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Items: 1 to 50 of 52

1.

The BTK Inhibitor ARQ 531 Targets Ibrutinib-Resistant CLL and Richter Transformation.

Reiff SD, Mantel R, Smith LL, Greene JT, Muhowski EM, Fabian CA, Goettl VM, Tran M, Harrington BK, Rogers KA, Awan FT, Maddocks K, Andritsos L, Lehman AM, Sampath D, Lapalombella R, Eathiraj S, Abbadessa G, Schwartz B, Johnson AJ, Byrd JC, Woyach JA.

Cancer Discov. 2018 Aug 9. doi: 10.1158/2159-8290.CD-17-1409. [Epub ahead of print]

PMID:
30093506
2.

Targeting the C481S Ibrutinib-Resistance Mutation in Bruton's Tyrosine Kinase Using PROTAC-Mediated Degradation.

Buhimschi AD, Armstrong HA, Toure M, Jaime-Figueroa S, Chen TL, Lehman AM, Woyach JA, Johnson AJ, Byrd JC, Crews CM.

Biochemistry. 2018 Jul 3;57(26):3564-3575. doi: 10.1021/acs.biochem.8b00391. Epub 2018 Jun 14.

PMID:
29851337
3.

Expression Patterns, Prognostic Value, and Intratumoral Heterogeneity of PD-L1 and PD-1 in Thymoma and Thymic Carcinoma.

Owen D, Chu B, Lehman AM, Annamalai L, Yearley JH, Shilo K, Otterson GA.

J Thorac Oncol. 2018 Aug;13(8):1204-1212. doi: 10.1016/j.jtho.2018.04.013. Epub 2018 Apr 24.

PMID:
29702286
4.

BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor.

Ozer HG, El-Gamal D, Powell B, Hing ZA, Blachly JS, Harrington B, Mitchell S, Grieselhuber NR, Williams K, Lai TH, Alinari L, Baiocchi RA, Brinton L, Baskin E, Cannon M, Beaver L, Goettl VM, Lucas DM, Woyach JA, Sampath D, Lehman AM, Yu L, Zhang J, Ma Y, Zhang Y, Spevak W, Shi S, Severson P, Shellooe R, Carias H, Tsang G, Dong K, Ewing T, Marimuthu A, Tantoy C, Walters J, Sanftner L, Rezaei H, Nespi M, Matusow B, Habets G, Ibrahim P, Zhang C, Mathé EA, Bollag G, Byrd JC, Lapalombella R.

Cancer Discov. 2018 Apr;8(4):458-477. doi: 10.1158/2159-8290.CD-17-0902. Epub 2018 Jan 31.

PMID:
29386193
5.

Bone marrow-derived cPLA2α contributes to renal fibrosis progression.

Montford JR, Lehman AMB, Bauer CD, Klawitter J, Klawitter J, Poczobutt JM, Scobey M, Weiser-Evans M, Nemenoff RA, Furgeson SB.

J Lipid Res. 2018 Feb;59(2):380-390. doi: 10.1194/jlr.M082362. Epub 2017 Dec 11.

PMID:
29229740
6.

Correlation of novel PAX6 gene abnormalities in aniridia and clinical presentation.

Sannan NS, Gregory-Evans CY, Lyons CJ, Lehman AM, Langlois S, Warner SJ, Zakrzewski H, Gregory-Evans K.

Can J Ophthalmol. 2017 Dec;52(6):570-577. doi: 10.1016/j.jcjo.2017.04.006. Epub 2017 Jul 6.

PMID:
29217025
7.

Ibrutinib treatment improves T cell number and function in CLL patients.

Long M, Beckwith K, Do P, Mundy BL, Gordon A, Lehman AM, Maddocks KJ, Cheney C, Jones JA, Flynn JM, Andritsos LA, Awan F, Fraietta JA, June CH, Maus MV, Woyach JA, Caligiuri MA, Johnson AJ, Muthusamy N, Byrd JC.

