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Advances in the science and treatment of alcohol use disorder.

Witkiewitz K, Litten RZ, Leggio L.

Sci Adv. 2019 Sep 25;5(9):eaax4043. doi: 10.1126/sciadv.aax4043. eCollection 2019 Sep. Review.


Endocrine effects of the novel ghrelin receptor inverse agonist PF-5190457: Results from a placebo-controlled human laboratory alcohol co-administration study in heavy drinkers.

Lee MR, Farokhnia M, Cobbina E, Saravanakumar A, Li X, Battista JT, Farinelli LA, Akhlaghi F, Leggio L.

Neuropharmacology. 2019 Sep 23:107788. doi: 10.1016/j.neuropharm.2019.107788. [Epub ahead of print]


Peripheral proinflammatory markers are upregulated in abstinent alcohol-dependent patients but are not affected by cognitive bias modification: Preliminary findings.

Portelli J, Wiers CE, Li X, Deschaine SL, McDiarmid GR, Bermpohl F, Leggio L.

Drug Alcohol Depend. 2019 Sep 11;204:107553. doi: 10.1016/j.drugalcdep.2019.107553. [Epub ahead of print]


Sex differences in the response to opioids for pain relief: A systematic review and meta-analysis.

Pisanu C, Franconi F, Gessa GL, Mameli S, Pisanu GM, Campesi I, Leggio L, Agabio R.

Pharmacol Res. 2019 Sep 6:104447. doi: 10.1016/j.phrs.2019.104447. [Epub ahead of print] Review.


Evolutionary adaptation in fucosyllactose uptake systems supports bifidobacteria-infant symbiosis.

Sakanaka M, Hansen ME, Gotoh A, Katoh T, Yoshida K, Odamaki T, Yachi H, Sugiyama Y, Kurihara S, Hirose J, Urashima T, Xiao JZ, Kitaoka M, Fukiya S, Yokota A, Lo Leggio L, Abou Hachem M, Katayama T.

Sci Adv. 2019 Aug 28;5(8):eaaw7696. doi: 10.1126/sciadv.aaw7696. eCollection 2019 Aug.


Insights into an unusual Auxiliary Activity 9 family member lacking the histidine brace motif of lytic polysaccharide monooxygenases.

Frandsen KEH, Tovborg M, Jørgensen CI, Spodsberg N, Rosso MN, Hemsworth GR, Garman EF, Grime GW, Poulsen JN, Batth TS, Miyauchi S, Lipzen A, Daum C, Grigoriev IV, Johansen KS, Henrissat B, Berrin JG, Lo Leggio L.

J Biol Chem. 2019 Aug 30. pii: jbc.RA119.009223. doi: 10.1074/jbc.RA119.009223. [Epub ahead of print]


Using Machine Learning to Classify Individuals With Alcohol Use Disorder Based on Treatment Seeking Status.

Lee MR, Sankar V, Hammer A, Kennedy WG, Barb JJ, McQueen PG, Leggio L.

EClinicalMedicine. 2019 Jun 17;12:70-78. doi: 10.1016/j.eclinm.2019.05.008. eCollection 2019 Jul.


A role for the CD38 rs3796863 polymorphism in alcohol and monetary reward: evidence from CD38 knockout mice and alcohol self-administration, [11C]-raclopride binding, and functional MRI in humans.

Lee MR, Shin JH, Deschaine S, Daurio AM, Stangl BL, Yan J, Ramchandani VA, Schwandt ML, Grodin EN, Momenan R, Corral-Frias NS, Hariri AR, Bogdan R, Alvarez VA, Leggio L.

Am J Drug Alcohol Abuse. 2019 Jul 31:1-13. doi: 10.1080/00952990.2019.1638928. [Epub ahead of print]


Intravenous administration of ghrelin increases serum cortisol and aldosterone concentrations in heavy-drinking alcohol-dependent individuals: Results from a double-blind, placebo-controlled human laboratory study.

Haass-Koffler CL, Long VM, Farokhnia M, Magill M, Kenna GA, Swift RM, Leggio L.

Neuropharmacology. 2019 Nov 1;158:107711. doi: 10.1016/j.neuropharm.2019.107711. Epub 2019 Jul 13.


Structure of Aspergillus aculeatus β-1,4-galactanase in complex with galactobiose.

