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Kinetics and Phenotype of the CD4 T Cell Response to Influenza Virus Infections.

Hornick EE, Zacharias ZR, Legge KL.

Front Immunol. 2019 Oct 2;10:2351. doi: 10.3389/fimmu.2019.02351. eCollection 2019.


Dendritic cell NLRC4 regulates influenza A virus-specific CD4 T cell responses through FasL expression.

Hornick EE, Dagvadorj J, Zacharias ZR, Miller AM, Langlois RA, Chen P, Legge KL, Bishop GA, Sutterwala FS, Cassel SL.

J Clin Invest. 2019 Apr 30;129(7):2888-2897. doi: 10.1172/JCI124937.


Polyanhydride Nanovaccine Induces Robust Pulmonary B and T Cell Immunity and Confers Protection Against Homologous and Heterologous Influenza A Virus Infections.

Zacharias ZR, Ross KA, Hornick EE, Goodman JT, Narasimhan B, Waldschmidt TJ, Legge KL.

Front Immunol. 2018 Aug 28;9:1953. doi: 10.3389/fimmu.2018.01953. eCollection 2018.


Natural Killer Cell Recruitment to the Lung During Influenza A Virus Infection Is Dependent on CXCR3, CCR5, and Virus Exposure Dose.

Carlin LE, Hemann EA, Zacharias ZR, Heusel JW, Legge KL.

Front Immunol. 2018 Apr 17;9:781. doi: 10.3389/fimmu.2018.00781. eCollection 2018.


Nlrp12 Mediates Adverse Neutrophil Recruitment during Influenza Virus Infection.

Hornick EE, Banoth B, Miller AM, Zacharias ZR, Jain N, Wilson ME, Gibson-Corley KN, Legge KL, Bishop GA, Sutterwala FS, Cassel SL.

J Immunol. 2018 Feb 1;200(3):1188-1197. doi: 10.4049/jimmunol.1700999. Epub 2017 Dec 27.


Antigen Exposure History Defines CD8 T Cell Dynamics and Protection during Localized Pulmonary Infections.

Van Braeckel-Budimir N, Martin MD, Hartwig SM, Legge KL, Badovinac VP, Harty JT.

Front Immunol. 2017 Jan 27;8:40. doi: 10.3389/fimmu.2017.00040. eCollection 2017.


Polymicrobial Sepsis Diminishes Dendritic Cell Numbers and Function Directly Contributing to Impaired Primary CD8 T Cell Responses In Vivo.

Strother RK, Danahy DB, Kotov DI, Kucaba TA, Zacharias ZR, Griffith TS, Legge KL, Badovinac VP.

J Immunol. 2016 Dec 1;197(11):4301-4311. Epub 2016 Oct 26.


Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment.

Ulland TK, Jain N, Hornick EE, Elliott EI, Clay GM, Sadler JJ, Mills KA, Janowski AM, Volk AP, Wang K, Legge KL, Gakhar L, Bourdi M, Ferguson PJ, Wilson ME, Cassel SL, Sutterwala FS.

Nat Commun. 2016 Oct 25;7:13180. doi: 10.1038/ncomms13180.


Plasmacytoid Dendritic Cells Require Direct Infection To Sustain the Pulmonary Influenza A Virus-Specific CD8 T Cell Response.

Hemann EA, Sjaastad LE, Langlois RA, Legge KL.

J Virol. 2015 Dec 30;90(6):2830-7. doi: 10.1128/JVI.02546-15.


Vaccine technologies against avian influenza: current approaches and new directions.

Ross KA, Huntimer LM, Vela Ramirez JE, Adams JR, Carpenter SL, Kohut ML, Bronich T, Webby R, Legge KL, Mallapragadal SK, Wannemuehler MJ, Narasimhan B.

J Biomed Nanotechnol. 2014 Sep;10(9):2261-94. Review.


Diet-induced obesity does not impact the generation and maintenance of primary memory CD8 T cells.

Khan SH, Hemann EA, Legge KL, Norian LA, Badovinac VP.

J Immunol. 2014 Dec 15;193(12):5873-82. doi: 10.4049/jimmunol.1401685. Epub 2014 Nov 5.


Chronic ethanol exposure selectively inhibits the influenza-specific CD8 T cell response during influenza a virus infection.

Hemann EA, McGill JL, Legge KL.

Alcohol Clin Exp Res. 2014 Sep;38(9):2403-13. doi: 10.1111/acer.12522. Epub 2014 Aug 26.


Primary and long-term B-cell responses in the upper airway and lung after influenza A virus infection.

