1085/jgp.201912446. Epub 2019 Sep 30. Review.


Perfusion is Not Measurably Decreased in Idiopathic Clubfoot.

Forrester LA, Grissom HE, Shakked RJ, Danna NR, Sala DA, Lehman WB, Otsuka NY, Chu A.

Bull Hosp Jt Dis (2013). 2018 Sep;76(3):203-206.


Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1.

Janco M, Rynkiewicz MJ, Li L, Hook J, Eiffe E, Ghosh A, Böcking T, Lehman WJ, Hardeman EC, Gunning PW.

Sci Rep. 2019 Aug 2;9(1):11262. doi: 10.1038/s41598-019-47592-9.


The role of physical and psychological health problems in the drug use treatment process.

Joe GW, Lehman WEK, Rowan GA, Knight K, Flynn PM.

J Subst Abuse Treat. 2019 Jul;102:23-32. doi: 10.1016/j.jsat.2019.03.011. Epub 2019 Mar 30.


The Effect of Tropomyosin Mutations on Actin-Tropomyosin Binding: In Search of Lost Time.

Lehman W, Moore JR, Campbell SG, Rynkiewicz MJ.

Biophys J. 2019 Jun 18;116(12):2275-2284. doi: 10.1016/j.bpj.2019.05.009. Epub 2019 May 13.


The Validity of Patient-reported Outcome Measurement Information System (PROMIS) Parent Proxy Instruments to Assess Function in Children With Talipes Equinovarus.

Masrouha KZ, Moses MJ, Sala DA, Litrenta J, Lehman WB, Chu A.

J Pediatr Orthop. 2019 Nov/Dec;39(10):e787-e790. doi: 10.1097/BPO.0000000000001368.


A new twist on tropomyosin binding to actin filaments: perspectives on thin filament function, assembly and biomechanics.

Lehman W, Rynkiewicz MJ, Moore JR.

J Muscle Res Cell Motil. 2019 Feb 15. doi: 10.1007/s10974-019-09501-5. [Epub ahead of print]


Spontaneous transitions of actin-bound tropomyosin toward blocked and closed states.

Kiani FA, Lehman W, Fischer S, Rynkiewicz MJ.

J Gen Physiol. 2019 Jan 7;151(1):4-8. doi: 10.1085/jgp.201812188. Epub 2018 Nov 15.


Precise Binding of Tropomyosin on Actin Involves Sequence-Dependent Variance in Coiled-Coil Twisting.

Lehman W, Li X, Kiani FA, Moore JR, Campbell SG, Fischer S, Rynkiewicz MJ.

Biophys J. 2018 Sep 18;115(6):1082-1092. doi: 10.1016/j.bpj.2018.08.017. Epub 2018 Aug 18.


StaySafe: A self-administered android tablet application for helping individuals on probation make better decisions pertaining to health risk behaviors.

Lehman WEK, Pankow J, Rowan GA, Gray J, Blue TR, Muiruri R, Knight K.

Contemp Clin Trials Commun. 2018 Mar 31;10:86-93. doi: 10.1016/j.conctc.2018.03.010. eCollection 2018 Jun.


Current Methods for Skeletal Muscle Tissue Repair and Regeneration.

Liu J, Saul D, Böker KO, Ernst J, Lehman W, Schilling AF.

Biomed Res Int. 2018 Apr 16;2018:1984879. doi: 10.1155/2018/1984879. eCollection 2018. Review.


Perceived importance of substance use prevention in juvenile justice: a multi-level analysis.

Sales JM, Wasserman G, Elkington KS, Lehman W, Gardner S, McReynolds L, Wiley T, Knudsen H.

Health Justice. 2018 May 15;6(1):12. doi: 10.1186/s40352-018-0070-9.


HCM and DCM cardiomyopathy-linked α-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments.

Farman GP, Rynkiewicz MJ, Orzechowski M, Lehman W, Moore JR.

Arch Biochem Biophys. 2018 Jun 1;647:84-92. doi: 10.1016/ Epub 2018 Apr 5.


