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Deficiency of the Fanconi anemia E2 ubiqitin conjugase UBE2T only partially abrogates Alu-mediated recombination in a new model of homology dependent recombination.

Lewis TW, Barthelemy JR, Virts EL, Kennedy FM, Gadgil RY, Wiek C, Linka RM, Zhang F, Andreassen PR, Hanenberg H, Leffak M.

Nucleic Acids Res. 2019 Apr 23;47(7):3503-3520. doi: 10.1093/nar/gkz026.


Interaction between DUE-B and Treslin is required to load Cdc45 on chromatin in human cells.

Poudel S, Yao J, Kemp MG, Leffak M.

J Biol Chem. 2018 Sep 14;293(37):14497-14506. doi: 10.1074/jbc.RA118.004519. Epub 2018 Jul 23.


Break-induced replication links microsatellite expansion to complex genome rearrangements.

Leffak M.

Bioessays. 2017 Aug;39(8). doi: 10.1002/bies.201700025. Epub 2017 Jun 16. Review.


Replication stalling and DNA microsatellite instability.

Gadgil R, Barthelemy J, Lewis T, Leffak M.

Biophys Chem. 2017 Jun;225:38-48. doi: 10.1016/j.bpc.2016.11.007. Epub 2016 Nov 22. Review.


FANCJ is essential to maintain microsatellite structure genome-wide during replication stress.

Barthelemy J, Hanenberg H, Leffak M.

Nucleic Acids Res. 2017 Jan 9;45(1):509-511. doi: 10.1093/nar/gkw1091. Epub 2016 Oct 27. No abstract available.


MutSβ promotes trinucleotide repeat expansion by recruiting DNA polymerase β to nascent (CAG)n or (CTG)n hairpins for error-prone DNA synthesis.

Guo J, Gu L, Leffak M, Li GM.

Cell Res. 2016 Jul;26(7):775-86. doi: 10.1038/cr.2016.66. Epub 2016 Jun 3.


FANCJ is essential to maintain microsatellite structure genome-wide during replication stress.

Barthelemy J, Hanenberg H, Leffak M.

Nucleic Acids Res. 2016 Aug 19;44(14):6803-16. doi: 10.1093/nar/gkw433. Epub 2016 May 13. Erratum in: Nucleic Acids Res. 2016 Oct 27;:.


AluY-mediated germline deletion, duplication and somatic stem cell reversion in UBE2T defines a new subtype of Fanconi anemia.

Virts EL, Jankowska A, Mackay C, Glaas MF, Wiek C, Kelich SL, Lottmann N, Kennedy FM, Marchal C, Lehnert E, Scharf RE, Dufour C, Lanciotti M, Farruggia P, Santoro A, Savasan S, Scheckenbach K, Schipper J, Wagenmann M, Lewis T, Leffak M, Farlow JL, Foroud TM, Honisch E, Niederacher D, Chakraborty SC, Vance GH, Pruss D, Timms KM, Lanchbury JS, Alpi AF, Hanenberg H.

Hum Mol Genet. 2015 Sep 15;24(18):5093-108. doi: 10.1093/hmg/ddv227. Epub 2015 Jun 17.


Protein phosphatase 2A and Cdc7 kinase regulate the DNA unwinding element-binding protein in replication initiation.

Gao Y, Yao J, Poudel S, Romer E, Abu-Niaaj L, Leffak M.

J Biol Chem. 2014 Dec 26;289(52):35987-6000. doi: 10.1074/jbc.M114.589119. Epub 2014 Sep 25.


Activation of a human chromosomal replication origin by protein tethering.

Chen X, Liu G, Leffak M.

Nucleic Acids Res. 2013 Jul;41(13):6460-74. doi: 10.1093/nar/gkt368. Epub 2013 May 8.


Hypothesis: local dNTP depletion as the cause of microsatellite repeat instability during replication (comment on DOI 10.1002/bies.201200128).

Leffak M.

Bioessays. 2013 Apr;35(4):305. doi: 10.1002/bies.201300026. No abstract available. Erratum in: Bioessays. 2014 Jun;36(6):627.


