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Items: 15


Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates.

Staben LR, Koenig SG, Lehar SM, Vandlen R, Zhang D, Chuh J, Yu SF, Ng C, Guo J, Liu Y, Fourie-O'Donohue A, Go M, Linghu X, Segraves NL, Wang T, Chen J, Wei B, Phillips GD, Xu K, Kozak KR, Mariathasan S, Flygare JA, Pillow TH.

Nat Chem. 2016 Dec;8(12):1112-1119. doi: 10.1038/nchem.2635. Epub 2016 Oct 17.


Novel antibody-antibiotic conjugate eliminates intracellular S. aureus.

Lehar SM, Pillow T, Xu M, Staben L, Kajihara KK, Vandlen R, DePalatis L, Raab H, Hazenbos WL, Morisaki JH, Kim J, Park S, Darwish M, Lee BC, Hernandez H, Loyet KM, Lupardus P, Fong R, Yan D, Chalouni C, Luis E, Khalfin Y, Plise E, Cheong J, Lyssikatos JP, Strandh M, Koefoed K, Andersen PS, Flygare JA, Wah Tan M, Brown EJ, Mariathasan S.

Nature. 2015 Nov 19;527(7578):323-8. doi: 10.1038/nature16057. Epub 2015 Nov 4.


The Staphylococcus aureus ABC-Type Manganese Transporter MntABC Is Critical for Reinitiation of Bacterial Replication Following Exposure to Phagocytic Oxidative Burst.

Coady A, Xu M, Phung Q, Cheung TK, Bakalarski C, Alexander MK, Lehar SM, Kim J, Park S, Tan MW, Nishiyama M.

PLoS One. 2015 Sep 17;10(9):e0138350. doi: 10.1371/journal.pone.0138350. eCollection 2015.


Novel staphylococcal glycosyltransferases SdgA and SdgB mediate immunogenicity and protection of virulence-associated cell wall proteins.

Hazenbos WL, Kajihara KK, Vandlen R, Morisaki JH, Lehar SM, Kwakkenbos MJ, Beaumont T, Bakker AQ, Phung Q, Swem LR, Ramakrishnan S, Kim J, Xu M, Shah IM, Diep BA, Sai T, Sebrell A, Khalfin Y, Oh A, Koth C, Lin SJ, Lee BC, Strandh M, Koefoed K, Andersen PS, Spits H, Brown EJ, Tan MW, Mariathasan S.

PLoS Pathog. 2013;9(10):e1003653. doi: 10.1371/journal.ppat.1003653. Epub 2013 Oct 10.


T cells develop normally in the absence of both Deltex1 and Deltex2.

Lehar SM, Bevan MJ.

Mol Cell Biol. 2006 Oct;26(20):7358-71. Epub 2006 Aug 21.


Notch ligands Delta 1 and Jagged1 transmit distinct signals to T-cell precursors.

Lehar SM, Dooley J, Farr AG, Bevan MJ.

Blood. 2005 Feb 15;105(4):1440-7. Epub 2004 Oct 14.


Immunology: polarizing a T-cell response.

Lehar SM, Bevan MJ.

Nature. 2004 Jul 8;430(6996):150-1. No abstract available.


Surface expression of Notch1 on thymocytes: correlation with the double-negative to double-positive transition.

Huang EY, Gallegos AM, Richards SM, Lehar SM, Bevan MJ.

J Immunol. 2003 Sep 1;171(5):2296-304.


T cell development in culture.

Lehar SM, Bevan MJ.

Immunity. 2002 Dec;17(6):689-92. Review.


CD8(+) but not CD8(-) dendritic cells cross-prime cytotoxic T cells in vivo.

den Haan JM, Lehar SM, Bevan MJ.

J Exp Med. 2000 Dec 18;192(12):1685-96.


Identification and cloning of EI24, a gene induced by p53 in etoposide-treated cells.

Lehar SM, Nacht M, Jacks T, Vater CA, Chittenden T, Guild BC.

Oncogene. 1996 Mar 21;12(6):1181-7.


Mutational and structural analysis of the lectin activity in binding domain 2 of ricin B chain.

Lehar SM, Pedersen JT, Kamath RS, Swimmer C, Goldmacher VS, Lambert JM, Bl├Ąttler WA, Guild BC.

Protein Eng. 1994 Oct;7(10):1261-6.


Phage display of ricin B chain and its single binding domains: system for screening galactose-binding mutants.

Swimmer C, Lehar SM, McCafferty J, Chiswell DJ, Bl├Ąttler WA, Guild BC.

Proc Natl Acad Sci U S A. 1992 May 1;89(9):3756-60.


Temporal expression of HIV-1 envelope proteins in baculovirus-infected insect cells: implications for glycosylation and CD4 binding.

Murphy CI, Lennick M, Lehar SM, Beltz GA, Young E.

Genet Anal Tech Appl. 1990 Oct;7(6):160-71.


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