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Items: 1 to 50 of 56

1.

Computational systems biology approach to identify novel pharmacological targets for diabetic retinopathy.

Platania CBM, Leggio GM, Drago F, Salomone S, Bucolo C.

Biochem Pharmacol. 2018 Sep 14. pii: S0006-2952(18)30398-8. doi: 10.1016/j.bcp.2018.09.016. [Epub ahead of print]

PMID:
30222965
2.

Retinal Protection and Distribution of Curcumin in Vitro and in Vivo.

Platania CBM, Fidilio A, Lazzara F, Piazza C, Geraci F, Giurdanella G, Leggio GM, Salomone S, Drago F, Bucolo C.

Front Pharmacol. 2018 Jun 22;9:670. doi: 10.3389/fphar.2018.00670. eCollection 2018.

3.

International Union of Basic and Clinical Pharmacology CIV: The Neurobiology of Treatment-resistant Depression: From Antidepressant Classifications to Novel Pharmacological Targets.

Caraci F, Calabrese F, Molteni R, Bartova L, Dold M, Leggio GM, Fabbri C, Mendlewicz J, Racagni G, Kasper S, Riva MA, Drago F.

Pharmacol Rev. 2018 Jul;70(3):475-504. doi: 10.1124/pr.117.014977.

PMID:
29884653
4.

Identification of Dysregulated microRNA Networks in Schwann Cell-Like Cultures Exposed to Immune Challenge: Potential Crosstalk with the Protective VIP/PACAP Neuropeptide System.

Musumeci G, Leggio GM, Marzagalli R, Al-Badri G, Drago F, Castorina A.

Int J Mol Sci. 2018 Mar 25;19(4). pii: E981. doi: 10.3390/ijms19040981.

5.

Tackling dipeptidyl peptidase IV in neurological disorders.

Al-Badri G, Leggio GM, Musumeci G, Marzagalli R, Drago F, Castorina A.

Neural Regen Res. 2018 Jan;13(1):26-34. doi: 10.4103/1673-5374.224365. Review.

6.

Neurobiological links between depression and AD: The role of TGF-β1 signaling as a new pharmacological target.

Caraci F, Spampinato SF, Morgese MG, Tascedda F, Salluzzo MG, Giambirtone MC, Caruso G, Munafò A, Torrisi SA, Leggio GM, Trabace L, Nicoletti F, Drago F, Sortino MA, Copani A.

Pharmacol Res. 2018 Apr;130:374-384. doi: 10.1016/j.phrs.2018.02.007. Epub 2018 Feb 10. Review.

PMID:
29438781
7.

Buspirone Counteracts MK-801-Induced Schizophrenia-Like Phenotypes through Dopamine D3 Receptor Blockade.

Torrisi SA, Salomone S, Geraci F, Caraci F, Bucolo C, Drago F, Leggio GM.

Front Pharmacol. 2017 Oct 4;8:710. doi: 10.3389/fphar.2017.00710. eCollection 2017.

8.

Topical Ocular Delivery of TGF-β1 to the Back of the Eye: Implications in Age-Related Neurodegenerative Diseases.

Platania CBM, Fisichella V, Fidilio A, Geraci F, Lazzara F, Leggio GM, Salomone S, Drago F, Pignatello R, Caraci F, Bucolo C.

Int J Mol Sci. 2017 Sep 30;18(10). pii: E2076. doi: 10.3390/ijms18102076.

9.

Sulodexide prevents activation of the PLA2/COX-2/VEGF inflammatory pathway in human retinal endothelial cells by blocking the effect of AGE/RAGE.

Giurdanella G, Lazzara F, Caporarello N, Lupo G, Anfuso CD, Eandi CM, Leggio GM, Drago F, Bucolo C, Salomone S.

Biochem Pharmacol. 2017 Oct 15;142:145-154. doi: 10.1016/j.bcp.2017.06.130. Epub 2017 Jun 23.

PMID:
28651842
10.

P2X7 receptor antagonism: Implications in diabetic retinopathy.

Platania CBM, Giurdanella G, Di Paola L, Leggio GM, Drago F, Salomone S, Bucolo C.

