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BCL-3 promotes a cancer stem cell phenotype by enhancing β-catenin signalling in colorectal tumour cells.

Legge DN, Shephard AP, Collard TJ, Greenhough A, Chambers AC, Clarkson RW, Paraskeva C, Williams AC.

Dis Model Mech. 2019 Mar 4;12(3). pii: dmm037697. doi: 10.1242/dmm.037697.


Optimized delivery of siRNA into 3D tumor spheroid cultures in situ.

Morgan RG, Chambers AC, Legge DN, Coles SJ, Greenhough A, Williams AC.

Sci Rep. 2018 May 21;8(1):7952. doi: 10.1038/s41598-018-26253-3.


LGR5 expression is regulated by EGF in early colorectal adenomas and governs EGFR inhibitor sensitivity.

Morgan RG, Mortensson E, Legge DN, Gupta B, Collard TJ, Greenhough A, Williams AC.

Br J Cancer. 2018 Feb 20;118(4):558-565. doi: 10.1038/bjc.2017.412. Epub 2017 Nov 16.

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