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Update in Antibiotic Therapy in Intensive Care Unit Report from the 2019 Nimes International Symposium.

Leone M, Roberts JA, Bassetti M, Bouglé A, Lavigne JP, Legrand M, Neely M, Paiva JA, Payen D, Rello J, Roger C, Sjövall F, Jung B.

Anaesth Crit Care Pain Med. 2019 Oct 10. pii: S2352-5568(19)30427-8. doi: 10.1016/j.accpm.2019.09.009. [Epub ahead of print] Review.


Reply to: "Potential role of ketamine in burn-associated cholestasis".

Legrand M, de Tymowski C, Hodjat K, Mallet V.

J Hepatol. 2019 Sep 30. pii: S0168-8278(19)30542-2. doi: 10.1016/j.jhep.2019.09.006. [Epub ahead of print] No abstract available.


One-Year Prognosis of Kidney Injury at Discharge From the ICU: A Multicenter Observational Study.

Legrand M, Hollinger A, Vieillard-Baron A, Dépret F, Cariou A, Deye N, Fournier MC, Jaber S, Damoisel C, Lu Q, Monnet X, Rennuit I, Darmon M, Zafrani L, Leone M, Guidet B, Friedman D, Sonneville R, Montravers P, Pili-Floury S, Lefrant JY, Duranteau J, Laterre PF, Brechot N, Oueslati H, Cholley B, Launay JM, Ishihara S, Sato N, Mebazaa A, Gayat E; French and euRopean Outcome reGistry in ICUs (FROG-ICU) Investigators.

Crit Care Med. 2019 Sep 27. doi: 10.1097/CCM.0000000000004010. [Epub ahead of print]


Correction to: Recruiting the microcirculation in septic shock.

Legrand M, De Backer D, Dépret F, Ait-Oufella H.

Ann Intensive Care. 2019 Sep 24;9(1):107. doi: 10.1186/s13613-019-0581-0.


Management of Burns.

Legrand M, Dépret F, Mallet V.

N Engl J Med. 2019 Sep 19;381(12):1188-1189. doi: 10.1056/NEJMc1909342. No abstract available.


Recruiting the microcirculation in septic shock.

Legrand M, De Backer D, Dépret F, Ait-Oufella H.

Ann Intensive Care. 2019 Sep 11;9(1):102. doi: 10.1186/s13613-019-0577-9. No abstract available. Erratum in: Ann Intensive Care. 2019 Sep 24;9(1):107.


Homogeneous sulfur isotope signature in East Antarctica and implication for sulfur source shifts through the last glacial-interglacial cycle.

Ishino S, Hattori S, Savarino J, Legrand M, Albalat E, Albarede F, Preunkert S, Jourdain B, Yoshida N.

Sci Rep. 2019 Aug 27;9(1):12378. doi: 10.1038/s41598-019-48801-1.


[A systemic disease mimicking a rheumatoid arthritis].

Legrand M, Nouvier M, Paulin L, Deschamps B, Pialat JB, Coury F.

Rev Med Interne. 2019 Aug 20. pii: S0248-8663(19)30616-2. doi: 10.1016/j.revmed.2019.07.015. [Epub ahead of print] French.


Hyperkalemia in the Emergency Department: Urgent Need for a Rigorous Evaluation of the First-Line Treatments.

Lemoine L, Chouihed T, Legrand M, Rossignol P, Potel G, Montassier E.

J Emerg Med. 2019 Jul;57(1):102-103. doi: 10.1016/j.jemermed.2018.11.024. No abstract available.


Understanding the renal response to brain injury.

Legrand M, Sonneville R.

Intensive Care Med. 2019 Aug;45(8):1112-1115. doi: 10.1007/s00134-019-05685-z. Epub 2019 Jul 11. No abstract available.


Contributing factors and outcomes of burn-associated cholestasis.

de Tymowski C, Dépret F, Soussi S, Nabila M, Vauchel T, Chaussard M, Benyamina M, Ferry A, Cupaciu A, Jully M, Oueslati H, Fratani A, Coutrot M, Sogni P, Mimoun M, Chaouat M, Zagdanski AM, De Kerviler E, Mebazaa A, Moreau R, Mallet V, Legrand M; PRONOBURN group.

