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Items: 22

1.

A novel series of IKKβ inhibitors part I: Initial SAR studies of a HTS hit.

Cushing TD, Baichwal V, Berry K, Billedeau R, Bordunov V, Broka C, Cardozo M, Cheng P, Clark D, Dalrymple S, DeGraffenreid M, Gill A, Hao X, Hawley RC, He X, Jaen JC, Labadie SS, Labelle M, Lehel C, Lu PP, McIntosh J, Miao S, Parast C, Shin Y, Sjogren EB, Smith ML, Talamas FX, Tonn G, Walker KM, Walker NP, Wesche H, Whitehead C, Wright M, Browner MF.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):417-22. doi: 10.1016/j.bmcl.2010.10.126. Epub 2010 Oct 29.

PMID:
21074993
2.

A novel series of IKKβ inhibitors part II: description of a potent and pharmacologically active series of analogs.

Cushing TD, Baichwal V, Berry K, Billedeau R, Bordunov V, Broka C, Browner MF, Cardozo M, Cheng P, Clark D, Dalrymple S, DeGraffenreid M, Gill A, Hao X, Hawley RC, He X, Labadie SS, Labelle M, Lehel C, Lu PP, McIntosh J, Miao S, Parast C, Shin Y, Sjogren EB, Smith ML, Talamas FX, Tonn G, Walker KM, Walker NP, Wesche H, Whitehead C, Wright M, Jaen JC.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):423-6. doi: 10.1016/j.bmcl.2010.10.125. Epub 2010 Oct 29.

PMID:
21074992
3.

Protein kinase Cepsilon mediates PMA-induced growth inhibition of low population density NIH 3T3 fibroblasts.

Petrovics G, Bird T, Lehel C, Oravecz T, Anderson WB.

Arch Biochem Biophys. 2002 Jan 15;397(2):217-23.

PMID:
11795874
4.

Overexpression of protein kinase C-epsilon and its regulatory domains in fibroblasts inhibits phorbol ester-induced phospholipase D activity.

Kiss Z, Petrovics G, Olàh Z, Lehel C, Anderson WB.

Arch Biochem Biophys. 1999 Mar 1;363(1):121-8.

PMID:
10049506
5.

Interactions between protein kinase C and pleckstrin homology domains. Inhibition by phosphatidylinositol 4,5-bisphosphate and phorbol 12-myristate 13-acetate.

Yao L, Suzuki H, Ozawa K, Deng J, Lehel C, Fukamachi H, Anderson WB, Kawakami Y, Kawakami T.

J Biol Chem. 1997 May 16;272(20):13033-9.

6.

A chemiluminescent microtiter plate assay for sensitive detection of protein kinase activity.

Lehel C, Daniel-Issakani S, Brasseur M, Strulovici B.

Anal Biochem. 1997 Jan 15;244(2):340-6.

PMID:
9025951
7.

Influence of various domains of protein kinase C epsilon on its PMA-induced translocation from the Golgi to the plasma membrane.

Lehel C, Oláh Z, Petrovics G, Jakab G, Anderson WB.

Biochem Biophys Res Commun. 1996 Jun 5;223(1):98-103.

PMID:
8660386
8.

Development of a rapid approach to identification of tyrosine phosphorylation sites: application to PKC delta phosphorylated upon activation of the high affinity receptor for IgE in rat basophilic leukemia cells.

Szallasi Z, Denning MF, Chang EY, Rivera J, Yuspa SH, Lehel C, Olah Z, Anderson WB, Blumberg PM.

Biochem Biophys Res Commun. 1995 Sep 25;214(3):888-94.

PMID:
7575560
9.

The 33-kDa C-terminal domain of Raf-1 protein kinase exhibits a Ras-independent serum- and phorbol ester-induced shift in gel mobility.

Oláh Z, Ferrier A, Lehel C, Anderson WB.

Biochem Biophys Res Commun. 1995 Sep 14;214(2):340-7.

PMID:
7545901
10.

Protein kinase C epsilon subcellular localization domains and proteolytic degradation sites. A model for protein kinase C conformational changes.

Lehel C, Oláh Z, Jakab G, Szállási Z, Petrovics G, Harta G, Blumberg PM, Anderson WB.

J Biol Chem. 1995 Aug 18;270(33):19651-8.

11.

Expression of protein kinase C family members in the cerebral endothelial cells.

Krizbai I, Szabó G, Deli M, Maderspach K, Lehel C, Oláh Z, Wolff JR, Joó F.

J Neurochem. 1995 Jul;65(1):459-62.

PMID:
7790892
12.

Protein kinase C epsilon is localized to the Golgi via its zinc-finger domain and modulates Golgi function.

Lehel C, Olah Z, Jakab G, Anderson WB.

Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1406-10.

14.

Subnanomolar concentration of VIP induces the nuclear translocation of protein kinase C in neonatal rat cortical astrocytes.

Oláh Z, Lehel C, Anderson WB, Brenneman DE, van Agoston D.

J Neurosci Res. 1994 Nov 1;39(4):355-63.

PMID:
7884816
15.

The cellular receptor for gibbon ape leukemia virus is a novel high affinity sodium-dependent phosphate transporter.

Olah Z, Lehel C, Anderson WB, Eiden MV, Wilson CA.

J Biol Chem. 1994 Oct 14;269(41):25426-31.

16.
18.

GABA-induced chemokinesis and NGF-induced chemotaxis of embryonic spinal cord neurons.

Behar TN, Schaffner AE, Colton CA, Somogyi R, Olah Z, Lehel C, Barker JL.

J Neurosci. 1994 Jan;14(1):29-38.

19.
20.

A second groEL-like gene, organized in a groESL operon is present in the genome of Synechocystis sp. PCC 6803.

Lehel C, Los D, Wada H, Györgyei J, Horváth I, Kovács E, Murata N, Vigh L.

J Biol Chem. 1993 Jan 25;268(3):1799-804.

21.

Heat shock protein synthesis of the cyanobacterium Synechocystis PCC 6803: purification of the GroEL-related chaperonin.

Lehel C, Wada H, Kovács E, Török Z, Gombos Z, Horváth I, Murata N, Vigh L.

Plant Mol Biol. 1992 Jan;18(2):327-36.

PMID:
1346251
22.

The phosphorylation site of Ca(2+)-dependent protein kinase from alfalfa.

Olah Z, Bogre L, Lehel C, Farago A, Seprodi J, Dudits D.

Plant Mol Biol. 1989 Apr;12(4):453-61. doi: 10.1007/BF00017584.

PMID:
24272905

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