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Items: 1 to 50 of 68

1.

Accelerated thymopoiesis and improved T-cell responses in HLA-A2/-DR2 transgenic BRGS-based human immune system mice.

Masse-Ranson G, Dusséaux M, Fiquet O, Darche S, Boussand M, Li Y, Lopez-Lastra S, Legrand N, Corcuff E, Toubert A, Centlivre M, Bruel T, Spits H, Schwartz O, Lévy Y, Strick-Marchand H, Di Santo JP.

Eur J Immunol. 2019 Jun;49(6):954-965. doi: 10.1002/eji.201848001. Epub 2019 Apr 2.

PMID:
30888052
2.

AU-rich element-binding proteins in colorectal cancer.

Legrand N, Dixon DA, Sobolewski C.

World J Gastrointest Oncol. 2019 Feb 15;11(2):71-90. doi: 10.4251/wjgo.v11.i2.71. Review.

3.

Impact of KIR/HLA Incompatibilities on NK Cell Reconstitution and Clinical Outcome after T Cell-Replete Haploidentical Hematopoietic Stem Cell Transplantation with Posttransplant Cyclophosphamide.

Willem C, Makanga DR, Guillaume T, Maniangou B, Legrand N, Gagne K, Peterlin P, Garnier A, Béné MC, Cesbron A, Le Bourgeois A, Chevallier P, Retière C.

J Immunol. 2019 Apr 1;202(7):2141-2152. doi: 10.4049/jimmunol.1801489. Epub 2019 Feb 20.

PMID:
30787107
4.

Overexpression of MicroRNA miR-7-5p Is a Potential Biomarker in Neuroendocrine Neoplasms of the Small Intestine.

Heverhagen AE, Legrand N, Wagner V, Fendrich V, Bartsch DK, Slater EP.

Neuroendocrinology. 2018;106(4):312-317. doi: 10.1159/000480121. Epub 2017 Aug 19.

PMID:
28848144
5.

Killer Immunoglobulin-Like Receptor Allele Determination Using Next-Generation Sequencing Technology.

Maniangou B, Legrand N, Alizadeh M, Guyet U, Willem C, David G, Charpentier E, Walencik A, Retière C, Gagne K.

Front Immunol. 2017 May 19;8:547. doi: 10.3389/fimmu.2017.00547. eCollection 2017.

6.

Impact of Graft-Versus-Graft Natural Killer Cell Alloreactivity on Single Unit Dominance After Double Umbilical Cord Blood Transplantation.

Rettman P, Willem C, Volteau C, Legrand N, Chevallier P, Lodé L, Esbelin J, Cesbron A, Bonneville M, Moreau P, Senitzer D, Retière C, Gagne K.

Transplantation. 2017 Sep;101(9):2092-2101. doi: 10.1097/TP.0000000000001545.

PMID:
27798515
7.

Impact of KIR/HLA genetic combinations on double umbilical cord blood transplantation outcomes. Results of a French multicentric retrospective study on behalf of the Société Francophone de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC) and the Société Francophone d'Histocompatibilité et d'Immunogénétique (SFHI).

Rettman P, Malard F, Legrand N, Avinens O, Eliaou JF, Picard C, Dormoy A, Lafarge X, de Matteis M, Kennel A, Loiseau P, Devys A, Boudifa A, Absi L, Fort M, Masson D, Quainon F, Theodorou I, Batho A, Parissiadis A, Delbos F, Drouet M, Senitzer D, Marry E, Raus N, Yakoub-Agha I, Cesbron A, Retière C, Gagne K.

Bone Marrow Transplant. 2016 Nov;51(11):1499-1503. doi: 10.1038/bmt.2016.151. Epub 2016 Jun 6. No abstract available.

PMID:
27272444
8.

New insights on the natural killer cell repertoire from a thorough analysis of cord blood cells.

Rettman P, Willem C, David G, Riou R, Legrand N, Esbelin J, Cesbron A, Senitzer D, Gagne K, Retière C.

J Leukoc Biol. 2016 Sep;100(3):471-9. doi: 10.1189/jlb.1HI0116-036R. Epub 2016 Apr 11.

PMID:
27067451
9.

A novel Flt3-deficient HIS mouse model with selective enhancement of human DC development.

Li Y, Mention JJ, Court N, Masse-Ranson G, Toubert A, Spits H, Legrand N, Corcuff E, Strick-Marchand H, Di Santo JP.

Eur J Immunol. 2016 May;46(5):1291-9. doi: 10.1002/eji.201546132. Epub 2016 Mar 1.

