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Observation of quantum many-body effects due to zero point fluctuations in superconducting circuits.

Léger S, Puertas-Martínez J, Bharadwaj K, Dassonneville R, Delaforce J, Foroughi F, Milchakov V, Planat L, Buisson O, Naud C, Hasch-Guichard W, Florens S, Snyman I, Roch N.

Nat Commun. 2019 Nov 20;10(1):5259. doi: 10.1038/s41467-019-13199-x.


Pairwise visual comparison of small RNA secondary structures with base pair probabilities.

Léger S, Costa MBW, Tulpan D.

BMC Bioinformatics. 2019 May 29;20(1):293. doi: 10.1186/s12859-019-2902-6.


Assessing robustness of radiomic features by image perturbation.

Zwanenburg A, Leger S, Agolli L, Pilz K, Troost EGC, Richter C, Löck S.

Sci Rep. 2019 Jan 24;9(1):614. doi: 10.1038/s41598-018-36938-4.


Risk factors for treatment failure in scabies: a cohort study.

Aussy A, Houivet E, Hébert V, Colas-Cailleux H, Laaengh N, Richard C, Ouvry M, Boulard C, Léger S, Litrowski N, Benichou J, Joly P; investigators from the Normandy Association of Medical Education in Dermatology.

Br J Dermatol. 2019 Apr;180(4):888-893. doi: 10.1111/bjd.17348. Epub 2019 Mar 4.


Preliminary Study to Determinate the Effect of the Rearing Managements Applied during Heifers' Whole Life on Carcass and Flank Steak Quality.

Soulat J, Picard B, Léger S, Ellies-Oury MP, Monteils V.

Foods. 2018 Oct 1;7(10). pii: E160. doi: 10.3390/foods7100160.


CT imaging during treatment improves radiomic models for patients with locally advanced head and neck cancer.

Leger S, Zwanenburg A, Pilz K, Zschaeck S, Zöphel K, Kotzerke J, Schreiber A, Zips D, Krause M, Baumann M, Troost EGC, Richter C, Löck S.

Radiother Oncol. 2019 Jan;130:10-17. doi: 10.1016/j.radonc.2018.07.020. Epub 2018 Aug 4.


In utero exposure to arsenic in tap water and congenital anomalies: A French semi-ecological study.

Marie C, Léger S, Guttmann A, Marchiset N, Rivière O, Perthus I, Lémery D, Vendittelli F, Sauvant-Rochat MP.

Int J Hyg Environ Health. 2018 Sep;221(8):1116-1123. doi: 10.1016/j.ijheh.2018.07.012. Epub 2018 Jul 30.


A screening focusing on aftereffects of alcohol consumption in a student population. A National cross-sectional survey.

Hazart J, Blanquet M, Debost-Legrand A, Perreve A, Leger S, Martoia V, Maurice S, Brousse G, Gerbaud L.

J Prev Med Hyg. 2018 Mar 30;59(1):E48-E62. doi: 10.15167/2421-4248/jpmh2018.59.1.780. eCollection 2018 Mar.


Prediction of beef carcass and meat quality traits from factors characterising the rearing management system applied during the whole life of heifers.

Soulat J, Picard B, Léger S, Monteils V.

Meat Sci. 2018 Jun;140:88-100. doi: 10.1016/j.meatsci.2018.03.009. Epub 2018 Mar 10.


Development and Validation of a Gene Signature for Patients with Head and Neck Carcinomas Treated by Postoperative Radio(chemo)therapy.

Schmidt S, Linge A, Zwanenburg A, Leger S, Lohaus F, Krenn C, Appold S, Gudziol V, Nowak A, von Neubeck C, Tinhofer I, Budach V, Sak A, Stuschke M, Balermpas P, Rödel C, Bunea H, Grosu AL, Abdollahi A, Debus J, Ganswindt U, Belka C, Pigorsch S, Combs SE, Mönnich D, Zips D, Baretton GB, Buchholz F, Baumann M, Krause M, Löck S; DKTK-ROG.