Biochem Pharmacol. 2017 Aug 15;138:130-139. doi: 10.1016/j.bcp.2017.05.001. Epub 2017 May 4.

PMID:
28479300
11.

New drugs in psychiatry: focus on new pharmacological targets.

Caraci F, Leggio GM, Salomone S, Drago F.

F1000Res. 2017 Mar 30;6:397. doi: 10.12688/f1000research.10233.1. eCollection 2017. Review.

12.

Fluoxetine Prevents Aβ1-42-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth-Factor-β1.

Caraci F, Tascedda F, Merlo S, Benatti C, Spampinato SF, Munafò A, Leggio GM, Nicoletti F, Brunello N, Drago F, Sortino MA, Copani A.

Front Pharmacol. 2016 Oct 25;7:389. eCollection 2016.

13.

Nanosystems based on siRNA silencing HuR expression counteract diabetic retinopathy in rat.

Amadio M, Pascale A, Cupri S, Pignatello R, Osera C, D Agata V, D Amico AG, Leggio GM, Ruozi B, Govoni S, Drago F, Bucolo C.

Pharmacol Res. 2016 Sep;111:713-720. doi: 10.1016/j.phrs.2016.07.042. Epub 2016 Jul 27.

PMID:
27475885
14.

Current drug treatments targeting dopamine D3 receptor.

Leggio GM, Bucolo C, Platania CB, Salomone S, Drago F.

Pharmacol Ther. 2016 Sep;165:164-77. doi: 10.1016/j.pharmthera.2016.06.007. Epub 2016 Jun 22. Review.

PMID:
27343365
15.

The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ß1-42 oligomers in mice.

Leggio GM, Catania MV, Puzzo D, Spatuzza M, Pellitteri R, Gulisano W, Torrisi SA, Giurdanella G, Piazza C, Impellizzeri AR, Gozzo L, Navarria A, Bucolo C, Nicoletti F, Palmeri A, Salomone S, Copani A, Caraci F, Drago F.

Pharmacol Res. 2016 Apr;106:10-20. doi: 10.1016/j.phrs.2016.02.007. Epub 2016 Feb 10.

PMID:
26875816
16.

TGF-β1 prevents rat retinal insult induced by amyloid-β (1-42) oligomers.

Fisichella V, Giurdanella G, Platania CB, Romano GL, Leggio GM, Salomone S, Drago F, Caraci F, Bucolo C.

Eur J Pharmacol. 2016 Sep 15;787:72-7. doi: 10.1016/j.ejphar.2016.02.002. Epub 2016 Feb 2.

PMID:
26845696
17.

Genetic blockade of the dopamine D3 receptor enhances hippocampal expression of PACAP and receptors and alters their cortical distribution.

Marzagalli R, Leggio GM, Bucolo C, Pricoco E, Keay KA, Cardile V, Castorina S, Salomone S, Drago F, Castorina A.

Neuroscience. 2016 Mar 1;316:279-95. doi: 10.1016/j.neuroscience.2015.12.034. Epub 2015 Dec 21.

PMID:
26718601
18.

Effects of Topical Fucosyl-Lactose, a Milk Oligosaccharide, on Dry Eye Model: An Example of Nutraceutical Candidate.

Bucolo C, Musumeci M, Salomone S, Romano GL, Leggio GM, Gagliano C, Reibaldi M, Avitabile T, Uva MG, Musumeci S, Drago F.

Front Pharmacol. 2015 Nov 18;6:280. doi: 10.3389/fphar.2015.00280. eCollection 2015.

19.

Molecular features of interaction between VEGFA and anti-angiogenic drugs used in retinal diseases: a computational approach.

Platania CB, Di Paola L, Leggio GM, Romano GL, Drago F, Salomone S, Bucolo C.

Front Pharmacol. 2015 Oct 29;6:248. doi: 10.3389/fphar.2015.00248. eCollection 2015. Erratum in: Front Pharmacol. 2016;7:165.

20.

Dopamine D3 receptor-dependent changes in alpha6 GABAA subunit expression in striatum modulate anxiety-like behaviour: Responsiveness and tolerance to diazepam.

