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Items: 1 to 50 of 133

1.

Discovery of an intrasubunit nicotinic acetylcholine receptor binding site for the positive allosteric modulator Br-PBTC.

Norleans J, Wang J, Kuryatov A, Leffler A, Doebelin C, Kamenecka TM, Lindstrom J.

J Biol Chem. 2019 Jun 20. pii: jbc.RA118.006253. doi: 10.1074/jbc.RA118.006253. [Epub ahead of print]

2.

Acetaminophen-induced liver injury is mediated by the ion channel TRPV4.

Echtermeyer F, Eberhardt M, Risser L, Herzog C, Gueler F, Khalil M, Engel M, Vondran F, Leffler A.

FASEB J. 2019 Jun 17:fj201802233R. doi: 10.1096/fj.201802233R. [Epub ahead of print]

PMID:
31207191
3.

Albumin combined with Mannitol impairs whole blood coagulation and platelet function in vitro.

Palmaers T, Hinsenkamp J, Krämer E, Leffler A, Flentje M, Sieg L, Eismann H.

J Neurosurg Sci. 2019 May 6. doi: 10.23736/S0390-5616.19.04679-4. [Epub ahead of print]

PMID:
31079437
4.

[Erratum to: Catheterization of the subclavian vein and the risk of pneumothorax : Mechanical ventilation increases the risk of pneumothorax during infraclavicular subclavian vein catheterization: a prospective randomized trial].

Palmaers T, Frank P, Eismann H, Sieg L, Leffler A, Schmitt H, Scholler A.

Anaesthesist. 2019 May;68(5):308. doi: 10.1007/s00101-019-0593-z. German. No abstract available.

PMID:
30980184
5.

[Catheterization of the subclavian vein and the risk of pneumothorax : Mechanical ventilation increases the risk of pneumothorax during infraclavicular landmark-guided subclavian vein puncture: a prospective randomized study].

Palmaers T, Frank P, Eismann H, Sieg L, Leffler A, Schmitt H, Scholler A.

Anaesthesist. 2019 May;68(5):309-316. doi: 10.1007/s00101-019-0579-x. German. Erratum in: Anaesthesist. 2019 Apr 12;:.

PMID:
30899972
6.

Standardised electronic algorithms for monitoring prophylaxis of postoperative nausea and vomiting.

Gillmann HJ, Wasilenko S, Züger J, Petersen A, Klemann A, Leffler A, Stueber T.

Arch Med Sci. 2019 Mar;15(2):408-415. doi: 10.5114/aoms.2019.83293. Epub 2019 Mar 4.

7.

Impact of the laryngeal tube as supraglottic airway device on blood flow of the internal carotid artery in patients undergoing general anaesthesia.

Eismann H, Sieg L, Otten O, Leffler A, Palmaers T.

Resuscitation. 2019 May;138:141-145. doi: 10.1016/j.resuscitation.2019.03.010. Epub 2019 Mar 15.

PMID:
30885823
8.

Migratory goose arrival time plays a larger role in influencing forage quality than advancing springs in an Arctic coastal wetland.

Beard KH, Choi RT, Leffler AJ, Carlson LG, Kelsey KC, Schmutz JA, Welker JM.

PLoS One. 2019 Mar 13;14(3):e0213037. doi: 10.1371/journal.pone.0213037. eCollection 2019.

9.

Etomidate and propylene glycol activate nociceptive TRP ion channels.

Niedermirtl F, Eberhardt M, Namer B, Leffler A, Nau C, Reeh PW, Kistner K.

Mol Pain. 2018 Jan-Dec;14:1744806918811699. doi: 10.1177/1744806918811699. Epub 2018 Oct 22.

PMID:
30345869
10.

Delayed herbivory by migratory geese increases summer-long CO2 uptake in coastal western Alaska.

Leffler AJ, Beard KH, Kelsey KC, Choi RT, Schmutz JA, Welker JM.

Glob Chang Biol. 2019 Jan;25(1):277-289. doi: 10.1111/gcb.14473. Epub 2018 Nov 18.

