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Items: 1 to 50 of 167

1.

Histochemical quantification of collagen content in articular cartilage.

Rieppo L, Janssen L, Rahunen K, Lehenkari P, Finnilä MAJ, Saarakkala S.

PLoS One. 2019 Nov 7;14(11):e0224839. doi: 10.1371/journal.pone.0224839. eCollection 2019.

2.

Quantifying Subresolution 3D Morphology of Bone with Clinical Computed Tomography.

Karhula SS, Finnilä MAJ, Rytky SJO, Cooper DM, Thevenot J, Valkealahti M, Pritzker KPH, Haapea M, Joukainen A, Lehenkari P, Kröger H, Korhonen RK, Nieminen HJ, Saarakkala S.

Ann Biomed Eng. 2019 Oct 3. doi: 10.1007/s10439-019-02374-2. [Epub ahead of print]

PMID:
31583552
3.

The association between knee breadth and body mass: The Northern Finland Birth Cohort 1966 case study.

Keisu A, Oura P, Niskanen M, Ruff CB, Niinimäki J, Arvola T, Auvinen J, Tuukkanen J, Lehenkari P, Junno JA.

Am J Phys Anthropol. 2019 Oct;170(2):196-206. doi: 10.1002/ajpa.23905. Epub 2019 Aug 7.

PMID:
31390059
4.

Polyunsaturated fatty acids modify the extracellular vesicle membranes and increase the production of proresolving lipid mediators of human mesenchymal stromal cells.

Holopainen M, Colas RA, Valkonen S, Tigistu-Sahle F, Hyvärinen K, Mazzacuva F, Lehenkari P, Käkelä R, Dalli J, Kerkelä E, Laitinen S.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Oct;1864(10):1350-1362. doi: 10.1016/j.bbalip.2019.06.010. Epub 2019 Jun 15.

PMID:
31207356
5.

Distinct fatty acid signatures in infrapatellar fat pad and synovial fluid of patients with osteoarthritis versus rheumatoid arthritis.

Mustonen AM, Käkelä R, Lehenkari P, Huhtakangas J, Turunen S, Joukainen A, Kääriäinen T, Paakkonen T, Kröger H, Nieminen P.

Arthritis Res Ther. 2019 May 22;21(1):124. doi: 10.1186/s13075-019-1914-y.

6.

Quantifying Complex Micro-Topography of Degenerated Articular Cartilage Surface by Contrast-Enhanced Micro-Computed Tomography and Parametric Analyses.

Ylitalo T, Finnilä MAJ, Gahunia HK, Karhula SS, Suhonen H, Valkealahti M, Lehenkari P, Haeggström E, Pritzker KPH, Saarakkala S, Nieminen HJ.

J Orthop Res. 2019 Apr;37(4):855-866. doi: 10.1002/jor.24245. Epub 2019 Mar 5.

7.

Denosumab Treatment for Aggressive Multiple Recurrent Familial Central Giant-cell Granulomas.

Rytkönen E, Ottavainen V, Rytkönen A, Uusitalo S, Lehenkari P, Sándor GK.

Ann Maxillofac Surg. 2018 Jul-Dec;8(2):265-269. doi: 10.4103/ams.ams_192_18.

8.

Classification of bone flap resorption after cranioplasty: a proposal for a computed tomography-based scoring system.

Korhonen TK, Salokorpi N, Ohtonen P, Lehenkari P, Serlo W, Niinimäki J, Tetri S.

Acta Neurochir (Wien). 2019 Mar;161(3):473-481. doi: 10.1007/s00701-018-03791-3. Epub 2019 Jan 14.

9.

Osteoclasts secrete osteopontin into resorption lacunae during bone resorption.

Luukkonen J, Hilli M, Nakamura M, Ritamo I, Valmu L, Kauppinen K, Tuukkanen J, Lehenkari P.

Histochem Cell Biol. 2019 Jun;151(6):475-487. doi: 10.1007/s00418-019-01770-y. Epub 2019 Jan 14.

10.

Pharmacokinetics of intra-articular vitamin D analogue calcipotriol in sheep and metabolism in human synovial and mesenchymal stromal cells.

Huovinen J, Haj Hussain M, Niemelä M, Laaksonen S, Voipio HM, Jyrkäs J, Mannila J, Lassila T, Tolonen A, Turunen S, Bergmann U, Lehenkari P, Huhtakangas JA.