Leggio GM, Torrisi SA, Castorina A, Platania CB, Impellizzeri AA, Fidilio A, Caraci F, Bucolo C, Drago F, Salomone S.

Eur Neuropsychopharmacol. 2015 Sep;25(9):1427-36. doi: 10.1016/j.euroneuro.2014.11.004. Epub 2014 Nov 15.

PMID:
25482686
21.

The dual blocker of FAAH/TRPV1 N-arachidonoylserotonin reverses the behavioral despair induced by stress in rats and modulates the HPA-axis.

Navarria A, Tamburella A, Iannotti FA, Micale V, Camillieri G, Gozzo L, Verde R, Imperatore R, Leggio GM, Drago F, Di Marzo V.

Pharmacol Res. 2014 Sep;87:151-9. doi: 10.1016/j.phrs.2014.04.014. Epub 2014 May 23.

PMID:
24861565
22.

Dopamine D3 receptor is necessary for ethanol consumption: an approach with buspirone.

Leggio GM, Camillieri G, Platania CB, Castorina A, Marrazzo G, Torrisi SA, Nona CN, D'Agata V, Nobrega J, Stark H, Bucolo C, Le Foll B, Drago F, Salomone S.

Neuropsychopharmacology. 2014 Jul;39(8):2017-28. doi: 10.1038/npp.2014.51. Epub 2014 Mar 3.

23.

Increased hippocampal CREB phosphorylation in dopamine D3 receptor knockout mice following passive avoidance conditioning.

D'Amico AG, Scuderi S, Leggio GM, Castorina A, Drago F, D'Agata V.

Neurochem Res. 2013 Dec;38(12):2516-23. doi: 10.1007/s11064-013-1164-3. Epub 2013 Oct 8.

PMID:
24100927
24.

Regulation of intraocular pressure in mice: structural analysis of dopaminergic and serotonergic systems in response to cabergoline.

Platania CB, Leggio GM, Drago F, Salomone S, Bucolo C.

Biochem Pharmacol. 2013 Nov 1;86(9):1347-56. doi: 10.1016/j.bcp.2013.08.010. Epub 2013 Aug 17.

PMID:
23962442
25.

Clinical pharmacology of novel anti-Alzheimer disease modifying medications.

Caraci F, Bosco P, Leggio GM, Malaguarnera M, Drago F, Bucolo C, Salomone S.

Curr Top Med Chem. 2013;13(15):1853-63. Review.

PMID:
23931438
26.

Dopamine D3 receptor deletion increases tissue plasminogen activator (tPA) activity in prefrontal cortex and hippocampus.

Castorina A, D'Amico AG, Scuderi S, Leggio GM, Drago F, D'Agata V.

Neuroscience. 2013 Oct 10;250:546-56. doi: 10.1016/j.neuroscience.2013.07.053. Epub 2013 Jul 29.

PMID:
23906635
27.

Dopamine D(3) receptor as a new pharmacological target for the treatment of depression.

Leggio GM, Salomone S, Bucolo C, Platania C, Micale V, Caraci F, Drago F.

Eur J Pharmacol. 2013 Nov 5;719(1-3):25-33. doi: 10.1016/j.ejphar.2013.07.022. Epub 2013 Jul 18. Review.

PMID:
23872400
28.

Fortified extract of red berry, Ginkgo biloba, and white willow bark in experimental early diabetic retinopathy.

Bucolo C, Marrazzo G, Platania CB, Drago F, Leggio GM, Salomone S.

J Diabetes Res. 2013;2013:432695. doi: 10.1155/2013/432695. Epub 2013 May 23.

29.

Hippocampal neurofibromin and amyloid precursor protein expression in dopamine D3 receptor knock-out mice following passive avoidance conditioning.

D'Amico AG, Castorina A, Leggio GM, Drago F, D'Agata V.

Neurochem Res. 2013 Mar;38(3):564-72. doi: 10.1007/s11064-012-0949-0. Epub 2012 Dec 16.

PMID:
23242790
30.

Homology modeling of dopamine D2 and D3 receptors: molecular dynamics refinement and docking evaluation.