Boyden AW, Frickman AM, Legge KL, Waldschmidt TJ.

Immunol Res. 2014 Aug;59(1-3):73-80. doi: 10.1007/s12026-014-8541-0. Review.


Peripheral regulation of T cells by dendritic cells during infection.

Hemann EA, Legge KL.

Immunol Res. 2014 Aug;59(1-3):66-72. doi: 10.1007/s12026-014-8530-3. Review.


Lymphopenia associated with highly virulent H5N1 virus infection due to plasmacytoid dendritic cell-mediated apoptosis of T cells.

Boonnak K, Vogel L, Feldmann F, Feldmann H, Legge KL, Subbarao K.

J Immunol. 2014 Jun 15;192(12):5906-12. doi: 10.4049/jimmunol.1302992. Epub 2014 May 14.


Protective CD8 T cell-mediated immunity against influenza A virus infection following influenza virus-like particle vaccination.

Hemann EA, Kang SM, Legge KL.

J Immunol. 2013 Sep 1;191(5):2486-94. doi: 10.4049/jimmunol.1300954. Epub 2013 Jul 24.


Neurohormonal modulation of the innate immune system is proinflammatory in the prehypertensive spontaneously hypertensive rat, a genetic model of essential hypertension.

Harwani SC, Chapleau MW, Legge KL, Ballas ZK, Abboud FM.

Circ Res. 2012 Oct 12;111(9):1190-7. doi: 10.1161/CIRCRESAHA.112.277475. Epub 2012 Aug 17.


Pulmonary infection with influenza A virus induces site-specific germinal center and T follicular helper cell responses.

Boyden AW, Legge KL, Waldschmidt TJ.

PLoS One. 2012;7(7):e40733. doi: 10.1371/journal.pone.0040733. Epub 2012 Jul 11.


The magnitude of the T cell response to a clinically significant dose of influenza virus is regulated by TRAIL.

Brincks EL, Gurung P, Langlois RA, Hemann EA, Legge KL, Griffith TS.

J Immunol. 2011 Nov 1;187(9):4581-8. doi: 10.4049/jimmunol.1002241. Epub 2011 Sep 21.


T regulatory cells participate in the control of germinal centre reactions.

Alexander CM, Tygrett LT, Boyden AW, Wolniak KL, Legge KL, Waldschmidt TJ.

Immunology. 2011 Aug;133(4):452-68. doi: 10.1111/j.1365-2567.2011.03456.x. Epub 2011 Jun 3.


Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge.

Case AJ, McGill JL, Tygrett LT, Shirasawa T, Spitz DR, Waldschmidt TJ, Legge KL, Domann FE.

Free Radic Biol Med. 2011 Feb 1;50(3):448-58. doi: 10.1016/j.freeradbiomed.2010.11.025. Epub 2010 Dec 2.


Mechanisms by which chronic ethanol feeding limits the ability of dendritic cells to stimulate T-cell proliferation.

Fan J, Edsen-Moore MR, Turner LE, Cook RT, Legge KL, Waldschmidt TJ, Schlueter AJ.

Alcohol Clin Exp Res. 2011 Jan;35(1):47-59. doi: 10.1111/j.1530-0277.2010.01321.x. Epub 2010 Oct 6.


Quantification of the frequency and multiplicity of infection of respiratory- and lymph node-resident dendritic cells during influenza virus infection.

VanoOsten Anderson R, McGill J, Legge KL.

PLoS One. 2010 Sep 23;5(9):e12902. doi: 10.1371/journal.pone.0012902.


Exploiting cross-priming to generate protective CD8 T-cell immunity rapidly.

Pham NL, Pewe LL, Fleenor CJ, Langlois RA, Legge KL, Badovinac VP, Harty JT.

Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12198-203. doi: 10.1073/pnas.1004661107. Epub 2010 Jun 21.


Oseltamivir treatment prevents the increased influenza virus disease severity and lethality occurring in chronic ethanol consuming mice.

Langlois RA, Meyerholz DK, Coleman RA, Cook RT, Waldschmidt TJ, Legge KL.

Alcohol Clin Exp Res. 2010 Aug;34(8):1425-31. doi: 10.1111/j.1530-0277.2010.01226.x. Epub 2010 May 21.


Plasmacytoid dendritic cells enhance mortality during lethal influenza infections by eliminating virus-specific CD8 T cells.

Langlois RA, Legge KL.

J Immunol. 2010 Apr 15;184(8):4440-6. doi: 10.4049/jimmunol.0902984. Epub 2010 Mar 10.


IL-15 trans-presentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection.

McGill J, Van Rooijen N, Legge KL.