PMID:
30295398
11.

Potent and Orally Bioavailable Inverse Agonists of RORγt Resulting from Structure-Based Design.

Narjes F, Xue Y, von Berg S, Malmberg J, Llinas A, Olsson RI, Jirholt J, Grindebacke H, Leffler A, Hossain N, Lepistö M, Thunberg L, Leek H, Aagaard A, McPheat J, Hansson EL, Bäck E, Tångefjord S, Chen R, Xiong Y, Hongbin G, Hansson TG.

J Med Chem. 2018 Sep 13;61(17):7796-7813. doi: 10.1021/acs.jmedchem.8b00783. Epub 2018 Aug 27.

PMID:
30095900
12.

Canine urinary bladder transitional cell carcinoma tumor volume is dependent on imaging modality and measurement technique.

Leffler AJ, Hostnik ET, Warry EE, Habing GG, Auld DM, Green EM, Drost WT.

Vet Radiol Ultrasound. 2018 Nov;59(6):767-776. doi: 10.1111/vru.12652. Epub 2018 Jul 10.

PMID:
29989254
13.

Heat-resistant action potentials require TTX-resistant sodium channels NaV1.8 and NaV1.9.

Touska F, Turnquist B, Vlachova V, Reeh PW, Leffler A, Zimmermann K.

J Gen Physiol. 2018 Aug 6;150(8):1125-1144. doi: 10.1085/jgp.201711786. Epub 2018 Jul 3.

14.

Arctic plant ecophysiology and water source utilization in response to altered snow: isotopic (δ18O and δ2H) evidence for meltwater subsidies to deciduous shrubs.

Jespersen RG, Leffler AJ, Oberbauer SF, Welker JM.

Oecologia. 2018 Aug;187(4):1009-1023. doi: 10.1007/s00442-018-4196-1. Epub 2018 Jun 28.

PMID:
29955988
15.

Dynamic mechanical allodynia in the secondary hyperalgesic area in the capsaicin model-Perceptually similar phenomena as in painful neuropathy?

Samuelsson M, Leffler AS, Hansson P.

Scand J Pain. 2011 Apr 1;2(2):85-92. doi: 10.1016/j.sjpain.2011.01.003.

PMID:
29913725
16.

Calcium, Sodium, and Transient Receptor Potential Channel Expression in Human Fetal Midbrain-Derived Neural Progenitor Cells.

Stanslowsky N, Tharmarasa S, Staege S, Kalmbach N, Klietz M, Schwarz SC, Leffler A, Wegner F.

Stem Cells Dev. 2018 Jul 15;27(14):976-984. doi: 10.1089/scd.2017.0281. Epub 2018 Jun 14.

PMID:
29779467
17.

[Epigenetics: more interesting than relevant for clinicians?]

Leffler A.

Anaesthesist. 2018 Apr;67(4):245. doi: 10.1007/s00101-018-0436-3. German. No abstract available.

PMID:
29632998
18.

Sodium Channel Nav1.3 Is Expressed by Polymorphonuclear Neutrophils during Mouse Heart and Kidney Ischemia In Vivo and Regulates Adhesion, Transmigration, and Chemotaxis of Human and Mouse Neutrophils In Vitro.

Poffers M, Bühne N, Herzog C, Thorenz A, Chen R, Güler F, Hage A, Leffler A, Echtermeyer F.

Anesthesiology. 2018 Jun;128(6):1151-1166. doi: 10.1097/ALN.0000000000002135.

PMID:
29509584
19.

Opening Remarks.

Leffler A, Spivak H.

J Interpers Violence. 2018 Mar;33(5):715-718. doi: 10.1177/0886260517752233. No abstract available.

PMID:
29411693
20.

Compatibility of common IV drugs with 6% hydroxyethyl starch 130/0.42 and 4% gelatin.

Heiderich S, Auf der Springe A, Jürgens J, Koppert W, Leffler A, Sümpelmann R, Dennhardt N.

Paediatr Anaesth. 2018 Feb;28(2):87-93. doi: 10.1111/pan.13309. Epub 2018 Jan 9.