10.

[Neuroscience and collective memory: memory schemas linking brain, societies and cultures].

Legrand N, Gagnepain P, Peschanski D, Eustache F.

Biol Aujourdhui. 2015;209(3):273-86. doi: 10.1051/jbio/2015025. Epub 2016 Jan 28. Review. French.

PMID:
26820833
11.

Homogeneous single-label tyrosine kinase activity assay for high throughput screening.

Tong-Ochoa N, Kopra K, Syrjänpää M, Legrand N, Härmä H.

Anal Chim Acta. 2015 Oct 15;897:96-101. doi: 10.1016/j.aca.2015.09.032. Epub 2015 Oct 8.

PMID:
26515010
12.

2,5-Dimethyl-celecoxib inhibits cell cycle progression and induces apoptosis in human leukemia cells.

Sobolewski C, Rhim J, Legrand N, Muller F, Cerella C, Mack F, Chateauvieux S, Kim JG, Yoon AY, Kim KW, Dicato M, Diederich M.

J Pharmacol Exp Ther. 2015 Nov;355(2):308-28. doi: 10.1124/jpet.115.225011. Epub 2015 Sep 1.

PMID:
26330537
13.

The impact of the phosphomimetic eIF2αS/D on global translation, reinitiation and the integrated stress response is attenuated in N2a cells.

Legrand N, Jaquier-Gubler P, Curran J.

Nucleic Acids Res. 2015 Sep 30;43(17):8392-404. doi: 10.1093/nar/gkv827. Epub 2015 Aug 11.

14.

TRM6/61 connects PKCα with translational control through tRNAi(Met) stabilization: impact on tumorigenesis.

Macari F, El-Houfi Y, Boldina G, Xu H, Khoury-Hanna S, Ollier J, Yazdani L, Zheng G, Bièche I, Legrand N, Paulet D, Durrieu S, Byström A, Delbecq S, Lapeyre B, Bauchet L, Pannequin J, Hollande F, Pan T, Teichmann M, Vagner S, David A, Choquet A, Joubert D.

Oncogene. 2016 Apr 7;35(14):1785-96. doi: 10.1038/onc.2015.244. Epub 2015 Aug 3.

PMID:
26234676
15.

Use of killer cell immunoglobulin-like receptor genes as early markers of hematopoietic chimerism after double-umbilical cord blood transplantation.

Rettman P, Legrand N, Willem C, Lodé L, Chevallier P, Cesbron A, Senitzer D, Retière C, Gagne K.

Haematologica. 2015 Nov;100(11):e475-9. doi: 10.3324/haematol.2015.127993. Epub 2015 Jul 23. No abstract available.

16.

Deregulation of PPARβ/δ target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment.

Schumann T, Adhikary T, Wortmann A, Finkernagel F, Lieber S, Schnitzer E, Legrand N, Schober Y, Nockher WA, Toth PM, Diederich WE, Nist A, Stiewe T, Wagner U, Reinartz S, Müller-Brüsselbach S, Müller R.

Oncotarget. 2015 May 30;6(15):13416-33.

17.

A novel mouse model for stable engraftment of a human immune system and human hepatocytes.

Strick-Marchand H, Dusséaux M, Darche S, Huntington ND, Legrand N, Masse-Ranson G, Corcuff E, Ahodantin J, Weijer K, Spits H, Kremsdorf D, Di Santo JP.

PLoS One. 2015 Mar 17;10(3):e0119820. doi: 10.1371/journal.pone.0119820. eCollection 2015.

18.

Air quality in New York City hookah bars.

Zhou S, Weitzman M, Vilcassim R, Wilson J, Legrand N, Saunders E, Travers M, Chen LC, Peltier R, Gordon T.

Tob Control. 2015 Oct;24(e3):e193-8. doi: 10.1136/tobaccocontrol-2014-051763. Epub 2014 Sep 16.

19.

Health-related quality of life in patients with melanoma expressed as utilities and disability weights.

Tromme I, Devleesschauwer B, Beutels P, Richez P, Leroy A, Baurain JF, Cornelis F, Bertrand C, Legrand N, Degueldre J, Thomas L, Legrand C, Lambert J, Haagsma J, Speybroeck N.

Br J Dermatol. 2014 Dec;171(6):1443-50. doi: 10.1111/bjd.13262. Epub 2014 Nov 19.

PMID:
25039853
20.

An AUG codon conserved for protein function rather than translational initiation: the story of the protein sElk1.

Legrand N, Araud T, Conne B, Kuijpers O, Jaquier-Gubler P, Curran J.