Oligodeoxynucleotide binding to (CTG) · (CAG) microsatellite repeats inhibits replication fork stalling, hairpin formation, and genome instability.

Liu G, Chen X, Leffak M.

Mol Cell Biol. 2013 Feb;33(3):571-81. doi: 10.1128/MCB.01265-12. Epub 2012 Nov 19.


Replication fork stalling and checkpoint activation by a PKD1 locus mirror repeat polypurine-polypyrimidine (Pu-Py) tract.

Liu G, Myers S, Chen X, Bissler JJ, Sinden RR, Leffak M.

J Biol Chem. 2012 Sep 28;287(40):33412-23. Epub 2012 Aug 6.


Treslin, DUE-B, and GEMC1 cannot complement Sld3 mutants in fission yeast.

Wang Z, Kim E, Leffak M, Xu YJ.

FEMS Yeast Res. 2012 Jun;12(4):486-90. doi: 10.1111/j.1567-1364.2012.00794.x. Epub 2012 Mar 20.


Instability of (CTG)n•(CAG)n trinucleotide repeats and DNA synthesis.

Liu G, Leffak M.

Cell Biosci. 2012 Feb 27;2(1):7. doi: 10.1186/2045-3701-2-7.


Altered replication in human cells promotes DMPK (CTG)(n) · (CAG)(n) repeat instability.

Liu G, Chen X, Gao Y, Lewis T, Barthelemy J, Leffak M.

Mol Cell Biol. 2012 May;32(9):1618-32. doi: 10.1128/MCB.06727-11. Epub 2012 Feb 21.


Replication-dependent instability at (CTG) x (CAG) repeat hairpins in human cells.

Liu G, Chen X, Bissler JJ, Sinden RR, Leffak M.

Nat Chem Biol. 2010 Sep;6(9):652-9. doi: 10.1038/nchembio.416. Epub 2010 Aug 1.


ATRIP from TopBP1 to ATR--in vitro activation of a DNA damage checkpoint.

Xu YJ, Leffak M.

Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13561-2. doi: 10.1073/pnas.1008909107. Epub 2010 Jul 26. No abstract available.


The DNA unwinding element binding protein DUE-B interacts with Cdc45 in preinitiation complex formation.

Chowdhury A, Liu G, Kemp M, Chen X, Katrangi N, Myers S, Ghosh M, Yao J, Gao Y, Bubulya P, Leffak M.

Mol Cell Biol. 2010 Mar;30(6):1495-507. doi: 10.1128/MCB.00710-09. Epub 2010 Jan 11.


Structure and function of the c-myc DNA-unwinding element-binding protein DUE-B.

Kemp M, Bae B, Yu JP, Ghosh M, Leffak M, Nair SK.

J Biol Chem. 2007 Apr 6;282(14):10441-8. Epub 2007 Jan 30.


Differential binding of replication proteins across the human c-myc replicator.

Ghosh M, Kemp M, Liu G, Ritzi M, Schepers A, Leffak M.

Mol Cell Biol. 2006 Jul;26(14):5270-83.


The synthesis and initial characterization of an immobilized DNA unwinding element binding (DUE-B) protein chromatographic stationary phase.

Moaddel R, Price GB, Juteau JM, Leffak M, Wainer IW.

J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Jun 25;820(2):197-203. Epub 2005 Apr 25.


The c-myc DNA-unwinding element-binding protein modulates the assembly of DNA replication complexes in vitro.

Casper JM, Kemp MG, Ghosh M, Randall GM, Vaillant A, Leffak M.

J Biol Chem. 2005 Apr 1;280(13):13071-83. Epub 2005 Jan 14.


The histone deacetylase inhibitor trichostatin A alters the pattern of DNA replication origin activity in human cells.

Kemp MG, Ghosh M, Liu G, Leffak M.

Nucleic Acids Res. 2005 Jan 13;33(1):325-36. Print 2005. Erratum in: Nucleic Acids Res. 2005;33(2):805.


Transcription factor binding and induced transcription alter chromosomal c-myc replicator activity.

Ghosh M, Liu G, Randall G, Bevington J, Leffak M.