J Clin Invest. 2017 Aug 1;127(8):3052-3064. doi: 10.1172/JCI89756. Epub 2017 Jul 17.

8.

NF-κB p50 (nfkb1) contributes to pathogenesis in the Eμ-TCL1 mouse model of chronic lymphocytic leukemia.

Chen TL, Tran M, Lakshmanan A, Harrington BK, Gupta N, Goettl VM, Lehman AM, Trudeau S, Lucas DM, Johnson AJ, Byrd JC, Hertlein E.

Blood. 2017 Jul 20;130(3):376-379. doi: 10.1182/blood-2017-01-761130. Epub 2017 May 17. No abstract available.

9.

Cost Analysis of Patients Referred for Inherited Heart Rhythm Disorder Evaluation.

Janzen ML, Cheung C, Sanatani S, Cunningham T, Kerr C, Steinberg C, Sherwin E, Arbour L, Deyell MW, Andrade JG, Lehman AM, Gula LJ, Krahn AD.

Can J Cardiol. 2017 Jun;33(6):814-821. doi: 10.1016/j.cjca.2016.12.009. Epub 2016 Dec 20.

PMID:
28347582
10.

Cytosolic phospholipase A2α increases proliferation and de-differentiation of human renal tubular epithelial cells.

Montford JR, Lehman AM, Scobey MS, Weiser-Evans MC, Nemenoff RA, Furgeson SB.

Prostaglandins Other Lipid Mediat. 2016 Nov;126:1-8. doi: 10.1016/j.prostaglandins.2016.08.001. Epub 2016 Aug 21.

11.

Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies.

Hing ZA, Fung HY, Ranganathan P, Mitchell S, El-Gamal D, Woyach JA, Williams K, Goettl VM, Smith J, Yu X, Meng X, Sun Q, Cagatay T, Lehman AM, Lucas DM, Baloglu E, Shacham S, Kauffman MG, Byrd JC, Chook YM, Garzon R, Lapalombella R.

Leukemia. 2016 Dec;30(12):2364-2372. doi: 10.1038/leu.2016.136. Epub 2016 May 20.

12.

Exome Sequencing and the Management of Neurometabolic Disorders.

Tarailo-Graovac M, Shyr C, Ross CJ, Horvath GA, Salvarinova R, Ye XC, Zhang LH, Bhavsar AP, Lee JJ, Drögemöller BI, Abdelsayed M, Alfadhel M, Armstrong L, Baumgartner MR, Burda P, Connolly MB, Cameron J, Demos M, Dewan T, Dionne J, Evans AM, Friedman JM, Garber I, Lewis S, Ling J, Mandal R, Mattman A, McKinnon M, Michoulas A, Metzger D, Ogunbayo OA, Rakic B, Rozmus J, Ruben P, Sayson B, Santra S, Schultz KR, Selby K, Shekel P, Sirrs S, Skrypnyk C, Superti-Furga A, Turvey SE, Van Allen MI, Wishart D, Wu J, Wu J, Zafeiriou D, Kluijtmans L, Wevers RA, Eydoux P, Lehman AM, Vallance H, Stockler-Ipsiroglu S, Sinclair G, Wasserman WW, van Karnebeek CD.

N Engl J Med. 2016 Jun 9;374(23):2246-55. doi: 10.1056/NEJMoa1515792. Epub 2016 May 25.

13.

Selinexor is effective in acquired resistance to ibrutinib and synergizes with ibrutinib in chronic lymphocytic leukemia.

Hing ZA, Mantel R, Beckwith KA, Guinn D, Williams E, Smith LL, Williams K, Johnson AJ, Lehman AM, Byrd JC, Woyach JA, Lapalombella R.

Blood. 2015 May 14;125(20):3128-32. doi: 10.1182/blood-2015-01-621391. Epub 2015 Apr 2.

14.

Characterization of CLL exosomes reveals a distinct microRNA signature and enhanced secretion by activation of BCR signaling.