Clin Cancer Res. 2018 Mar 15;24(6):1364-1374. doi: 10.1158/1078-0432.CCR-17-2345. Epub 2018 Jan 3.


Exposure to arsenic in tap water and gestational diabetes: A French semi-ecological study.

Marie C, Léger S, Guttmann A, Rivière O, Marchiset N, Lémery D, Vendittelli F, Sauvant-Rochat MP.

Environ Res. 2018 Feb;161:248-255. doi: 10.1016/j.envres.2017.11.016. Epub 2017 Nov 21.


A comparative study of machine learning methods for time-to-event survival data for radiomics risk modelling.

Leger S, Zwanenburg A, Pilz K, Lohaus F, Linge A, Zöphel K, Kotzerke J, Schreiber A, Tinhofer I, Budach V, Sak A, Stuschke M, Balermpas P, Rödel C, Ganswindt U, Belka C, Pigorsch S, Combs SE, Mönnich D, Zips D, Krause M, Baumann M, Troost EGC, Löck S, Richter C.

Sci Rep. 2017 Oct 16;7(1):13206. doi: 10.1038/s41598-017-13448-3.


The Plant Orthology Browser: An Orthology and Gene-Order Visualizer for Plant Comparative Genomics.

Tulpan D, Leger S.

Plant Genome. 2017 Mar;10(1). doi: 10.3835/plantgenome2016.08.0078.


FDG uptake in normal tissues assessed by PET during treatment has prognostic value for treatment results in head and neck squamous cell carcinomas undergoing radiochemotherapy.

Zschaeck S, Löck S, Leger S, Haase R, Bandurska-Luque A, Appold S, Kotzerke J, Zips D, Richter C, Gudziol V, Schreiber A, Zöphel K, Baumann M, Krause M.

Radiother Oncol. 2017 Mar;122(3):437-444. doi: 10.1016/j.radonc.2017.01.019. Epub 2017 Feb 17.


Effects of tibial intraosseous and intravenous administration of Hextend on time of administration and hemodynamics in a hypovolemic swine model.

Wilson J, Passmore A, Leger S, Lannan J, Bentley M, Johnson D.

Am J Disaster Med. 2016 Summer;11(3):193-201. doi: 10.5055/ajdm.2016.0239.


Smoking during pregnancy: a difficult problem to face. Results of a French multi-center study.

Blanquet M, Leger S, Gerbaud L, Vendittelli F; regional hospital research programme, DATAMATER group and the interregional hospital research programme, CAFE group.

J Prev Med Hyg. 2016;57(2):E95-E101. Review.


Knowledge, opinions and practices of French general practitioners in the assessment of caries risk: results of a national survey.

Doméjean S, Léger S, Simon A, Boucharel N, Holmgren C.

Clin Oral Investig. 2017 Mar;21(2):653-663. doi: 10.1007/s00784-016-1932-y. Epub 2016 Aug 22.


In-vivo heat retention comparison of eyelid warming masks.

Bitton E, Lacroix Z, Léger S.

Cont Lens Anterior Eye. 2016 Aug;39(4):311-5. doi: 10.1016/j.clae.2016.04.002. Epub 2016 May 6.


Prediction of beef carcass and meat traits from rearing factors in young bulls and cull cows.

Soulat J, Picard B, Léger S, Monteils V.

J Anim Sci. 2016 Apr;94(4):1712-26. doi: 10.2527/jas.2015-0164.


Changes in Occlusal Caries Lesion Management in France from 2002 to 2012: A Persistent Gap between Evidence and Clinical Practice.

Doméjean S, Léger S, Maltrait M, Espelid I, Tveit AB, Tubert-Jeannin S.

Caries Res. 2015;49(4):408-16. doi: 10.1159/000381355. Epub 2015 Jun 24.


A quality indicator can be biased by intra-hospital heterogeneity: the case for quality of patient record keeping in France.

