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Items: 1 to 50 of 68

1.

Engineering of Nanobodies Recognizing the Human Chemokine Receptor CCR7.

Jakobs BD, Spannagel L, Purvanov V, Uetz-von Allmen E, Matti C, Legler DF.

Int J Mol Sci. 2019 May 27;20(10). pii: E2597. doi: 10.3390/ijms20102597.

2.

IL-4 receptor engagement in human neutrophils impairs their migration and extracellular trap formation.

Impellizzieri D, Ridder F, Raeber ME, Egholm C, Woytschak J, Kolios AGA, Legler DF, Boyman O.

J Allergy Clin Immunol. 2019 Feb 12. pii: S0091-6749(19)30203-9. doi: 10.1016/j.jaci.2019.01.042. [Epub ahead of print]

PMID:
30768990
3.

CCR7 Is Recruited to the Immunological Synapse, Acts as Co-stimulatory Molecule and Drives LFA-1 Clustering for Efficient T Cell Adhesion Through ZAP70.

Laufer JM, Kindinger I, Artinger M, Pauli A, Legler DF.

Front Immunol. 2019 Jan 14;9:3115. doi: 10.3389/fimmu.2018.03115. eCollection 2018.

4.

Role of Mechanotransduction and Tension in T Cell Function.

Rossy J, Laufer JM, Legler DF.

Front Immunol. 2018 Nov 15;9:2638. doi: 10.3389/fimmu.2018.02638. eCollection 2018. Review.

5.

Fluorescently Tagged CCL19 and CCL21 to Monitor CCR7 and ACKR4 Functions.

Purvanov V, Matti C, Samson GPB, Kindinger I, Legler DF.

Int J Mol Sci. 2018 Dec 4;19(12). pii: E3876. doi: 10.3390/ijms19123876.

6.

CCL19 with CCL21-tail displays enhanced glycosaminoglycan binding with retained chemotactic potency in dendritic cells.

Jørgensen AS, Adogamhe PE, Laufer JM, Legler DF, Veldkamp CT, Rosenkilde MM, Hjortø GM.

J Leukoc Biol. 2018 Aug;104(2):401-411. doi: 10.1002/JLB.2VMA0118-008R. Epub 2018 May 16.

PMID:
29768676
7.

Beyond migration-Chemokines in lymphocyte priming, differentiation, and modulating effector functions.

Laufer JM, Legler DF.

J Leukoc Biol. 2018 Aug;104(2):301-312. doi: 10.1002/JLB.2MR1217-494R. Epub 2018 Apr 18. Review.

PMID:
29668063
8.

A unique signal sequence of the chemokine receptor CCR7 promotes package into COPII vesicles for efficient receptor trafficking.

Uetz-von Allmen E, Rippl AV, Farhan H, Legler DF.

J Leukoc Biol. 2018 Aug;104(2):375-389. doi: 10.1002/JLB.2VMA1217-492R. Epub 2018 Mar 30.

PMID:
29603364
9.

ZAP70 expression enhances chemokine-driven chronic lymphocytic leukemia cell migration and arrest by valency regulation of integrins.

Laufer JM, Lyck R, Legler DF.

FASEB J. 2018 Sep;32(9):4824-4835. doi: 10.1096/fj.201701452RR. Epub 2018 Mar 28.

PMID:
29589978
10.

Membrane lipid environment: Potential modulation of chemokine receptor function.

Thelen M, Legler DF.

Cytokine. 2018 Sep;109:72-75. doi: 10.1016/j.cyto.2018.02.011. Epub 2018 Feb 9.

PMID:
29433906
11.

New insights in chemokine signaling.

Legler DF, Thelen M.

F1000Res. 2018 Jan 23;7:95. doi: 10.12688/f1000research.13130.1. eCollection 2018. Review.

12.

A structure-activity relationship linking non-planar PCBs to functional deficits of neural crest cells: new roles for connexins.

Nyffeler J, Chovancova P, Dolde X, Holzer AK, Purvanov V, Kindinger I, Kerins A, Higton D, Silvester S, van Vugt-Lussenburg BMA, Glaab E, van der Burg B, Maclennan R, Legler DF, Leist M.

Arch Toxicol. 2018 Mar;92(3):1225-1247. doi: 10.1007/s00204-017-2125-4. Epub 2017 Nov 21.

PMID:
29164306
13.

Chemokines: Chemistry, Biochemistry and Biological Function.

Legler DF, Thelen M.