Torpenholt S, Poulsen JCN, Muderspach SJ, De Maria L, Lo Leggio L.

Acta Crystallogr F Struct Biol Commun. 2019 Jun 1;75(Pt 6):399-404. doi: 10.1107/S2053230X19005612. Epub 2019 May 10.


Substrate preference of an ABC importer corresponds to selective growth on β-(1,6)-galactosides in Bifidobacterium animalis subsp. lactis.

Theilmann MC, Fredslund F, Svensson B, Lo Leggio L, Abou Hachem M.

J Biol Chem. 2019 Aug 2;294(31):11701-11711. doi: 10.1074/jbc.RA119.008843. Epub 2019 Jun 11.


Role of Molybdenum-Containing Enzymes in the Biotransformation of the Novel Ghrelin Receptor Inverse Agonist PF-5190457: A Reverse Translational Bed-to-Bench Approach.

Adusumalli S, Jamwal R, Obach RS, Ryder TF, Leggio L, Akhlaghi F.

Drug Metab Dispos. 2019 Aug;47(8):874-882. doi: 10.1124/dmd.119.087015. Epub 2019 Jun 10.


Parsing out the role of dopamine D4 receptor gene (DRD4) on alcohol-related phenotypes: A meta-analysis and systematic review.

Daurio AM, Deschaine SL, Modabbernia A, Leggio L.

Addict Biol. 2019 May 31:e12770. doi: 10.1111/adb.12770. [Epub ahead of print]


HIV and alcohol use disorder: we cannot ignore the elephant in the room.

Agabio R, Leggio L.

Lancet HIV. 2019 Aug;6(8):e485-e486. doi: 10.1016/S2352-3018(19)30074-8. Epub 2019 May 17. No abstract available.


Prospects for pharmacotherapies to treat alcohol use disorder: an update on recent human studies.

Farokhnia M, Browning BD, Leggio L.

Curr Opin Psychiatry. 2019 Jul;32(4):255-265. doi: 10.1097/YCO.0000000000000519.


Effect of systemically administered oxytocin on dose response for methylphenidate self-administration and mesolimbic dopamine levels.

Lee MR, Rohn MCH, Zanettini C, Coggiano MA, Leggio L, Tanda G.

Ann N Y Acad Sci. 2019 May 10. doi: 10.1111/nyas.14101. [Epub ahead of print]


Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala.

Tunstall BJ, Kirson D, Zallar LJ, McConnell SA, Vendruscolo JCM, Ho CP, Oleata CS, Khom S, Manning M, Lee MR, Leggio L, Koob GF, Roberto M, Vendruscolo LF.

PLoS Biol. 2019 Apr 16;17(4):e2006421. doi: 10.1371/journal.pbio.2006421. eCollection 2019 Apr.


Structure-function analyses reveal that a glucuronoyl esterase from Teredinibacter turnerae interacts with carbohydrates and aromatic compounds.

Arnling Bååth J, Mazurkewich S, Poulsen JN, Olsson L, Lo Leggio L, Larsbrink J.

J Biol Chem. 2019 Apr 19;294(16):6635-6644. doi: 10.1074/jbc.RA119.007831. Epub 2019 Feb 27.


Ghrelin Receptor Influence on Cocaine Reward is Not Directly Dependent on Peripheral Acyl-Ghrelin.

Wenthur CJ, Gautam R, Zhou B, Vendruscolo LF, Leggio L, Janda KD.

Sci Rep. 2019 Feb 12;9(1):1841. doi: 10.1038/s41598-019-38549-z.


Ghrelin: From a gut hormone to a potential therapeutic target for alcohol use disorder.

Farokhnia M, Faulkner ML, Piacentino D, Lee MR, Leggio L.

Physiol Behav. 2019 May 15;204:49-57. doi: 10.1016/j.physbeh.2019.02.008. Epub 2019 Feb 7. Review.


The Use of Baclofen as a Treatment for Alcohol Use Disorder: A Clinical Practice Perspective.

de Beaurepaire R, Sinclair JMA, Heydtmann M, Addolorato G, Aubin HJ, Beraha EM, Caputo F, Chick JD, de La Selle P, Franchitto N, Garbutt JC, Haber PS, Jaury P, Lingford-Hughes AR, Morley KC, Müller CA, Owens L, Pastor A, Paterson LM, Pélissier F, Rolland B, Stafford A, Thompson A, van den Brink W, Leggio L, Agabio R.