Yeh YY, Ozer HG, Lehman AM, Maddocks K, Yu L, Johnson AJ, Byrd JC.

Blood. 2015 May 21;125(21):3297-305. doi: 10.1182/blood-2014-12-618470. Epub 2015 Apr 1.

15.

Up-regulation of CDK9 kinase activity and Mcl-1 stability contributes to the acquired resistance to cyclin-dependent kinase inhibitors in leukemia.

Yeh YY, Chen R, Hessler J, Mahoney E, Lehman AM, Heerema NA, Grever MR, Plunkett W, Byrd JC, Johnson AJ.

Oncotarget. 2015 Feb 20;6(5):2667-79.

16.

Effect of pulmonary hypertension on survival in patients with idiopathic pulmonary fibrosis after lung transplantation: an analysis of the United Network of Organ Sharing registry.

Hayes D Jr, Higgins RS, Black SM, Wehr AM, Lehman AM, Kirkby S, Whitson BA.

J Heart Lung Transplant. 2015 Mar;34(3):430-7. doi: 10.1016/j.healun.2014.09.004. Epub 2014 Sep 8.

PMID:
25444371
17.

Effects of bilateral salpingo-oophorectomy at the time of hysterectomy on pelvic organ prolapse: results from the Women's Health Initiative trial.

Shveiky D, Kudish BI, Iglesia CB, Park AJ, Sokol AI, Lehman AM, Shara N, Howard BV.

Menopause. 2015 May;22(5):483-8. doi: 10.1097/GME.0000000000000375.

PMID:
25423323
18.

Pharmacist-driven renal medication dosing intervention in a primary care patient-centered medical home.

Barnes KD, Tayal NH, Lehman AM, Beatty SJ.

Pharmacotherapy. 2014 Dec;34(12):1330-5. doi: 10.1002/phar.1508. Epub 2014 Oct 25.

PMID:
25346347
19.

Activation of the retinoid X receptor modulates angiotensin II-induced smooth muscle gene expression and inflammation in vascular smooth muscle cells.

Lehman AM, Montford JR, Horita H, Ostriker AC, Weiser-Evans MC, Nemenoff RA, Furgeson SB.

Mol Pharmacol. 2014 Nov;86(5):570-9. doi: 10.1124/mol.114.092163. Epub 2014 Aug 28.

20.

Survival benefit of induction immunosuppression in cystic fibrosis lung transplant recipients.

Kirkby S, Whitson BA, Wehr AM, Lehman AM, Higgins RS, Hayes D Jr.

J Cyst Fibros. 2015 Jan;14(1):104-10. doi: 10.1016/j.jcf.2014.05.010. Epub 2014 Jun 16.

21.

MIF antagonist (CPSI-1306) protects against UVB-induced squamous cell carcinoma.

Nagarajan P, Tober KL, Riggenbach JA, Kusewitt DF, Lehman AM, Sielecki T, Pruitt J, Satoskar AR, Oberyszyn TM.

Mol Cancer Res. 2014 Sep;12(9):1292-302. doi: 10.1158/1541-7786.MCR-14-0255-T. Epub 2014 May 21.

22.

Anterolateral diaphragmatic hernia with body wall defect understood in relation to the abaxial domain.

Lehman AM, Cowan JR, McFadden DE, Patel MS.

Am J Med Genet A. 2014 Jul;164A(7):1860-2. doi: 10.1002/ajmg.a.36529. Epub 2014 Apr 3. No abstract available.

PMID:
24700809
23.

Prenatal ultrasound and MRI findings of temporal and occipital lobe dysplasia in a twin with achondroplasia.

Pugash D, Lehman AM, Langlois S.

Ultrasound Obstet Gynecol. 2014 Sep;44(3):365-8. doi: 10.1002/uog.13359.

24.