J Hepatol. 2019 Sep;71(3):563-572. doi: 10.1016/j.jhep.2019.05.009. Epub 2019 May 30.


Acute Kidney Injury Related to Sepsis-Reply.

Legrand M, Kellum JA.

JAMA. 2019 May 14;321(18):1828-1829. doi: 10.1001/jama.2019.2072. No abstract available.


Association of Age With Short-term and Long-term Mortality Among Patients Discharged From Intensive Care Units in France.

Atramont A, Lindecker-Cournil V, Rudant J, Tajahmady A, Drewniak N, Fouard A, Singer M, Leone M, Legrand M.

JAMA Netw Open. 2019 May 3;2(5):e193215. doi: 10.1001/jamanetworkopen.2019.3215.


Is the Renin-Angiotensin-Aldosterone System Good for the Kidney in Acute Settings?

Dudoignon E, Dépret F, Legrand M.

Nephron. 2019 Apr 18:1-5. doi: 10.1159/000499940. [Epub ahead of print] Review.


[Punctal and canalicular plugs: Indications, efficacy and safety (French translation of the article)].

Best AL, Labetoulle M, Legrand M, M'garrech M, Barreau E, Rousseau A.

J Fr Ophtalmol. 2019 Apr;42(4):404-414. doi: 10.1016/j.jfo.2018.10.003. Epub 2019 Mar 15. Review. French.


Is Nitric Oxide Nephro- or Cardioprotective?

Coutrot M, Dépret F, Legrand M.

Am J Respir Crit Care Med. 2019 Jun 1;199(11):1441-1442. doi: 10.1164/rccm.201812-2344LE. No abstract available.


Impact of renin-angiotensin system inhibitors continuation versus discontinuation on outcome after major surgery: protocol of a multicenter randomized, controlled trial (STOP-or-NOT trial).

Legrand M, Futier E, Leone M, Deniau B, Mebazaa A, Plaud B, Coriat P, Rossignol P, Vicaut E, Gayat E; STOP-OR-NOT study investigators.

Trials. 2019 Mar 5;20(1):160. doi: 10.1186/s13063-019-3247-1.


Candida albicans: An Emerging Yeast Model to Study Eukaryotic Genome Plasticity.

Legrand M, Jaitly P, Feri A, d'Enfert C, Sanyal K.

Trends Genet. 2019 Apr;35(4):292-307. doi: 10.1016/j.tig.2019.01.005. Epub 2019 Feb 28. Review.


Management of hyperkalemia in the acutely ill patient.

Dépret F, Peacock WF, Liu KD, Rafique Z, Rossignol P, Legrand M.

Ann Intensive Care. 2019 Feb 28;9(1):32. doi: 10.1186/s13613-019-0509-8. Review.


Identification of Recessive Lethal Alleles in the Diploid Genome of a Candida albicans Laboratory Strain Unveils a Potential Role of Repetitive Sequences in Buffering Their Deleterious Impact.

Marton T, Feri A, Commere PH, Maufrais C, d'Enfert C, Legrand M.

mSphere. 2019 Feb 13;4(1). pii: e00709-18. doi: 10.1128/mSphere.00709-18.


[Microcystic serous cystadenoma: An uncommon neoplasm of pancreas. Report of two cases].

Legrand M, Delalande F, Blechet C, Kerdraon R, Saint-Marc O, Michenet P.

Ann Pathol. 2019 Aug;39(4):292-296. doi: 10.1016/j.annpat.2018.12.007. Epub 2019 Jan 31. French.


Punctal and canalicular plugs: Indications, efficacy and safety.

Best AL, Labetoulle M, Legrand M, M'garrech M, Barreau E, Rousseau A.

J Fr Ophtalmol. 2019 Mar;42(3):e95-e104. doi: 10.1016/j.jfo.2018.12.003. Epub 2019 Jan 26. Review.


Endogenous Retroviruses Transcriptional Modulation After Severe Infection, Trauma and Burn.

Tabone O, Mommert M, Jourdan C, Cerrato E, Legrand M, Lepape A, Allaouchiche B, Rimmelé T, Pachot A, Monneret G, Venet F, Mallet F, Textoris J.