J Steroid Biochem Mol Biol. 2019 Apr;188:172-184. doi: 10.1016/j.jsbmb.2018.12.006. Epub 2018 Dec 15.

PMID:
30562554
11.

Tenascin C, Fibronectin, and Tumor-Stroma Ratio in Pancreatic Ductal Adenocarcinoma.

Leppänen J, Lindholm V, Isohookana J, Haapasaari KM, Karihtala P, Lehenkari PP, Saarnio J, Kauppila JH, Karttunen TJ, Helminen O, Huhta H.

Pancreas. 2019 Jan;48(1):43-48. doi: 10.1097/MPA.0000000000001195.

12.

Toll-like receptors 2, 4 and 9 and hypoxia markers HIF-1alpha and CAIX in pancreatic intraepithelial neoplasia.

Leppänen J, Helminen O, Huhta H, Kauppila JH, Isohookana J, Haapasaari KM, Karihtala P, Parkkila S, Saarnio J, Lehenkari PP, Karttunen TJ.

APMIS. 2018 Nov;126(11):852-863. doi: 10.1111/apm.12894.

PMID:
30357962
13.

Peripheral blood monocytes show increased osteoclast differentiation potential compared to bone marrow monocytes.

Kylmäoja E, Nakamura M, Turunen S, Patlaka C, Andersson G, Lehenkari P, Tuukkanen J.

Heliyon. 2018 Sep 12;4(9):e00780. doi: 10.1016/j.heliyon.2018.e00780. eCollection 2018 Sep.

14.

Whole exome sequencing in Finnish families identifies new candidate genes for osteoarthritis.

Skarp S, Kämäräinen OP, Wei GH, Jakkula E, Kiviranta I, Kröger H, Auvinen J, Lehenkari P, Ala-Kokko L, Männikkö M.

PLoS One. 2018 Aug 29;13(8):e0203313. doi: 10.1371/journal.pone.0203313. eCollection 2018.

15.

Osteogenic Differentiation of Human Mesenchymal Stem cells in a 3D Woven Scaffold.

Persson M, Lehenkari PP, Berglin L, Turunen S, Finnilä MAJ, Risteli J, Skrifvars M, Tuukkanen J.

Sci Rep. 2018 Jul 11;8(1):10457. doi: 10.1038/s41598-018-28699-x.

16.

Weak HIF-1alpha expression indicates poor prognosis in resectable pancreatic ductal adenocarcinoma.

Leppänen J, Helminen O, Huhta H, Kauppila JH, Isohookana J, Haapasaari KM, Parkkila S, Saarnio J, Lehenkari PP, Karttunen TJ.

World J Surg Oncol. 2018 Jul 4;16(1):127. doi: 10.1186/s12957-018-1432-4.

17.

Corrigendum to "Gap junctional communication is involved in differentiation of osteoclasts from bone marrow and peripheral blood monocytes".

Kylmäoja E, Nakamura M, Kokkonen-Puuperä H, Ronkainen VP, Lehenkari P, Tuukkanen J.

Heliyon. 2018 May 18;4(5):e00630. doi: 10.1016/j.heliyon.2018.e00630. eCollection 2018 May.

18.

Gap junctional communication is involved in differentiation of osteoclasts from bone marrow and peripheral blood monocytes.

Kylmäoja E, Nakamura M, Kokkonen-Puuperä H, Ronkainen VP, Lehenkari P, Tuukkanen J.

Heliyon. 2018 May 7;4(5):e00621. doi: 10.1016/j.heliyon.2018.e00621. eCollection 2018 May. Erratum in: Heliyon. 2018 May 18;4(5):e00630.

19.

Mesenchymal Stromal Cells and Their Extracellular Vesicles Enhance the Anti-Inflammatory Phenotype of Regulatory Macrophages by Downregulating the Production of Interleukin (IL)-23 and IL-22.

Hyvärinen K, Holopainen M, Skirdenko V, Ruhanen H, Lehenkari P, Korhonen M, Käkelä R, Laitinen S, Kerkelä E.

Front Immunol. 2018 Apr 12;9:771. doi: 10.3389/fimmu.2018.00771. eCollection 2018.

20.

Microtubule defects in mesenchymal stromal cells distinguish patients with Progressive Supranuclear Palsy.

Calogero AM, Viganò M, Budelli S, Galimberti D, Fenoglio C, Cartelli D, Lazzari L, Lehenkari P, Canesi M, Giordano R, Cappelletti G, Pezzoli G.