Front Psychiatry. 2019 Jan 4;9:708. doi: 10.3389/fpsyt.2018.00708. eCollection 2018. Review.


Structure and Dynamics of a Promiscuous Xanthan Lyase from Paenibacillus nanensis and the Design of Variants with Increased Stability and Activity.

Jensen PF, Kadziola A, Comamala G, Segura DR, Anderson L, Poulsen JN, Rasmussen KK, Agarwal S, Sainathan RK, Monrad RN, Svendsen A, Nielsen JE, Lo Leggio L, Rand KD.

Cell Chem Biol. 2019 Feb 21;26(2):191-202.e6. doi: 10.1016/j.chembiol.2018.10.016. Epub 2018 Nov 29.


Ghrelin receptor deletion reduces binge-like alcohol drinking in rats.

Zallar LJ, Beurmann S, Tunstall BJ, Fraser CM, Koob GF, Vendruscolo LF, Leggio L.

J Neuroendocrinol. 2019 Jul;31(7):e12663. doi: 10.1111/jne.12663. Epub 2019 Jan 16.


Baclofen for the treatment of alcohol use disorder: the Cagliari Statement.

Agabio R, Sinclair JM, Addolorato G, Aubin HJ, Beraha EM, Caputo F, Chick JD, de La Selle P, Franchitto N, Garbutt JC, Haber PS, Heydtmann M, Jaury P, Lingford-Hughes AR, Morley KC, Müller CA, Owens L, Pastor A, Paterson LM, Pélissier F, Rolland B, Stafford A, Thompson A, van den Brink W, de Beaurepaire R, Leggio L.

Lancet Psychiatry. 2018 Dec;5(12):957-960. doi: 10.1016/S2215-0366(18)30303-1. Epub 2018 Nov 6. No abstract available.


Baclofen and alcohol in France - Authors' reply.

Agabio R, Sinclair JM, Leggio L; Cagliari group.

Lancet Psychiatry. 2018 Dec;5(12):962-963. doi: 10.1016/S2215-0366(18)30433-4. Epub 2018 Nov 6. No abstract available.


Gabapentin Enacarbil Extended-Release for Alcohol Use Disorder: A Randomized, Double-Blind, Placebo-Controlled, Multisite Trial Assessing Efficacy and Safety.

Falk DE, Ryan ML, Fertig JB, Devine EG, Cruz R, Brown ES, Burns H, Salloum IM, Newport DJ, Mendelson J, Galloway G, Kampman K, Brooks C, Green AI, Brunette MF, Rosenthal RN, Dunn KE, Strain EC, Ray L, Shoptaw S, Ait-Daoud Tiouririne N, Gunderson EW, Ransom J, Scott C, Leggio L, Caras S, Mason BJ, Litten RZ; National Institute on Alcohol Abuse and Alcoholism Clinical Investigations Group (NCIG) Study Group.

Alcohol Clin Exp Res. 2019 Jan;43(1):158-169. doi: 10.1111/acer.13917. Epub 2018 Dec 9.


Reduced plasma ghrelin concentrations are associated with decreased brain reactivity to food cues after laparoscopic sleeve gastrectomy.

Li G, Ji G, Hu Y, Liu L, Jin Q, Zhang W, Liu L, Wang Y, Zhao J, von Deneen KM, Chen A, Cui G, Han Y, Wang H, Zhao Q, Wu K, Wiers CE, Tomasi D, Leggio L, Volkow ND, Nie Y, Zhang Y, Wang GJ.

Psychoneuroendocrinology. 2019 Feb;100:229-236. doi: 10.1016/j.psyneuen.2018.10.022. Epub 2018 Oct 25.


A deeper insight into how GABA-B receptor agonism via baclofen may affect alcohol seeking and consumption: lessons learned from a human laboratory investigation.

Farokhnia M, Deschaine SL, Sadighi A, Farinelli LA, Lee MR, Akhlaghi F, Leggio L.

Mol Psychiatry. 2018 Oct 31. doi: 10.1038/s41380-018-0287-y. [Epub ahead of print]


Recent insights into lytic polysaccharide monooxygenases (LPMOs).

Tandrup T, Frandsen KEH, Johansen KS, Berrin JG, Lo Leggio L.