Front Immunol. 2019 Jan 8;9:3091. doi: 10.3389/fimmu.2018.03091. eCollection 2018.


Hydroxocobalamin as a Cause of Oxalate Nephropathy.

Legrand M.

Kidney Int Rep. 2018 Oct 26;4(1):185. doi: 10.1016/j.ekir.2018.10.010. eCollection 2019 Jan. No abstract available.


Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study.

Mebazaa A, Geven C, Hollinger A, Wittebole X, Chousterman BG, Blet A, Gayat E, Hartmann O, Scigalla P, Struck J, Bergmann A, Antonelli M, Beishuizen A, Constantin JM, Damoisel C, Deye N, Di Somma S, Dugernier T, François B, Gaudry S, Huberlant V, Lascarrou JB, Marx G, Mercier E, Oueslati H, Pickkers P, Sonneville R, Legrand M, Laterre PF; AdrenOSS-1 study investigators.

Crit Care. 2018 Dec 21;22(1):354. doi: 10.1186/s13054-018-2243-2.


French intensive care unit organisation.

Leone M, Constantin JM, Dahyot-Fizelier C, Duracher-Gout C, Joannes-Boyau O, Langeron O, Legrand M, Mahjoub Y, Mirek S, Mrozek S, Muller L, Orban JC, Quesnel C, Roquilly A, Virat A, Capdevila X.

Anaesth Crit Care Pain Med. 2018 Dec;37(6):625-627. doi: 10.1016/j.accpm.2018.10.011. Epub 2018 Oct 25.


Incidence, risk factors and outcome of multi-drug resistant Acinetobacter baumannii nosocomial infections during an outbreak in a burn unit.

Munier AL, Biard L, Legrand M, Rousseau C, Lafaurie M, Donay JL, Flicoteaux R, Mebazaa A, Mimoun M, Molina JM.

Int J Infect Dis. 2019 Feb;79:179-184. doi: 10.1016/j.ijid.2018.11.371. Epub 2018 Dec 6.


Impact of an Acinetobacter baumannii outbreak on kidney events in a burn unit: A targeted machine learning analysis.

Vauchel T, Pirracchio R, Chaussard M, Lafaurie M, Rouveau M, Rousseau C, Benyamina M, Soussi S, Dépret F, Ferry A, Oueslati H, Chaouat M, Mimoun M, Jarlier V, Moreno N, Mebazaa A, Legrand M.

Am J Infect Control. 2019 Apr;47(4):435-438. doi: 10.1016/j.ajic.2018.09.010. Epub 2018 Nov 29.


Outcome and potentially modifiable risk factors for candidemia in critically ill burns patients: A matched cohort study.

Dudoignon E, Alanio A, Anstey J, Depret F, Coutrot M, Fratani A, Jully M, Cupaciu A, Chaussard M, Oueslati H, Ferry A, Benyamina M, de Tymowski C, Boccara D, Serror K, Chaouat M, Mimoun M, Lafaurie M, Denis B, Gits-Muselli M, Bretagne S, Mebazaa A, Legrand M, Soussi S; PRONOBURN group.

Mycoses. 2019 Mar;62(3):237-246. doi: 10.1111/myc.12872. Epub 2018 Dec 18.


Serum Creatinine in the Critically Ill Patient With Sepsis.

Legrand M, Kellum JA.

JAMA. 2018 Dec 11;320(22):2369-2370. doi: 10.1001/jama.2018.16627. No abstract available.


Proenkephalin A 119-159 (Penkid) Is an Early Biomarker of Septic Acute Kidney Injury: The Kidney in Sepsis and Septic Shock (Kid-SSS) Study.

Hollinger A, Wittebole X, François B, Pickkers P, Antonelli M, Gayat E, Chousterman BG, Lascarrou JB, Dugernier T, Di Somma S, Struck J, Bergmann A, Beishuizen A, Constantin JM, Damoisel C, Deye N, Gaudry S, Huberlant V, Marx G, Mercier E, Oueslati H, Hartmann O, Sonneville R, Laterre PF, Mebazaa A, Legrand M.

Kidney Int Rep. 2018 Aug 22;3(6):1424-1433. doi: 10.1016/j.ekir.2018.08.006. eCollection 2018 Nov. Erratum in: Kidney Int Rep. 2018 Nov 17;4(1):187.