J Cell Mol Med. 2018 May;22(5):2670-2679. doi: 10.1111/jcmm.13545. Epub 2018 Mar 4.

21.

Quantitative and qualitative analysis of bone flap resorption in patients undergoing cranioplasty after decompressive craniectomy.

Korhonen TK, Salokorpi N, Niinimäki J, Serlo W, Lehenkari P, Tetri S.

J Neurosurg. 2018 Feb 23;130(1):312-321. doi: 10.3171/2017.8.JNS171857.

PMID:
29473777
22.

Automatic Knee Osteoarthritis Diagnosis from Plain Radiographs: A Deep Learning-Based Approach.

Tiulpin A, Thevenot J, Rahtu E, Lehenkari P, Saarakkala S.

Sci Rep. 2018 Jan 29;8(1):1727. doi: 10.1038/s41598-018-20132-7.

23.

Electromechanical properties of human osteoarthritic and asymptomatic articular cartilage are sensitive and early detectors of degeneration.

Hadjab I, Sim S, Karhula SS, Kauppinen S, Garon M, Quenneville E, Lavigne P, Lehenkari PP, Saarakkala S, Buschmann MD.

Osteoarthritis Cartilage. 2018 Mar;26(3):405-413. doi: 10.1016/j.joca.2017.12.002. Epub 2017 Dec 9.

24.

Tenascin-C and fibronectin in normal esophageal mucosa, Barrett's esophagus, dysplasia and adenocarcinoma.

Leppänen J, Bogdanoff S, Lehenkari PP, Saarnio J, Kauppila JH, Karttunen TJ, Huhta H, Helminen O.

Oncotarget. 2017 Jul 12;8(40):66865-66877. doi: 10.18632/oncotarget.19196. eCollection 2017 Sep 15.

25.

Methylome Analysis of Human Bone Marrow MSCs Reveals Extensive Age- and Culture-Induced Changes at Distal Regulatory Elements.

Pasumarthy KK, Doni Jayavelu N, Kilpinen L, Andrus C, Battle SL, Korhonen M, Lehenkari P, Lund R, Laitinen S, Hawkins RD.

Stem Cell Reports. 2017 Sep 12;9(3):999-1015. doi: 10.1016/j.stemcr.2017.07.018. Epub 2017 Aug 24.

26.

Two novel direct SPIO labels and in vivo MRI detection of labeled cells after acute myocardial infarct.

Korpi RM, Alestalo K, Ruuska T, Lammentausta E, Borra R, Yannopoulos F, Lehtonen S, Korpi JT, Lappi-Blanco E, Anttila V, Lehenkari P, Juvonen T, Blanco Sequieros R.

Acta Radiol Open. 2017 Aug 2;6(8):2058460117718407. doi: 10.1177/2058460117718407. eCollection 2017 Aug.

27.

Increased amount of phosphorylated proinflammatory osteopontin in rheumatoid arthritis synovia is associated to decreased tartrate-resistant acid phosphatase 5B/5A ratio.

Luukkonen J, Pascual LM, Patlaka C, Lång P, Turunen S, Halleen J, Nousiainen T, Valkealahti M, Tuukkanen J, Andersson G, Lehenkari P.

PLoS One. 2017 Aug 8;12(8):e0182904. doi: 10.1371/journal.pone.0182904. eCollection 2017.

28.

Perfluoroalkyl substances in human bone: concentrations in bones and effects on bone cell differentiation.

Koskela A, Koponen J, Lehenkari P, Viluksela M, Korkalainen M, Tuukkanen J.

Sci Rep. 2017 Jul 28;7(1):6841. doi: 10.1038/s41598-017-07359-6.

29.

Magnetic resonance imaging (MRI)-defined cartilage degeneration and joint pain are associated with poor physical function in knee osteoarthritis - the Oulu Knee Osteoarthritis study.

Kaukinen P, Podlipská J, Guermazi A, Niinimäki J, Lehenkari P, Roemer FW, Nieminen MT, Koski JM, Saarakkala S, Arokoski JPA.

Osteoarthritis Cartilage. 2017 Nov;25(11):1829-1840. doi: 10.1016/j.joca.2017.07.002. Epub 2017 Jul 8.

30.

3D histopathological grading of osteochondral tissue using contrast-enhanced micro-computed tomography.

Nieminen HJ, Gahunia HK, Pritzker KPH, Ylitalo T, Rieppo L, Karhula SS, Lehenkari P, Hæggström E, Saarakkala S.