Biochem Soc Trans. 2018 Dec 17;46(6):1431-1447. doi: 10.1042/BST20170549. Epub 2018 Oct 31. Review.


Alcohol and Alcoholism: Then, Now and The Future of 'The Red Journal'.

Leggio L, de Witte P, Chick J.

Alcohol Alcohol. 2018 Nov 1;53(6):637-638. doi: 10.1093/alcalc/agy075. No abstract available.


Baclofen in the Treatment of Patients With Alcohol Use Disorder and Other Mental Health Disorders.

Agabio R, Leggio L.

Front Psychiatry. 2018 Sep 28;9:464. doi: 10.3389/fpsyt.2018.00464. eCollection 2018. Review.


Reliability of a Novel Video-Based Method for Assessing Age-Related Changes in Upper Limb Kinematics.

Pupo DA, Kakareka JW, Krynitsky J, Leggio L, Pohida T, Studenski S, Harvey BK.

Front Aging Neurosci. 2018 Sep 24;10:281. doi: 10.3389/fnagi.2018.00281. eCollection 2018.


Structure of a lytic polysaccharide monooxygenase from Aspergillus fumigatus and an engineered thermostable variant.

Lo Leggio L, Weihe CD, Poulsen JN, Sweeney M, Rasmussen F, Lin J, De Maria L, Wogulis M.

Carbohydr Res. 2018 Nov;469:55-59. doi: 10.1016/j.carres.2018.08.009. Epub 2018 Aug 14.


Recruitment and Retention of Community Preceptors.

Ryan MS, Leggio LE, Peltier CB, Chatterjee A, Arenberg S, Byerley JS, Belkowitz JL, Rabalais GP, Barone MA.

Pediatrics. 2018 Sep;142(3). pii: e20180673. doi: 10.1542/peds.2018-0673. Epub 2018 Aug 16.


Extracellular esterase activity as an indicator of endoplasmic reticulum calcium depletion.

Trychta KA, Heathward EJ, Sulima A, Bäck S, Farokhnia M, Richie CT, Leggio L, Rice KC, Harvey BK.

Biomarkers. 2018 Dec;23(8):756-765. doi: 10.1080/1354750X.2018.1490968. Epub 2018 Aug 10.


Biochemical and structural features of diverse bacterial glucuronoyl esterases facilitating recalcitrant biomass conversion.

Arnling Bååth J, Mazurkewich S, Knudsen RM, Poulsen JN, Olsson L, Lo Leggio L, Larsbrink J.

Biotechnol Biofuels. 2018 Aug 1;11:213. doi: 10.1186/s13068-018-1213-x. eCollection 2018.


Pharmacological manipulation of the ghrelin system and alcohol hangover symptoms in heavy drinking individuals: Is there a link?

Farokhnia M, Lee MR, Farinelli LA, Ramchandani VA, Akhlaghi F, Leggio L.

Pharmacol Biochem Behav. 2018 Sep;172:39-49. doi: 10.1016/j.pbb.2018.07.004. Epub 2018 Jul 17.


N-acetyl cysteine in the treatment of alcohol use disorder in patients with liver disease: Rationale for further research.

Morley KC, Baillie A, Van Den Brink W, Chitty KE, Brady K, Back SE, Seth D, Sutherland G, Leggio L, Haber PS.

Expert Opin Investig Drugs. 2018 Aug;27(8):667-675. doi: 10.1080/13543784.2018.1501471. Epub 2018 Aug 1. Review.


Identifying and Characterizing Subpopulations of Heavy Alcohol Drinkers Via a Sucrose Preference Test: A Sweet Road to a Better Phenotypic Characterization?

Bouhlal S, Farokhnia M, Lee MR, Akhlaghi F, Leggio L.

Alcohol Alcohol. 2018 Sep 1;53(5):560-569. doi: 10.1093/alcalc/agy048.


Oxytocin receptor mRNA expression in dorsolateral prefrontal cortex in major psychiatric disorders: A human post-mortem study.

Lee MR, Sheskier MB, Farokhnia M, Feng N, Marenco S, Lipska BK, Leggio L.

Psychoneuroendocrinology. 2018 Oct;96:143-147. doi: 10.1016/j.psyneuen.2018.05.039. Epub 2018 May 30.