PLoS One. 2014 Jul 18;9(7):e102890. doi: 10.1371/journal.pone.0102890. eCollection 2014.

21.

Critical assessment of human antibody generation in humanized mouse models.

Villaudy J, Schotte R, Legrand N, Spits H.

J Immunol Methods. 2014 Aug;410:18-27. doi: 10.1016/j.jim.2014.06.010. Epub 2014 Jun 18. Review.

PMID:
24952244
22.

Human fetal liver cells for regulated ex vivo erythropoietin gene therapy.

El Filali E, Duijst S, Hiralall JK, Legrand N, van Gulik T, Hoekstra R, Seppen J.

Mol Ther Methods Clin Dev. 2014 Mar 12;1:14003. doi: 10.1038/mtm.2014.3. eCollection 2014.

23.

Simple nanoparticle-based luminometric method for molecular weight determination of polymeric compounds.

Pihlasalo S, Virtamo M, Legrand N, Hänninen P, Härmä H.

Anal Chem. 2014 Jan 21;86(2):1038-44. doi: 10.1021/ac401797m. Epub 2013 Dec 30.

PMID:
24328326
24.

High-throughput identification of antigen-specific TCRs by TCR gene capture.

Linnemann C, Heemskerk B, Kvistborg P, Kluin RJ, Bolotin DA, Chen X, Bresser K, Nieuwland M, Schotte R, Michels S, Gomez-Eerland R, Jahn L, Hombrink P, Legrand N, Shu CJ, Mamedov IZ, Velds A, Blank CU, Haanen JB, Turchaninova MA, Kerkhoven RM, Spits H, Hadrup SR, Heemskerk MH, Blankenstein T, Chudakov DM, Bendle GM, Schumacher TN.

Nat Med. 2013 Nov;19(11):1534-41. doi: 10.1038/nm.3359. Epub 2013 Oct 13.

PMID:
24121928
25.

Anti-inflammatory and anticancer drugs from nature.

Orlikova B, Legrand N, Panning J, Dicato M, Diederich M.

Cancer Treat Res. 2014;159:123-43. doi: 10.1007/978-3-642-38007-5_8. Review.

PMID:
24114478
26.

Large spectrum of HLA-C recognition by killer Ig-like receptor (KIR)2DL2 and KIR2DL3 and restricted C1 SPECIFICITY of KIR2DS2: dominant impact of KIR2DL2/KIR2DS2 on KIR2D NK cell repertoire formation.

David G, Djaoud Z, Willem C, Legrand N, Rettman P, Gagne K, Cesbron A, Retière C.

J Immunol. 2013 Nov 1;191(9):4778-88. doi: 10.4049/jimmunol.1301580. Epub 2013 Sep 27.

27.

Preclinical in vivo evaluation of the safety of a multi-shRNA-based gene therapy against HIV-1.

Centlivre M, Legrand N, Klamer S, Liu YP, Jasmijn von Eije K, Bohne M, Rijnstra ES, Weijer K, Blom B, Voermans C, Spits H, Berkhout B.

Mol Ther Nucleic Acids. 2013 Sep 3;2:e120. doi: 10.1038/mtna.2013.48.

28.

Amplified NKG2C+ NK cells in cytomegalovirus (CMV) infection preferentially express killer cell Ig-like receptor 2DL: functional impact in controlling CMV-infected dendritic cells.

Djaoud Z, David G, Bressollette C, Willem C, Rettman P, Gagne K, Legrand N, Mehlal S, Cesbron A, Imbert-Marcille BM, Retière C.

J Immunol. 2013 Sep 1;191(5):2708-16. doi: 10.4049/jimmunol.1301138. Epub 2013 Aug 5.

29.

Both the nature of KIR3DL1 alleles and the KIR3DL1/S1 allele combination affect the KIR3DL1 NK-cell repertoire in the French population.

Gagne K, Willem C, Legrand N, Djaoud Z, David G, Rettman P, Bressollette-Bodin C, Senitzer D, Esbelin J, Cesbron-Gautier A, Schneider T, Retière C.

Eur J Immunol. 2013 Apr;43(4):1085-98. doi: 10.1002/eji.201243007. Epub 2013 Mar 4.

30.

Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues.

Bernink JH, Peters CP, Munneke M, te Velde AA, Meijer SL, Weijer K, Hreggvidsdottir HS, Heinsbroek SE, Legrand N, Buskens CJ, Bemelman WA, Mjösberg JM, Spits H.