Chimia (Aarau). 2016 Dec 21;70(12):856-859. doi: 10.2533/chimia.2016.856. Review.

PMID:
28661356
14.

Epithelial chemokine CXCL14 synergizes with CXCL12 via allosteric modulation of CXCR4.

Collins PJ, McCully ML, Martínez-Muñoz L, Santiago C, Wheeldon J, Caucheteux S, Thelen S, Cecchinato V, Laufer JM, Purvanov V, Monneau YR, Lortat-Jacob H, Legler DF, Uguccioni M, Thelen M, Piguet V, Mellado M, Moser B.

FASEB J. 2017 Jul;31(7):3084-3097. doi: 10.1096/fj.201700013R. Epub 2017 Mar 30.

15.

Modulation of Chemokine Receptor Function by Cholesterol: New Prospects for Pharmacological Intervention.

Legler DF, Matti C, Laufer JM, Jakobs BD, Purvanov V, Uetz-von Allmen E, Thelen M.

Mol Pharmacol. 2017 Apr;91(4):331-338. doi: 10.1124/mol.116.107151. Epub 2017 Jan 12. Review.

PMID:
28082305
16.

Chemokine axes in breast cancer: factors of the tumor microenvironment reshape the CCR7-driven metastatic spread of luminal-A breast tumors.

Weitzenfeld P, Kossover O, Körner C, Meshel T, Wiemann S, Seliktar D, Legler DF, Ben-Baruch A.

J Leukoc Biol. 2016 Jun;99(6):1009-25. doi: 10.1189/jlb.3MA0815-373R. Epub 2016 Mar 2.

PMID:
26936935
17.

Distinct CCR7 glycosylation pattern shapes receptor signaling and endocytosis to modulate chemotactic responses.

Hauser MA, Kindinger I, Laufer JM, Späte AK, Bucher D, Vanes SL, Krueger WA, Wittmann V, Legler DF.

J Leukoc Biol. 2016 Jun;99(6):993-1007. doi: 10.1189/jlb.2VMA0915-432RR. Epub 2016 Jan 27.

PMID:
26819318
18.

Inflammation-Induced CCR7 Oligomers Form Scaffolds to Integrate Distinct Signaling Pathways for Efficient Cell Migration.

Hauser MA, Schaeuble K, Kindinger I, Impellizzieri D, Krueger WA, Hauck CR, Boyman O, Legler DF.

Immunity. 2016 Jan 19;44(1):59-72. doi: 10.1016/j.immuni.2015.12.010.

19.

Common and biased signaling pathways of the chemokine receptor CCR7 elicited by its ligands CCL19 and CCL21 in leukocytes.

Hauser MA, Legler DF.

J Leukoc Biol. 2016 Jun;99(6):869-82. doi: 10.1189/jlb.2MR0815-380R. Epub 2016 Jan 4. Review.

PMID:
26729814
20.

The STEAP1(262-270) peptide encapsulated into PLGA microspheres elicits strong cytotoxic T cell immunity in HLA-A*0201 transgenic mice--A new approach to immunotherapy against prostate carcinoma.

Herrmann VL, Wieland DE, Legler DF, Wittmann V, Groettrup M.

Prostate. 2016 Apr;76(5):456-68. doi: 10.1002/pros.23136. Epub 2015 Dec 30.

PMID:
26715028
21.

Loss of Gadkin Affects Dendritic Cell Migration In Vitro.

Schachtner H, Weimershaus M, Stache V, Plewa N, Legler DF, Höpken UE, Maritzen T.

PLoS One. 2015 Dec 1;10(12):e0143883. doi: 10.1371/journal.pone.0143883. eCollection 2015.

22.
23.

Loss of GM130 in breast cancer cells and its effects on cell migration, invasion and polarity.

Baschieri F, Uetz-von Allmen E, Legler DF, Farhan H.

Cell Cycle. 2015;14(8):1139-47. doi: 10.1080/15384101.2015.1007771.

24.

Analysis of CCR7 mediated T cell transfectant migration using a microfluidic gradient generator.

Wu X, Wu J, Li H, Legler DF, Marshall AJ, Lin F.

J Immunol Methods. 2015 Apr;419:9-17. doi: 10.1016/j.jim.2015.02.008. Epub 2015 Feb 27.

PMID:
25733353
25.

On the move: endocytic trafficking in cell migration.

Maritzen T, Schachtner H, Legler DF.