PMID:
29315987
21.

A systematic decision-making process on the need for updating clinical practice guidelines proved to be feasible in a pilot study.

Becker M, Jaschinski T, Eikermann M, Mathes T, Bühn S, Koppert W, Leffler A, Neugebauer E, Pieper D.

J Clin Epidemiol. 2018 Apr;96:101-109. doi: 10.1016/j.jclinepi.2017.12.011. Epub 2017 Dec 28.

PMID:
29289763
22.

Activation of the capsaicin-receptor TRPV1 by the acetaminophen metabolite N-arachidonoylaminophenol results in cytotoxicity.

Stueber T, Meyer S, Jangra A, Hage A, Eberhardt M, Leffler A.

Life Sci. 2018 Feb 1;194:67-74. doi: 10.1016/j.lfs.2017.12.024. Epub 2017 Dec 19.

PMID:
29273526
23.

TRPA1 and TRPV1 are required for lidocaine-evoked calcium influx and neuropeptide release but not cytotoxicity in mouse sensory neurons.

Eberhardt M, Stueber T, de la Roche J, Herzog C, Leffler A, Reeh PW, Kistner K.

PLoS One. 2017 Nov 15;12(11):e0188008. doi: 10.1371/journal.pone.0188008. eCollection 2017.

24.

Differential cytotoxicity and intracellular calcium-signalling following activation of the calcium-permeable ion channels TRPV1 and TRPA1.

Stueber T, Eberhardt MJ, Caspi Y, Lev S, Binshtok A, Leffler A.

Cell Calcium. 2017 Dec;68:34-44. doi: 10.1016/j.ceca.2017.10.003. Epub 2017 Oct 18.

PMID:
29129206
25.

Reactive metabolites of acetaminophen activate and sensitize the capsaicin receptor TRPV1.

Eberhardt MJ, Schillers F, Eberhardt EM, Risser L, de la Roche J, Herzog C, Echtermeyer F, Leffler A.

Sci Rep. 2017 Oct 6;7(1):12775. doi: 10.1038/s41598-017-13054-3.

26.

Investigation into the role of an extracellular loop in mediating proton-evoked inhibition of voltage-gated sodium channels.

Harms E, Stoetzer C, Stueber T, O'Reilly AO, Leffler A.

Neurosci Lett. 2017 Nov 20;661:5-10. doi: 10.1016/j.neulet.2017.09.039. Epub 2017 Sep 20.

PMID:
28939386
27.

Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models.

Leffler AE, Kuryatov A, Zebroski HA, Powell SR, Filipenko P, Hussein AK, Gorson J, Heizmann A, Lyskov S, Tsien RW, Poget SF, Nicke A, Lindstrom J, Rudy B, Bonneau R, Holford M.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E8100-E8109. doi: 10.1073/pnas.1703952114. Epub 2017 Sep 5.

28.

Inhibition of Voltage-Gated Na+ Channels by Bupivacaine Is Enhanced by the Adjuvants Buprenorphine, Ketamine, and Clonidine.

Stoetzer C, Martell C, de la Roche J, Leffler A.

Reg Anesth Pain Med. 2017 Jul/Aug;42(4):462-468. doi: 10.1097/AAP.0000000000000596.

PMID:
28394849
29.

[Antipyretics in intensive care patients].

Simon A, Leffler A.

Anaesthesist. 2017 Jul;66(7):511-517. doi: 10.1007/s00101-017-0301-9. Review. German.

PMID:
28364306
30.

The use of dipyrone in the ICU is associated with acute kidney injury: A retrospective cohort analysis.

Stueber T, Buessecker L, Leffler A, Gillmann HJ.

Eur J Anaesthesiol. 2017 Oct;34(10):673-680. doi: 10.1097/EJA.0000000000000627.

PMID:
28306590
31.

The leukotriene B4 receptors BLT1 and BLT2 form an antagonistic sensitizing system in peripheral sensory neurons.