Tropomyosin Must Interact Weakly with Actin to Effectively Regulate Thin Filament Function.

Rynkiewicz MJ, Prum T, Hollenberg S, Kiani FA, Fagnant PM, Marston SB, Trybus KM, Fischer S, Moore JR, Lehman W.

Biophys J. 2017 Dec 5;113(11):2444-2451. doi: 10.1016/j.bpj.2017.10.004.


Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy.

Viswanathan MC, Schmidt W, Rynkiewicz MJ, Agarwal K, Gao J, Katz J, Lehman W, Cammarato A.

Cell Rep. 2017 Sep 12;20(11):2612-2625. doi: 10.1016/j.celrep.2017.08.070.


Age of Recurrence in Idiopathic Clubfoot Treated with the Ponseti Method.

Goldstein R, Chu A, Sala D, Lehman W.

Bull Hosp Jt Dis (2013). 2017 May;75(3):193-197.


Switching Muscles On and Off in Steps: The McKillop-Geeves Three-State Model of Muscle Regulation.

Lehman W.

Biophys J. 2017 Jun 20;112(12):2459-2466. doi: 10.1016/j.bpj.2017.04.053. Epub 2017 May 25.


Predicting Effects of Tropomyosin Mutations on Cardiac Muscle Contraction through Myofilament Modeling.

Sewanan LR, Moore JR, Lehman W, Campbell SG.

Front Physiol. 2016 Oct 26;7:473. eCollection 2016.


The propensity for tropomyosin twisting in the presence and absence of F-actin.

Rynkiewicz MJ, Fischer S, Lehman W.

Arch Biochem Biophys. 2016 Nov 1;609:51-58. doi: 10.1016/ Epub 2016 Sep 20.


Influence of Organizational Characteristics on Success in Implementing Process Improvement Goals in Correctional Treatment Settings.

Prendergast M, Welsh WN, Stein L, Lehman W, Melnick G, Warda U, Shafer M, Ulaszek W, Rodis E, Abdel-Salam S, Duvall J.

J Behav Health Serv Res. 2017 Oct;44(4):625-646. doi: 10.1007/s11414-016-9531-x.


A Brief Assessment for HIV Risk: The TCU HVHP Form.

Rowan GA, Joe GW, Lehman WE, Knight K.

J Correct Health Care. 2016 Jul;22(3):225-39. doi: 10.1177/1078345816653871.


Thin Filament Structure and the Steric Blocking Model.

Lehman W.

Compr Physiol. 2016 Mar 15;6(2):1043-69. doi: 10.1002/cphy.c150030. Review.


Structural determinants of muscle thin filament cooperativity.

Moore JR, Campbell SG, Lehman W.

Arch Biochem Biophys. 2016 Mar 15;594:8-17. doi: 10.1016/ Epub 2016 Feb 15. Review.


Tropomyosin diffusion over actin subunits facilitates thin filament assembly.

Fischer S, Rynkiewicz MJ, Moore JR, Lehman W.

Struct Dyn. 2016 Jan 14;3(1):012002. doi: 10.1063/1.4940223. eCollection 2016 Jan.


Treatment of Idiopathic Clubfoot in the Ponseti Era and Beyond.

Chu A, Lehman WB.

Foot Ankle Clin. 2015 Dec;20(4):555-62. doi: 10.1016/j.fcl.2015.08.002. Epub 2015 Oct 23. Review.


Electrostatic interaction map reveals a new binding position for tropomyosin on F-actin.

Rynkiewicz MJ, Schott V, Orzechowski M, Lehman W, Fischer S.

J Muscle Res Cell Motil. 2015 Dec;36(6):525-33. doi: 10.1007/s10974-015-9419-z. Epub 2015 Aug 19.


Evaluation of WaySafe: A Disease-Risk Reduction Curriculum for Substance-Abusing Offenders.

Lehman WE, Rowan GA, Greener JM, Joe GW, Yang Y, Knight K.