Nat Immunol. 2013 Mar;14(3):221-9. doi: 10.1038/ni.2534. Epub 2013 Jan 20.

PMID:
23334791
31.

A doxycycline-dependent human immunodeficiency virus type 1 replicates in vivo without inducing CD4+ T-cell depletion.

Legrand N, van der Velden GJ, Ho Tsong Fang R, Douaisi M, Weijer K, Das AT, Blom B, Uittenbogaart CH, Berkhout B, Centlivre M.

J Gen Virol. 2012 Sep;93(Pt 9):2017-27. doi: 10.1099/vir.0.042796-0. Epub 2012 May 30.

32.

Efficient CRM197-mediated drug targeting to monocytes.

Schenk GJ, Haasnoot PC, Centlivre M, Legrand N, Rip J, de Boer AG, Berkhout B.

J Control Release. 2012 Feb 28;158(1):139-47. doi: 10.1016/j.jconrel.2011.09.091. Epub 2011 Oct 1.

PMID:
21982901
33.

Stem cell factor consistently improves thymopoiesis after experimental transplantation of murine or human hematopoietic stem cells in immunodeficient mice.

Wils EJ, Rombouts EJ, van Mourik I, Spits H, Legrand N, Braakman E, Cornelissen JJ.

J Immunol. 2011 Sep 15;187(6):2974-81. doi: 10.4049/jimmunol.1004209. Epub 2011 Aug 22.

34.

Functional CD47/signal regulatory protein alpha (SIRP(alpha)) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo.

Legrand N, Huntington ND, Nagasawa M, Bakker AQ, Schotte R, Strick-Marchand H, de Geus SJ, Pouw SM, Böhne M, Voordouw A, Weijer K, Di Santo JP, Spits H.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13224-9. doi: 10.1073/pnas.1101398108. Epub 2011 Jul 25.

35.

Autonomous and extrinsic regulation of thymopoiesis in human immune system (HIS) mice.

Huntington ND, Alves NL, Legrand N, Lim A, Strick-Marchand H, Plet A, Weijer K, Jacques Y, Spits H, Di Santo JP.

Eur J Immunol. 2011 Oct;41(10):2883-93. doi: 10.1002/eji.201141586. Epub 2011 Aug 30.

36.

AF1q/MLLT11 regulates the emergence of human prothymocytes through cooperative interaction with the Notch signaling pathway.

Parcelier A, Maharzi N, Delord M, Robledo-Sarmiento M, Nelson E, Belakhdar-Mekid H, Pla M, Kuranda K, Parietti V, Goodhardt M, Legrand N, Bernstein ID, Gluckman JC, Sigaux F, Canque B.

Blood. 2011 Aug 18;118(7):1784-96. doi: 10.1182/blood-2011-01-333179. Epub 2011 Jun 28.

37.

Integrated cellular pathology--systems biology of human diseases.

Sobolewski C, Viry E, Legrand N, Muller F, Morceau F, Diederich M.

Biochem Pharmacol. 2011 Nov 15;82(10):1253-5. doi: 10.1016/j.bcp.2011.05.032. Epub 2011 Jun 16. No abstract available.

PMID:
21704021
38.

IL-15 transpresentation promotes both human T-cell reconstitution and T-cell-dependent antibody responses in vivo.

Huntington ND, Alves NL, Legrand N, Lim A, Strick-Marchand H, Mention JJ, Plet A, Weijer K, Jacques Y, Becker PD, Guzman C, Soussan P, Kremsdorf D, Spits H, Di Santo JP.

Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6217-22. doi: 10.1073/pnas.1019167108. Epub 2011 Mar 28.

39.

Altered dynamics and differential infection profiles of lymphoid and myeloid cell subsets during acute and chronic HIV-1 infection.

Centlivre M, Legrand N, Steingrover R, van der Sluis R, Grijsen ML, Bakker M, Jurriaans S, Berkhout B, Paxton WA, Prins JM, Pollakis G.

J Leukoc Biol. 2011 May;89(5):785-95. doi: 10.1189/jlb.0410231. Epub 2011 Feb 10.

PMID:
21310820
40.

Generation of human antigen-specific monoclonal IgM antibodies using vaccinated "human immune system" mice.

Becker PD, Legrand N, van Geelen CM, Noerder M, Huntington ND, Lim A, Yasuda E, Diehl SA, Scheeren FA, Ott M, Weijer K, Wedemeyer H, Di Santo JP, Beaumont T, Guzman CA, Spits H.

PLoS One. 2010 Oct 4;5(10). pii: e13137. doi: 10.1371/journal.pone.0013137.