Mitochondrial carbonic anhydrase VA deficiency resulting from CA5A alterations presents with hyperammonemia in early childhood.

van Karnebeek CD, Sly WS, Ross CJ, Salvarinova R, Yaplito-Lee J, Santra S, Shyr C, Horvath GA, Eydoux P, Lehman AM, Bernard V, Newlove T, Ukpeh H, Chakrapani A, Preece MA, Ball S, Pitt J, Vallance HD, Coulter-Mackie M, Nguyen H, Zhang LH, Bhavsar AP, Sinclair G, Waheed A, Wasserman WW, Stockler-Ipsiroglu S.

Am J Hum Genet. 2014 Mar 6;94(3):453-61. doi: 10.1016/j.ajhg.2014.01.006. Epub 2014 Feb 13.

25.

Impact of pulmonary hypertension on survival in patients with cystic fibrosis undergoing lung transplantation: an analysis of the UNOS registry.

Hayes D Jr, Higgins RS, Kirkby S, McCoy KS, Wehr AM, Lehman AM, Whitson BA.

J Cyst Fibros. 2014 Jul;13(4):416-23. doi: 10.1016/j.jcf.2013.12.004. Epub 2013 Dec 30.

26.

A contemporary analysis of induction immunosuppression in pediatric lung transplant recipients.

Hayes D Jr, Kirkby S, Wehr AM, Lehman AM, McConnell PI, Galantowicz M, Higgins RS, Whitson BA.

Transpl Int. 2014 Feb;27(2):211-8. doi: 10.1111/tri.12240. Epub 2013 Dec 16.

27.

Defects in the IFT-B component IFT172 cause Jeune and Mainzer-Saldino syndromes in humans.

Halbritter J, Bizet AA, Schmidts M, Porath JD, Braun DA, Gee HY, McInerney-Leo AM, Krug P, Filhol E, Davis EE, Airik R, Czarnecki PG, Lehman AM, Trnka P, Nitschké P, Bole-Feysot C, Schueler M, Knebelmann B, Burtey S, Szabó AJ, Tory K, Leo PJ, Gardiner B, McKenzie FA, Zankl A, Brown MA, Hartley JL, Maher ER, Li C, Leroux MR, Scambler PJ, Zhan SH, Jones SJ, Kayserili H, Tuysuz B, Moorani KN, Constantinescu A, Krantz ID, Kaplan BS, Shah JV; UK10K Consortium, Hurd TW, Doherty D, Katsanis N, Duncan EL, Otto EA, Beales PL, Mitchison HM, Saunier S, Hildebrandt F.

Am J Hum Genet. 2013 Nov 7;93(5):915-25. doi: 10.1016/j.ajhg.2013.09.012. Epub 2013 Oct 17.

28.

Evidence of ancillary trigeminal innervation of levator palpebrae in the general population.

Lehman AM, Dong CC, Harries AM, Patel A, Honey CR, Patel MS.

J Clin Neurosci. 2014 Feb;21(2):301-4. doi: 10.1016/j.jocn.2013.03.029. Epub 2013 Oct 10.

PMID:
24120706
29.

Debating deposits: an interobserver variability study of lymph nodes and pericolonic tumor deposits in colonic adenocarcinoma.

Rock JB, Washington MK, Adsay NV, Greenson JK, Montgomery EA, Robert ME, Yantiss RK, Lehman AM, Frankel WL.

Arch Pathol Lab Med. 2014 May;138(5):636-42. doi: 10.5858/arpa.2013-0166-OA. Epub 2013 Jul 31.

30.

Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes.

Dubovsky JA, Beckwith KA, Natarajan G, Woyach JA, Jaglowski S, Zhong Y, Hessler JD, Liu TM, Chang BY, Larkin KM, Stefanovski MR, Chappell DL, Frissora FW, Smith LL, Smucker KA, Flynn JM, Jones JA, Andritsos LA, Maddocks K, Lehman AM, Furman R, Sharman J, Mishra A, Caligiuri MA, Satoskar AR, Buggy JJ, Muthusamy N, Johnson AJ, Byrd JC.

Blood. 2013 Oct 10;122(15):2539-49. doi: 10.1182/blood-2013-06-507947. Epub 2013 Jul 25.