Osteoarthritis Cartilage. 2017 Oct;25(10):1680-1689. doi: 10.1016/j.joca.2017.05.021. Epub 2017 Jun 9.

31.

Correlations of low-field NMR and variable-field NMR parameters with osteoarthritis in human articular cartilage under load.

Rössler E, Mattea C, Saarakkala S, Lehenkari P, Finnilä M, Rieppo L, Karhula S, Nieminen MT, Stapf S.

NMR Biomed. 2017 Aug;30(8). doi: 10.1002/nbm.3738. Epub 2017 May 24.

PMID:
28543921
32.

Cytokine data obtained from synovial stromal cells of patients with rheumatoid arthritis or osteoarthritis.

Huhtakangas JA, Veijola J, Turunen S, Karjalainen A, Valkealahti M, Nousiainen T, Yli-Luukko S, Vuolteenaho O, Lehenkari P.

Data Brief. 2017 Apr 29;12:593-602. doi: 10.1016/j.dib.2017.04.041. eCollection 2017 Jun.

33.

Niche matters: The comparison between bone marrow stem cells and endometrial stem cells and stromal fibroblasts reveal distinct migration and cytokine profiles in response to inflammatory stimulus.

Khatun M, Sorjamaa A, Kangasniemi M, Sutinen M, Salo T, Liakka A, Lehenkari P, Tapanainen JS, Vuolteenaho O, Chen JC, Lehtonen S, Piltonen TT.

PLoS One. 2017 Apr 18;12(4):e0175986. doi: 10.1371/journal.pone.0175986. eCollection 2017.

34.

Subchondral bone histology and grading in osteoarthritis.

Aho OM, Finnilä M, Thevenot J, Saarakkala S, Lehenkari P.

PLoS One. 2017 Mar 20;12(3):e0173726. doi: 10.1371/journal.pone.0173726. eCollection 2017.

35.

Association between height and osteoarthritis of the knee and hip: The Northern Finland Birth Cohort 1966 Study.

Welling M, Auvinen J, Lehenkari P, Männikkö M, Karppinen J, Eskola PJ.

Int J Rheum Dis. 2017 Sep;20(9):1095-1104. doi: 10.1111/1756-185X.13059. Epub 2017 Mar 10.

PMID:
28296269
36.

Intratumoral lactate metabolism in Barrett's esophagus and adenocarcinoma.

Huhta H, Helminen O, Palomäki S, Kauppila JH, Saarnio J, Lehenkari PP, Karttunen TJ.

Oncotarget. 2017 Apr 4;8(14):22894-22902. doi: 10.18632/oncotarget.15284.

37.

High toll-like receptor (TLR) 9 expression is associated with better prognosis in surgically treated pancreatic cancer patients.

Leppänen J, Helminen O, Huhta H, Kauppila JH, Isohookana J, Haapasaari KM, Lehenkari P, Saarnio J, Karttunen TJ.

Virchows Arch. 2017 Apr;470(4):401-410. doi: 10.1007/s00428-017-2087-1. Epub 2017 Feb 12.

PMID:
28191612
38.

1,25(OH)2D3 and calcipotriol, its hypocalcemic analog, exert a long-lasting anti-inflammatory and anti-proliferative effect in synoviocytes cultured from patients with rheumatoid arthritis and osteoarthritis.

Huhtakangas JA, Veijola J, Turunen S, Karjalainen A, Valkealahti M, Nousiainen T, Yli-Luukko S, Vuolteenaho O, Lehenkari P.

J Steroid Biochem Mol Biol. 2017 Oct;173:13-22. doi: 10.1016/j.jsbmb.2017.01.017. Epub 2017 Feb 3.

PMID:
28167299
39.

Tenascin-C and fibronectin expression divide early stage tongue cancer into low- and high-risk groups.

Sundquist E, Kauppila JH, Veijola J, Mroueh R, Lehenkari P, Laitinen S, Risteli J, Soini Y, Kosma VM, Sawazaki-Calone I, Macedo CC, Bloigu R, Coletta RD, Salo T.

Br J Cancer. 2017 Feb 28;116(5):640-648. doi: 10.1038/bjc.2016.455. Epub 2017 Jan 17.

40.

Localization of nucleic acid-sensing toll-like receptors in human and mouse pancreas.

Helminen O, Huhta H, Kauppila JH, Lehenkari PP, Saarnio J, Karttunen TJ.