41.

E-SovTox: An online database of the main publicly-available sources of toxicity data concerning REACH-relevant chemicals published in the Russian language.

Sihtmäe M, Blinova I, Aruoja V, Dubourguier HC, Legrand N, Kahru A.

Altern Lab Anim. 2010 Aug;38(4):297-301.

PMID:
20822322
42.

Inflammation: novel arrows for an ancient target.

Sobolewski C, Legrand N, Morceau F, Diederich M.

Biochem Pharmacol. 2010 Dec 15;80(12):1769-70. doi: 10.1016/j.bcp.2010.06.026. Epub 2010 Jun 23. No abstract available.

PMID:
20599801
43.

Thymic stromal lymphopoietin induces early human B-cell proliferation and differentiation.

Scheeren FA, van Lent AU, Nagasawa M, Weijer K, Spits H, Legrand N, Blom B.

Eur J Immunol. 2010 Apr;40(4):955-65. doi: 10.1002/eji.200939419.

44.

In vivo modulation of gene expression by lentiviral transduction in "human immune system" Rag2-/- gamma c -/- mice.

van Lent AU, Centlivre M, Nagasawa M, Karrich JJ, Pouw SM, Weijer K, Spits H, Blom B, Legrand N.

Methods Mol Biol. 2010;595:87-115. doi: 10.1007/978-1-60761-421-0_6.

PMID:
19941107
45.

IL-7 enhances thymic human T cell development in "human immune system" Rag2-/-IL-2Rgammac-/- mice without affecting peripheral T cell homeostasis.

van Lent AU, Dontje W, Nagasawa M, Siamari R, Bakker AQ, Pouw SM, Maijoor KA, Weijer K, Cornelissen JJ, Blom B, Di Santo JP, Spits H, Legrand N.

J Immunol. 2009 Dec 15;183(12):7645-55. doi: 10.4049/jimmunol.0902019.

46.

Autoregulatory lentiviral vectors allow multiple cycles of doxycycline-inducible gene expression in human hematopoietic cells in vivo.

Centlivre M, Zhou X, Pouw SM, Weijer K, Kleibeuker W, Das AT, Blom B, Seppen J, Berkhout B, Legrand N.

Gene Ther. 2010 Jan;17(1):14-25. doi: 10.1038/gt.2009.109. Epub 2009 Sep 3.

PMID:
19727135
47.

Repopulation efficiencies of adult hepatocytes, fetal liver progenitor cells, and embryonic stem cell-derived hepatic cells in albumin-promoter-enhancer urokinase-type plasminogen activator mice.

Haridass D, Yuan Q, Becker PD, Cantz T, Iken M, Rothe M, Narain N, Bock M, Nörder M, Legrand N, Wedemeyer H, Weijer K, Spits H, Manns MP, Cai J, Deng H, Di Santo JP, Guzman CA, Ott M.

Am J Pathol. 2009 Oct;175(4):1483-92. doi: 10.2353/ajpath.2009.090117. Epub 2009 Aug 28.

48.

Humanized mice for modeling human infectious disease: challenges, progress, and outlook.

Legrand N, Ploss A, Balling R, Becker PD, Borsotti C, Brezillon N, Debarry J, de Jong Y, Deng H, Di Santo JP, Eisenbarth S, Eynon E, Flavell RA, Guzman CA, Huntington ND, Kremsdorf D, Manns MP, Manz MG, Mention JJ, Ott M, Rathinam C, Rice CM, Rongvaux A, Stevens S, Spits H, Strick-Marchand H, Takizawa H, van Lent AU, Wang C, Weijer K, Willinger T, Ziegler P.

Cell Host Microbe. 2009 Jul 23;6(1):5-9. doi: 10.1016/j.chom.2009.06.006. Review.

49.

A sensitive cell-based assay to measure the doxycycline concentration in biological samples.

Kleibeuker W, Zhou X, Centlivre M, Legrand N, Page M, Almond N, Berkhout B, Das AT.

Hum Gene Ther. 2009 May;20(5):524-30. doi: 10.1089/hum.2008.182.

PMID:
19203210
50.

IL-15 trans-presentation promotes human NK cell development and differentiation in vivo.

Huntington ND, Legrand N, Alves NL, Jaron B, Weijer K, Plet A, Corcuff E, Mortier E, Jacques Y, Spits H, Di Santo JP.

J Exp Med. 2009 Jan 16;206(1):25-34. doi: 10.1084/jem.20082013. Epub 2008 Dec 22.

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