J Subst Abuse Treat. 2015 Nov;58:25-32. doi: 10.1016/j.jsat.2015.05.007. Epub 2015 May 16.


Tarantula myosin free head regulatory light chain phosphorylation stiffens N-terminal extension, releasing it and blocking its docking back.

Alamo L, Li XE, Espinoza-Fonseca LM, Pinto A, Thomas DD, Lehman W, Padrón R.

Mol Biosyst. 2015 Aug;11(8):2180-9. doi: 10.1039/c5mb00163c.


Direct observation of tropomyosin binding to actin filaments.

Schmidt WM, Lehman W, Moore JR.

Cytoskeleton (Hoboken). 2015 Jun;72(6):292-303. doi: 10.1002/cm.21225. Epub 2015 Jun 30.


Effects of a strategy to improve offender assessment practices: Staff perceptions of implementation outcomes.

Welsh WN, Lin HJ, Peters RH, Stahler GJ, Lehman WE, Stein LA, Monico L, Eggers M, Abdel-Salam S, Pierce JC, Hunt E, Gallagher C, Frisman LK.

Drug Alcohol Depend. 2015 Jul 1;152:230-8. doi: 10.1016/j.drugalcdep.2015.03.033. Epub 2015 Apr 9.


FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets.

Begonja AJ, Pluthero FG, Suphamungmee W, Giannini S, Christensen H, Leung R, Lo RW, Nakamura F, Lehman W, Plomann M, Hoffmeister KM, Kahr WH, Hartwig JH, Falet H.

Blood. 2015 Jul 2;126(1):80-8. doi: 10.1182/blood-2014-07-587600. Epub 2015 Apr 2.


Potocki-Lupski syndrome in conjunction with bilateral clubfoot.

Dhanaraj D, Chu A, Pappas JG, Moran E, Lehman WB.

J Pediatr Orthop B. 2015 Jul;24(4):373-6. doi: 10.1097/BPB.0000000000000131.


Phosphorylation of Ser283 enhances the stiffness of the tropomyosin head-to-tail overlap domain.

Lehman W, Medlock G, Li XE, Suphamungmee W, Tu AY, Schmidtmann A, Ujfalusi Z, Fischer S, Moore JR, Geeves MA, Regnier M.

Arch Biochem Biophys. 2015 Apr 1;571:10-5. doi: 10.1016/ Epub 2015 Feb 26.


A Voxel-by-Voxel Comparison of Deformable Vector Fields Obtained by Three Deformable Image Registration Algorithms Applied to 4DCT Lung Studies.

Fatyga M, Dogan N, Weiss E, Sleeman WC 4th, Zhang B, Lehman WJ, Williamson JF, Wijesooriya K, Christensen GE.

Front Oncol. 2015 Feb 4;5:17. doi: 10.3389/fonc.2015.00017. eCollection 2015.


Structure of the F-actin-tropomyosin complex.

von der Ecken J, Müller M, Lehman W, Manstein DJ, Penczek PA, Raunser S.

Nature. 2015 Mar 5;519(7541):114-7. doi: 10.1038/nature14033. Epub 2014 Dec 1.


Idiopathic clubfoot treated with the Ponseti method: factors associated with patient follow-up.

Kim S, Goldstein RY, Park J, Shapiro P, Yoo AE, Sala DA, Chu A, Lehman WB.

Bull Hosp Jt Dis (2013). 2014;72(3):204-9.


Energy landscapes reveal the myopathic effects of tropomyosin mutations.

Orzechowski M, Fischer S, Moore JR, Lehman W, Farman GP.

Arch Biochem Biophys. 2014 Dec 15;564:89-99. doi: 10.1016/ Epub 2014 Sep 18.


Gender as a moderator in predicting re-arrest among treated drug-involved offenders.

Yang Y, Knight K, Joe GW, Rowan GA, Lehman WE, Flynn PM.

J Subst Abuse Treat. 2015 Feb;49:65-70. doi: 10.1016/j.jsat.2014.08.001. Epub 2014 Aug 7.