APMIS. 2017 Feb;125(2):85-92. doi: 10.1111/apm.12632. Epub 2016 Dec 28.

PMID:
28028829
41.

Metabolism and phospholipid assembly of polyunsaturated fatty acids in human bone marrow mesenchymal stromal cells.

Tigistu-Sahle F, Lampinen M, Kilpinen L, Holopainen M, Lehenkari P, Laitinen S, Käkelä R.

J Lipid Res. 2017 Jan;58(1):92-110. doi: 10.1194/jlr.M070680. Epub 2016 Nov 16.

42.

Expansion induced microRNA changes in bone marrow mesenchymal stromal cells reveals interplay between immune regulation and cell cycle.

Kilpinen L, Parmar A, Greco D, Korhonen M, Lehenkari P, Saavalainen P, Laitinen S.

Aging (Albany NY). 2016 Nov 9;8(11):2799-2813. doi: 10.18632/aging.101088.

43.

Rheumatoid arthritis antigens homocitrulline and citrulline are generated by local myeloperoxidase and peptidyl arginine deiminases 2, 3 and 4 in rheumatoid nodule and synovial tissue.

Turunen S, Huhtakangas J, Nousiainen T, Valkealahti M, Melkko J, Risteli J, Lehenkari P.

Arthritis Res Ther. 2016 Oct 20;18(1):239.

44.

Doublecortin-like kinase 1-positive enterocyte - a new cell type in human intestine.

Leppänen J, Helminen O, Huhta H, Kauppila JH, Miinalainen I, Ronkainen VP, Saarnio J, Lehenkari PP, Karttunen TJ.

APMIS. 2016 Nov;124(11):958-965. doi: 10.1111/apm.12599. Epub 2016 Sep 28.

PMID:
27677532
45.

Erratum: Comparison of Diagnostic Performance of Semi-Quantitative Knee Ultrasound and Knee Radiography with MRI: Oulu Knee Osteoarthritis Study.

Podlipská J, Guermazi A, Lehenkari P, Niinimäki J, Roemer FW, Arokoski JP, Kaukinen P, Liukkonen E, Lammentausta E, Nieminen MT, Tervonen O, Koski JM, Saarakkala S.

Sci Rep. 2016 Sep 16;6:33109. doi: 10.1038/srep33109. No abstract available.

46.

Nucleic acid-sensing toll-like receptors 3, 7 and 8 in esophageal epithelium, barrett's esophagus, dysplasia and adenocarcinoma.

Helminen O, Huhta H, Lehenkari PP, Saarnio J, Karttunen TJ, Kauppila JH.

Oncoimmunology. 2016 Jan 25;5(5):e1127495. doi: 10.1080/2162402X.2015.1127495. eCollection 2016 May.

47.

Imaging of Osteoarthritic Human Articular Cartilage using Fourier Transform Infrared Microspectroscopy Combined with Multivariate and Univariate Analysis.

Oinas J, Rieppo L, Finnilä MA, Valkealahti M, Lehenkari P, Saarakkala S.

Sci Rep. 2016 Jul 21;6:30008. doi: 10.1038/srep30008.

48.

Nuclear localization of Toll-like receptor 5 in Barrett's esophagus and esophageal adenocarcinoma is associated with metastatic behavior.

Helminen O, Huhta H, Leppänen J, Kauppila JH, Takala H, Lehenkari PP, Saarnio J, Karttunen TJ.

Virchows Arch. 2016 Oct;469(4):465-70. doi: 10.1007/s00428-016-1989-7. Epub 2016 Jul 9.

PMID:
27392931
49.

The Expression of Toll-like Receptors in Normal Human and Murine Gastrointestinal Organs and the Effect of Microbiome and Cancer.

Huhta H, Helminen O, Kauppila JH, Salo T, Porvari K, Saarnio J, Lehenkari PP, Karttunen TJ.

J Histochem Cytochem. 2016 Aug;64(8):470-82. doi: 10.1369/0022155416656154. Epub 2016 Jul 1.

50.

Association between subchondral bone structure and osteoarthritis histopathological grade.

Finnilä MAJ, Thevenot J, Aho OM, Tiitu V, Rautiainen J, Kauppinen S, Nieminen MT, Pritzker K, Valkealahti M, Lehenkari P, Saarakkala S.

J Orthop Res. 2017 Apr;35(4):785-792. doi: 10.1002/jor.23312. Epub 2016 Jun 22.

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