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Items: 32

1.

In vitro iCLIP-based modeling uncovers how the splicing factor U2AF2 relies on regulation by cofactors.

Sutandy FXR, Ebersberger S, Huang L, Busch A, Bach M, Kang HS, Fallmann J, Maticzka D, Backofen R, Stadler PF, Zarnack K, Sattler M, Legewie S, König J.

Genome Res. 2018 May;28(5):699-713. doi: 10.1101/gr.229757.117. Epub 2018 Apr 11.

PMID:
29643205
2.

Estrogen-dependent control and cell-to-cell variability of transcriptional bursting.

Fritzsch C, Baumgärtner S, Kuban M, Steinshorn D, Reid G, Legewie S.

Mol Syst Biol. 2018 Feb 23;14(2):e7678. doi: 10.15252/msb.20177678.

3.

Cell-specific responses to the cytokine TGFβ are determined by variability in protein levels.

Strasen J, Sarma U, Jentsch M, Bohn S, Sheng C, Horbelt D, Knaus P, Legewie S, Loewer A.

Mol Syst Biol. 2018 Jan 25;14(1):e7733. doi: 10.15252/msb.20177733.

4.

Sharing of Phosphatases Promotes Response Plasticity in Phosphorylation Cascades.

Ghosh B, Sarma U, Sourjik V, Legewie S.

Biophys J. 2018 Jan 9;114(1):223-236. doi: 10.1016/j.bpj.2017.10.037.

PMID:
29320690
5.

Correlated receptor transport processes buffer single-cell heterogeneity.

Kallenberger SM, Unger AL, Legewie S, Lymperopoulos K, Klingmüller U, Eils R, Herten DP.

PLoS Comput Biol. 2017 Sep 25;13(9):e1005779. doi: 10.1371/journal.pcbi.1005779. eCollection 2017 Sep. Erratum in: PLoS Comput Biol. 2018 Mar 1;14 (3):e1006037.

6.

Modelling Systemic Iron Regulation during Dietary Iron Overload and Acute Inflammation: Role of Hepcidin-Independent Mechanisms.

Enculescu M, Metzendorf C, Sparla R, Hahnel M, Bode J, Muckenthaler MU, Legewie S.

PLoS Comput Biol. 2017 Jan 9;13(1):e1005322. doi: 10.1371/journal.pcbi.1005322. eCollection 2017 Jan.

7.

Identifying Novel Transcriptional Regulators with Circadian Expression.

Schick S, Becker K, Thakurela S, Fournier D, Hampel MH, Legewie S, Tiwari VK.

Mol Cell Biol. 2015 Dec 7;36(4):545-58. doi: 10.1128/MCB.00701-15. Print 2016 Feb 15.

8.

Robust Ordering of Anaphase Events by Adaptive Thresholds and Competing Degradation Pathways.

Kamenz J, Mihaljev T, Kubis A, Legewie S, Hauf S.

Mol Cell. 2015 Nov 5;60(3):446-59. doi: 10.1016/j.molcel.2015.09.022. Epub 2015 Oct 29.

9.

Silence on the relevant literature and errors in implementation.

Bastiaens P, Birtwistle MR, Blüthgen N, Bruggeman FJ, Cho KH, Cosentino C, de la Fuente A, Hoek JB, Kiyatkin A, Klamt S, Kolch W, Legewie S, Mendes P, Naka T, Santra T, Sontag E, Westerhoff HV, Kholodenko BN.

Nat Biotechnol. 2015 Apr;33(4):336-9. doi: 10.1038/nbt.3185. No abstract available.

PMID:
25850052
10.

Intra- and interdimeric caspase-8 self-cleavage controls strength and timing of CD95-induced apoptosis.

Kallenberger SM, Beaudouin J, Claus J, Fischer C, Sorger PK, Legewie S, Eils R.

Sci Signal. 2014 Mar 11;7(316):ra23. doi: 10.1126/scisignal.2004738.

11.

A multi-scale model of hepcidin promoter regulation reveals factors controlling systemic iron homeostasis.

Casanovas G, Banerji A, d'Alessio F, Muckenthaler MU, Legewie S.

PLoS Comput Biol. 2014 Jan;10(1):e1003421. doi: 10.1371/journal.pcbi.1003421. Epub 2014 Jan 2.

12.

Determinants of cell-to-cell variability in protein kinase signaling.

Jeschke M, Baumgärtner S, Legewie S.

PLoS Comput Biol. 2013;9(12):e1003357. doi: 10.1371/journal.pcbi.1003357. Epub 2013 Dec 5.

13.

Robustness of signal transduction pathways.

Blüthgen N, Legewie S.

Cell Mol Life Sci. 2013 Jul;70(13):2259-69. doi: 10.1007/s00018-012-1162-7. Epub 2012 Sep 25. Review.

PMID:
23007845
14.

Multi-target regulation by small RNAs synchronizes gene expression thresholds and may enhance ultrasensitive behavior.

Schmiedel JM, Axmann IM, Legewie S.

PLoS One. 2012;7(8):e42296. doi: 10.1371/journal.pone.0042296. Epub 2012 Aug 21. Erratum in: PLoS One. 2013;8(12). doi:10.1371/annotation/1bf75d98-6104-4ddf-b897-bfc362f95a5f.

15.

Reverse engineering a hierarchical regulatory network downstream of oncogenic KRAS.