NCAM2 Fibronectin type-III domains form a rigid structure that binds and activates the Fibroblast Growth Factor Receptor.

Rasmussen KK, Falkesgaard MH, Winther M, Roed NK, Quistgaard CL, Teisen MN, Edslev SM, Petersen DL, Aljubouri A, Christensen C, Thulstrup PW, Lo Leggio L, Teilum K, Walmod PS.

Sci Rep. 2018 Jun 12;8(1):8957. doi: 10.1038/s41598-018-27089-7.


Repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex may improve symptoms of anhedonia in individuals with cocaine use disorder: A pilot study.

Pettorruso M, Spagnolo PA, Leggio L, Janiri L, Di Giannantonio M, Gallimberti L, Bonci A, Martinotti G.

Brain Stimul. 2018 Sep - Oct;11(5):1195-1197. doi: 10.1016/j.brs.2018.06.001. Epub 2018 Jun 5. No abstract available.


Stress, Motivation, and the Gut-Brain Axis: A Focus on the Ghrelin System and Alcohol Use Disorder.

Morris LS, Voon V, Leggio L.

Alcohol Clin Exp Res. 2018 May 24. doi: 10.1111/acer.13781. [Epub ahead of print] Review.


The novel ghrelin receptor inverse agonist PF-5190457 administered with alcohol: preclinical safety experiments and a phase 1b human laboratory study.

Lee MR, Tapocik JD, Ghareeb M, Schwandt ML, Dias AA, Le AN, Cobbina E, Farinelli LA, Bouhlal S, Farokhnia M, Heilig M, Akhlaghi F, Leggio L.

Mol Psychiatry. 2018 May 4. doi: 10.1038/s41380-018-0064-y. [Epub ahead of print]


Corrigendum: Comparing and Combining Topiramate and Aripiprazole on Alcohol-Related Outcomes in a Human Laboratory Study.

Haass-Koffler CL, Goodyear K, Zywiak WH, Leggio L, Kenna GA, Swift RM.

Alcohol Alcohol. 2018 Jul 1;53(4):500. doi: 10.1093/alcalc/agy030. No abstract available.


Structure of a hyperthermostable carbonic anhydrase identified from an active hydrothermal vent chimney.

Fredslund F, Borchert MS, Poulsen JN, Mortensen SB, Perner M, Streit WR, Lo Leggio L.

Enzyme Microb Technol. 2018 Jul;114:48-54. doi: 10.1016/j.enzmictec.2018.03.009. Epub 2018 Mar 30.


Structural basis of the bacteriophage TP901-1 CI repressor dimerization and interaction with DNA.

Rasmussen KK, Varming AK, Schmidt SN, Frandsen KEH, Thulstrup PW, Jensen MR, Lo Leggio L.

FEBS Lett. 2018 May;592(10):1738-1750. doi: 10.1002/1873-3468.13060. Epub 2018 May 13.


Neuroendocrine response to GABA-B receptor agonism in alcohol-dependent individuals: Results from a combined outpatient and human laboratory experiment.

Farokhnia M, Sheskier MB, Lee MR, Le AN, Singley E, Bouhlal S, Ton T, Zhao Z, Leggio L.

Neuropharmacology. 2018 Jul 15;137:230-239. doi: 10.1016/j.neuropharm.2018.04.011. Epub 2018 Apr 14.


Mechanism of translation control of the alternative Drosophila melanogaster Voltage Dependent Anion-selective Channel 1 mRNAs.

Leggio L, Guarino F, Magrì A, Accardi-Gheit R, Reina S, Specchia V, Damiano F, Tomasello MF, Tommasino M, Messina A.

Sci Rep. 2018 Mar 28;8(1):5347. doi: 10.1038/s41598-018-23730-7.


Microglia Polarization, Gene-Environment Interactions and Wnt/β-Catenin Signaling: Emerging Roles of Glia-Neuron and Glia-Stem/Neuroprogenitor Crosstalk for Dopaminergic Neurorestoration in Aged Parkinsonian Brain.

L'Episcopo F, Tirolo C, Serapide MF, Caniglia S, Testa N, Leggio L, Vivarelli S, Iraci N, Pluchino S, Marchetti B.

Front Aging Neurosci. 2018 Feb 12;10:12. doi: 10.3389/fnagi.2018.00012. eCollection 2018. Review.

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