Alpine ice evidence of a three-fold increase in atmospheric iodine deposition since 1950 in Europe due to increasing oceanic emissions.

Legrand M, McConnell JR, Preunkert S, Arienzo M, Chellman N, Gleason K, Sherwen T, Evans MJ, Carpenter LJ.

Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):12136-12141. doi: 10.1073/pnas.1809867115. Epub 2018 Nov 12.


Hyperkalemia in the emergency department: Consider the use of nebulized salbutamol.

Montassier E, Legrand M, Rossignol P, Potel G.

Am J Emerg Med. 2019 May;37(5):1004. doi: 10.1016/j.ajem.2018.10.024. Epub 2018 Oct 16. No abstract available.


CRRT and ECMO: Dialysis catheter or connection to the ECMO circuit?

Schetz M, Legrand M.

Anaesth Crit Care Pain Med. 2018 Dec;37(6):519-520. doi: 10.1016/j.accpm.2018.10.005. Epub 2018 Oct 19. No abstract available.


Prediction of major adverse kidney events in critically ill burn patients.

Dépret F, Boutin L, Jarkovský J, Chaussard M, Soussi S, Bataille A, Oueslati H, Moreno N, de Tymowski C, Parenica J, Benešová K, Vauchel T, Ferry A, Benyamina M, Cupaciu A, Coutrot M, Garnier JP, Serror K, Chaouat M, Mebazaa A, Legrand M; PRONOBURN group.

Burns. 2018 Dec;44(8):1887-1894. doi: 10.1016/j.burns.2018.08.007. Epub 2018 Oct 12.


Negative trials in critical care medicine and the hurdles.

Legrand M.

Lancet Respir Med. 2018 Oct;6(10):e53. doi: 10.1016/S2213-2600(18)30342-4. Epub 2018 Sep 26. No abstract available.


Performance of Doppler-based resistive index and semi-quantitative renal perfusion in predicting persistent AKI: results of a prospective multicenter study.

Darmon M, Bourmaud A, Reynaud M, Rouleau S, Meziani F, Boivin A, Benyamina M, Vincent F, Lautrette A, Leroy C, Cohen Y, Legrand M, Morel J, Terreaux J, Schnell D.

Intensive Care Med. 2018 Nov;44(11):1904-1913. doi: 10.1007/s00134-018-5386-3. Epub 2018 Oct 5.


Planned enteral nutrition over-prescription to cover caloric and protein requirements in severely-ill burn patients.

Grangé C, Dépret F, Oueslati H, Legrand M, Soussi S.

Burns. 2018 Dec;44(8):2106-2107. doi: 10.1016/j.burns.2018.09.005. Epub 2018 Sep 29. No abstract available.


Prefrontal cortex rTMS reverses behavioral impairments and differentially activates c-Fos in a mouse model of post-traumatic stress disorder.

Legrand M, Troubat R, Brizard B, Le Guisquet AM, Belzung C, El-Hage W.

Brain Stimul. 2019 Jan - Feb;12(1):87-95. doi: 10.1016/j.brs.2018.09.003. Epub 2018 Sep 8.


PARP-1-dependent RND1 transcription induced by topoisomerase I cleavage complexes confers cellular resistance to camptothecin.

Mouly L, Mamouni K, Gence R, Cristini A, Cherier J, Castinel A, Legrand M, Favre G, Sordet O, Monferran S.

Cell Death Dis. 2018 Sep 12;9(9):931. doi: 10.1038/s41419-018-0981-3.


Hemodynamic management of critically ill burn patients: an international survey.

Soussi S, Berger MM, Colpaert K, Dünser MW, Guttormsen AB, Juffermans NP, Knape P, Koksal G, Lavrentieva A, Leclerc T, Lorente JA, Martin-Loeches I, Metnitz P, Pantet O, Pelosi P, Rousseau AF, Sjöberg F, Legrand M; ESICM Burn ICU working group.

Crit Care. 2018 Aug 17;22(1):194. doi: 10.1186/s13054-018-2129-3. No abstract available.


Erratum: Generating genomic platforms to study Candida albicans pathogenesis.