31.

Fetal progeria: prenatal sonographic findings in petty syndrome.

Pugash D, Schrader KA, Dunham CP, Popescu OE, Sargent MA, Lehman AM, Yong SL, Clarke LA.

J Ultrasound Med. 2013 May;32(5):881-3. doi: 10.7863/ultra.32.5.881. No abstract available.

PMID:
23620331
32.

The long-term effects of semiconductor diode laser transscleral cyclophotocoagulation on the normal equine eye and intraocular pressure(a).

Cavens VJ, Gemensky-Metzler AJ, Wilkie DA, Weisbrode SE, Lehman AM.

Vet Ophthalmol. 2012 Nov;15(6):369-75. doi: 10.1111/j.1463-5224.2012.00996.x. Epub 2012 Jan 31.

PMID:
22288723
33.

Phase II trial of neoadjuvant exemestane in combination with celecoxib in postmenopausal women who have breast cancer.

Lustberg MB, Povoski SP, Zhao W, Ziegler RM, Sugimoto Y, Ruppert AS, Lehman AM, Shiels DR, Mrozek E, Ramaswamy B, Layman RM, Brueggemeier RW, Shapiro CL.

Clin Breast Cancer. 2011 Aug;11(4):221-7. doi: 10.1016/j.clbc.2011.03.022. Epub 2011 May 19.

34.

Evaluating the efficacy of lay health advisors for increasing risk-appropriate Pap test screening: a randomized controlled trial among Ohio Appalachian women.

Paskett ED, McLaughlin JM, Lehman AM, Katz ML, Tatum CM, Oliveri JM.

Cancer Epidemiol Biomarkers Prev. 2011 May;20(5):835-43. doi: 10.1158/1055-9965.EPI-10-0880. Epub 2011 Mar 23.

35.

19p13.2 microduplication causes a Sotos syndrome-like phenotype and alters gene expression.

Lehman AM, du Souich C, Chai D, Eydoux P, Huang JL, Fok AK, Avila L, Swingland J, Delaney AD, McGillivray B, Goldowitz D, Argiropoulos B, Kobor MS, Boerkoel CF.

Clin Genet. 2012 Jan;81(1):56-63. doi: 10.1111/j.1399-0004.2010.01615.x. Epub 2011 Jan 19.

PMID:
21204797
36.

Co-occurrence of Joubert syndrome and Jeune asphyxiating thoracic dystrophy.

Lehman AM, Eydoux P, Doherty D, Glass IA, Chitayat D, Chung BY, Langlois S, Yong SL, Lowry RB, Hildebrandt F, Trnka P.

Am J Med Genet A. 2010 Jun;152A(6):1411-9. doi: 10.1002/ajmg.a.33416.

37.

Intracranial calcification after cord blood neonatal transplantation for krabbe disease.

Lehman AM, Schultz KR, Poskitt K, Bjornson B, Keyes R, Waters PJ, Clarke LA, Everett R, McConnell D, Stockler S.

Neuropediatrics. 2009 Aug;40(4):189-91. doi: 10.1055/s-0029-1243189. Epub 2010 Feb 4.

PMID:
20135576
38.

A characteristic syndrome associated with microduplication of 8q12, inclusive of CHD7.

Lehman AM, Friedman JM, Chai D, Zahir FR, Marra MA, Prisman L, Tsang E, Eydoux P, Armstrong L.

Eur J Med Genet. 2009 Nov-Dec;52(6):436-9. doi: 10.1016/j.ejmg.2009.09.006. Epub 2009 Sep 17.

PMID:
19772954
39.

Psychosocial predictors of adherence to risk-appropriate cervical cancer screening guidelines: a cross sectional study of women in Ohio Appalachia participating in the Community Awareness Resources and Education (CARE) project.

Paskett ED, McLaughlin JM, Reiter PL, Lehman AM, Rhoda DA, Katz ML, Hade EM, Post DM, Ruffin MT.