Zinn S, Sisignano M, Kern K, Pierre S, Tunaru S, Jordan H, Suo J, Treutlein EM, Angioni C, Ferreiros N, Leffler A, DeBruin N, Offermanns S, Geisslinger G, Scholich K.

J Biol Chem. 2017 Apr 14;292(15):6123-6134. doi: 10.1074/jbc.M116.769125. Epub 2017 Feb 27.

32.

Optimization of initial propofol bolus dose for EEG Narcotrend Index-guided transition from sevoflurane induction to intravenous anesthesia in children.

Dennhardt N, Boethig D, Beck C, Heiderich S, Boehne M, Leffler A, Schultz B, Sümpelmann R.

Paediatr Anaesth. 2017 Apr;27(4):425-432. doi: 10.1111/pan.13118. Epub 2017 Feb 18.

PMID:
28213945
33.

Epigenetic divergence in the TRPA1 promoter correlates with pressure pain thresholds in healthy individuals.

Gombert S, Rhein M, Eberhardt M, Münster T, Bleich S, Leffler A, Frieling H.

Pain. 2017 Apr;158(4):698-704. doi: 10.1097/j.pain.0000000000000815.

PMID:
28030472
34.

Cardiotoxic Antiemetics Metoclopramide and Domperidone Block Cardiac Voltage-Gated Na+ Channels.

Stoetzer C, Voelker M, Doll T, Heineke J, Wegner F, Leffler A.

Anesth Analg. 2017 Jan;124(1):52-60.

PMID:
27861438
35.

Lactate is a potent inhibitor of the capsaicin receptor TRPV1.

de la Roche J, Walther I, Leonow W, Hage A, Eberhardt M, Fischer M, Reeh PW, Sauer S, Leffler A.

Sci Rep. 2016 Nov 9;6:36740. doi: 10.1038/srep36740.

36.

Propacetamol-Induced Injection Pain Is Associated with Activation of Transient Receptor Potential Vanilloid 1 Channels.

Schillers F, Eberhardt E, Leffler A, Eberhardt M.

J Pharmacol Exp Ther. 2016 Oct;359(1):18-25. doi: 10.1124/jpet.116.233452. Epub 2016 Jul 25.

PMID:
27457427
37.

Oxidation differentially modulates the recombinant voltage-gated Na(+) channel α-subunits Nav1.7 and Nav1.8.

Schlüter F, Leffler A.

Brain Res. 2016 Oct 1;1648(Pt A):127-135. doi: 10.1016/j.brainres.2016.07.031. Epub 2016 Jul 19.

PMID:
27450927
38.

[Pain and analgesia : Mutations of voltage-gated sodium channels].

Eberhardt MJ, Leffler A.

Schmerz. 2017 Feb;31(1):14-22. doi: 10.1007/s00482-016-0139-0. German.

PMID:
27402262
39.

Local-anesthetic like inhibition of the cardiac sodium channel Nav1.5 α-subunit by 5-HT3 receptor antagonists.

Van't Klooster MP, Foadi N, Hage A, Stoetzer C, Wegner F, Eberhardt M, Leffler A.

Eur J Pharmacol. 2016 Oct 15;789:119-126. doi: 10.1016/j.ejphar.2016.07.020. Epub 2016 Jul 9.

PMID:
27401036
40.

Human TRPA1 is a heat sensor displaying intrinsic U-shaped thermosensitivity.

Moparthi L, Kichko TI, Eberhardt M, Högestätt ED, Kjellbom P, Johanson U, Reeh PW, Leffler A, Filipovic MR, Zygmunt PM.

Sci Rep. 2016 Jun 28;6:28763. doi: 10.1038/srep28763.

41.

Optimized preoperative fasting times decrease ketone body concentration and stabilize mean arterial blood pressure during induction of anesthesia in children younger than 36 months: a prospective observational cohort study.

Dennhardt N, Beck C, Huber D, Sander B, Boehne M, Boethig D, Leffler A, Sümpelmann R.

Paediatr Anaesth. 2016 Aug;26(8):838-43. doi: 10.1111/pan.12943. Epub 2016 Jun 13.

PMID:
27291355
42.