Lelong A, Léger S, Vendittelli F, Blanquet M, Thuong CT, Belgacem B, Gerbaud L.

Eur J Public Health. 2015 Oct;25(5):787-91. doi: 10.1093/eurpub/ckv085. Epub 2015 May 16.


Argenta clinical classification of deformational plagiocephaly.

Branch LG, Kesty K, Krebs E, Wright L, Leger S, David LR.

J Craniofac Surg. 2015 May;26(3):606-10. doi: 10.1097/SCS.0000000000001511.


Enrichment of Triticum aestivum gene annotations using ortholog cliques and gene ontologies in other plants.

Tulpan D, Leger S, Tchagang A, Pan Y.

BMC Genomics. 2015 Apr 15;16:299. doi: 10.1186/s12864-015-1496-2.


Ex vivo heat retention of different eyelid warming masks.

Lacroix Z, Léger S, Bitton E.

Cont Lens Anterior Eye. 2015 Jun;38(3):152-6. doi: 10.1016/j.clae.2015.01.005. Epub 2015 Feb 27.


How do dental students determine patients' caries risk level using the Caries Management By Risk Assessment (CAMBRA) system?

Doméjean S, Léger S, Rechmann P, White JM, Featherstone JD.

J Dent Educ. 2015 Mar;79(3):278-85.


Resin infiltration of non-cavitated caries lesions: a systematic review.

Doméjean S, Ducamp R, Léger S, Holmgren C.

Med Princ Pract. 2015;24(3):216-21. doi: 10.1159/000371709. Epub 2015 Feb 6. Review.


Deformational plagiocephaly and craniosynostosis: trends in diagnosis and treatment after the "back to sleep" campaign.

Branch LG, Kesty K, Krebs E, Wright L, Leger S, David LR.

J Craniofac Surg. 2015 Jan;26(1):147-50. doi: 10.1097/SCS.0000000000001401.


Positive and cost-effectiveness effect of spa therapy on the resumption of occupational and non-occupational activities in women in breast cancer remission: a French multicentre randomised controlled trial.

Mourgues C, Gerbaud L, Leger S, Auclair C, Peyrol F, Blanquet M, Kwiatkowski F, Leger-Enreille A, Bignon YJ.

Eur J Oncol Nurs. 2014 Oct;18(5):505-11. doi: 10.1016/j.ejon.2014.04.008. Epub 2014 May 29.


HyDEn: a hybrid steganocryptographic approach for data encryption using randomized error-correcting DNA codes.

Tulpan D, Regoui C, Durand G, Belliveau L, Léger S.

Biomed Res Int. 2013;2013:634832. doi: 10.1155/2013/634832. Epub 2013 Jul 28.


Prognostic factors of paraneoplastic pemphigus.

Leger S, Picard D, Ingen-Housz-Oro S, Arnault JP, Aubin F, Carsuzaa F, Chaumentin G, Chevrant-Breton J, Chosidow O, Crickx B, D'incan M, Dandurand M, Debarbieux S, Delaporte E, Dereure O, Doutre MS, Guillet G, Jullien D, Kupfer I, Lacour JP, Leonard F, Lok C, Machet L, Martin L, Paul C, Pignon JM, Robert C, Thomas L, Weiller PJ, Ferranti V, Gilbert D, Courville P, Houivet E, Benichou J, Joly P.

Arch Dermatol. 2012 Oct;148(10):1165-72.


Novel and recurrent non-truncating mutations of the MITF basic domain: genotypic and phenotypic variations in Waardenburg and Tietz syndromes.

Léger S, Balguerie X, Goldenberg A, Drouin-Garraud V, Cabot A, Amstutz-Montadert I, Young P, Joly P, Bodereau V, Holder-Espinasse M, Jamieson RV, Krause A, Chen H, Baumann C, Nunes L, Dollfus H, Goossens M, Pingault V.