Platania CB, Salomone S, Leggio GM, Drago F, Bucolo C.

PLoS One. 2012;7(9):e44316. doi: 10.1371/journal.pone.0044316. Epub 2012 Sep 6. Erratum in: PLoS One. 2013;8(1). doi:10.1371/annotation/bd61cc74-2a2c-4433-a78d-84fa2310e919.

31.

Epigenetic drugs for Alzheimer's disease: hopes and challenges.

Caraci F, Leggio GM, Drago F, Salomone S.

Br J Clin Pharmacol. 2013 Apr;75(4):1154-5. doi: 10.1111/j.1365-2125.2012.04443.x. No abstract available.

32.

Behavioural and neurochemical changes induced by stress-related conditions are counteracted by the neurokinin-2 receptor antagonist saredutant.

Tamburella A, Leggio GM, Micale V, Navarria A, Bucolo C, Cicirata V, Drago F, Salomone S.

Int J Neuropsychopharmacol. 2013 May;16(4):813-23. doi: 10.1017/S1461145712000612. Epub 2012 Jun 14.

PMID:
22695046
33.

Eriodictyol prevents early retinal and plasma abnormalities in streptozotocin-induced diabetic rats.

Bucolo C, Leggio GM, Drago F, Salomone S.

Biochem Pharmacol. 2012 Jul 1;84(1):88-92. doi: 10.1016/j.bcp.2012.03.019. Epub 2012 Mar 30.

PMID:
22484312
34.

Dopamine-₃ receptor modulates intraocular pressure: implications for glaucoma.

Bucolo C, Leggio GM, Maltese A, Castorina A, D'Agata V, Drago F.

Biochem Pharmacol. 2012 Mar 1;83(5):680-6. doi: 10.1016/j.bcp.2011.11.031. Epub 2011 Dec 8.

PMID:
22178719
35.

New pharmacological strategies for treatment of Alzheimer's disease: focus on disease modifying drugs.

Salomone S, Caraci F, Leggio GM, Fedotova J, Drago F.

Br J Clin Pharmacol. 2012 Apr;73(4):504-17. doi: 10.1111/j.1365-2125.2011.04134.x. Review.

36.

Tin chloride enhances parvalbumin-positive interneuron survival by modulating heme metabolism in a model of cerebral ischemia.

Li Volti G, Zappalà A, Leggio GM, Mazzola C, Drago F, La Delia F, Serapide MF, Pellitteri R, Giannone I, Spatuzza M, Cicirata V, Cicirata F.

Neurosci Lett. 2011 Mar 29;492(1):33-8. doi: 10.1016/j.neulet.2011.01.048. Epub 2011 Jan 27.

PMID:
21276833
37.

Neurofibromin and amyloid precursor protein expression in dopamine D3 receptor knock-out mice brains.

Castorina A, Leggio GM, Giunta S, Magro G, Scapagnini G, Drago F, D'Agata V.

Neurochem Res. 2011 Mar;36(3):426-34. doi: 10.1007/s11064-010-0359-0. Epub 2010 Dec 19.

PMID:
21170735
38.

Dopamine D3 receptor knock-out mice exhibit increased behavioral sensitivity to the anxiolytic drug diazepam.

Leggio GM, Micale V, Le Foll B, Mazzola C, Nobrega JN, Drago F.

Eur Neuropsychopharmacol. 2011 Apr;21(4):325-32. doi: 10.1016/j.euroneuro.2010.05.006. Epub 2010 Jun 8.

PMID:
20627473
39.

The PKCbeta/HuR/VEGF pathway in diabetic retinopathy.

Amadio M, Bucolo C, Leggio GM, Drago F, Govoni S, Pascale A.

Biochem Pharmacol. 2010 Oct 15;80(8):1230-7. doi: 10.1016/j.bcp.2010.06.033. Epub 2010 Jul 1.

PMID:
20599775
40.

The beta3 adrenoceptor agonist, amibegron (SR58611A) counteracts stress-induced behavioral and neurochemical changes.

Tamburella A, Micale V, Leggio GM, Drago F.

Eur Neuropsychopharmacol. 2010 Oct;20(10):704-13. doi: 10.1016/j.euroneuro.2010.04.006. Epub 2010 May 26.