Misexpression of Tbx18 in cardiac chambers of fetal mice interferes with chamber-specific developmental programs but does not induce a pacemaker-like gene signature.

Greulich F, Trowe MO, Leffler A, Stoetzer C, Farin HF, Kispert A.

J Mol Cell Cardiol. 2016 Aug;97:140-9. doi: 10.1016/j.yjmcc.2016.05.004. Epub 2016 May 11.

PMID:
27180262
43.

Differential inhibition of cardiac and neuronal Na(+) channels by the selective serotonin-norepinephrine reuptake inhibitors duloxetine and venlafaxine.

Stoetzer C, Papenberg B, Doll T, Völker M, Heineke J, Stoetzer M, Wegner F, Leffler A.

Eur J Pharmacol. 2016 Jul 15;783:1-10. doi: 10.1016/j.ejphar.2016.04.051. Epub 2016 Apr 27.

PMID:
27130441
44.

From Mollusks to Medicine: A Venomics Approach for the Discovery and Characterization of Therapeutics from Terebridae Peptide Toxins.

Verdes A, Anand P, Gorson J, Jannetti S, Kelly P, Leffler A, Simpson D, Ramrattan G, Holford M.

Toxins (Basel). 2016 Apr 19;8(4):117. doi: 10.3390/toxins8040117. Review.

45.

Compatibility of common drugs with acetate-containing balanced electrolyte solutions in pediatric anesthesia.

Heiderich S, Jürgens J, Rudolf D, Dennhardt N, Echtermeyer F, Leffler A, Sümpelmann R, Lichtinghagen R, Witt L.

Paediatr Anaesth. 2016 Jun;26(6):590-8. doi: 10.1111/pan.12889. Epub 2016 Mar 24.

PMID:
27012479
46.

Tetrodotoxin-sensitive α-subunits of voltage-gated sodium channels are relevant for inhibition of cardiac sodium currents by local anesthetics.

Stoetzer C, Doll T, Stueber T, Herzog C, Echtermeyer F, Greulich F, Rudat C, Kispert A, Wegner F, Leffler A.

Naunyn Schmiedebergs Arch Pharmacol. 2016 Jun;389(6):625-36. doi: 10.1007/s00210-016-1231-9. Epub 2016 Mar 22.

PMID:
27000037
47.

Quaternary Lidocaine Derivative QX-314 Activates and Permeates Human TRPV1 and TRPA1 to Produce Inhibition of Sodium Channels and Cytotoxicity.

Stueber T, Eberhardt MJ, Hadamitzky C, Jangra A, Schenk S, Dick F, Stoetzer C, Kistner K, Reeh PW, Binshtok AM, Leffler A.

Anesthesiology. 2016 May;124(5):1153-65. doi: 10.1097/ALN.0000000000001050.

PMID:
26859646
48.

Coupled long-term summer warming and deeper snow alters species composition and stimulates gross primary productivity in tussock tundra.

Leffler AJ, Klein ES, Oberbauer SF, Welker JM.

Oecologia. 2016 May;181(1):287-97. doi: 10.1007/s00442-015-3543-8. Epub 2016 Jan 8.

PMID:
26747269
49.

Impact of high doses of 6% hydroxyethyl starch 130/0.42 and 4% gelatin on renal function in a pediatric animal model.

Witt L, Glage S, Lichtinghagen R, Pape L, Boethig D, Dennhardt N, Heiderich S, Leffler A, Sümpelmann R.

Paediatr Anaesth. 2016 Mar;26(3):259-65. doi: 10.1111/pan.12834. Epub 2015 Dec 30.

PMID:
26714833
50.

Inhibition of the cardiac Na⁺ channel α-subunit Nav1.5 by propofol and dexmedetomidine.

Stoetzer C, Reuter S, Doll T, Foadi N, Wegner F, Leffler A.

Naunyn Schmiedebergs Arch Pharmacol. 2016 Mar;389(3):315-25. doi: 10.1007/s00210-015-1195-1. Epub 2015 Dec 15.

PMID:
26667357

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