Legrand M, Bachellier-Bassi S, Lee KK, Chaudhari Y, Tournu H, Arbogast L, Boyer H, Chauvel M, Cabral V, Maufrais C, Nesseir A, Maslanka I, Permal E, Rossignol T, Walker LA, Zeidler U, Znaidi S, Schoeters F, Majgier C, Julien RA, Ma L, Tichit M, Bouchier C, Van Dijck P, Munro CA, d'Enfert C.

Nucleic Acids Res. 2018 Sep 19;46(16):8664. doi: 10.1093/nar/gky747. No abstract available.


Movement-Based Control for Upper-Limb Prosthetics: Is the Regression Technique the Key to a Robust and Accurate Control?

Legrand M, Merad M, de Montalivet E, Roby-Brami A, Jarrassé N.

Front Neurorobot. 2018 Jul 26;12:41. doi: 10.3389/fnbot.2018.00041. eCollection 2018.


Determining the editorial policy of Anaesthesia Critical Care and Pain Medicine (ACCPM).

Lefrant JY, Lorne E, Asehnoune K, Ausset S, Beaulieu P, Biais M, Brichant JF, Charbit B, Constantin JM, Cuvillon P, Dadure C, Dahmani S, David JS, Fuchs-Buder T, Geeraerts T, Godier A, Hanouz JL, Joannes-Boyau O, Kipnis E, Laudenbach V, Le Guen M, Legrand M, Lescot T, Marret E, Mongardon N, Ouattara A, Pierre S, Roberts J, Schneider A, Tourtier JP, Tran L, Pirracchio R, Capdevila X.

Anaesth Crit Care Pain Med. 2018 Aug;37(4):299-301. doi: 10.1016/j.accpm.2018.07.001. No abstract available.


When ethics collides with a legal gap in emergency life-threatening conditions.

Legrand M, Bastien O, Chaouat M, Mebazaa A, Séval F, Mimoun M, Vallet B.

Br J Anaesth. 2018 Aug;121(2):513-514. doi: 10.1016/j.bja.2018.04.037. Epub 2018 May 25. No abstract available.


Generating genomic platforms to study Candida albicans pathogenesis.

Legrand M, Bachellier-Bassi S, Lee KK, Chaudhari Y, Tournu H, Arbogast L, Boyer H, Chauvel M, Cabral V, Maufrais C, Nesseir A, Maslanka I, Permal E, Rossignol T, Walker LA, Zeidler U, Znaidi S, Schoeters F, Majgier C, Julien RA, Ma L, Tichit M, Bouchier C, Van Dijck P, Munro CA, d'Enfert C.

Nucleic Acids Res. 2018 Aug 21;46(14):6935-6949. doi: 10.1093/nar/gky594. Erratum in: Nucleic Acids Res. 2018 Sep 19;46(16):8664.


Early Hemodynamic Management of Critically Ill Burn Patients.

Soussi S, Dépret F, Benyamina M, Legrand M.

Anesthesiology. 2018 Sep;129(3):583-589. doi: 10.1097/ALN.0000000000002314. Review. No abstract available.


Methods used to assess the performance of biomarkers for the diagnosis of acute kidney injury: a systematic review and meta-analysis.

Codorniu A, Lemasle L, Legrand M, Blet A, Mebazaa A, Gayat E.

Biomarkers. 2018 Dec;23(8):766-772. doi: 10.1080/1354750X.2018.1493616. Epub 2018 Aug 23.


New-onset atrial fibrillation in critically ill patients and its association with mortality: A report from the FROG-ICU study.

Arrigo M, Ishihara S, Feliot E, Rudiger A, Deye N, Cariou A, Guidet B, Jaber S, Leone M, Resche-Rigon M, Vieillard Baron A, Legrand M, Gayat E, Mebazaa A.

Int J Cardiol. 2018 Sep 1;266:95-99. doi: 10.1016/j.ijcard.2018.03.051.


Pressure guided surgery of compartment syndrome of the limbs in burn patients.

Boccara D, Lavocat R, Soussi S, Legrand M, Chaouat M, Mebazaa A, Mimoun M, Blet A, Serror K.

Ann Burns Fire Disasters. 2017 Sep 30;30(3):193-197.

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