PMID:
20537869
41.

Enhanced cognitive performance of dopamine D3 receptor "knock-out" mice in the step-through passive-avoidance test: assessing the role of the endocannabinoid/endovanilloid systems.

Micale V, Cristino L, Tamburella A, Petrosino S, Leggio GM, Di Marzo V, Drago F.

Pharmacol Res. 2010 Jun;61(6):531-6. doi: 10.1016/j.phrs.2010.02.003. Epub 2010 Feb 10.

PMID:
20149873
42.

In vivo evidence that constitutive activity of serotonin2C receptors in the medial prefrontal cortex participates in the control of dopamine release in the rat nucleus accumbens: differential effects of inverse agonist versus antagonist.

Leggio GM, Cathala A, Neny M, Rouge-Pont F, Drago F, Piazza PV, Spampinato U.

J Neurochem. 2009 Oct;111(2):614-23. doi: 10.1111/j.1471-4159.2009.06356.x. Epub 2009 Aug 22.

43.

Altered responses of dopamine D3 receptor null mice to excitotoxic or anxiogenic stimuli: Possible involvement of the endocannabinoid and endovanilloid systems.

Micale V, Cristino L, Tamburella A, Petrosino S, Leggio GM, Drago F, Di Marzo V.

Neurobiol Dis. 2009 Oct;36(1):70-80. doi: 10.1016/j.nbd.2009.06.015. Epub 2009 Jul 8.

PMID:
19591935
44.

A water-soluble carbon monoxide-releasing molecule (CORM-3) lowers intraocular pressure in rabbits.

Stagni E, Privitera MG, Bucolo C, Leggio GM, Motterlini R, Drago F.

Br J Ophthalmol. 2009 Feb;93(2):254-7. doi: 10.1136/bjo.2007.137034. Epub 2008 Oct 31.

PMID:
18977789
45.

Serotonin2C receptors in the medial prefrontal cortex facilitate cocaine-induced dopamine release in the rat nucleus accumbens.

Leggio GM, Cathala A, Moison D, Cunningham KA, Piazza PV, Spampinato U.

Neuropharmacology. 2009 Feb;56(2):507-13. doi: 10.1016/j.neuropharm.2008.10.005. Epub 2008 Oct 17.

46.

Parkin expression profile in dopamine d3 receptor knock-out mice brains.

D'Agata V, Tiralongo A, Castorina A, Leggio GM, Micale V, Carnazza ML, Drago F.

Neurochem Res. 2009 Feb;34(2):327-32. doi: 10.1007/s11064-008-9781-y. Epub 2008 Jul 9.

PMID:
18612813
47.

Anxiolytic effects in mice of a dual blocker of fatty acid amide hydrolase and transient receptor potential vanilloid type-1 channels.

Micale V, Cristino L, Tamburella A, Petrosino S, Leggio GM, Drago F, Di Marzo V.

Neuropsychopharmacology. 2009 Feb;34(3):593-606. doi: 10.1038/npp.2008.98. Epub 2008 Jun 25.

48.

Behavioral effects of saredutant, a tachykinin NK2 receptor antagonist, in experimental models of mood disorders under basal and stress-related conditions.

Micale V, Tamburella A, Leggio GM, Mazzola C, Li Volsi V, Drago F.

Pharmacol Biochem Behav. 2008 Sep;90(3):463-9. doi: 10.1016/j.pbb.2008.04.003. Epub 2008 Apr 12.

PMID:
18495229
49.

Influence of inulin on plasma isoflavone concentrations in healthy postmenopausal women.

Piazza C, Privitera MG, Melilli B, Incognito T, Marano MR, Leggio GM, Roxas MA, Drago F.

Am J Clin Nutr. 2007 Sep;86(3):775-80.

PMID:
17823445
50.

Increased sensitivity to antidepressants of D3 dopamine receptor-deficient mice in the forced swim test (FST).

Leggio GM, Micale V, Drago F.

Eur Neuropsychopharmacol. 2008 Apr;18(4):271-7. Epub 2007 Sep 4.

PMID:
17804207

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