Eur J Hum Genet. 2012 May;20(5):584-7. doi: 10.1038/ejhg.2011.234. Epub 2012 Jan 18.


Discovery of potent and liver-targeted stearoyl-CoA desaturase (SCD) inhibitors in a bispyrrolidine series.

Lachance N, Gareau Y, Guiral S, Huang Z, Isabel E, Leclerc JP, Léger S, Martins E, Nadeau C, Oballa RM, Ouellet SG, Powell DA, Ramtohul YK, Tranmer GK, Trinh T, Wang H, Zhang L.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):980-4. doi: 10.1016/j.bmcl.2011.12.002. Epub 2011 Dec 8.


Addressing children's oral health inequalities: caries experience before and after the implementation of an oral health promotion program.

Tubert-Jeannin S, Leger S, Manevy R.

Acta Odontol Scand. 2012 May;70(3):255-64. doi: 10.3109/00016357.2011.645059. Epub 2012 Feb 3.


MetaboHunter: an automatic approach for identification of metabolites from 1H-NMR spectra of complex mixtures.

Tulpan D, Léger S, Belliveau L, Culf A, Cuperlović-Culf M.

BMC Bioinformatics. 2011 Oct 14;12:400. doi: 10.1186/1471-2105-12-400.


Bicyclic heteroaryl inhibitors of stearoyl-CoA desaturase: from systemic to liver-targeting inhibitors.

Ramtohul YK, Powell D, Leclerc JP, Leger S, Oballa R, Black C, Isabel E, Li CS, Crane S, Robichaud J, Guay J, Guiral S, Zhang L, Huang Z.

Bioorg Med Chem Lett. 2011 Oct 1;21(19):5692-6. doi: 10.1016/j.bmcl.2011.08.037. Epub 2011 Aug 12.


[Interstitial pneumonia after infliximab therapy for psoriasis].

Leger S, Etienne M, Duval-Modeste AB, Roussel A, Caron F, Thiberville L.

Ann Dermatol Venereol. 2011 Jun-Jul;138(6-7):499-503. doi: 10.1016/j.annder.2011.01.043. Epub 2011 Mar 21. French.


Difluoroethylamines as an amide isostere in inhibitors of cathepsin K.

Isabel E, Mellon C, Boyd MJ, Chauret N, Deschênes D, Desmarais S, Falgueyret JP, Gauthier JY, Khougaz K, Lau CK, Léger S, Levorse DA, Li CS, Massé F, Percival MD, Roy B, Scheigetz J, Thérien M, Truong VL, Wesolowski G, Young RN, Zamboni R, Black WC.

Bioorg Med Chem Lett. 2011 Feb 1;21(3):920-3. doi: 10.1016/j.bmcl.2010.12.070. Epub 2010 Dec 19.


The microarray manual curation tool (MMCT): A Web server for microarray probe evaluations.

Tulpan D, Belliveau L, Léger S.

Bioinformation. 2010 Feb 28;4(8):344-6.


Time to recovery in diabetes and comorbidities following Hurricane Katrina.

Thethi TK, Yau CL, Shi L, Leger S, Nagireddy P, Waddadar J, Surampudi P, John-Kalarickal J, Yenoby L, Fonseca V.

Disaster Med Public Health Prep. 2010 Sep;4 Suppl 1:S33-8. doi: 10.1001/dmp.2010.10.


Free energy estimation of short DNA duplex hybridizations.

Tulpan D, Andronescu M, Leger S.

BMC Bioinformatics. 2010 Feb 24;11:105. doi: 10.1186/1471-2105-11-105.


The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor.

Isabel E, Bateman KP, Chauret N, Cromlish W, Desmarais S, Duong LT, Falgueyret JP, Gauthier JY, Lamontagne S, Lau CK, Léger S, LeRiche T, Lévesque JF, Li CS, Massé F, McKay DJ, Mellon C, Nicoll-Griffith DA, Oballa RM, Percival MD, Riendeau D, Robichaud J, Rodan GA, Rodan SB, Seto C, Thérien M, Truong VL, Wesolowski G, Young RN, Zamboni R, Black WC.