J Exp Med. 2010 Mar 15;207(3):521-34. doi: 10.1084/jem.20091711. Epub 2010 Mar 8.


Innate immune control and regulation of influenza virus infections.

McGill J, Heusel JW, Legge KL.

J Leukoc Biol. 2009 Oct;86(4):803-12. doi: 10.1189/jlb.0509368. Epub 2009 Jul 30. Review.


Fetal exposure to ethanol has long-term effects on the severity of influenza virus infections.

McGill J, Meyerholz DK, Edsen-Moore M, Young B, Coleman RA, Schlueter AJ, Waldschmidt TJ, Cook RT, Legge KL.

J Immunol. 2009 Jun 15;182(12):7803-8. doi: 10.4049/jimmunol.0803881.


Chronic ethanol induces inhibition of antigen-specific CD8+ but not CD4+ immunodominant T cell responses following Listeria monocytogenes inoculation.

Gurung P, Young BM, Coleman RA, Wiechert S, Turner LE, Ray NB, Waldschmidt TJ, Legge KL, Cook RT.

J Leukoc Biol. 2009 Jan;85(1):34-43. doi: 10.1189/jlb.0208101. Epub 2008 Sep 26.


CD8 T cells utilize TRAIL to control influenza virus infection.

Brincks EL, Katewa A, Kucaba TA, Griffith TS, Legge KL.

J Immunol. 2008 Oct 1;181(7):4918-25. Erratum in: J Immunol. 2008 Nov 15;181(10)7428.


Influenza-induced expression of functional tumor necrosis factor-related apoptosis-inducing ligand on human peripheral blood mononuclear cells.

Brincks EL, Kucaba TA, Legge KL, Griffith TS.

Hum Immunol. 2008 Oct;69(10):634-46. doi: 10.1016/j.humimm.2008.07.012. Epub 2008 Aug 22.


Protective influenza-specific CD8 T cell responses require interactions with dendritic cells in the lungs.

McGill J, Van Rooijen N, Legge KL.

J Exp Med. 2008 Jul 7;205(7):1635-46. doi: 10.1084/jem.20080314.


Chronic alcohol consumption increases the severity of murine influenza virus infections.

Meyerholz DK, Edsen-Moore M, McGill J, Coleman RA, Cook RT, Legge KL.

J Immunol. 2008 Jul 1;181(1):641-8.


Dendritic cells in chronic in vivo ethanol exposure models.

Legge KL, Schlueter AJ.

Methods Mol Biol. 2008;447:213-33. doi: 10.1007/978-1-59745-242-7_16.


Respiratory dendritic cells: mediators of tolerance and immunity.

Langlois RA, Legge KL.

Immunol Res. 2007;39(1-3):128-45. Review.


Sequential activation of CD8+ T cells in the draining lymph nodes in response to pulmonary virus infection.

Yoon H, Legge KL, Sung SS, Braciale TJ.

J Immunol. 2007 Jul 1;179(1):391-9.


Lymph node dendritic cells control CD8+ T cell responses through regulated FasL expression.

Legge KL, Braciale TJ.

Immunity. 2005 Dec;23(6):649-59. Erratum in: Immunity. 2006 Feb;24(2):231.


On the role of dendritic cells in peripheral T cell tolerance and modulation of autoimmunity.

Legge KL, Gregg RK, Maldonado-Lopez R, Li L, Caprio JC, Moser M, Zaghouani H.

J Exp Med. 2002 Jul 15;196(2):217-27.


Multi-modal antigen specific therapy for autoimmunity.

Legge KL, Bell JJ, Li L, Gregg R, Caprio JC, Zaghouani H.

Int Rev Immunol. 2001 Oct;20(5):593-611. Review.


Neonatal exposure to antigen primes the immune system to develop responses in various lymphoid organs and promotes bystander regulation of diverse T cell specificities.

Pack CD, Cestra AE, Min B, Legge KL, Li L, Caprio-Young JC, Bell JJ, Gregg RK, Zaghouani H.

J Immunol. 2001 Oct 15;167(8):4187-95.


Neonatal tolerant immunity for vaccination against autoimmunity.

Min B, Legge KL, Li L, Caprio JC, Pack CD, Gregg R, McGavin D, Slauson D, Zaghouani H.

Int Rev Immunol. 2000;19(2-3):247-64. Review.


Differential control of neonatal tolerance by antigen dose versus extended exposure and adjuvant.

Min B, Legge KL, Caprio JC, Li L, Gregg R, Zaghouani H.

Cell Immunol. 2000 Feb 25;200(1):45-55.


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