Cell Mol Life Sci. 2015 Jun;72(11):2119-34. doi: 10.1007/s00018-015-1855-9. Epub 2015 Feb 15. Review.

PMID:
25681867
26.

Regulation of Sec16 levels and dynamics links proliferation and secretion.

Tillmann KD, Reiterer V, Baschieri F, Hoffmann J, Millarte V, Hauser MA, Mazza A, Atias N, Legler DF, Sharan R, Weiss M, Farhan H.

J Cell Sci. 2015 Feb 15;128(4):670-82. doi: 10.1242/jcs.157115. Epub 2014 Dec 19.

27.

CCR7: roles in cancer cell dissemination, migration and metastasis formation.

Legler DF, Uetz-von Allmen E, Hauser MA.

Int J Biochem Cell Biol. 2014 Sep;54:78-82. doi: 10.1016/j.biocel.2014.07.002. Epub 2014 Jul 11.

PMID:
25019368
28.

Interstitial dendritic cell guidance by haptotactic chemokine gradients.

Weber M, Hauschild R, Schwarz J, Moussion C, de Vries I, Legler DF, Luther SA, Bollenbach T, Sixt M.

Science. 2013 Jan 18;339(6117):328-32. doi: 10.1126/science.1228456.

29.

Converse regulation of CCR7-driven human dendritic cell migration by prostaglandin E₂ and liver X receptor activation.

Bruckner M, Dickel D, Singer E, Legler DF.

Eur J Immunol. 2012 Nov;42(11):2949-58. doi: 10.1002/eji.201242523. Epub 2012 Sep 26.

30.

Ubiquitylation of the chemokine receptor CCR7 enables efficient receptor recycling and cell migration.

Schaeuble K, Hauser MA, Rippl AV, Bruderer R, Otero C, Groettrup M, Legler DF.

J Cell Sci. 2012 Oct 1;125(Pt 19):4463-74. doi: 10.1242/jcs.097519. Epub 2012 Jul 13.

31.

Distinct modulation of chemokine expression patterns in human monocyte-derived dendritic cells by prostaglandin E(2).

Bruckner M, Dickel D, Singer E, Legler DF.

Cell Immunol. 2012 Mar-Apr;276(1-2):52-8. doi: 10.1016/j.cellimm.2012.03.008. Epub 2012 Apr 4.

PMID:
22565056
32.

Cross-talk between TCR and CCR7 signaling sets a temporal threshold for enhanced T lymphocyte migration.

Schaeuble K, Hauser MA, Singer E, Groettrup M, Legler DF.

J Immunol. 2011 Dec 1;187(11):5645-52. doi: 10.4049/jimmunol.1101850. Epub 2011 Oct 31.

33.

Definition of key variables for the induction of optimal NY-ESO-1-specific T cells in HLA transgene mice.

Johannsen A, Genolet R, Legler DF, Luther SA, Luescher IF.

J Immunol. 2010 Sep 15;185(6):3445-55. doi: 10.4049/jimmunol.1001397. Epub 2010 Aug 23.

34.

Immobilized chemokine fields and soluble chemokine gradients cooperatively shape migration patterns of dendritic cells.

Schumann K, Lämmermann T, Bruckner M, Legler DF, Polleux J, Spatz JP, Schuler G, Förster R, Lutz MB, Sorokin L, Sixt M.

Immunity. 2010 May 28;32(5):703-13. doi: 10.1016/j.immuni.2010.04.017. Epub 2010 May 13.

35.

Prostaglandin E2 at new glance: novel insights in functional diversity offer therapeutic chances.

Legler DF, Bruckner M, Uetz-von Allmen E, Krause P.

Int J Biochem Cell Biol. 2010 Feb;42(2):198-201. doi: 10.1016/j.biocel.2009.09.015. Epub 2009 Sep 27. Review.

PMID:
19788928
36.

Angiogenesis and lymphangiogenesis are downregulated in primary breast cancer.

Boneberg EM, Legler DF, Hoefer MM, Ohlschlegel C, Steininger H, Füzesi L, Beer GM, Dupont-Lampert V, Otto F, Senn HJ, Fürstenberger G.

Br J Cancer. 2009 Aug 18;101(4):605-14. doi: 10.1038/sj.bjc.6605219.

37.

Soluble CD146 is generated by ectodomain shedding of membrane CD146 in a calcium-induced, matrix metalloprotease-dependent process.

Boneberg EM, Illges H, Legler DF, Fürstenberger G.