Mol Cell Biol. 2004 Dec;24(23):10193-207. Erratum in: Mol Cell Biol. 2005 Feb;25(3):1213.


Unpaired structures in SCA10 (ATTCT)n.(AGAAT)n repeats.

Potaman VN, Bissler JJ, Hashem VI, Oussatcheva EA, Lu L, Shlyakhtenko LS, Lyubchenko YL, Matsuura T, Ashizawa T, Leffak M, Benham CJ, Sinden RR.

J Mol Biol. 2003 Feb 28;326(4):1095-111.


Multiple functional elements comprise a Mammalian chromosomal replicator.

Liu G, Malott M, Leffak M.

Mol Cell Biol. 2003 Mar;23(5):1832-42.


Replication from oriP of Epstein-Barr virus requires human ORC and is inhibited by geminin.

Dhar SK, Yoshida K, Machida Y, Khaira P, Chaudhuri B, Wohlschlegel JA, Leffak M, Yates J, Dutta A.

Cell. 2001 Aug 10;106(3):287-96.


Multiple sites of replication initiation in the human beta-globin gene locus.

Kamath S, Leffak M.

Nucleic Acids Res. 2001 Feb 1;29(3):809-17.


Major DNA replication initiation sites in the c-myc locus in human cells.

Tao L, Dong Z, Leffak M, Zannis-Hadjopoulos M, Price G.

J Cell Biochem. 2000 Jun 6;78(3):442-57.


Continuing damage to rat retinal DNA during darkness following light exposure.

Specht S, Organisciak DT, Darrow RM, Leffak M.

Photochem Photobiol. 2000 May;71(5):559-66.


DNA methylation at mammalian replication origins.

Rein T, Kobayashi T, Malott M, Leffak M, DePamphilis ML.

J Biol Chem. 1999 Sep 3;274(36):25792-800.


Activity of the c-myc replicator at an ectopic chromosomal location.

Malott M, Leffak M.

Mol Cell Biol. 1999 Aug;19(8):5685-95. Erratum in: Mol Cell Biol 1999 Dec;19(12):8694.


A bifunctional regulatory element of the human ApoA-I gene responsive to a distal enhancer.

Jones DR, Leffak M.

DNA Cell Biol. 1999 Feb;18(2):107-19.


Damage to rat retinal DNA induced in vivo by visible light.

Specht S, Leffak M, Darrow RM, Organisciak DT.

Photochem Photobiol. 1999 Jan;69(1):91-8.


Multiple initiations in the c-myc replication origin independent of chromosomal location.

Trivedi A, Waltz SE, Kamath S, Leffak M.

DNA Cell Biol. 1998 Oct;17(10):885-96.


Amplification of the translocated c-myc genes in three Burkitt lymphoma cell lines.

Khaira P, James CD, Leffak M.

Gene. 1998 Apr 28;211(1):101-8.


DNA replication initiates non-randomly at multiple sites near the c-myc gene in HeLa cells.

Waltz SE, Trivedi AA, Leffak M.

Nucleic Acids Res. 1996 May 15;24(10):1887-94.


In vitro replication of plasmids containing human c-myc DNA.

Berberich S, Trivedi A, Daniel DC, Johnson EM, Leffak M.

J Mol Biol. 1995 Jan 13;245(2):92-109.


Sequence of a tRNA gene cluster from the thermophilic Bacillus sp. strain PS3.

Fink PS, Zhao YM, Leffak M, Prochaska LJ.

Nucleic Acids Res. 1991 Nov 25;19(22):6334. No abstract available.


Conserved chromatin structure in c-myc 5'flanking DNA after viral transduction.

Kumar S, Leffak M.

J Mol Biol. 1991 Nov 5;222(1):45-57.


Nucleotide sequence of a 23S and a 5S-like rRNA gene from the thermophilic Bacillus sp. strain PS3.

Fink PS, Zhao Y, Prochaska LJ, Leffak M.

Nucleic Acids Res. 1991 Oct 11;19(19):5437. No abstract available.


DNA topology of the ordered chromatin domain 5' to the human c-myc gene.

Kumar S, Leffak M.

Nucleic Acids Res. 1989 Apr 11;17(7):2819-33.

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