An atomic model of the tropomyosin cable on F-actin.

Orzechowski M, Li XE, Fischer S, Lehman W.

Biophys J. 2014 Aug 5;107(3):694-699. doi: 10.1016/j.bpj.2014.06.034.


Predicting the need for surgical intervention in patients with idiopathic clubfoot.

Goldstein RY, Seehausen DA, Chu A, Sala DA, Lehman WB.

J Pediatr Orthop. 2015 Jun;35(4):395-402. doi: 10.1097/BPO.0000000000000282.


Regulation of dynamin oligomerization in cells: the role of dynamin-actin interactions and its GTPase activity.

Gu C, Chang J, Shchedrina VA, Pham VA, Hartwig JH, Suphamungmee W, Lehman W, Hyman BT, Bacskai BJ, Sever S.

Traffic. 2014 Aug;15(8):819-38. doi: 10.1111/tra.12178. Epub 2014 Jun 24.


Structure and flexibility of the tropomyosin overlap junction.

Li XE, Orzechowski M, Lehman W, Fischer S.

Biochem Biophys Res Commun. 2014 Mar 28;446(1):304-8. doi: 10.1016/j.bbrc.2014.02.097. Epub 2014 Mar 4.


Three-dimensional organization of troponin on cardiac muscle thin filaments in the relaxed state.

Yang S, Barbu-Tudoran L, Orzechowski M, Craig R, Trinick J, White H, Lehman W.

Biophys J. 2014 Feb 18;106(4):855-64. doi: 10.1016/j.bpj.2014.01.007.


Calcaneocuboid arthrodesis for recurrent clubfeet: what is the outcome at 17-year follow-up?

Chu A, Chaudhry S, Sala DA, Atar D, Lehman WB.

J Child Orthop. 2014 Feb;8(1):43-8. doi: 10.1007/s11832-014-0557-4. Epub 2014 Feb 7.


Tropomyosin movement on F-actin during muscle activation explained by energy landscapes.

Orzechowski M, Moore JR, Fischer S, Lehman W.

Arch Biochem Biophys. 2014 Mar 1;545:63-8. doi: 10.1016/ Epub 2014 Jan 8.


A Drosophila melanogaster model of diastolic dysfunction and cardiomyopathy based on impaired troponin-T function.

Viswanathan MC, Kaushik G, Engler AJ, Lehman W, Cammarato A.

Circ Res. 2014 Jan 17;114(2):e6-17. doi: 10.1161/CIRCRESAHA.114.302028. Epub 2013 Nov 12. Erratum in: Circ Res. 2014 Feb 14;114(4):e28.


The structural dynamics of α-tropomyosin on F-actin shape the overlap complex between adjacent tropomyosin molecules.

Lehman W, Li XE, Orzechowski M, Fischer S.

Arch Biochem Biophys. 2014 Jun 15;552-553:68-73. doi: 10.1016/ Epub 2013 Sep 23.


Mutations in repeating structural motifs of tropomyosin cause gain of function in skeletal muscle myopathy patients.

Marston S, Memo M, Messer A, Papadaki M, Nowak K, McNamara E, Ong R, El-Mezgueldi M, Li X, Lehman W.

Hum Mol Genet. 2013 Dec 15;22(24):4978-87. doi: 10.1093/hmg/ddt345. Epub 2013 Jul 25.


Polymorphism in tropomyosin structure and function.

Janco M, Suphamungmee W, Li X, Lehman W, Lehrer SS, Geeves MA.

J Muscle Res Cell Motil. 2013 Aug;34(3-4):177-87. doi: 10.1007/s10974-013-9353-x. Epub 2013 Jul 7. Review.


Gestalt-binding of tropomyosin on actin during thin filament activation.

Lehman W, Orzechowski M, Li XE, Fischer S, Raunser S.

J Muscle Res Cell Motil. 2013 Aug;34(3-4):155-63. doi: 10.1007/s10974-013-9342-0. Epub 2013 May 12. Review.

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