Microvasc Res. 2009 Dec;78(3):325-31. doi: 10.1016/j.mvr.2009.06.012. Epub 2009 Jul 15.

PMID:
19615385
38.

Prostaglandin E(2) enhances T-cell proliferation by inducing the costimulatory molecules OX40L, CD70, and 4-1BBL on dendritic cells.

Krause P, Bruckner M, Uermösi C, Singer E, Groettrup M, Legler DF.

Blood. 2009 Mar 12;113(11):2451-60. doi: 10.1182/blood-2008-05-157123. Epub 2008 Nov 24.

39.

Distinct motifs in the chemokine receptor CCR7 regulate signal transduction, receptor trafficking and chemotaxis.

Otero C, Eisele PS, Schaeuble K, Groettrup M, Legler DF.

J Cell Sci. 2008 Aug 15;121(Pt 16):2759-67. doi: 10.1242/jcs.029074. Epub 2008 Jul 29.

40.

Reduced expression of cyclooxygenase-2 in primary breast cancer.

Boneberg EM, Legler DF, Senn HJ, Fürstenberger G.

J Natl Cancer Inst. 2008 Jul 16;100(14):1042-3. doi: 10.1093/jnci/djn194. Epub 2008 Jul 8. No abstract available.

PMID:
18612134
41.

Increased mobility of major histocompatibility complex I-peptide complexes decreases the sensitivity of antigen recognition.

Segura JM, Guillaume P, Mark S, Dojcinovic D, Johannsen A, Bosshard G, Angelov G, Legler DF, Vogel H, Luescher IF.

J Biol Chem. 2008 Aug 29;283(35):24254-63. doi: 10.1074/jbc.M803549200. Epub 2008 Jun 25.

42.

Proinflammatory cytokines cause FAT10 upregulation in cancers of liver and colon.

Lukasiak S, Schiller C, Oehlschlaeger P, Schmidtke G, Krause P, Legler DF, Autschbach F, Schirmacher P, Breuhahn K, Groettrup M.

Oncogene. 2008 Oct 9;27(46):6068-74. doi: 10.1038/onc.2008.201. Epub 2008 Jun 23.

PMID:
18574467
43.

V domain of RAGE interacts with AGEs on prostate carcinoma cells.

Allmen EU, Koch M, Fritz G, Legler DF.

Prostate. 2008 May 15;68(7):748-58. doi: 10.1002/pros.20736.

PMID:
18302220
44.

A novel cytosolic class I antigen-processing pathway for endoplasmic-reticulum-targeted proteins.

Schlosser E, Otero C, Wuensch C, Kessler B, Edelmann M, Brunisholz R, Drexler I, Legler DF, Groettrup M.

EMBO Rep. 2007 Oct;8(10):945-51. Epub 2007 Sep 14.

45.

Prostaglandin E2 is a key factor for monocyte-derived dendritic cell maturation: enhanced T cell stimulatory capacity despite IDO.

Krause P, Singer E, Darley PI, Klebensberger J, Groettrup M, Legler DF.

J Leukoc Biol. 2007 Nov;82(5):1106-14. Epub 2007 Aug 14.

PMID:
17698915
46.

Opposite fate of endocytosed CCR7 and its ligands: recycling versus degradation.

Otero C, Groettrup M, Legler DF.

J Immunol. 2006 Aug 15;177(4):2314-23.

47.

Preformed reggie/flotillin caps: stable priming platforms for macrodomain assembly in T cells.

Langhorst MF, Reuter A, Luxenhofer G, Boneberg EM, Legler DF, Plattner H, Stuermer CA.

FASEB J. 2006 Apr;20(6):711-3. Epub 2006 Feb 1.

PMID:
16452278
48.

Prostaglandin E2 is generally required for human dendritic cell migration and exerts its effect via EP2 and EP4 receptors.

Legler DF, Krause P, Scandella E, Singer E, Groettrup M.

J Immunol. 2006 Jan 15;176(2):966-73.

49.

Posttranscriptional regulation of Fas (CD95) ligand killing activity by lipid rafts.

Nachbur U, Kassahn D, Yousefi S, Legler DF, Brunner T.

Blood. 2006 Apr 1;107(7):2790-6. Epub 2005 Dec 6.

50.

Differential insertion of GPI-anchored GFPs into lipid rafts of live cells.

Legler DF, Doucey MA, Schneider P, Chapatte L, Bender FC, Bron C.

FASEB J. 2005 Jan;19(1):73-5. Epub 2004 Oct 29.

PMID:
15516372

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