Prev Med. 2010 Jan-Feb;50(1-2):74-80. doi: 10.1016/j.ypmed.2009.09.001. Epub 2009 Sep 8.

40.

Childhood-onset hemiatrophy caused by unilateral morphea.

Lehman AM, Patel MS.

Clin Dysmorphol. 2009 Oct;18(4):213-4. doi: 10.1097/MCD.0b013e32832a9e0c. No abstract available.

PMID:
19543082
41.

Computed tomographic arthrography of the stifle for detection of cranial and caudal cruciate ligament and meniscal tears in dogs.

Samii VF, Dyce J, Pozzi A, Drost WT, Mattoon JS, Green EM, Kowaleski MP, Lehman AM.

Vet Radiol Ultrasound. 2009 Mar-Apr;50(2):144-50.

PMID:
19400459
42.

Plasma and ear tissue concentrations of enrofloxacin and its metabolite ciprofloxacin in dogs with chronic end-stage otitis externa after intravenous administration of enrofloxacin.

Cole LK, Papich MG, Kwochka KW, Hillier A, Smeak DD, Lehman AM.

Vet Dermatol. 2009 Feb;20(1):51-9. doi: 10.1111/j.1365-3164.2008.00730.x.

PMID:
19152587
43.

Schinzel-Giedion syndrome: report of splenopancreatic fusion and proposed diagnostic criteria.

Lehman AM, McFadden D, Pugash D, Sangha K, Gibson WT, Patel MS.

Am J Med Genet A. 2008 May 15;146A(10):1299-306. doi: 10.1002/ajmg.a.32277.

PMID:
18398855
44.

IFN-alpha-2b-induced signal transduction and gene regulation in patient peripheral blood mononuclear cells is not enhanced by a dose increase from 5 to 10 megaunits/m2.

Zimmerer JM, Lehman AM, Ruppert AS, Noble CW, Olencki T, Walker MJ, Kendra K, Carson WE 3rd.

Clin Cancer Res. 2008 Mar 1;14(5):1438-45. doi: 10.1158/1078-0432.CCR-07-4178.

45.

Peritubular capillary C4d staining in late acute renal allograft rejection--is it relevant?

Satoskar AA, Lehman AM, Nadasdy GM, Sedmak DD, Pesavento TE, Henry ML, Pelletier RP, Ferguson RM, Nadasdy T.

Clin Transplant. 2008 Jan-Feb;22(1):61-7. doi: 10.1111/j.1399-0012.2007.00745.x.

PMID:
18217907
46.

Quantification of plasma DNA as a prognostic indicator in canine lymphoid neoplasia.

Schaefer DM, Forman MA, Kisseberth WC, Lehman AM, Kelbick NT, Harper P, Rush LJ.

Vet Comp Oncol. 2007 Sep;5(3):145-55. doi: 10.1111/j.1476-5829.2007.00122.x.

PMID:
19754786
47.

Vestibular, vaginal, and urethral relations in spayed dogs with and without lower urinary tract signs.

Wang KY, Samii VF, Chew DJ, McLoughlin MA, DiBartola SP, Masty J, Lehman AM.

J Vet Intern Med. 2006 Sep-Oct;20(5):1065-73.

48.

Combination therapy with anti-CTL antigen-4 and anti-4-1BB antibodies enhances cancer immunity and reduces autoimmunity.

Kocak E, Lute K, Chang X, May KF Jr, Exten KR, Zhang H, Abdessalam SF, Lehman AM, Jarjoura D, Zheng P, Liu Y.

Cancer Res. 2006 Jul 15;66(14):7276-84.

49.

Vestibular, vaginal and urethral relationships in spayed and intact normal dogs.

Wang KY, Samii VF, Chew DJ, McLoughlin MA, Dibartola SP, Masty J, Lehman AM.

Theriogenology. 2006 Sep 1;66(4):726-35. Epub 2006 Mar 9.

PMID:
16527342
50.

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