Bioorg Med Chem Lett. 2010 Feb 1;20(3):887-92. doi: 10.1016/j.bmcl.2009.12.083. Epub 2009 Dec 28.


Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438).

Léger S, Black WC, Deschenes D, Dolman S, Falgueyret JP, Gagnon M, Guiral S, Huang Z, Guay J, Leblanc Y, Li CS, Massé F, Oballa R, Zhang L.

Bioorg Med Chem Lett. 2010 Jan 15;20(2):499-502. doi: 10.1016/j.bmcl.2009.11.111. Epub 2009 Nov 26.


Responses of hepatic blood flows to changes in intake in sheep: a meta-analysis.

Vernet J, Nozière P, Léger S, Sauvant D, Ortigues-Marty I.

Animal. 2009 Oct;3(10):1387-400. doi: 10.1017/S1751731109004625.


Caries management decision: influence of dentist and patient factors in the provision of dental services.

Doméjean-Orliaguet S, Léger S, Auclair C, Gerbaud L, Tubert-Jeannin S.

J Dent. 2009 Nov;37(11):827-34. doi: 10.1016/j.jdent.2009.06.012. Epub 2009 Jun 27.


Impact of a natural disaster on diabetes: exacerbation of disparities and long-term consequences.

Fonseca VA, Smith H, Kuhadiya N, Leger SM, Yau CL, Reynolds K, Shi L, McDuffie RH, Thethi T, John-Kalarickal J.

Diabetes Care. 2009 Sep;32(9):1632-8. doi: 10.2337/dc09-0670. Epub 2009 Jun 19.


Lethal bluetongue virus serotype 1 infection in llamas.

Meyer G, Lacroux C, Léger S, Top S, Goyeau K, Deplanche M, Lemaire M.

Emerg Infect Dis. 2009 Apr;15(4):608-10. doi: 10.3201/eid1504.081514. No abstract available.


Identification of a nonbasic, nitrile-containing cathepsin K inhibitor (MK-1256) that is efficacious in a monkey model of osteoporosis.

Robichaud J, Black WC, Thérien M, Paquet J, Oballa RM, Bayly CI, McKay DJ, Wang Q, Isabel E, Léger S, Mellon C, Kimmel DB, Wesolowski G, Percival MD, Massé F, Desmarais S, Falgueyret JP, Crane SN.

J Med Chem. 2008 Oct 23;51(20):6410-20. doi: 10.1021/jm800610j. Epub 2008 Sep 24.


Early changes in biomarkers of skeletal metabolism and their association to the occurrence of osteochondrosis (OC) in the horse.

Donabédian M, van Weeren PR, Perona G, Fleurance G, Robert C, Léger S, Bergero D, Lepage O, Martin-Rosset W.

Equine Vet J. 2008 May;40(3):253-9. doi: 10.2746/042516408X273657.


The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K.

Gauthier JY, Chauret N, Cromlish W, Desmarais S, Duong LT, Falgueyret JP, Kimmel DB, Lamontagne S, Léger S, LeRiche T, Li CS, Massé F, McKay DJ, Nicoll-Griffith DA, Oballa RM, Palmer JT, Percival MD, Riendeau D, Robichaud J, Rodan GA, Rodan SB, Seto C, Thérien M, Truong VL, Venuti MC, Wesolowski G, Young RN, Zamboni R, Black WC.

Bioorg Med Chem Lett. 2008 Feb 1;18(3):923-8. doi: 10.1016/j.bmcl.2007.12.047. Epub 2008 Jan 15.


How to combine hygiene and radiation protection for radiopharmaceuticals preparation? Analysis in France and propositions.

Biechlin ML, Léger S, Vial F, Desruet MD.

Nucl Med Commun. 2007 Nov;28(11):876-8.


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