Stelniec-Klotz I, Legewie S, Tchernitsa O, Witzel F, Klinger B, Sers C, Herzel H, Blüthgen N, Schäfer R.

Mol Syst Biol. 2012;8:601. doi: 10.1038/msb.2012.32.

16.

Multiparametric image analysis reveals role of Caveolin1 in endosomal progression rather than internalization of EGFR.

Schmidt-Glenewinkel H, Reinz E, Bulashevska S, Beaudouin J, Legewie S, Alonso A, Eils R.

FEBS Lett. 2012 Apr 24;586(8):1179-89. doi: 10.1016/j.febslet.2012.02.041. Epub 2012 Mar 1.

17.

Caspase-8 activity has an essential role in CD95/Fas-mediated MAPK activation.

Kober AM, Legewie S, Pforr C, Fricker N, Eils R, Krammer PH, Lavrik IN.

Cell Death Dis. 2011 Oct 6;2:e212. doi: 10.1038/cddis.2011.93.

18.

Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes development.

Paulsen M, Legewie S, Eils R, Karaulanov E, Niehrs C.

Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10202-7. doi: 10.1073/pnas.1100179108. Epub 2011 Jun 1.

19.

Atypical protein kinase C zeta exhibits a proapoptotic function in ovarian cancer.

Nazarenko I, Jenny M, Keil J, Gieseler C, Weisshaupt K, Sehouli J, Legewie S, Herbst L, Weichert W, Darb-Esfahani S, Dietel M, Schäfer R, Ueberall F, Sers C.

Mol Cancer Res. 2010 Jun;8(6):919-34. doi: 10.1158/1541-7786.MCR-09-0358. Epub 2010 May 25.

20.

Systems-level interactions between insulin-EGF networks amplify mitogenic signaling.

Borisov N, Aksamitiene E, Kiyatkin A, Legewie S, Berkhout J, Maiwald T, Kaimachnikov NP, Timmer J, Hoek JB, Kholodenko BN.

Mol Syst Biol. 2009;5:256. doi: 10.1038/msb.2009.19. Epub 2009 Apr 7.

21.

A systems biological approach suggests that transcriptional feedback regulation by dual-specificity phosphatase 6 shapes extracellular signal-related kinase activity in RAS-transformed fibroblasts.

Blüthgen N, Legewie S, Kielbasa SM, Schramme A, Tchernitsa O, Keil J, Solf A, Vingron M, Schäfer R, Herzel H, Sers C.

FEBS J. 2009 Feb;276(4):1024-35. doi: 10.1111/j.1742-4658.2008.06846.x. Epub 2009 Jan 12.

22.

Kinetic mechanisms for overexpression insensitivity and oncogene cooperation.

Legewie S, Sers C, Herzel H.

FEBS Lett. 2009 Jan 5;583(1):93-6. doi: 10.1016/j.febslet.2008.11.027. Epub 2008 Dec 4.

23.

Systems analysis of MAPK signal transduction.

Blüthgen N, Legewie S.

Essays Biochem. 2008;45:95-107. doi: 10.1042/BSE0450095. Review.

PMID:
18793126
24.

Small RNAs establish delays and temporal thresholds in gene expression.

Legewie S, Dienst D, Wilde A, Herzel H, Axmann IM.

Biophys J. 2008 Oct;95(7):3232-8. doi: 10.1529/biophysj.108.133819. Epub 2008 Jul 3.

25.

A minimal circadian clock model.

Axmann IM, Legewie S, Herzel H.

Genome Inform. 2007;18:54-64.

PMID:
18546474
26.

Recurrent design patterns in the feedback regulation of the mammalian signalling network.

Legewie S, Herzel H, Westerhoff HV, Blüthgen N.

Mol Syst Biol. 2008;4:190. doi: 10.1038/msb.2008.29. Epub 2008 May 6.

27.

A mesoscale model of G1/S phase transition in liver regeneration.

Chauhan A, Legewie S, Westermark PO, Lorenzen S, Herzel H.

J Theor Biol. 2008 Jun 7;252(3):465-73. doi: 10.1016/j.jtbi.2008.01.020. Epub 2008 Feb 1.

PMID:
18339403
28.

Competing docking interactions can bring about bistability in the MAPK cascade.

Legewie S, Schoeberl B, Blüthgen N, Herzel H.

Biophys J. 2007 Oct 1;93(7):2279-88. Epub 2007 May 25.

29.

Mathematical modeling identifies inhibitors of apoptosis as mediators of positive feedback and bistability.

Legewie S, Blüthgen N, Herzel H.

PLoS Comput Biol. 2006 Sep 15;2(9):e120. Epub 2006 Jul 28.

30.

Effects of sequestration on signal transduction cascades.

Blüthgen N, Bruggeman FJ, Legewie S, Herzel H, Westerhoff HV, Kholodenko BN.

FEBS J. 2006 Mar;273(5):895-906.

31.

Ultrasensitization: switch-like regulation of cellular signaling by transcriptional induction.

Legewie S, Blüthgen N, Schäfer R, Herzel H.

PLoS Comput Biol. 2005 Oct;1(5):e54. Epub 2005 Oct 28.

32.

Quantitative analysis of ultrasensitive responses.

Legewie S, Blüthgen N, Herzel H.

FEBS J. 2005 Aug;272(16):4071-9.

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